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Volumn 9, Issue 8, 2013, Pages

The Protein Kinase Double-Stranded RNA-Dependent (PKR) Enhances Protection against Disease Cause by a Non-Viral Pathogen

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD40 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 1; INTERLEUKIN 12; NITRIC OXIDE; PROTEIN KINASE R; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; TUMOR NECROSIS FACTORRECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; NOS2 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR;

EID: 84883347520     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003557     Document Type: Article
Times cited : (31)

References (96)
  • 1
    • 0030664277 scopus 로고    scopus 로고
    • PKR - A protein kinase regulated by double-stranded RNA
    • Clemens MJ, (1997) PKR- A protein kinase regulated by double-stranded RNA. Am J Biochem Cell Biol 29: 945-949.
    • (1997) Am J Biochem Cell Biol , vol.29 , pp. 945-949
    • Clemens, M.J.1
  • 2
    • 0035800333 scopus 로고    scopus 로고
    • Signal integration via PKR
    • Williams BRG, (2001) Signal integration via PKR. Sci STKE 89: re2.
    • (2001) Sci STKE , vol.89
    • Williams, B.R.G.1
  • 3
    • 33845627785 scopus 로고    scopus 로고
    • Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
    • Garcia MA, Gil J, Ventoso I, Guerra S, Domingo E, et al. (2006) Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev 70: 1032-1060.
    • (2006) Microbiol Mol Biol Rev , vol.70 , pp. 1032-1060
    • Garcia, M.A.1    Gil, J.2    Ventoso, I.3    Guerra, S.4    Domingo, E.5
  • 4
    • 0032530310 scopus 로고    scopus 로고
    • Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation
    • Nanduri S, Carpick BW, Yang Y, Williams BR, Qin J, (1998) Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. EMBO J 17: 5458-5465.
    • (1998) EMBO J , vol.17 , pp. 5458-5465
    • Nanduri, S.1    Carpick, B.W.2    Yang, Y.3    Williams, B.R.4    Qin, J.5
  • 6
    • 0033679958 scopus 로고    scopus 로고
    • Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection
    • Balachandran S, Roberts PC, Brown LE, Truong H, Pattnaik AK, et al. (2000) Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity 13: 129-141.
    • (2000) Immunity , vol.13 , pp. 129-141
    • Balachandran, S.1    Roberts, P.C.2    Brown, L.E.3    Truong, H.4    Pattnaik, A.K.5
  • 7
    • 0033809383 scopus 로고    scopus 로고
    • The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus
    • Stojdl DF, Abraham N, Knowles S, Marius R, Brasey A, et al. (2000) The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus. J Virol 74: 9580-9585.
    • (2000) J Virol , vol.74 , pp. 9580-9585
    • Stojdl, D.F.1    Abraham, N.2    Knowles, S.3    Marius, R.4    Brasey, A.5
  • 9
    • 33746050680 scopus 로고    scopus 로고
    • The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simples virus type 2 infection
    • Carr DJJ, Wuest T, Tomanek L, Silverman RH, Williams BRG, (2006) The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simples virus type 2 infection. Immunology 118: 520-526.
    • (2006) Immunology , vol.118 , pp. 520-526
    • Carr, D.J.J.1    Wuest, T.2    Tomanek, L.3    Silverman, R.H.4    Williams, B.R.G.5
  • 10
    • 17444449609 scopus 로고    scopus 로고
    • Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-κB
    • Kumar A, Yang Y-L, Flati V, Der S, Kadereit S, et al. (1997) Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-κB. EMBO J 16: 406-416.
    • (1997) EMBO J , vol.16 , pp. 406-416
    • Kumar, A.1    Yang, Y.-L.2    Flati, V.3    Der, S.4    Kadereit, S.5
  • 11
    • 79960986612 scopus 로고    scopus 로고
    • Protein kinase R as mediator of the effects of interferon (IFN) γ and tumor necrosis factor (TNF) α on normal and dysplastic hematopoiesis
    • Sharma B, Altman JK, Goussetis DJ, Verma AK, Platanias LC, (2011) Protein kinase R as mediator of the effects of interferon (IFN) γ and tumor necrosis factor (TNF) α on normal and dysplastic hematopoiesis. J Biol Chem 286: 27506-27514.
    • (2011) J Biol Chem , vol.286 , pp. 27506-27514
    • Sharma, B.1    Altman, J.K.2    Goussetis, D.J.3    Verma, A.K.4    Platanias, L.C.5
  • 12
    • 34347225099 scopus 로고    scopus 로고
    • The dsRNA protein kinase PKR: virus and cell control
    • Garcia MA, Meurs EF, Esteban M, (2007) The dsRNA protein kinase PKR: virus and cell control. Biochemie 89: 799-811.
    • (2007) Biochemie , vol.89 , pp. 799-811
    • Garcia, M.A.1    Meurs, E.F.2    Esteban, M.3
  • 13
    • 0034663942 scopus 로고    scopus 로고
    • The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
    • Goh KC, deVeer MJ, Williams BRG, (2000) The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J 19: 4292-4297.
