메뉴 건너뛰기




Volumn 58, Issue 22, 1998, Pages 5137-5143

Biliary excretion mechanism of CPT-11 and its metabolites in humans: Involvement of primary active transporters

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; DRUG METABOLITE; IRINOTECAN;

EID: 0032533498     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (95)

References (53)
  • 1
    • 0023395222 scopus 로고
    • Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I
    • Andoh, T., Ishii, K., and Suzuki, Y. Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I. Proc. Natl. Acad. Sci. USA, 84: 5565-5569, 1987.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 5565-5569
    • Andoh, T.1    Ishii, K.2    Suzuki, Y.3
  • 3
    • 0024560495 scopus 로고
    • Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and a relation to antitumor activity
    • Jaxel, C., Kohn, K. W., Wani, M. C., Wall, M. E., and Pommier, Y. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity. Cancer Res., 49: 1465-1469, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 1465-1469
    • Jaxel, C.1    Kohn, K.W.2    Wani, M.C.3    Wall, M.E.4    Pommier, Y.5
  • 4
    • 0027584926 scopus 로고
    • Cytogenetic effects of CPT-11 and its active metabolite, SN-38, on human lymphocytes
    • Kojima, A., Shinkai, T., and Saijo, N. Cytogenetic effects of CPT-11 and its active metabolite, SN-38, on human lymphocytes. Jpn. J. Clin. Oncol., 23: 116-122, 1993.
    • (1993) Jpn. J. Clin. Oncol. , vol.23 , pp. 116-122
    • Kojima, A.1    Shinkai, T.2    Saijo, N.3
  • 5
    • 0025996996 scopus 로고
    • Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
    • Kawato, Y., Aonuma, M., Hirota, Y., Kuga, H., and Sato, K. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res., 51: 4187-4191, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4187-4191
    • Kawato, Y.1    Aonuma, M.2    Hirota, Y.3    Kuga, H.4    Sato, K.5
  • 6
    • 0025342506 scopus 로고
    • Nonlinear pharmacokinetics of CPT-11 in rats
    • Kaneda, N., and Yokokura, T. Nonlinear pharmacokinetics of CPT-11 in rats. Cancer Res., 50: 1721-1725, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 1721-1725
    • Kaneda, N.1    Yokokura, T.2
  • 7
    • 0025272187 scopus 로고
    • Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse
    • Kaneda, N., Nagata, H., Furuta, T., and Yokokura, T. Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse. Cancer Res., 50: 1715-1720, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 1715-1720
    • Kaneda, N.1    Nagata, H.2    Furuta, T.3    Yokokura, T.4
  • 8
    • 0025858296 scopus 로고
    • Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion
    • Atsumi, R., Suzuki, W., and Hakusui, H. Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion. Xenobiotica, 21: 1159-1169, 1991.
    • (1991) Xenobiotica , vol.21 , pp. 1159-1169
    • Atsumi, R.1    Suzuki, W.2    Hakusui, H.3
  • 9
    • 0029760995 scopus 로고    scopus 로고
    • Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients
    • Rivory, L. P., Riou, J-F., Haaz, M-C., Sable, S., Vuilhorgne, M., Commercon, A., Pond, S. M., and Robert, J. Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients. Cancer Res., 56: 3689-3694, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 3689-3694
    • Rivory, L.P.1    Riou, J.-F.2    Haaz, M.-C.3    Sable, S.4    Vuilhorgne, M.5    Commercon, A.6    Pond, S.M.7    Robert, J.8
  • 10
    • 0032005259 scopus 로고    scopus 로고
    • Metabolism of irinotecan (CPT-11) by human hepatic microsome: Participation of cytochrome P-450 3A and drug interactions
    • Hazz, M-C., Rivory, L., Riche, C., Vernillet, L., and Robert, J. Metabolism of irinotecan (CPT-11) by human hepatic microsome: participation of cytochrome P-450 3A and drug interactions. Cancer Res., 58: 468-472, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 468-472
    • Hazz, M.-C.1    Rivory, L.2    Riche, C.3    Vernillet, L.4    Robert, J.5
  • 13
    • 0027242140 scopus 로고
    • Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11
    • Araki, E., Ishikawa, M., Iigo, M., Koide, T., Itabashi, M., and Hoshi, A. Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11. Jpn. J. Cancer Res., 84: 697-702, 1993.
