Pilot study of nelarabine in combination with intensive chemotherapy in high-risk T-cell acute lymphoblastic leukemia: A report from the Children's Oncology Group

Journal of Clinical Oncology

Volumn 30, Issue 22, 2012, Pages 2753-2759

  Dunsmore, Kimberly P ^a   Devidas, Meenakshi ^b   Linda, Stephen B ^b   Borowitz, Michael J ^c   Winick, Naomi ^d   Hunger, Stephen P ^e   Carroll, William L ^f   Camitta, Bruce M ^g  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^g MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINASE; ASPARAGINASE MACROGOL; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; FOLINIC ACID; MERCAPTOPURINE; METHOTREXATE; NELARABINE; PAROXETINE; PREDNISONE; TIOGUANINE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; BONE MARROW SUPPRESSION; BRAIN HEMORRHAGE; BRAIN PSEUDOTUMOR; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHILD; DRUG SAFETY; DRUG TOLERABILITY; EVENT FREE SURVIVAL; FEMALE; GUILLAIN BARRE SYNDROME; HUMAN; INFECTION; LETHARGY; MAJOR CLINICAL STUDY; MALE; MOTOR NEUROPATHY; MULTIPLE CYCLE TREATMENT; MUSCLE WEAKNESS; NERVE CONDUCTION DISORDER; NEUROTOXICITY; NEUTROPENIA; PANCREATITIS; PERIPHERAL NEUROPATHY; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEIZURE; SENSORY NEUROPATHY; SIDE EFFECT; SOMNOLENCE; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADOLESCENT; ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ARABINONUCLEOSIDES; CHILD; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; INFANT; MALE; PERIPHERAL NERVOUS SYSTEM DISEASES; PILOT PROJECTS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84864566041     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.40.8724     Document Type: Article

References (27)