    • (2000) EMBO J , vol.19 , pp. 4292-4297
    • Goh, K.C.1    deVeer, M.J.2    Williams, B.R.G.3
  • 14
    • 0028852619 scopus 로고
    • Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction
    • Mundschau LJ, Faller DV, (1995) Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction. J Biol Chem 270: 3100-3106.
    • (1995) J Biol Chem , vol.270 , pp. 3100-3106
    • Mundschau, L.J.1    Faller, D.V.2
  • 15
    • 0033056848 scopus 로고    scopus 로고
    • RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling
    • Ito T, Yang M, May WS, (1999) RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. J Biol Chem 274: 15427-15432.
    • (1999) J Biol Chem , vol.274 , pp. 15427-15432
    • Ito, T.1    Yang, M.2    May, W.S.3
  • 16
    • 0032480017 scopus 로고    scopus 로고
    • PACT, a protein activator of the interferon-induced protein kinase, PKR
    • Patel RC, Sen GC, (1998) PACT, a protein activator of the interferon-induced protein kinase, PKR. EMBO J 17: 4379-4390.
    • (1998) EMBO J , vol.17 , pp. 4379-4390
    • Patel, R.C.1    Sen, G.C.2
  • 18
    • 28244437069 scopus 로고    scopus 로고
    • A role for double-stranded RNA-activated protein kinase PKR in Mycobacterium-induced cytokine expression
    • Cheung BK, Lee DC, Li JC, Lau YL, Lau AS, (2005) A role for double-stranded RNA-activated protein kinase PKR in Mycobacterium-induced cytokine expression. J Immunol 175: 7218-7225.
    • (2005) J Immunol , vol.175 , pp. 7218-7225
    • Cheung, B.K.1    Lee, D.C.2    Li, J.C.3    Lau, Y.L.4    Lau, A.S.5
  • 19
    • 76149113276 scopus 로고    scopus 로고
    • Novel role for the double-stranded RNA-activated protein kinase PKR: modulation of macrophage infection by the protozoan parasite Leishmania
    • Pereira RMS, Dias Teixeira KL, Barreto-de-Souza V, Calegari-Silva TC, De-Melo LDB, et al. (2010) Novel role for the double-stranded RNA-activated protein kinase PKR: modulation of macrophage infection by the protozoan parasite Leishmania. FASEB J 24: 617-626.
    • (2010) FASEB J , vol.24 , pp. 617-626
    • Pereira, R.M.S.1    Dias Teixeira, K.L.2    Barreto-de-Souza, V.3    Calegari-Silva, T.C.4    De-Melo, L.D.B.5
  • 20
    • 84857127328 scopus 로고    scopus 로고
    • Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R
    • Wu KK, Koo J, Jiang X, Chen R, Cohen SN, et al. (2012) Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. Plos One 7: e30512.
    • (2012) Plos One , vol.7
    • Wu, K.K.1    Koo, J.2    Jiang, X.3    Chen, R.4    Cohen, S.N.5
  • 21
    • 0031278412 scopus 로고    scopus 로고
    • Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanisms of entry
    • Mordue DG, Sibley LD, (1997) Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanisms of entry. J Immunol 159: 4452-4459.
    • (1997) J Immunol , vol.159 , pp. 4452-4459
    • Mordue, D.G.1    Sibley, L.D.2
  • 22
    • 0023937713 scopus 로고
    • Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in mice
    • Suzuki Y, Remington JS, (1988) Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in mice. J Immunol 140: 3943-3946.
    • (1988) J Immunol , vol.140 , pp. 3943-3946
    • Suzuki, Y.1    Remington, J.S.2
  • 23
    • 0026749880 scopus 로고
    • Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii
    • Gazzinelli R, Xu Y, Hieny S, Cheever A, Sher A, (1992) Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol 149: 175-180.
    • (1992) J Immunol , vol.149 , pp. 175-180
    • Gazzinelli, R.1    Xu, Y.2    Hieny, S.3    Cheever, A.4    Sher, A.5
  • 24
    • 0031736936 scopus 로고    scopus 로고
    • Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection
    • Denkers EY, Gazzinelli RT, (1998) Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 11: 569-588.
    • (1998) Clin Microbiol Rev , vol.11 , pp. 569-588
    • Denkers, E.Y.1    Gazzinelli, R.T.2
  • 25
    • 0024438401 scopus 로고
    • Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice
    • Suzuki Y, Conley FK, Remington JS, (1989) Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice. J Immunol 143: 2045-2050.
    • (1989) J Immunol , vol.143 , pp. 2045-2050
    • Suzuki, Y.1    Conley, F.K.2    Remington, J.S.3
  • 26
    • 0027208743 scopus 로고
    • Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation
    • Gazzinelli RT, Eltoum I, Wynn TA, Sher A, (1993) Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J Immunol 151: 3672-3681.
