메뉴 건너뛰기




Volumn 172, Issue 1, 2013, Pages 48-61

Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38

Author keywords

7 Ethyl 10 hydroxy camptothecin; Macromolecule; Polymer drug conjugate; Targeted delivery

Indexed keywords

ANTI-CANCER AGENTS; CAMPTOTHECIN (CPT); DIRECT FORMULATION; LIPID NANOCAPSULES; PHYSIOLOGICAL ENVIRONMENT; POLYMER DRUGS; TARGETED DELIVERY; WATER-SOLUBLE PRODRUGS;

EID: 84883508947     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.07.022     Document Type: Review
Times cited : (176)

References (111)
  • 1
    • 0018901322 scopus 로고
    • Plant antitumor agents: Synthesis and biological activity of camptothecin analogues
    • DOI 10.1021/jm00179a016
    • M.C. Wani, P.E. Ronman, J.T. Lindley, and M.E. Wall Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs J. Med. Chem. 23 1980 554 560 (Pubitemid 10153550)
    • (1980) Journal of Medicinal Chemistry , vol.23 , Issue.5 , pp. 554-560
    • Wani, M.C.1    Ronman, P.E.2    Lindley, J.T.3    Wall, M.E.4
  • 3
    • 0015378084 scopus 로고
    • Phase i clinical trial of weekly and daily treatment with camptothecin (NSC-100880): Correlation with preclinical studies
    • F.M. Muggia, P. Creaven, H. Hansen, M. Cohen, and O. Selawry Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies Cancer Chemother. Rep. 1 56 1972 515
    • (1972) Cancer Chemother. Rep. 1 , vol.56 , pp. 515
    • Muggia, F.M.1    Creaven, P.2    Hansen, H.3    Cohen, M.4    Selawry, O.5
  • 4
    • 0023629292 scopus 로고
    • 6,8-tetrahydroindolizine: Total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin
    • DOI 10.1021/jm00395a024
    • 6,8-tetrahydroindolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin J. Med. Chem. 30 1987 2317 2319 (Pubitemid 17167484)
    • (1987) Journal of Medicinal Chemistry , vol.30 , Issue.12 , pp. 2317-2319
    • Wani, M.C.1    Nicholas, A.W.2    Wall, M.E.3
  • 5
    • 77954348873 scopus 로고    scopus 로고
    • Cytotoxicity and Topo i targeting activity of substituted 10 - Nitrogenous heterocyclic aromatic group derivatives of SN-38
    • Q. Li, X.-q. Deng, Y.-g. Zu, H. Lv, L. Su, L. Yao, Y. Zhang, and L. Li Cytotoxicity and Topo I targeting activity of substituted 10 - nitrogenous heterocyclic aromatic group derivatives of SN-38 Eur. J. Med. Chem. 45 2010 3200 3206
    • (2010) Eur. J. Med. Chem. , vol.45 , pp. 3200-3206
    • Li, Q.1    Deng, X.-Q.2    Zu, Y.-G.3    Lv, H.4    Su, L.5    Yao, L.6    Zhang, Y.7    Li, L.8
  • 6
    • 0036399299 scopus 로고    scopus 로고
    • Camptothecins: A review of their chemotherapeutic potential
    • H. Ulukan, and P.W. Swaan Camptothecins: a review of their chemotherapeutic potential Drugs 62 2002 2039 2057 (Pubitemid 35204037)
    • (2002) Drugs , vol.62 , Issue.14 , pp. 2039-2057
    • Ulukan, H.1    Swaan, P.W.2
  • 7
    • 0036304427 scopus 로고    scopus 로고
    • Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins
    • R. Garcia-Carbonero, and J.G. Supko Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins Clin. Cancer Res. 8 2002 641 661 (Pubitemid 34742090)
    • (2002) Clinical Cancer Research , vol.8 , Issue.3 , pp. 641-661
    • Garcia-Carbonero, R.1    Supko, J.G.2
  • 8
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Y.H. Hsiang, R. Hertzberg, S. Hecht, and L. Liu Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I J. Biol. Chem. 260 1985 14873 14878 (Pubitemid 16211028)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.27 , pp. 14873-14878
    • Hsiang, Y.-H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 9
    • 0028225471 scopus 로고
    • Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials
    • A. Tanizawa, A. Fujimori, Y. Fujimori, and Y. Pommier Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials J. Natl. Cancer Inst. 86 1994 836 842 (Pubitemid 24164661)
    • (1994) Journal of the National Cancer Institute , vol.86 , Issue.11 , pp. 836-842
    • Tanizawa, A.1    Fujimori, A.2    Fujimori, Y.3    Pommier, Y.4
  • 10
    • 7144248725 scopus 로고
    • Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata1,2
    • M.E. Wall, M.C. Wani, C.E. Cook, K.H. Palmer, A.T. McPhail, and G.A. Sim Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata1,2 J. Am. Chem. Soc. 88 1966 3888 3890
