Forodesine (BCX-1777, immucillin H) - A new purine nucleoside analogue: Mechanism of action and potential clinical application

Mini-Reviews in Medicinal Chemistry

Volumn 7, Issue 9, 2007, Pages 976-983

  Korycka, Anna ^a   Błoński, Jerzy Z ^a   Robak, Tadeusz ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

BCX 1777; Forodesine; Immucillin H; Purine nucleoside analogue; Purine nucleoside phosphorylase inhibitor

Indexed keywords

9 (3 THENYL) 9 DEAZAGUANINE; CLADRIBINE; CLOFARABINE; DEOXYCYTIDINE KINASE; DEOXYGUANOSINE PHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; FLUDARABINE; GUANINE; IMMUCILLIN H; INTERLEUKIN 2; NELARABINE; PELDESINE; PENTOSTATIN; PHOSPHORYLASE; PHYTOHEMAGGLUTININ; PURINE NUCLEOSIDE DERIVATIVE; RIBONUCLEOTIDE REDUCTASE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANEMIA; APOPTOSIS; ASTHENIA; AUTOIMMUNE HEMOLYTIC ANEMIA; B CELL LEUKEMIA; CELL DIVISION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL TRIAL; CUTANEOUS T CELL LYMPHOMA; DNA SYNTHESIS; DRUG BIOAVAILABILITY; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HAIRY CELL LEUKEMIA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IC 50; INTRACELLULAR SPACE; LEUKOPENIA; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; LYMPHOPROLIFERATIVE DISEASE; MIXED LYMPHOCYTE REACTION; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; MULTIPLE MYELOMA; NAUSEA; NONHODGKIN LYMPHOMA; NONHUMAN; PNEUMONIA; REVIEW; RHEUMATOID ARTHRITIS; SIDE EFFECT; SINGLE DRUG DOSE; SYSTEMIC LUPUS ERYTHEMATOSUS; T CELL LEUKEMIA; T CELL LYMPHOMA; T LYMPHOCYTE; THROMBOCYTOPENIA;

ANIMALS; ENZYME INHIBITORS; HUMANS; PURINE NUCLEOSIDES; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES;

EID: 35048849848     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955707781662636     Document Type: Review

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