    • (1993) J Immunol , vol.151 , pp. 3672-3681
    • Gazzinelli, R.T.1    Eltoum, I.2    Wynn, T.A.3    Sher, A.4
  • 27
    • 0028235657 scopus 로고
    • Toxoplasma gondii: acquired ocular toxoplasmosis in the murine model, protective role of TNF-α and IFN-γ
    • Gazzinelli RT, Brezin A, Li Q, Nussenblatt RB, Chan CC, (1994) Toxoplasma gondii: acquired ocular toxoplasmosis in the murine model, protective role of TNF-α and IFN-γ. Exp Parasitol 78: 217-229.
    • (1994) Exp Parasitol , vol.78 , pp. 217-229
    • Gazzinelli, R.T.1    Brezin, A.2    Li, Q.3    Nussenblatt, R.B.4    Chan, C.C.5
  • 29
    • 0030970867 scopus 로고    scopus 로고
    • Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii
    • Scharton-Kersten T, Yap G, Magram J, Sher A, (1997) Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med 185: 1261-1273.
    • (1997) J Exp Med , vol.185 , pp. 1261-1273
    • Scharton-Kersten, T.1    Yap, G.2    Magram, J.3    Sher, A.4
  • 30
    • 0031940206 scopus 로고    scopus 로고
    • Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo
    • Yap GS, Scharton-Kersten T, Charest H, Sher A, (1998) Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo. J Immunol 160: 1340-1345.
    • (1998) J Immunol , vol.160 , pp. 1340-1345
    • Yap, G.S.1    Scharton-Kersten, T.2    Charest, H.3    Sher, A.4
  • 31
    • 0032055198 scopus 로고    scopus 로고
    • Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis
    • Deckert-Schluter M, Bluethmann H, Rang A, Hof H, Schluter D, (1998) Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J Immunol 160: 3427-3436.
    • (1998) J Immunol , vol.160 , pp. 3427-3436
    • Deckert-Schluter, M.1    Bluethmann, H.2    Rang, A.3    Hof, H.4    Schluter, D.5
  • 32
    • 35148820081 scopus 로고    scopus 로고
    • West Nile Virus-induced interferon production is mediated by the double-stranded RNA-dependent protein kinase PKR
    • Gilfoy FD, Mason PW, (2007) West Nile Virus-induced interferon production is mediated by the double-stranded RNA-dependent protein kinase PKR. J Virol 81: 11148-11158.
    • (2007) J Virol , vol.81 , pp. 11148-11158
    • Gilfoy, F.D.1    Mason, P.W.2
  • 33
    • 54449092414 scopus 로고    scopus 로고
    • Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA
    • Chakrabarti A, Sadler AJ, Kar N, Young HA, Silverman RH, et al. (2008) Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA. J Biol Chem 282: 25132-25139.
    • (2008) J Biol Chem , vol.282 , pp. 25132-25139
    • Chakrabarti, A.1    Sadler, A.J.2    Kar, N.3    Young, H.A.4    Silverman, R.H.5
  • 34
    • 0034661669 scopus 로고    scopus 로고
    • Central role of double-stranded RNA-activated protein kinase in microbial induction of nitric oxide synthase
    • Uetani K, Der SD, Zamanian-Daryoush M, de la Motte C, Lieberman BY, et al. (2000) Central role of double-stranded RNA-activated protein kinase in microbial induction of nitric oxide synthase. J Immunol 165: 988-996.
    • (2000) J Immunol , vol.165 , pp. 988-996
    • Uetani, K.1    Der, S.D.2    Zamanian-Daryoush, M.3    de la Motte, C.4    Lieberman, B.Y.5
  • 35
    • 0023895411 scopus 로고
    • Interferon-γ: the major mediator of resistance against Toxoplasma gondii
    • Suzuki Y, Orellana MA, Schreiber RD, Remington JS, (1988) Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 240: 516-518.
    • (1988) Science , vol.240 , pp. 516-518
    • Suzuki, Y.1    Orellana, M.A.2    Schreiber, R.D.3    Remington, J.S.4
  • 36
    • 0027939611 scopus 로고
    • Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii
    • Gazzinelli RT, Wysocka M, Hayashi S, Denkers EY, Hieny S, et al. (1994) Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 153: 2533-2543.
    • (1994) J Immunol , vol.153 , pp. 2533-2543
    • Gazzinelli, R.T.1    Wysocka, M.2    Hayashi, S.3    Denkers, E.Y.4    Hieny, S.5
  • 37
    • 0034662258 scopus 로고    scopus 로고
    • IL-12 is required for the maintenance of IFN-γ production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii
    • Yap G, Pesin M, Sher A, (2000) IL-12 is required for the maintenance of IFN-γ production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J Immunol 165: 628-631.
    • (2000) J Immunol , vol.165 , pp. 628-631
    • Yap, G.1    Pesin, M.2    Sher, A.3
  • 38
    • 0027433208 scopus 로고
    • Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii
    • Hunter CA, Abrams JS, Beaman MH, Remington JS, (1993) Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii. Infect Immun 61: 4033-4044.
    • (1993) Infect Immun , vol.61 , pp. 4033-4044
    • Hunter, C.A.1    Abrams, J.S.2    Beaman, M.H.3    Remington, J.S.4
  • 39
    • 0030914438 scopus 로고    scopus 로고
    • Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice
    • Suzuki Y, Rani S, Liesenfeld O, Kojima T, Lim S, et al. (1997) Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice. Infect Immun 65: 2339-2345.