    • (1966) J. Am. Chem. Soc. , vol.88 , pp. 3888-3890
    • Wall, M.E.1    Wani, M.C.2    Cook, C.E.3    Palmer, K.H.4    McPhail, A.T.5    Sim, G.A.6
  • 11
    • 0028999826 scopus 로고
    • Differential stabilization of eukaryotic DNA topoisomerase i cleavable complexes by camptothecin derivatives
    • A. Tanizawa, K.W. Kohn, G. Kohlhagen, F. Leteurtre, and Y. Pommier Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives Biochemistry 34 1995 7200 7206
    • (1995) Biochemistry , vol.34 , pp. 7200-7206
    • Tanizawa, A.1    Kohn, K.W.2    Kohlhagen, G.3    Leteurtre, F.4    Pommier, Y.5
  • 12
    • 0027184132 scopus 로고
    • Ethyl substitution at the 7 position extends the half-life of 10- hydroxycamptothecin in the presence of human serum albumin
    • T.G. Burke, and Z. Mi Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin J. Med. Chem. 36 1993 2580 2582 (Pubitemid 23270812)
    • (1993) Journal of Medicinal Chemistry , vol.36 , Issue.17 , pp. 2580-2582
    • Burke, T.G.1    Mi, Z.2
  • 13
    • 77951785011 scopus 로고    scopus 로고
    • Thermodynamic studies and loading of 7-ethyl-10-hydroxycamptothecin into mesoporous silica particles MCM-41 in strongly acidic solutions
    • R. Thakur, B. Sivakumar, and M. Savva Thermodynamic studies and loading of 7-ethyl-10-hydroxycamptothecin into mesoporous silica particles MCM-41 in strongly acidic solutions J. Phys. Chem. B 114 2010 5903 5911
    • (2010) J. Phys. Chem. B , vol.114 , pp. 5903-5911
    • Thakur, R.1    Sivakumar, B.2    Savva, M.3
  • 15
    • 80052264440 scopus 로고    scopus 로고
    • Development and characterization of a novel lipid nanocapsule formulation of SN38 for oral administration
    • E. Roger, F. Lagarce, and J.-P. Benoit Development and characterization of a novel lipid nanocapsule formulation of SN38 for oral administration Eur. J. Pharm. Biopharm. 79 2011 181 188
    • (2011) Eur. J. Pharm. Biopharm. , vol.79 , pp. 181-188
    • Roger, E.1    Lagarce, F.2    Benoit, J.-P.3
  • 16
    • 41549105038 scopus 로고    scopus 로고
    • Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model
    • DOI 10.1158/1078-0432.CCR-07-4456
    • P. Sapra, H. Zhao, M. Mehlig, J. Malaby, P. Kraft, C. Longley, L.M. Greenberger, and I.D. Horak Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11 - refractory model Clin. Cancer Res. 14 2008 1888 1896 (Pubitemid 351469476)
    • (2008) Clinical Cancer Research , vol.14 , Issue.6 , pp. 1888-1896
    • Sapra, P.1    Zhao, H.2    Mehlig, M.3    Malaby, J.4    Kraft, P.5    Longley, C.6    Greenberger, L.M.7    Horak, I.D.8
  • 18
    • 0033528709 scopus 로고    scopus 로고
    • Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase i - DNA binary complex†
    • X. Wang, X. Zhou, and S.M. Hecht Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I - DNA binary complex† Biochemistry 38 1999 4374 4381
    • (1999) Biochemistry , vol.38 , pp. 4374-4381
    • Wang, X.1    Zhou, X.2    Hecht, S.M.3
  • 21
    • 33750549679 scopus 로고    scopus 로고
    • Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors
    • DOI 10.1158/0008-5472.CAN-06-1605
    • F. Koizumi, M. Kitagawa, T. Negishi, T. Onda, S.-i. Matsumoto, T. Hamaguchi, and Y. Matsumura Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors Cancer Res. 66 2006 10048 10056 (Pubitemid 44672058)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 10048-10056
    • Koizumi, F.1    Kitagawa, M.2    Negishi, T.3    Onda, T.4    Matsumoto, S.-I.5    Hamaguchi, T.6    Matsumura, Y.7
  • 22
    • 0028854897 scopus 로고
    • Phase i and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients
    • D. Abigerges, G.G. Chabot, J.P. Armand, P. Hérait, A. Gouyette, and D. Gandia Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients J. Clin. Oncol. 13 1995 210 221
    • (1995) J. Clin. Oncol. , vol.13 , pp. 210-221
    • Abigerges, D.1    Chabot, G.G.2    Armand, J.P.3    Hérait, P.4    Gouyette, A.5    Gandia, D.6
  • 23
    • 0030958098 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients
    • E. Gupta, R. Mick, J. Ramirez, X. Wang, T.M. Lestingi, E.E. Vokes, and M.J. Ratain Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients J. Clin. Oncol. 15 1997 1502 1510 (Pubitemid 27167386)