    • (1993) Jpn. J. Cancer Res. , vol.84 , pp. 697-702
    • Araki, E.1    Ishikawa, M.2    Iigo, M.3    Koide, T.4    Itabashi, M.5    Hoshi, A.6
  • 14
    • 0027461221 scopus 로고
    • Inhibition of β-glucuronidase by natural glucuronides of kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate
    • Narita, M., Nagai, E., Hagiwara, H., Aburada, M., Yokoi, T., and Kamataki, T. Inhibition of β-glucuronidase by natural glucuronides of kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate. Xenobiotica, 23: 5-10, 1993.
    • (1993) Xenobiotica , vol.23 , pp. 5-10
    • Narita, M.1    Nagai, E.2    Hagiwara, H.3    Aburada, M.4    Yokoi, T.5    Kamataki, T.6
  • 15
    • 0028971415 scopus 로고
    • Protective effects of kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats
    • Takasuna, K., Kasai, Y., Kitano, Y., Mori, K., Kobayashi, R., Hagiwara, T., Kakihata, K., Hirohashi, M., Nomura, M., Nagai, E., and Kamataki, T. Protective effects of kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats. Jpn. J. Cancer Res., 86: 978-984, 1995.
    • (1995) Jpn. J. Cancer Res. , vol.86 , pp. 978-984
    • Takasuna, K.1    Kasai, Y.2    Kitano, Y.3    Mori, K.4    Kobayashi, R.5    Hagiwara, T.6    Kakihata, K.7    Hirohashi, M.8    Nomura, M.9    Nagai, E.10    Kamataki, T.11
  • 16
    • 0028022585 scopus 로고
    • Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
    • Gupta, E., Lestingi, T. M., Mick, R., Ramirez, J., Vokes, E. E., and Ratain, M. J. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res., 54: 3723-3725, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3723-3725
    • Gupta, E.1    Lestingi, T.M.2    Mick, R.3    Ramirez, J.4    Vokes, E.E.5    Ratain, M.J.6
  • 17
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
    • Iyer, L., King, C. D., Whitington, P. F., Green, M. D., Roy, S. K., Tephly, T. R., Coffman, B. L., and Ratain, M. J. Genetic predisposition to the metabolism of irinotecan (CPT-11): role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J. Clin. Invest., 101: 847-854, 1998.
    • (1998) J. Clin. Invest. , vol.101 , pp. 847-854
    • Iyer, L.1    King, C.D.2    Whitington, P.F.3    Green, M.D.4    Roy, S.K.5    Tephly, T.R.6    Coffman, B.L.7    Ratain, M.J.8
  • 18
    • 0030959378 scopus 로고    scopus 로고
    • Multispecific organic anion transporter (cMOAT) is responsible for biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats
    • Chu, X-Y., Kato, Y., Niinuma, K., Sudo, K., Hakusui, H., and Sugiyama, Y. Multispecific organic anion transporter (cMOAT) is responsible for biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats. J. Pharmacol. Exp. Ther., 281: 304-314, 1997.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 304-314
    • Chu, X.-Y.1    Kato, Y.2    Niinuma, K.3    Sudo, K.4    Hakusui, H.5    Sugiyama, Y.6
  • 19
    • 0030906434 scopus 로고    scopus 로고
    • Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats
    • Chu, X-Y., Kato, Y., and Sugiyama, Y. Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats. Cancer Res., 57: 1934-1938, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 1934-1938
    • Chu, X.-Y.1    Kato, Y.2    Sugiyama, Y.3
  • 21
    • 0028158012 scopus 로고
    • Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11) administered as a ninety-min infusion every 3 weeks
    • Rowinsky, E. K., Grochow, L. B., Ettinger, D. S., Sartorius, S. E., Lubejko, B. G., Chen, T. L., Rock, M. K., and Donehower, R. C. Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11) administered as a ninety-min infusion every 3 weeks. Cancer Res., 54: 427-436, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 427-436
    • Rowinsky, E.K.1    Grochow, L.B.2    Ettinger, D.S.3    Sartorius, S.E.4    Lubejko, B.G.5    Chen, T.L.6    Rock, M.K.7    Donehower, R.C.8
  • 23
    • 0027933519 scopus 로고
    • Phase I and pharmacokinetic study of the camptothecin derivative irinotecan administered on a weekly schedule in cancer patients
    • de Forni, M., Bugat, R., Chabot, G. G., Culine, S., Extra, J-M., Gouyette, A., Madelaine, I., Marty, M. E., and Mathieu-Boue, A. Phase I and pharmacokinetic study of the camptothecin derivative irinotecan administered on a weekly schedule in cancer patients. Cancer Res., 54: 4347-4354, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 4347-4354
    • De Forni, M.1    Bugat, R.2    Chabot, G.G.3    Culine, S.4    Extra, J.-M.5    Gouyette, A.6    Madelaine, I.7    Marty, M.E.8    Mathieu-Boue, A.9
  • 27
    • 0024371025 scopus 로고
    • The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
    • Kamimoto, Y., Gatmaitan, Z., Hsu, J., and Arias, I. M. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J. Biol. Chem., 264: 11693-11698, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 11693-11698
    • Kamimoto, Y.1    Gatmaitan, Z.2    Hsu, J.3    Arias, I.M.4
  • 28
    • 0021349075 scopus 로고
    • Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles
    • Meier, P. J., Sztul, E. S., Reuben, A., and Boyer, J. L. Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. J. Cell Biol., 98: 991-1000, 1984.
