Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 22, 2004, Pages 5481-5484

  Smith, Nicholas D ^a   Poon, Steve F ^a   Huang, Dehua ^a   Green, Mitchell ^a   King, Christopher ^a   Tehrani, Lida ^a   Roppe, Jeffrey R ^a   Chung, Janice ^a   Chapman, Deborah P ^a   Cramer, Merryl ^a   Cosford, Nicholas D P ^a  

^a GENERAL ATOMICS   (United States)

Author keywords

Antagonist; Cytochrome P450 1A2; Metabotropic glutamate; Tetrazole

Indexed keywords

CYTOCHROME P450 1B1; IMIDAZOLE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 5144233794     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.018     Document Type: Article

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