    • (1997) Infect Immun , vol.65 , pp. 2339-2345
    • Suzuki, Y.1    Rani, S.2    Liesenfeld, O.3    Kojima, T.4    Lim, S.5
  • 40
    • 22144487678 scopus 로고    scopus 로고
    • A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
    • Wilson EH, Wille-Reece U, Dzierszinski F, Hunter CA, (2005) A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J Neuroimmunol 165: 63-74.
    • (2005) J Neuroimmunol , vol.165 , pp. 63-74
    • Wilson, E.H.1    Wille-Reece, U.2    Dzierszinski, F.3    Hunter, C.A.4
  • 41
    • 0029148470 scopus 로고
    • IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR
    • Kirchhoff S, Koromilas AE, Schaper F, Grashoff M, Sonenberg N, et al. (1995) IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR. Oncogene 11: 439-445.
    • (1995) Oncogene , vol.11 , pp. 439-445
    • Kirchhoff, S.1    Koromilas, A.E.2    Schaper, F.3    Grashoff, M.4    Sonenberg, N.5
  • 42
    • 0028290902 scopus 로고
    • The interferon-inducced double-stranded RNA-activated protein kinase induces apoptosis
    • Lee SB, Esteban M, (1994) The interferon-inducced double-stranded RNA-activated protein kinase induces apoptosis. Virology 199: 491-496.
    • (1994) Virology , vol.199 , pp. 491-496
    • Lee, S.B.1    Esteban, M.2
  • 44
    • 33847144180 scopus 로고    scopus 로고
    • Conventional T-bet+Foxp3- Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    • Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, et al. (2007) Conventional T-bet+Foxp3- Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med 204: 273-283.
    • (2007) J Exp Med , vol.204 , pp. 273-283
    • Jankovic, D.1    Kullberg, M.C.2    Feng, C.G.3    Goldszmid, R.S.4    Collazo, C.M.5
  • 45
    • 83455210409 scopus 로고    scopus 로고
    • Protein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infection
    • Thakur SA, Zalinger ZB, Johnson TR, Imani F, (2011) Protein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infection. Clin Vaccine Immunol 18: 2060-2066.
    • (2011) Clin Vaccine Immunol , vol.18 , pp. 2060-2066
    • Thakur, S.A.1    Zalinger, Z.B.2    Johnson, T.R.3    Imani, F.4
  • 46
    • 0034161721 scopus 로고    scopus 로고
    • Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-γ, TNF-α, and inducible nitric oxide synthase
    • Kang H, Remington JS, Suzuki Y, (2000) Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-γ, TNF-α, and inducible nitric oxide synthase. J Immunol 164: 2629-2643.
    • (2000) J Immunol , vol.164 , pp. 2629-2643
    • Kang, H.1    Remington, J.S.2    Suzuki, Y.3
  • 47
    • 0030467716 scopus 로고    scopus 로고
    • Interferon-γ receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation
    • Deckert-Schluter M, Rang A, Weiner D, Huang S, Wiestler OD, et al. (1996) Interferon-γ receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation. Lab Invest 75: 827-841.
    • (1996) Lab Invest , vol.75 , pp. 827-841
    • Deckert-Schluter, M.1    Rang, A.2    Weiner, D.3    Huang, S.4    Wiestler, O.D.5
  • 48
    • 33646871748 scopus 로고    scopus 로고
    • Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction
    • Deckert M, Sedgwick JD, Fischer E, Schluter D, (2006) Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction. Acta Neuropathol 111: 548-558.
    • (2006) Acta Neuropathol , vol.111 , pp. 548-558
    • Deckert, M.1    Sedgwick, J.D.2    Fischer, E.3    Schluter, D.4
  • 49
    • 0033982191 scopus 로고    scopus 로고
    • The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis
    • Reichmann G, Walker W, Villegas EN, Craig L, Cai G, et al. (2000) The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis. Infect Immun 68: 1312-1318.
    • (2000) Infect Immun , vol.68 , pp. 1312-1318
    • Reichmann, G.1    Walker, W.2    Villegas, E.N.3    Craig, L.4    Cai, G.5
  • 50
    • 79251517741 scopus 로고    scopus 로고
    • The CD40-autophagy pathway is needed for host protection despite IFN-γ-dependent immunity and CD40 induces autophagy via control of p21 levels
    • Portillo J-AC, Okenka G, Reed E, Subauste A, Van Grol J, et al. (2010) The CD40-autophagy pathway is needed for host protection despite IFN-γ-dependent immunity and CD40 induces autophagy via control of p21 levels. Plos One pp. e14472.
    • (2010) Plos One
    • Portillo, J.-A.C.1    Okenka, G.2    Reed, E.3    Subauste, A.4    Van Grol, J.5
  • 51
    • 0345735831 scopus 로고    scopus 로고
    • CD154 activates macrophage anti-microbial activity in the absence of IFN-γ through a TNF-α-dependent mechanism
    • Andrade RM, Wessendarp M, Subauste CS, (2003) CD154 activates macrophage anti-microbial activity in the absence of IFN-γ through a TNF-α-dependent mechanism. J Immunol 171: 6750-6756.
