Cytotoxicity and Topo i targeting activity of substituted 10-nitrogenous heterocyclic aromatic group derivatives of SN-38

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 3200-3206

  Li, Qing Yong ^a   Deng, Xiao Qiu ^a   Zu, Yuan Gang ^a   Lv, Hongyan ^a   Su, Lin ^a   Yao, Liping ^a   Zhang, Yu ^a   Li, Lei ^a  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

Author keywords

Cytotoxicity; Derivatives; SN 38; Topo I inhibition

Indexed keywords

10 ( 2 PYRIDYLETHOXY) 7 ETHYL CAMPTOTHECIN BROMIDE; 10 ( 3 IMIDAZOLYLPROPOXY) 7 ETHYL CAMPTOTHECIN; 10 ( 3 PURINYLPROPOXY) 7 ETHYL CAMPTOTHECIN; 10 ( 3 PYRIDYLPROPOXY) 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 2 ( 3 ACETYLPYRIDYL)ETHOXY] 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 2 ( 3 FLUOROPYRIDYL)ETHOXY] 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 2 ( 3 HYDROXYPYRIDYL)ETHOXY] 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 2 ( 3 PICOLINYL)ETHOXY] 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 3 ( 3 ACETYLPYRIDYL)PROPOXY] 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 3 ( 3 FLUOROPYRIDYL)PROPOXY] 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 3 ( 3 HYDROXYPYRIDYL)PROPOXY] 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 3 ( 3 PICOLINYL)PROPOXY] 7 ETHYL CAMPTOTHECIN BROMIDE; 10 [ 3 ( 6 TRIFLUOROMETHYLPYRIMIDINE 4 YLOXY)PROPOXY] 7 ETHYL CAMPTOTHECIN; 10 [ 3 [ 1 ( 1,2,4 TRIAZOLYL)]PROPOXY] 7 ETHYL CAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; AROMATIC COMPOUND; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CPT; DNA TOPOISOMERASE; ETHANE; PYRIDINE DERIVATIVE; SODIUM CHLORIDE; TOPOTECAN; UNCLASSIFIED DRUG; WATER;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG SOLUBILITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 77954348873     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.03.013     Document Type: Article

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