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.4 , pp. 1502-1510
    • Gupta, E.1    Mick, R.2    Ramirez, J.3    Wang, X.4    Lestingi, T.M.5    Vokes, E.E.6    Ratain, M.J.7
  • 24
    • 0028840093 scopus 로고
    • Phase i and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every three weeks in patients with advanced solid tumors
    • G. Catimel, G.G. Chabot, J.P. Guastalla, A. Dumortier, C. Cote, C. Engel, A. Gouyette, A. Mathieu-Boué, M. Mahjoubi, and M. Clavel Phase I and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every three weeks in patients with advanced solid tumors Ann. Oncol. 6 1995 133 140
    • (1995) Ann. Oncol. , vol.6 , pp. 133-140
    • Catimel, G.1    Chabot, G.G.2    Guastalla, J.P.3    Dumortier, A.4    Cote, C.5    Engel, C.6    Gouyette, A.7    Mathieu-Boué, A.8    Mahjoubi, M.9    Clavel, M.10
  • 25
    • 0030856521 scopus 로고    scopus 로고
    • Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials
    • L.P. Rivory, M.C. Haaz, P. Canal, F. Lokiec, J.P. Armand, and J. Robert Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials Clin. Cancer Res. 3 1997 1261 1266 (Pubitemid 27362386)
    • (1997) Clinical Cancer Research , vol.3 , Issue.8 , pp. 1261-1266
    • Rivory, L.P.1    Haaz, M.-C.2    Canal, P.3    Lokiec, F.4    Armand, J.-P.5    Robert, J.6
  • 26
    • 34347371390 scopus 로고    scopus 로고
    • Insights, challenges, and future directions in irinogenetics
    • DOI 10.1097/FTD.0b013e318068623b, PII 0000769120070600000001
    • T.W. Kim, and F. Innocenti Insights, challenges, and future directions in irinogenetics Ther. Drug Monit. 29 2007 265 270 (Pubitemid 47262254)
    • (2007) Therapeutic Drug Monitoring , vol.29 , Issue.3 , pp. 265-270
    • Kim, T.W.1    Innocenti, F.2
  • 29
    • 77949629690 scopus 로고    scopus 로고
    • An overview of the recent progress in irinotecan pharmacogenetics
    • Y. Fujiwara An overview of the recent progress in irinotecan pharmacogenetics Pharmacogenomics 11 2010 391 406
    • (2010) Pharmacogenomics , vol.11 , pp. 391-406
    • Fujiwara, Y.1
  • 35
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: Camptothecins and beyond
    • DOI 10.1038/nrc1977, PII NRC1977
    • Y. Pommier Topoisomerase I inhibitors: camptothecins and beyond Nat. Rev. Cancer 6 2006 789 802 (Pubitemid 44450467)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.10 , pp. 789-802
    • Pommier, Y.1
  • 36
    • 84884354006 scopus 로고    scopus 로고
    • Topoisomerases inhibitors: A paradigm for interfacial inhibition
    • Y. Pommier, Springer New York
    • C. Marchand, and Y. Pommier Topoisomerases inhibitors: a paradigm for interfacial inhibition Y. Pommier, DNA Topoisomerases and Cancer 2012 Springer New York 175 184
    • (2012) DNA Topoisomerases and Cancer , pp. 175-184
    • Marchand, C.1    Pommier, Y.2
  • 37
    • 67650682519 scopus 로고    scopus 로고
    • DNA topoisomerase i inhibitors: Chemistry, biology and interfacial inhibition
    • Y. Pommier DNA topoisomerase I inhibitors: chemistry, biology and interfacial inhibition Chem. Rev. 109 2009 2894
    • (2009) Chem. Rev. , vol.109 , pp. 2894
    • Pommier, Y.1
  • 38
    • 0036085460 scopus 로고    scopus 로고
    • Cellular roles of DNA topoisomerases: A molecular perspective
    • DOI 10.1038/nrm831
    • J.C. Wang Cellular roles of DNA topoisomerases: a molecular perspective Nat. Rev. Mol. Cell Biol. 3 2002 430 440 (Pubitemid 34685700)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.6 , pp. 430-440
    • Wang, J.C.1
  • 42
    • 0028158012 scopus 로고
    • Phase i and pharmacological study of the novel topoisomerase i inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks
    • E.K. Rowinsky, L.B. Grochow, D.S. Ettinger, S.E. Sartorius, B.G. Lubejko, T.-L. Chen, M.K. Rock, and R.C. Donehower Phase I and pharmacological study of the novel topoisomerase i inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks Cancer Res. 54 1994 427 436
    • (1994) Cancer Res. , vol.54 , pp. 427-436
    • Rowinsky, E.K.1    Grochow, L.B.2    Ettinger, D.S.3    Sartorius, S.E.4    Lubejko, B.G.5    Chen, T.-L.6    Rock, M.K.7    Donehower, R.C.8
  • 43
    • 80052269036 scopus 로고    scopus 로고
    • Pharmacokinetics of SN2310, an injectable emulsion that incorporates a new derivative of SN-38 in patients with advanced solid tumors