    • (2003) J Immunol , vol.171 , pp. 6750-6756
    • Andrade, R.M.1    Wessendarp, M.2    Subauste, C.S.3
  • 52
    • 27144543529 scopus 로고    scopus 로고
    • TRAF6 signaling downstream of CD40 primes macrophages to acquire anti-microbial activity in response to TNF-α
    • Andrade RM, Wessendarp M, Portillo J-AC, Yang J-Q, Gomez FJ, et al. (2005) TRAF6 signaling downstream of CD40 primes macrophages to acquire anti-microbial activity in response to TNF-α. J Immunol 175: 6014-6021.
    • (2005) J Immunol , vol.175 , pp. 6014-6021
    • Andrade, R.M.1    Wessendarp, M.2    Portillo, J.-A.C.3    Yang, J.-Q.4    Gomez, F.J.5
  • 53
    • 33748331335 scopus 로고    scopus 로고
    • CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes
    • Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS, (2006) CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest 116: 2366-2377.
    • (2006) J Clin Invest , vol.116 , pp. 2366-2377
    • Andrade, R.M.1    Wessendarp, M.2    Gubbels, M.J.3    Striepen, B.4    Subauste, C.S.5
  • 54
    • 34248591490 scopus 로고    scopus 로고
    • CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages
    • Subauste CS, Andrade RM, Wessendarp M, (2007) CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages. Autophagy 3: 245-248.
    • (2007) Autophagy , vol.3 , pp. 245-248
    • Subauste, C.S.1    Andrade, R.M.2    Wessendarp, M.3
  • 55
    • 0037084504 scopus 로고    scopus 로고
    • All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction
    • Chung JY, Park YC, Ye H, Wu H, (2002) All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci 115: 679-688.
    • (2002) J Cell Sci , vol.115 , pp. 679-688
    • Chung, J.Y.1    Park, Y.C.2    Ye, H.3    Wu, H.4
  • 56
    • 5044223172 scopus 로고    scopus 로고
    • The multifaceted roles of TRAFs in the regulation of B-cell function
    • Bishop GA, (2004) The multifaceted roles of TRAFs in the regulation of B-cell function. Nat Rev Immunol 4: 775-786.
    • (2004) Nat Rev Immunol , vol.4 , pp. 775-786
    • Bishop, G.A.1
  • 58
    • 0032566341 scopus 로고    scopus 로고
    • CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
    • Pullen SS, Miller HG, Everdeen DS, Dang TT, Crute JJ, et al. (1998) CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. Biochemistry 37: 11836-11845.
    • (1998) Biochemistry , vol.37 , pp. 11836-11845
    • Pullen, S.S.1    Miller, H.G.2    Everdeen, D.S.3    Dang, T.T.4    Crute, J.J.5
  • 59
    • 27644531924 scopus 로고    scopus 로고
    • TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells
    • Davies CC, Mak TW, Young LS, Eliopoulos AG, (2005) TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol Cel Biol 25: 9806-9819.
    • (2005) Mol Cel Biol , vol.25 , pp. 9806-9819
    • Davies, C.C.1    Mak, T.W.2    Young, L.S.3    Eliopoulos, A.G.4
  • 61
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura S, Noda T, Yoshimori T, (2007) Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3: 452-460.
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 62
    • 0037169360 scopus 로고    scopus 로고
    • Human interferon-γ mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR
    • Ben-Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R, (2002) Human interferon-γ mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR. Cell 108: 221-232.
    • (2002) Cell , vol.108 , pp. 221-232
    • Ben-Asouli, Y.1    Banai, Y.2    Pel-Or, Y.3    Shir, A.4    Kaempfer, R.5
  • 63
    • 0025078211 scopus 로고
    • Treatment of toxoplasmic encephalitis in mice with recombinant gamma interferon
    • Suzuki Y, Conley FK, Remington JS, (1990) Treatment of toxoplasmic encephalitis in mice with recombinant gamma interferon. Infect Immun 58: 3050-3055.
    • (1990) Infect Immun , vol.58 , pp. 3050-3055
    • Suzuki, Y.1    Conley, F.K.2    Remington, J.S.3
  • 64
    • 0026021838 scopus 로고
    • Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-γ production and protective immunity induced by an attenuated Toxoplasma gondii vaccine
    • Gazzinelli RT, Hakim FT, Hieny S, Shearer GM, Sher A, (1991) Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-γ production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 146: 286-292.
    • (1991) J Immunol , vol.146 , pp. 286-292
    • Gazzinelli, R.T.1    Hakim, F.T.2    Hieny, S.3    Shearer, G.M.4    Sher, A.5
  • 65
    • 0031571269 scopus 로고    scopus 로고
    • Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii
    • Denkers EY, Yap G, Scharton-Kersten T, Charest H, Butcher BA, et al. (1997) Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii. J Immunol 159: 1903-1908.