    • (1984) J. Cell Biol. , vol.98 , pp. 991-1000
    • Meier, P.J.1    Sztul, E.S.2    Reuben, A.3    Boyer, J.L.4
  • 29
    • 0026077224 scopus 로고
    • ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles
    • Adachi, Y., Kobayashi, H., Kurumi, Y., Shouji, M., Kitano, M., and Yamamoto, T. ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles. Hepatology, 14: 655-659, 1991.
    • (1991) Hepatology , vol.14 , pp. 655-659
    • Adachi, Y.1    Kobayashi, H.2    Kurumi, Y.3    Shouji, M.4    Kitano, M.5    Yamamoto, T.6
  • 30
    • 0025132673 scopus 로고
    • ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane
    • Ishikawa, T., Müller, M., Klünemann, C., Schaub, T., and Keppler, D. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. J. Biol. Chem., 265: 19279-19286, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19279-19286
    • Ishikawa, T.1    Müller, M.2    Klünemann, C.3    Schaub, T.4    Keppler, D.5
  • 31
    • 0025861580 scopus 로고
    • ATP-dependent S-(2,4-dinitrophenyl) glutathione transport in canalicular plasma membrane vesicles from rat liver
    • Akerboom, T. P. M., Narayanaswami, V., Kunst, M., and Sies, H. ATP-dependent S-(2,4-dinitrophenyl) glutathione transport in canalicular plasma membrane vesicles from rat liver. J. Biol. Chem., 266: 13147-13152, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 13147-13152
    • Akerboom, T.P.M.1    Narayanaswami, V.2    Kunst, M.3    Sies, H.4
  • 33
    • 0031031247 scopus 로고    scopus 로고
    • Molecular cloning of canalicular multispecific organic anion transporter (cMOAT) whose expression is defective in mutant rats with hereditary conjugated hyperbilirubinemia (EHBR)
    • Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T., and Sugiyama, Y. Molecular cloning of canalicular multispecific organic anion transporter (cMOAT) whose expression is defective in mutant rats with hereditary conjugated hyperbilirubinemia (EHBR). Am. J. Physiol., 272: G16-G22, 1997.
    • (1997) Am. J. Physiol. , vol.272
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 36
    • 0028001416 scopus 로고
    • ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein
    • Jedlitschky, G., Leier, I., Buchholz, U., Center, M., and Keppler, D. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res., 54: 4833-4836, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 4833-4836
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Center, M.4    Keppler, D.5
  • 37
    • 0029133131 scopus 로고
    • Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
    • Mayer, R., Kartenbeck, J., Buchler, M., Jedlitschky, G., Leier, I., and Keppler, D. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J. Cell Biol., 131: 137-150, 1995.
    • (1995) J. Cell Biol. , vol.131 , pp. 137-150
    • Mayer, R.1    Kartenbeck, J.2    Buchler, M.3    Jedlitschky, G.4    Leier, I.5    Keppler, D.6
  • 39
    • 0030063480 scopus 로고    scopus 로고
    • Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
    • Jedlitschky, G., Leier, I., Buchholz, U., Barnouin, K., Kurz, G., and Keppler, D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res., 56: 988-994, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 988-994
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Barnouin, K.4    Kurz, G.5    Keppler, D.6
  • 40
    • 0029918142 scopus 로고    scopus 로고
    • ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP)
    • Loe, D. W., Almquist, K. C., Cole, S. P. C., and Deeley, R. G. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). J. Biol. Chem., 271: 9683-9689, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9683-9689
    • Loe, D.W.1    Almquist, K.C.2    Cole, S.P.C.3    Deeley, R.G.4
  • 41
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • Taniguchi, K., Wada, M., Kohno, K., Nakamura, T., Kawabe, T., Kawakami, M., Kagotani, K., Okumura, K., Akiyama, S., and Kuwano, M. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res., 56: 4124-4129, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3    Nakamura, T.4    Kawabe, T.5    Kawakami, M.6    Kagotani, K.7    Okumura, K.8    Akiyama, S.9    Kuwano, M.10
  • 42
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRPI), in human cancer cell lines
    • Kool, M., de Haas, M., Scheffer, G. L., Scheper, R. J., Eijk, M. J. T., and Juijn, J. A. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRPI), in human cancer cell lines. Cancer Res., 57: 3537-3547, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 3537-3547
    • Kool, M.1    De Haas, M.2    Scheffer, G.L.3    Scheper, R.J.4    Eijk, M.J.T.5    Juijn, J.A.6
  • 43
    • 0030814774 scopus 로고    scopus 로고
    • The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man
    • Paulusma, C. C., and Elferink, R. P. J. O. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man. J. Mol. Med., 75: 420-428, 1997.