    • J.-F. Marier, L. Pheng, M.M. Trinh, H.A. Burris, S. Jones, K. Anderson, S. Warner, and D. Porubek Pharmacokinetics of SN2310, an injectable emulsion that incorporates a new derivative of SN-38 in patients with advanced solid tumors J. Pharm. Sci. 100 2011 4536 4545
    • (2011) J. Pharm. Sci. , vol.100 , pp. 4536-4545
    • Marier, J.-F.1    Pheng, L.2    Trinh, M.M.3    Burris, H.A.4    Jones, S.5    Anderson, K.6    Warner, S.7    Porubek, D.8
  • 44
    • 0032833129 scopus 로고    scopus 로고
    • PH-dependent uptake of Irinotecan and its active metabolite, SN-38, by intestinal cells
    • DOI 10.1002/(SICI)1097-0215(19991112)83:4<491::AID-IJC10>3.0.CO;2-M
    • K. Kobayashi, B. Bouscarel, Y. Matsuzaki, S. Ceryak, S. Kudoh, and H. Fromm pH-dependent uptake of irinotecan and its active metabolite, SN-38, by intestinal cells Int. J. Cancer 83 1999 491 496 (Pubitemid 29489864)
    • (1999) International Journal of Cancer , vol.83 , Issue.4 , pp. 491-496
    • Kobayashi, K.1    Bouscarel, B.2    Matsuzaki, Y.3    Ceryak, S.4    Kudoh, S.5    Fromm, H.6
  • 47
    • 84884352696 scopus 로고    scopus 로고
    • First-in-human phase i and pharmacokinetic study of DTS-108 in patients with advanced carcinomas
    • American Society of Clinical Oncology
    • C. Romain, J.F. Sandrine, D. Chantal, M. Olivier, B. Mohamed, G. Francois, and R. Eric First-in-human phase I and pharmacokinetic study of DTS-108 in patients with advanced carcinomas 2012 ASCO Annual Meeting 2012 American Society of Clinical Oncology
    • (2012) 2012 ASCO Annual Meeting
    • Romain, C.1    Sandrine, J.F.2    Chantal, D.3    Olivier, M.4    Mohamed, B.5    Francois, G.6    Eric, R.7
  • 49
    • 44749084015 scopus 로고    scopus 로고
    • Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers
    • R. Kolhatkar, P. Swaan, and H. Ghandehari Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers Pharm. Res. 25 2008 1723 1729
    • (2008) Pharm. Res. , vol.25 , pp. 1723-1729
    • Kolhatkar, R.1    Swaan, P.2    Ghandehari, H.3
  • 50
    • 50249123111 scopus 로고    scopus 로고
    • PEGylated nanographene oxide for delivery of water-insoluble cancer drugs
    • Z. Liu, J.T. Robinson, X. Sun, and H. Dai PEGylated nanographene oxide for delivery of water-insoluble cancer drugs J. Am. Chem. Soc. 130 2008 10876 10877
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 10876-10877
    • Liu, Z.1    Robinson, J.T.2    Sun, X.3    Dai, H.4
  • 51
    • 0037430448 scopus 로고    scopus 로고
    • Cancer chemotherapy: A SN-38 (7-Ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug monoTherapy) strategy
    • DOI 10.1016/S0960-894X(02)01080-6
    • S. Angenault, S. Thirot, F. Schmidt, C. Monneret, B. Pfeiffer, and P. Renard Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug monoTherapy) strategy Bioorg. Med. Chem. Lett. 13 2003 947 950 (Pubitemid 36255573)
    • (2003) Bioorganic and Medicinal Chemistry Letters , vol.13 , Issue.5 , pp. 947-950
    • Angenault, S.1    Thirot, S.2    Schmidt, F.3    Monneret, C.4    Pfeiffer, B.5    Renard, P.6
  • 52
    • 77950254562 scopus 로고    scopus 로고
    • The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release
    • B. Huang, A. Desai, S. Tang, T.P. Thomas, and J.R. Baker The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release Org. Lett. 12 2010 1384 1387
    • (2010) Org. Lett. , vol.12 , pp. 1384-1387
    • Huang, B.1    Desai, A.2    Tang, S.3    Thomas, T.P.4    Baker, J.R.5
  • 53
    • 84856366351 scopus 로고    scopus 로고
    • RAFT-derived polymer-drug conjugates: Poly(hydroxypropyl methacrylamide) (hpma)-7-ethyl-10-hydroxycamptothecin (sn-38) conjugates
    • C.C. Williams, S.H. Thang, T. Hantke, U. Vogel, P.H. Seeberger, J. Tsanaktsidis, and B. Lepenies RAFT-derived polymer-drug conjugates: poly(hydroxypropyl methacrylamide) (hpma)-7-ethyl-10-hydroxycamptothecin (sn-38) conjugates ChemMedChem 7 2012 281 291
    • (2012) ChemMedChem , vol.7 , pp. 281-291
    • Williams, C.C.1    Thang, S.H.2    Hantke, T.3    Vogel, U.4    Seeberger, P.H.5    Tsanaktsidis, J.6    Lepenies, B.7
  • 54
    • 0031874686 scopus 로고    scopus 로고
    • Biologically active camptothecin derivatives for incorporation into liposome bilayers and lipid emulsions