    • (1997) J Immunol , vol.159 , pp. 1903-1908
    • Denkers, E.Y.1    Yap, G.2    Scharton-Kersten, T.3    Charest, H.4    Butcher, B.A.5
  • 66
    • 0025719117 scopus 로고
    • Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells
    • Subauste CS, Koniaris AH, Remington JS, (1991) Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells. J Immunol 147: 3955-3959.
    • (1991) J Immunol , vol.147 , pp. 3955-3959
    • Subauste, C.S.1    Koniaris, A.H.2    Remington, J.S.3
  • 67
    • 0025949660 scopus 로고
    • CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells
    • Hakim FT, Gazzinelli RT, Denkers EY, Hieny S, Shearer GM, et al. (1991) CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells. J Immunol 147: 2310-2316.
    • (1991) J Immunol , vol.147 , pp. 2310-2316
    • Hakim, F.T.1    Gazzinelli, R.T.2    Denkers, E.Y.3    Hieny, S.4    Shearer, G.M.5
  • 68
    • 77950565861 scopus 로고    scopus 로고
    • Removal of Toxoplasma gondii cysts from the brain by perforin-mediated activity of CD8+ T cells
    • Suzuki Y, Wang X, Jortner BS, Payne L, Ni Y, et al. (2010) Removal of Toxoplasma gondii cysts from the brain by perforin-mediated activity of CD8+ T cells. Am J Pathol 176: 1607-1613.
    • (2010) Am J Pathol , vol.176 , pp. 1607-1613
    • Suzuki, Y.1    Wang, X.2    Jortner, B.S.3    Payne, L.4    Ni, Y.5
  • 69
    • 0035873486 scopus 로고    scopus 로고
    • RNA-dependent protein kinase PKR is required for activation of NF-κB by IFN-γ in a STAT1-independent pathway
    • Deb A, Haque J, Morgesen T, Silverman RH, Williams BRG, (2001) RNA-dependent protein kinase PKR is required for activation of NF-κB by IFN-γ in a STAT1-independent pathway. J Immunol 166: 6170-6180.
    • (2001) J Immunol , vol.166 , pp. 6170-6180
    • Deb, A.1    Haque, J.2    Morgesen, T.3    Silverman, R.H.4    Williams, B.R.G.5
  • 70
    • 33847236171 scopus 로고    scopus 로고
    • Genetic deletion of PKR abrogates TNF-induced activation of IkBa kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation
    • Takada Y, Ichikawa HT, Pataer A, Swisher S, Aggarwal BB, (2007) Genetic deletion of PKR abrogates TNF-induced activation of IkBa kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. Oncogene 26: 1201-1212.
    • (2007) Oncogene , vol.26 , pp. 1201-1212
    • Takada, Y.1    Ichikawa, H.T.2    Pataer, A.3    Swisher, S.4    Aggarwal, B.B.5
  • 71
    • 0033582503 scopus 로고    scopus 로고
    • Involvement of double-stranded RNA-activated protein kinase in the synergistic activation of nuclear factor-κB by tumor necrosis factor-α and γ-interferon in preneural cells
    • Cheshire JL, Williams BRG, Baldwin AS, (1999) Involvement of double-stranded RNA-activated protein kinase in the synergistic activation of nuclear factor-κB by tumor necrosis factor-α and γ-interferon in preneural cells. J Biol Chem 274: 4801-4806.
    • (1999) J Biol Chem , vol.274 , pp. 4801-4806
    • Cheshire, J.L.1    Williams, B.R.G.2    Baldwin, A.S.3
  • 72
    • 0034679589 scopus 로고    scopus 로고
    • Potential role of PKR in double-stranded RNA-induced macrophage activation
    • Maggi LB, Heitmeier MR, Scheuner D, Kaufman RJ, Mark R, et al. (2000) Potential role of PKR in double-stranded RNA-induced macrophage activation. EMBO J 19: 3630-3636.
    • (2000) EMBO J , vol.19 , pp. 3630-3636
    • Maggi, L.B.1    Heitmeier, M.R.2    Scheuner, D.3    Kaufman, R.J.4    Mark, R.5
  • 73
    • 0042307304 scopus 로고    scopus 로고
    • Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
    • Diebold SS, Montoya M, Unger H, Alexopoulou L, Roy P, et al. (2003) Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 424: 324-328.
    • (2003) Nature , vol.424 , pp. 324-328
    • Diebold, S.S.1    Montoya, M.2    Unger, H.3    Alexopoulou, L.4    Roy, P.5
  • 74
    • 33947403181 scopus 로고    scopus 로고
    • Autophagic elimination of intracellular parasites. Convergent induction by IFN-γ and CD40 ligation?
    • Yap G, Ling YM, Zhao Y, (2007) Autophagic elimination of intracellular parasites. Convergent induction by IFN-γ and CD40 ligation? Autophagy 3: 163-165.
    • (2007) Autophagy , vol.3 , pp. 163-165
    • Yap, G.1    Ling, Y.M.2    Zhao, Y.3
  • 75
    • 33745214259 scopus 로고    scopus 로고
    • Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
    • Kuwajima S, Sato T, Ishida K, Tada H, Tezuka H, et al. (2006) Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol 7: 740-746.