    • (1997) J. Mol. Med. , vol.75 , pp. 420-428
    • Paulusma, C.C.1    Elferink, R.P.J.O.2
  • 45
    • 0025343017 scopus 로고
    • Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes
    • Kobayashi, K., Sogame, Y., Hara, H., and Hayashi, K. Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J. Biol. Chem., 265: 7737-7741, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 7737-7741
    • Kobayashi, K.1    Sogame, Y.2    Hara, H.3    Hayashi, K.4
  • 46
    • 0021325788 scopus 로고
    • Biliary transport of glutathione S-conjugate by rat liver canalicular membrane vesicles
    • Inoue, M., Akerboom, T. P. M., Sies, H., Kinne, R., Thao, T., and Arias, I. M. Biliary transport of glutathione S-conjugate by rat liver canalicular membrane vesicles. J. Biol. Chem., 259: 4998-5002, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 4998-5002
    • Inoue, M.1    Akerboom, T.P.M.2    Sies, H.3    Kinne, R.4    Thao, T.5    Arias, I.M.6
  • 47
    • 0029926676 scopus 로고    scopus 로고
    • Recent advances in carrier mediated hepatic uptake and biliary excretion of xenobiotics
    • Yamazaki, M., Suzuki, H., and Sugiyama, Y. Recent advances in carrier mediated hepatic uptake and biliary excretion of xenobiotics. Pharm. Res., 13: 497-513, 1996.
    • (1996) Pharm. Res. , vol.13 , pp. 497-513
    • Yamazaki, M.1    Suzuki, H.2    Sugiyama, Y.3
  • 49
    • 0027081369 scopus 로고
    • Adenosine triphosphate-dependent taurocholate transport in human liver plasma membranes
    • Wolters, H., Kuipers, F., Slooff, M. J. H., and Vonk, R. J. Adenosine triphosphate-dependent taurocholate transport in human liver plasma membranes. J. Clin. Invest., 90: 2321-2326, 1992.
    • (1992) J. Clin. Invest. , vol.90 , pp. 2321-2326
    • Wolters, H.1    Kuipers, F.2    Slooff, M.J.H.3    Vonk, R.J.4
  • 50
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microsomal quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. A rapid and sensitive method for the quantitation of microsomal quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 51
    • 0019854279 scopus 로고
    • A pharmacokinetic analysis program (MULTI) for microcomputer
    • Yamaoka, K., Tanigawara, Y., Nakagawa, T., and Uno, T. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobiol-Dyn., 4: 879-885, 1981.
    • (1981) J. Pharmacobiol-Dyn. , vol.4 , pp. 879-885
    • Yamaoka, K.1    Tanigawara, Y.2    Nakagawa, T.3    Uno, T.4
  • 52
    • 0018091195 scopus 로고
    • Application of Akaike's Criterion (AIC) in the evaluation of linear pharmacokinetic equations
    • Yamaoka, K., Nakagawa, T., and Uno, T. Application of Akaike's Criterion (AIC) in the evaluation of linear pharmacokinetic equations. J. Pharmacokinet. Biopharm., 6: 165-175, 1978.
    • (1978) J. Pharmacokinet. Biopharm. , vol.6 , pp. 165-175
    • Yamaoka, K.1    Nakagawa, T.2    Uno, T.3
  • 53
    • 0028843263 scopus 로고
    • Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11
    • Sasaki, Y., Yoshida, Y., Sudoh, K., Hakusui, H., Fujii, H., Ohtsu, T., Wakita, H., Igarashi, T., and Itoh, K. Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11. Jpn. J. Cancer Res., 86: 111-116, 1995.
    • (1995) Jpn. J. Cancer Res. , vol.86 , pp. 111-116
    • Sasaki, Y.1    Yoshida, Y.2    Sudoh, K.3    Hakusui, H.4    Fujii, H.5    Ohtsu, T.6    Wakita, H.7    Igarashi, T.8    Itoh, K.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.