    • B. Lundberg Biologically active camptothecin derivatives for incorporation into liposome bilayers and lipid emulsions Anticancer Drug Des. 13 1998 453 461 (Pubitemid 28334032)
    • (1998) Anti-Cancer Drug Design , vol.13 , Issue.5 , pp. 453-461
    • Lundberg, B.B.1
  • 55
    • 84861843891 scopus 로고    scopus 로고
    • Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters
    • E.-Y. Kwak, W.-S. Shim, J.-E. Chang, S. Chong, D.-D. Kim, S.-J. Chung, and C.-K. Shim Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters Xenobiotica 42 2012 603 613
    • (2012) Xenobiotica , vol.42 , pp. 603-613
    • Kwak, E.-Y.1    Shim, W.-S.2    Chang, J.-E.3    Chong, S.4    Kim, D.-D.5    Chung, S.-J.6    Shim, C.-K.7
  • 56
    • 84872767316 scopus 로고    scopus 로고
    • Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: In vitro and in vivo studies
    • H. Zhang, J. Wang, W. Mao, J. Huang, X. Wu, Y. Shen, and M. Sui Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: In vitro and in vivo studies J. Control. Release 166 2013 147 158
    • (2013) J. Control. Release , vol.166 , pp. 147-158
    • Zhang, H.1    Wang, J.2    Mao, W.3    Huang, J.4    Wu, X.5    Shen, Y.6    Sui, M.7
  • 58
    • 33748754360 scopus 로고    scopus 로고
    • Synthesis and antitumor activity of novel 10-substituted camptothecin analogues
    • DOI 10.1016/j.bmc.2006.06.061, PII S0968089606005359
    • Q. Li, Y. Zu, R. Shi, L. Yao, Y. Fu, Z. Yang, and L. Li Synthesis and antitumor activity of novel 10-substituted camptothecin analogues Bioorg. Med. Chem. 14 2006 7175 7182 (Pubitemid 44403111)
    • (2006) Bioorganic and Medicinal Chemistry , vol.14 , Issue.21 , pp. 7175-7182
    • Li, Q.1    Zu, Y.2    Shi, R.3    Yao, L.4    Fu, Y.5    Yang, Z.6    Li, L.7
  • 59
    • 22844436226 scopus 로고    scopus 로고
    • Recent advances in tumor-targeting anticancer drug conjugates
    • DOI 10.1016/j.bmc.2005.04.084, PII S0968089605003767
    • S. Jaracz, J. Chen, L.V. Kuznetsova, and I. Ojima Recent advances in tumor-targeting anticancer drug conjugates Bioorg. Med. Chem. 13 2005 5043 5054 (Pubitemid 41039965)
    • (2005) Bioorganic and Medicinal Chemistry , vol.13 , Issue.17 , pp. 5043-5054
    • Jaracz, S.1    Chen, J.2    Kuznetsova, L.V.3    Ojima, I.4
  • 62
    • 70349685092 scopus 로고    scopus 로고
    • CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates
    • S.V. Govindan, T.M. Cardillo, S.-J. Moon, H.J. Hansen, and D.M. Goldenberg CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates Clin. Cancer Res. 15 2009 6052 6061
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6052-6061
    • Govindan, S.V.1    Cardillo, T.M.2    Moon, S.-J.3    Hansen, H.J.4    Goldenberg, D.M.5
  • 63
    • 79956008677 scopus 로고    scopus 로고
    • Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: Preclinical studies in human cancer xenograft models and monkeys
    • T.M. Cardillo, S.V. Govindan, R.M. Sharkey, P. Trisal, and D.M. Goldenberg Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys Clin. Cancer Res. 17 2011 3157 3169
    • (2011) Clin. Cancer Res. , vol.17 , pp. 3157-3169
    • Cardillo, T.M.1    Govindan, S.V.2    Sharkey, R.M.3    Trisal, P.4    Goldenberg, D.M.5
  • 64
    • 84855675343 scopus 로고    scopus 로고
    • Epratuzumab-SN-38: A new antibody-drug conjugate for the therapy of hematologic malignancies
    • R.M. Sharkey, S.V. Govindan, T.M. Cardillo, and D.M. Goldenberg Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies Mol. Cancer Ther. 11 2012 224 234
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 224-234
    • Sharkey, R.M.1    Govindan, S.V.2    Cardillo, T.M.3    Goldenberg, D.M.4
  • 65
    • 84862680024 scopus 로고    scopus 로고
    • Investigation into the efficacy of Val-SN-38, a valine-ester prodrug of the anti-cancer agent SN-38
    • E.Y. Kwak, M.K. Choi, S.G. Yang, C.K. Shim, and W.S. Shim Investigation into the efficacy of Val-SN-38, a valine-ester prodrug of the anti-cancer agent SN-38 Biomol. Ther. 20 2012 326 331
    • (2012) Biomol. Ther. , vol.20 , pp. 326-331
    • Kwak, E.Y.1    Choi, M.K.2    Yang, S.G.3    Shim, C.K.4    Shim, W.S.5
  • 67
    • 79960942844 scopus 로고    scopus 로고
    • Polymer therapeutics as nanomedicines: New perspectives