    • (2006) Nat Immunol , vol.7 , pp. 740-746
    • Kuwajima, S.1    Sato, T.2    Ishida, K.3    Tada, H.4    Tezuka, H.5
  • 76
    • 18244367700 scopus 로고    scopus 로고
    • CD40 is a cellular receptor mediating Mycobacterial heat shock protein 70 stimulation of C-C chemokines
    • Wang Y, Kelly CG, Karttunen JT, Whithall T, Lehner PJ, et al. (2001) CD40 is a cellular receptor mediating Mycobacterial heat shock protein 70 stimulation of C-C chemokines. Immunity 15: 971-983.
    • (2001) Immunity , vol.15 , pp. 971-983
    • Wang, Y.1    Kelly, C.G.2    Karttunen, J.T.3    Whithall, T.4    Lehner, P.J.5
  • 77
    • 2642654218 scopus 로고    scopus 로고
    • Bradyzoite development in Toxoplasma gondii and the hsp70 stress response
    • Weiss LM, Ma YF, Takvorian PM, Tanowitz HB, Wittner M, (1998) Bradyzoite development in Toxoplasma gondii and the hsp70 stress response. Infect Immun 66: 3295-3302.
    • (1998) Infect Immun , vol.66 , pp. 3295-3302
    • Weiss, L.M.1    Ma, Y.F.2    Takvorian, P.M.3    Tanowitz, H.B.4    Wittner, M.5
  • 78
    • 0028858649 scopus 로고
    • Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes
    • Kiener PA, Moran-Davis P, Rankin BM, Wahl AF, Aruffo A, et al. (1995) Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J Immunol 155: 4917-4925.
    • (1995) J Immunol , vol.155 , pp. 4917-4925
    • Kiener, P.A.1    Moran-Davis, P.2    Rankin, B.M.3    Wahl, A.F.4    Aruffo, A.5
  • 79
    • 0033730051 scopus 로고    scopus 로고
    • Human T cells elicit IFN-α secretion from dendritic cells following cell to cell interactions
    • Foster GR, Germain C, Jones M, Lechler RI, Lombardi G, (2000) Human T cells elicit IFN-α secretion from dendritic cells following cell to cell interactions. Eur J Immunol 30: 3228-3235.
    • (2000) Eur J Immunol , vol.30 , pp. 3228-3235
    • Foster, G.R.1    Germain, C.2    Jones, M.3    Lechler, R.I.4    Lombardi, G.5
  • 80
    • 0033553392 scopus 로고    scopus 로고
    • CD40 signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs). Binding site specificity and activation of down-stream pathways by distinct TRAFs
    • Pullen SS, Dang TTA, Crute JJ, Kehry MR, (1999) CD40 signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs). Binding site specificity and activation of down-stream pathways by distinct TRAFs. J Biol Chem 274: 14246-14254.
    • (1999) J Biol Chem , vol.274 , pp. 14246-14254
    • Pullen, S.S.1    Dang, T.T.A.2    Crute, J.J.3    Kehry, M.R.4
  • 81
    • 80053616925 scopus 로고    scopus 로고
    • Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response
    • Pfaller CK, Li Z, George CX, Samuel CE, (2011) Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response. Curr Opin Immunol 23: 573-582.
    • (2011) Curr Opin Immunol , vol.23 , pp. 573-582
    • Pfaller, C.K.1    Li, Z.2    George, C.X.3    Samuel, C.E.4
  • 82
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine B, Mizushima N, Virgin HW, (2011) Autophagy in immunity and inflammation. Nature 469: 323-335.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 83
    • 0037039442 scopus 로고    scopus 로고
    • Regulation of starvation- and virus-induced autophagy by the eIF2α signaling pathway
    • Talloczy Z, Jiang W, Virgin HW, Leib DA, Scheuner D, et al. (2002) Regulation of starvation- and virus-induced autophagy by the eIF2α signaling pathway. Proc Natl Acad Sci USA 99: 190-195.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 190-195
    • Talloczy, Z.1    Jiang, W.2    Virgin, H.W.3    Leib, D.A.4    Scheuner, D.5
  • 84
    • 33644609471 scopus 로고    scopus 로고
    • PKR-dependent autophagic degradation of herpes simplex virus type 1
    • Talloczy Z, Virgin HW, Levine B, (2006) PKR-dependent autophagic degradation of herpes simplex virus type 1. Autophagy 2: 24-29.
    • (2006) Autophagy , vol.2 , pp. 24-29
    • Talloczy, Z.1    Virgin, H.W.2    Levine, B.3
  • 85
    • 33947715151 scopus 로고    scopus 로고
    • HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
    • Orvedahl A, Alexander D, Talloczy Z, Sun Q, Wei Y, et al. (2007) HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host & Microbe 1: 23-35.