1. Reiter A, Schrappe M, Ludwig WD, et al: Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients: Results and conclusions of the multicenter trial ALL-BFM 86. Blood 84:3122-3133, 1994 (Pubitemid 24328106)
2. Uckun FM, Reaman G, Steinherez PG, et al: Improved clinic outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: A Children's Cancer Group study. Leuk Lymphoma 24:57-70, 1996
3. Steinherz PG, Gaynon PS, Breneman JC, et al: Treatment of patients with acute lymphoblastic leukemia with bulky extramedullary disease and T-cell phenotype or other poor prognostic features. Cancer 82:600-612, 1998 (Pubitemid 28113001)
4. Laver J, Amylon M, Desai S, et al: Randomized trial of r-metHu granulocyte colony-stimulating factor in an intensive treatment for T-cell leukemia and advance-stage lymphoblastic lymphoma of childhood: A Pediatric Oncology Group pilot study. J Clin Oncol 16:522-526, 1998 (Pubitemid 28135594)
5. Amylon MD, Shuster J, Pullen J, et al: Intensive high-dose asparaginase consolidation improves survival for pediatric patients with T cell acute lymphoblastic leukemia and advance stage lymphoblastic lymphoma: A Pediatric Oncology Group study. Leukemia 13:335-342, 1999 (Pubitemid 29108071)
6. Pui CH, Boyett JM, Rivera GK, et al: Long-term results of total therapy studies 11, 12, 13A for childhood acute lymphoblastic leukemia at St. Jude Children's Research Hospital. Leukemia 14:2286-2294, 2000 (Pubitemid 32042269)
7. Schrappe M, Reiter A, Zimmerman M, et al: Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981-1995. Leukemia 14:2205-2222, 2000 (Pubitemid 32042262)
8. Goldberg J, Silverman L, Levy DE, et al: Childhood T-cell acute lymphoblastic leukemia: The Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium experience. J Clin Oncol 21:3616-3622, 2003 (Pubitemid 46594054)
9. Winter SS, Holdsworth MT, Devidas M, et al: Anti metabolite-based therapy in childhood T-cell acute lymphoblastic leukemia: A report of POG study 9296. Pediatr Blood Cancer 46:179-186, 2006 (Pubitemid 43076068)
10. Pui CH, Sandlund JT, Pei D, et al: Improved outcome for children with acute lymphoblastic leukemia: Results of total Therapy Study XIIIB at St. Jude Children's Research Hospital. Blood 104:2690-2696, 2004 (Pubitemid 39434949)
11. Seibel NL, Steinherz PG, Sather HN, et al: Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: A report from the Children's Oncology Group. Blood 111:2548-2555, 2008
12. Schrauder A, Reiter A, Gadner H, et al: Superiority of allogenic hematopoietic stem-cell transplantation compared with chemotherapy alone in high-risk childhood T-cell acute lymphoblastic leukemia: Results from ALL-BFM 90 and 95. J Clin Oncol 24:5742-5749, 2006 (Pubitemid 46631317)
13. Schrappe M, Valsecchi MG, Bartram CR, et al: Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: Results of the AIEOP-BFM-ALL 2000 study. Blood 118:2077-2084, 2011
14. Willemse MJ, Seriu T, Hettinger K, et al: Detection of minimal residual disease identifies difference in treatment response between T-ALL and precursor B-ALL. Blood 12:4386-4393, 2002 (Pubitemid 34627205)
15. Cavé H, van der Werff ten Bosh J, Suciu S, et al: Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. N Engl J Med 339:591-598, 1998 (Pubitemid 28385656)
16. Coustan-Smith E, Sancho J, Hancock ML, et al: Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia. Blood 96:2691-2696, 2005
17. Dibenedetto SP, Lo Nigro L, Mayer SP, et al: Detectable molecular residual disease at the beginning of maintenance therapy indicates poor outcome in children with T-cell acute lymphblastic leukemia. Blood 90:1226-1232, 1997 (Pubitemid 27314160)
18. Rodriguez CO Jr, Stellrecht CM, Ghandi V: Mechanisms for T-cell selective cytoxicity of arabinosylguanine. Blood 102:1842-1848, 2003 (Pubitemid 37022581)
19. Ravandi F, Gandhi V: Novel purine nucleoside analogues for T-cell lineage acute lymphoblastic leukaemia and lymphoma. Expert Opin Investig Drugs 15:1601-1613, 2006 (Pubitemid 44848982)
20. Beesley AH, Palmer ML, Ford J, et al: In vitro cytotoxicity of nelarabine, clofarabine, and flavopiridol in paediatric acute lymphoblastic leukemia. Br J Haematol 137:109-116, 2007 (Pubitemid 46474708)
21. Kurtzberg J, Ernst TJ, Keating MJ, et al: Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. J Clin Oncol 23:3396-3403, 2005
22. Berg SL, Blaney SM, Devidas M, et al: Phase II study of nelarabine (compound 506U78) in children and young adults with refactory T-cell malignancies: A report from the Children's Oncology Group. J Clin Oncol 15:3376-3382, 2005
23. Porwit-MacDonald A, Björklund E, Lucio P, et al: BIOMED-1 conerted action report: Flowcytometric characterization of CD7+ cell subsets in normal bone marrow as a basis for the diagnosis and follow-up of T cell acute lymphoblastic leukemia (T-ALL). Leukemia 14:816-825, 2000 (Pubitemid 30235058)
24. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
25. Peto R, Pike MC, Armitage P, et al: Design and analysis of randomized clinical trials requiring prolonged observation of each patient: II. Analysis and examples. Br J Cancer 35:1-39, 1977 (Pubitemid 8018922)
26. Rivera GK, Zhou Y, Hancock ML, et al: Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia. Cancer 103:368-376, 2005 (Pubitemid 40129297)
27. Einsiedel HG, von Stackelberg A, Hartmann R, et al: Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: Results of trial Acute Lymphoblastic Leukemia-Relapse study of the Berlin-Frankfurt-Münster Group 87. J Clin Oncol 23:7942-7950, 2005 (Pubitemid 46657394)