    • R. Duncan Polymer therapeutics as nanomedicines: new perspectives Curr. Opin. Biotechnol. 22 2011 492 501
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 492-501
    • Duncan, R.1
  • 68
    • 81855170441 scopus 로고    scopus 로고
    • Nanomedicine(s) under the microscope
    • R. Duncan, and R. Gaspar Nanomedicine(s) under the microscope Mol. Pharm. 8 2011 2101 2141
    • (2011) Mol. Pharm. , vol.8 , pp. 2101-2141
    • Duncan, R.1    Gaspar, R.2
  • 70
    • 79951577793 scopus 로고    scopus 로고
    • Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38
    • P. Ebrahimnejad, R. Dinarvand, M.R. Jafari, S.A.S. Tabasi, and F. Atyabi Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38 Int. J. Pharm. 406 2011 122 127
    • (2011) Int. J. Pharm. , vol.406 , pp. 122-127
    • Ebrahimnejad, P.1    Dinarvand, R.2    Jafari, M.R.3    Tabasi, S.A.S.4    Atyabi, F.5
  • 72
    • 0038121699 scopus 로고    scopus 로고
    • Characterisation of drug release from cubosomes using the pressure ultrafiltration method
    • DOI 10.1016/S0378-5173(03)00262-X
    • B.J. Boyd Characterisation of drug release from cubosomes using the pressure ultrafiltration method Int. J. Pharm. 260 2003 239 247 (Pubitemid 36773921)
    • (2003) International Journal of Pharmaceutics , vol.260 , Issue.2 , pp. 239-247
    • Boyd, B.J.1
  • 73
    • 84864040485 scopus 로고    scopus 로고
    • Drug release from nanomedicines: Selection of appropriate encapsulation and release methodology
    • S. Wallace, J. Li, R. Nation, and B. Boyd Drug release from nanomedicines: selection of appropriate encapsulation and release methodology Drug Deliv. Transl. Res. 2 2012 284 292
    • (2012) Drug Deliv. Transl. Res. , vol.2 , pp. 284-292
    • Wallace, S.1    Li, J.2    Nation, R.3    Boyd, B.4
  • 75
    • 84881333043 scopus 로고    scopus 로고
    • Hyaluronic Acid-decorated PLGA-PEG Nanoparticles for Targeted Delivery of SN-38 to Ovarian Cancer
    • K.K. Vangara, J.L. Liu, and S. Palakurthi Hyaluronic Acid-decorated PLGA-PEG Nanoparticles for Targeted Delivery of SN-38 to Ovarian Cancer Anticancer research 33 6 2013 2425 2434
    • (2013) Anticancer Research , vol.33 , Issue.6 , pp. 2425-2434
    • Vangara, K.K.1    Liu, J.L.2    Palakurthi, S.3
  • 77
    • 80052691602 scopus 로고    scopus 로고
    • Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects
    • P. Sapra, P. Kraft, F. Pastorino, D. Ribatti, M. Dumble, M. Mehlig, M. Wang, M. Ponzoni, L. Greenberger, and I. Horak Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects Angiogenesis 14 2011 245 253
    • (2011) Angiogenesis , vol.14 , pp. 245-253
    • Sapra, P.1    Kraft, P.2    Pastorino, F.3    Ribatti, D.4    Dumble, M.5    Mehlig, M.6    Wang, M.7    Ponzoni, M.8    Greenberger, L.9    Horak, I.10
  • 78
    • 79953897704 scopus 로고    scopus 로고
    • Abstract C216: Phase 1, first-in-human, dose-escalation study of EZN-2208, a novel anticancer agent, in patients (pts) with advanced malignancies
    • R. Kurzrock, J. Wheler, D.S. Hong, Z. Guo, M.F. Mulcahy, A.B. Benson, S. Goel, U. Swami, S. Mani, and A. Buchbinder Abstract C216: phase 1, first-in-human, dose-escalation study of EZN-2208, a novel anticancer agent, in patients (pts) with advanced malignancies Mol. Cancer Ther. 8 2009 C216
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 216
    • Kurzrock, R.1    Wheler, J.2    Hong, D.S.3    Guo, Z.4    Mulcahy, M.F.5    Benson, A.B.6    Goel, S.7    Swami, U.8    Mani, S.9    Buchbinder, A.10
  • 79
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • DOI 10.1038/nrd1632
    • V.P. Torchilin Recent advances with liposomes as pharmaceutical carriers Nat. Rev. Drug Discov. 4 2005 145 160 (Pubitemid 40282557)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.2 , pp. 145-160
    • Torchilin, V.P.1
  • 80
    • 27744580052 scopus 로고    scopus 로고
    • Liposomalization of SN-38 as active metabolite of CPT-11
    • DOI 10.1016/j.jconrel.2005.08.023, PII S0168365905004074
    • Y. Sadzuka, H. Takabe, and T. Sonobe Liposomalization of SN-38 as active metabolite of CPT-11 J. Control. Release 108 2005 453 459 (Pubitemid 41608676)
    • (2005) Journal of Controlled Release , vol.108 , Issue.2-3 , pp. 453-459