    • (2007) Cell Host & Microbe , vol.1 , pp. 23-35
    • Orvedahl, A.1    Alexander, D.2    Talloczy, Z.3    Sun, Q.4    Wei, Y.5
  • 86
    • 18744437901 scopus 로고    scopus 로고
    • Interferon-γ antagonizes transforming growth factor-β2-mediated immunosuppression in murine Toxoplasma encephalitis
    • Schluter D, Bertsch D, Frei K, Hubers SB, Wiestler OD, et al. (1998) Interferon-γ antagonizes transforming growth factor-β2-mediated immunosuppression in murine Toxoplasma encephalitis. J Neuroimmunol 81: 38-48.
    • (1998) J Neuroimmunol , vol.81 , pp. 38-48
    • Schluter, D.1    Bertsch, D.2    Frei, K.3    Hubers, S.B.4    Wiestler, O.D.5
  • 87
    • 0029590069 scopus 로고
    • Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
    • Yang Y-L, Reis LFL, Pavlovic J, Aguzzi A, Schafer R, et al. (1995) Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J 14: 6095-6106.
    • (1995) EMBO J , vol.14 , pp. 6095-6106
    • Yang, Y.-L.1    Reis, L.F.L.2    Pavlovic, J.3    Aguzzi, A.4    Schafer, R.5
  • 88
    • 0037228729 scopus 로고    scopus 로고
    • High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein
    • Gubbels MJ, Li C, Striepen B, (2003) High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein. Antimicrob Agents Chemother 47: 309-316.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 309-316
    • Gubbels, M.J.1    Li, C.2    Striepen, B.3
  • 89
    • 4043119714 scopus 로고    scopus 로고
    • Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii
    • McKee AS, Dzierszinski F, Boes M, Roos DS, Pearce EJ, (2004) Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol 173: 2632-2640.
    • (2004) J Immunol , vol.173 , pp. 2632-2640
    • McKee, A.S.1    Dzierszinski, F.2    Boes, M.3    Roos, D.S.4    Pearce, E.J.5
  • 90
    • 4444376796 scopus 로고    scopus 로고
    • Vaccination protects B cell-deficient mice against an oral challenge with mildly virulent Toxoplasma gondii
    • Johnson LL, Lanthier P, Hoffman J, Chen W, (2004) Vaccination protects B cell-deficient mice against an oral challenge with mildly virulent Toxoplasma gondii. Vaccine 22: 4054-4061.
    • (2004) Vaccine , vol.22 , pp. 4054-4061
    • Johnson, L.L.1    Lanthier, P.2    Hoffman, J.3    Chen, W.4
  • 91
    • 9444244375 scopus 로고    scopus 로고
    • Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury
    • Park E-M, Cho S, Frys K, Racchumi G, Zhou P, et al. (2004) Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury. Stroke 35: 2896-2901.
    • (2004) Stroke , vol.35 , pp. 2896-2901
    • Park, E.-M.1    Cho, S.2    Frys, K.3    Racchumi, G.4    Zhou, P.5
  • 92
    • 84855296038 scopus 로고    scopus 로고
    • A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans
    • Tomalka J, Ganesan S, Azodi E, Patel K, Majmundar P, et al. (2011) A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans. PLoS Pathog 7: e1002379.
    • (2011) PLoS Pathog , vol.7
    • Tomalka, J.1    Ganesan, S.2    Azodi, E.3    Patel, K.4    Majmundar, P.5
  • 93
    • 0033119065 scopus 로고    scopus 로고
    • Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR
    • Overbergh L, Valckx D, Waer M, Mathieu C, (1999) Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 11: 305-312.
    • (1999) Cytokine , vol.11 , pp. 305-312
    • Overbergh, L.1    Valckx, D.2    Waer, M.3    Mathieu, C.4
  • 94
    • 33846556939 scopus 로고    scopus 로고
    • Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4+ T cells from HIV-1-infected patients
    • Subauste CS, Subauste A, Wessendarp M, (2007) Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4+ T cells from HIV-1-infected patients. J Immunol 178: 1645-1653.
    • (2007) J Immunol , vol.178 , pp. 1645-1653
    • Subauste, C.S.1    Subauste, A.2    Wessendarp, M.3
  • 95
    • 17644425741 scopus 로고    scopus 로고
    • CD40 signaling in macrophages induces anti-microbial activity against an intracellular pathogen independently of IFN-γ and reactive nitrogen intermediates
    • Andrade RM, Portillo J-AC, Wessendarp M, Subauste CS, (2005) CD40 signaling in macrophages induces anti-microbial activity against an intracellular pathogen independently of IFN-γ and reactive nitrogen intermediates. Infect Immun 73: 3115-3123.
    • (2005) Infect Immun , vol.73 , pp. 3115-3123
    • Andrade, R.M.1    Portillo, J.-A.C.2    Wessendarp, M.3    Subauste, C.S.4
  • 96
    • 77955716367 scopus 로고    scopus 로고
    • Heat shock protein gp96 and NAD{sound recording copyright}H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury
    • Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens M, et al. (2010) Heat shock protein gp96 and NAD{sound recording copyright}H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury. Cell Death and Differ 17: 1474-1485.
    • (2010) Cell Death and Differ , vol.17 , pp. 1474-1485
    • Ben Mkaddem, S.1    Pedruzzi, E.2    Werts, C.3    Coant, N.4    Bens, M.5


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