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Volumn 100, Issue 10, 2011, Pages 4536-4545
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Pharmacokinetics of SN2310, an injectable emulsion that incorporates a new derivative of SN-38 in patients with advanced solid tumors
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Author keywords
Camptothecin; Clearance; Metabolite; Pharmacokinetics; Prodrug; SN 38; SN 38G; SN2310
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Indexed keywords
7 ETHYL 10 HYDROXYCAMPTOTHECIN;
7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE;
IRINOTECAN;
TENIFATECAN;
ALPHA TOCOPHEROL;
ANTINEOPLASTIC AGENT;
CAMPTOTHECIN;
EMULSION;
SUCCINIC ACID DERIVATIVE;
ABDOMINAL PAIN;
ADULT;
ADVANCED CANCER;
AGED;
ANOREXIA;
AREA UNDER THE CURVE;
ARTICLE;
BACKACHE;
BLOOD SAMPLING;
CANCER CHEMOTHERAPY;
CANCER PATIENT;
CLINICAL ARTICLE;
CONCENTRATION RESPONSE;
CONNECTIVE TISSUE DISEASE;
COUGHING;
DIARRHEA;
DIZZINESS;
DRUG BLOOD LEVEL;
DRUG DETERMINATION;
DRUG DOSE ESCALATION;
DRUG ELIMINATION;
DRUG FATALITY;
DRUG HALF LIFE;
DRUG SAFETY;
DRUG TOLERABILITY;
DYSPNEA;
EMULSION;
FATIGUE;
FEMALE;
GASTROINTESTINAL DISEASE;
HEADACHE;
HEPATOBILIARY DISEASE;
HUMAN;
INJECTION SITE REACTION;
MALE;
MAXIMUM PLASMA CONCENTRATION;
MAXIMUM TOLERATED DOSE;
MUSCULOSKELETAL DISEASE;
NAUSEA;
NEUTROPENIA;
SEPSIS;
SOLID TUMOR;
TIME TO MAXIMUM PLASMA CONCENTRATION;
VOMITING;
ANALOGS AND DERIVATIVES;
BLOOD;
CHEMICALLY INDUCED;
CHEMISTRY;
CLINICAL TRIAL;
COMPARATIVE STUDY;
HALF LIFE TIME;
INTRAVENOUS DRUG ADMINISTRATION;
MEDICINAL CHEMISTRY;
METABOLIC CLEARANCE RATE;
MIDDLE AGED;
MULTICENTER STUDY;
NEOPLASMS;
PHARMACEUTICS;
PHASE 1 CLINICAL TRIAL;
PROCEDURES;
VERY ELDERLY;
AGED;
AGED, 80 AND OVER;
ANTINEOPLASTIC AGENTS, PHYTOGENIC;
AREA UNDER CURVE;
CAMPTOTHECIN;
CHEMISTRY, PHARMACEUTICAL;
EMULSIONS;
FEMALE;
HALF-LIFE;
HUMANS;
INFUSIONS, INTRAVENOUS;
MALE;
MAXIMUM TOLERATED DOSE;
METABOLIC CLEARANCE RATE;
MIDDLE AGED;
NEOPLASMS;
NEUTROPENIA;
SUCCINATES;
TECHNOLOGY, PHARMACEUTICAL;
VITAMIN E;
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EID: 80052269036
PISSN: 00223549
EISSN: 15206017
Source Type: Journal
DOI: 10.1002/jps.22645 Document Type: Article |
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Times cited : (21)
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References (15)
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