    • Sadzuka, Y.1    Takabe, H.2    Sonobe, T.3
  • 84
    • 84872443002 scopus 로고    scopus 로고
    • 7-Ethyl-10-hydroxycamptothecin proliposomes with a novel preparation method: Optimized formulation, characterization and in-vivo evaluation
    • S. Wang, T. Ye, B. Yang, X. Yi, and H. Yao 7-Ethyl-10-hydroxycamptothecin proliposomes with a novel preparation method: optimized formulation, characterization and in-vivo evaluation Drug Dev. Ind. Pharm. 39 2013 393 401
    • (2013) Drug Dev. Ind. Pharm. , vol.39 , pp. 393-401
    • Wang, S.1    Ye, T.2    Yang, B.3    Yi, X.4    Yao, H.5
  • 85
    • 67651180631 scopus 로고    scopus 로고
    • Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice
    • F. Atyabi, A. Farkhondehfai, F. Esmaeili, and R. Dinarvand Preparation of pegylated nano-liposomal formulation containing SN-38: in vitro characterization and in vivo biodistribution in mice Acta Pharm. 59 2009 133 144
    • (2009) Acta Pharm. , vol.59 , pp. 133-144
    • Atyabi, F.1    Farkhondehfai, A.2    Esmaeili, F.3    Dinarvand, R.4
  • 87
    • 84878284094 scopus 로고    scopus 로고
    • Mechanisms of chitosan-coated poly(lactic-co-glycolic acid) nanoparticles for improving oral absorption of 7-ethyl-10-hydroxycamptothecin
    • M. Guo, W.-T. Rong, J. Hou, D.-F. Wang, Y. Lu, Y. Wang, S.-Q. Yu, and Q. Xu Mechanisms of chitosan-coated poly(lactic-co-glycolic acid) nanoparticles for improving oral absorption of 7-ethyl-10-hydroxycamptothecin Nanotechnology 24 2013 245101
    • (2013) Nanotechnology , vol.24 , pp. 245101
    • Guo, M.1    Rong, W.-T.2    Hou, J.3    Wang, D.-F.4    Lu, Y.5    Wang, Y.6    Yu, S.-Q.7    Xu, Q.8
  • 88
    • 79953112735 scopus 로고    scopus 로고
    • Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect
    • Y. Matsumura Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect Adv. Drug Deliv. Rev. 63 2011 184 192
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 184-192
    • Matsumura, Y.1
  • 89
    • 84860530546 scopus 로고    scopus 로고
    • SN-38 loaded polymeric micelles to enhance cancer therapy
    • Q. Gu, J.Z. Xing, M. Huang, C. He, and J. Chen SN-38 loaded polymeric micelles to enhance cancer therapy Nanotechnology 23 2012 205101
    • (2012) Nanotechnology , vol.23 , pp. 205101
    • Gu, Q.1    Xing, J.Z.2    Huang, M.3    He, C.4    Chen, J.5
  • 90
    • 75749154748 scopus 로고    scopus 로고
    • Fabrication of cationic nanomicelle from chitosan-graft-polycaprolactone as the carrier of 7-ethyl-10-hydroxy-camptothecin
    • K. Duan, X. Zhang, X. Tang, J. Yu, S. Liu, D. Wang, Y. Li, and J. Huang Fabrication of cationic nanomicelle from chitosan-graft-polycaprolactone as the carrier of 7-ethyl-10-hydroxy-camptothecin Colloids Surf. B Biointerfaces 76 2010 475 482
    • (2010) Colloids Surf. B Biointerfaces , vol.76 , pp. 475-482
    • Duan, K.1    Zhang, X.2    Tang, X.3    Yu, J.4    Liu, S.5    Wang, D.6    Li, Y.7    Huang, J.8
  • 91
    • 84863197348 scopus 로고    scopus 로고
    • Fabrication of biodegradable micelles with sheddable poly(ethylene glycol) shells as the carrier of 7-ethyl-10-hydroxy-camptothecin
    • Q. Guo, P. Luo, Y. Luo, F. Du, W. Lu, S. Liu, J. Huang, and J. Yu Fabrication of biodegradable micelles with sheddable poly(ethylene glycol) shells as the carrier of 7-ethyl-10-hydroxy-camptothecin Colloids Surf. B Biointerfaces 100 2012 138 145
    • (2012) Colloids Surf. B Biointerfaces , vol.100 , pp. 138-145
    • Guo, Q.1    Luo, P.2    Luo, Y.3    Du, F.4    Lu, W.5    Liu, S.6    Huang, J.7    Yu, J.8
  • 92
    • 46149127528 scopus 로고    scopus 로고
    • Self-assembled star-shaped chlorin-core poly(É-caprolactone)- poly(ethylene glycol) diblock copolymer micelles for dual chemo-photodynamic therapies
    • C.-L. Peng, M.-J. Shieh, M.-H. Tsai, C.-C. Chang, and P.-S. Lai Self-assembled star-shaped chlorin-core poly(É-caprolactone)- poly(ethylene glycol) diblock copolymer micelles for dual chemo-photodynamic therapies Biomaterials 29 2008 3599 3608
    • (2008) Biomaterials , vol.29 , pp. 3599-3608
    • Peng, C.-L.1    Shieh, M.-J.2    Tsai, M.-H.3    Chang, C.-C.4    Lai, P.-S.5
  • 93
    • 67349112911 scopus 로고    scopus 로고
    • Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles
