Clofarabine (2-chloro-2′-fluoro-2′-deoxyarabinosyladenine) - Biochemical aspects of anticancer activity

Acta Poloniae Pharmaceutica - Drug Research

Volumn 68, Issue 4, 2011, Pages 459-466

  Majda, Katarzyna ^a   Lubecka, Katarzyna ^a   Kaufman Szymczyk, Agnieszka ^a   Fabianowska Majewska, Krystyna ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

2 Chloro 2 fluoro 2 deoxyarabinosyladenine; Antileukemic adenosine analogues; Clofarabine

Indexed keywords

CLADRIBINE; CLOFARABINE; CYCLOPHOSPHAMIDE; CYTARABINE; DNA POLYMERASE; FLUDARABINE; MESSENGER RNA; RIBONUCLEOTIDE REDUCTASE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW APLASIA; BONE MARROW SUPPRESSION; CHILDHOOD LEUKEMIA; CLINICAL TRIAL (TOPIC); CYTOTOXICITY; DNA STRAND BREAKAGE; DNA SYNTHESIS INHIBITION; DRUG BIOAVAILABILITY; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; LIVER TOXICITY; LOW DRUG DOSE; LUNG MYCOSIS; LYMPHOPROLIFERATIVE DISEASE; MULTIPLE ORGAN FAILURE; MYELODYSPLASTIC SYNDROME; NONHUMAN; OPTIMAL DRUG DOSE; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN EXPRESSION; SOLID TUMOR; TREATMENT RESPONSE; UPREGULATION;

ADENINE NUCLEOTIDES; ADULT; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARABINONUCLEOSIDES; BIOTRANSFORMATION; CHILD; DNA REPLICATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR STRUCTURE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959587463     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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