    • C.-L. Peng, P.-S. Lai, F.-H. Lin, S. Yueh-Hsiu Wu, and M.-J. Shieh Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles Biomaterials 30 2009 3614 3625
    • (2009) Biomaterials , vol.30 , pp. 3614-3625
    • Peng, C.-L.1    Lai, P.-S.2    Lin, F.-H.3    Yueh-Hsiu Wu, S.4    Shieh, M.-J.5
  • 96
    • 33745560557 scopus 로고    scopus 로고
    • Hexosomes formed from glycerate surfactants-Formulation as a colloidal carrier for irinotecan
    • DOI 10.1016/j.ijpharm.2006.03.010, PII S0378517306002286
    • B.J. Boyd, D.V. Whittaker, S.-M. Khoo, and G. Davey Hexosomes formed from glycerate surfactants - formulation as a colloidal carrier for irinotecan Int. J. Pharm. 318 2006 154 162 (Pubitemid 43977801)
    • (2006) International Journal of Pharmaceutics , vol.318 , Issue.1-2 , pp. 154-162
    • Boyd, B.J.1    Whittaker, D.V.2    Khoo, S.-M.3    Davey, G.4
  • 99
    • 19044374435 scopus 로고    scopus 로고
    • Novel agents that potentially inhibit irinotecan-induced diarrhea
    • DOI 10.2174/0929867054020972
    • X. Yang, Z. Hu, S.Y. Chan, E. Chan, B.C. Goh, W. Duan, and S. Zhou Novel agents that potentially inhibit irinotecan-induced diarrhea Curr. Med. Chem. 12 2005 1343 1358 (Pubitemid 40711429)
    • (2005) Current Medicinal Chemistry , vol.12 , Issue.11 , pp. 1343-1358
    • Yang, X.1    Hu, Z.2    Chan, S.Y.3    Chan, E.4    Goh, B.C.5    Duan, W.6    Zhou, S.7
  • 100
    • 77958156329 scopus 로고    scopus 로고
    • Carboxyl-terminated PAMAM-SN38 conjugates: Synthesis, characterization, and in vitro evaluation
    • N. Vijayalakshmi, A. Ray, A. Malugin, and H. Ghandehari Carboxyl-terminated PAMAM-SN38 conjugates: synthesis, characterization, and in vitro evaluation Bioconjug. Chem. 21 2010 1804 1810
    • (2010) Bioconjug. Chem. , vol.21 , pp. 1804-1810
    • Vijayalakshmi, N.1    Ray, A.2    Malugin, A.3    Ghandehari, H.4
  • 101
    • 79955051898 scopus 로고    scopus 로고
    • G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity
    • D.S. Goldberg, N. Vijayalakshmi, P.W. Swaan, and H. Ghandehari G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity J. Control. Release 150 2011 318 325
    • (2011) J. Control. Release , vol.150 , pp. 318-325
    • Goldberg, D.S.1    Vijayalakshmi, N.2    Swaan, P.W.3    Ghandehari, H.4
  • 103
    • 0036297426 scopus 로고    scopus 로고
    • A novel phase inversion-based process for the preparation of lipid nanocarriers
    • DOI 10.1023/A:1016121319668
    • B. Heurtault, P. Saulnier, B. Pech, J.-E. Proust, and J.-P. Benoit A novel phase inversion-based process for the preparation of lipid nanocarriers Pharm. Res. 19 2002 875 880 (Pubitemid 34692585)
    • (2002) Pharmaceutical Research , vol.19 , Issue.6 , pp. 875-880
    • Heurtault, B.1    Saulnier, P.2    Pech, B.3    Proust, J.-E.4    Benoit, J.-P.5
  • 108
    • 84859053199 scopus 로고    scopus 로고
    • A cell-delivered and cell-activated SN38-dextran prodrug increases survival in a murine disseminated pancreatic cancer model
    • M.T. Basel, S. Balivada, T.B. Shrestha, G.-M. Seo, M.M. Pyle, M. Tamura, S.H. Bossmann, and D.L. Troyer A cell-delivered and cell-activated SN38-dextran prodrug increases survival in a murine disseminated pancreatic cancer model Small 8 2012 913 920
    • (2012) Small , vol.8 , pp. 913-920
    • Basel, M.T.1    Balivada, S.2    Shrestha, T.B.3    Seo, G.-M.4    Pyle, M.M.5    Tamura, M.6    Bossmann, S.H.7    Troyer, D.L.8
  • 110
    • 84869002489 scopus 로고    scopus 로고
    • Substrate mediated enzyme prodrug therapy
    • B. Fejerskov, and A.N. Zelikin Substrate mediated enzyme prodrug therapy PLoS One 7 2012 e49619
    • (2012) PLoS One , vol.7 , pp. 49619
    • Fejerskov, B.1    Zelikin, A.N.2
  • 111
    • 84865349900 scopus 로고    scopus 로고
    • Preparation and in vitro characterization of SN-38-loaded, self-forming polymeric depots as an injectable drug delivery system
    • C. Manaspon, S. Hongeng, A. Boongird, and N. Nasongkla Preparation and in vitro characterization of SN-38-loaded, self-forming polymeric depots as an injectable drug delivery system J. Pharm. Sci. 101 2012 3708 3717
    • (2012) J. Pharm. Sci. , vol.101 , pp. 3708-3717
    • Manaspon, C.1    Hongeng, S.2    Boongird, A.3    Nasongkla, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.