Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation

Virology

Volumn 396, Issue 1, 2010, Pages 21-29

  Johnson, Karen E ^a   Knipe, David M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

HSV 1; ICP27; Immune evasion; Innate immunity; Secreted protein; Type I interferon

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; ALPHA BETA INTERFERON RECEPTOR CHAIN 1; ALPHA BETA INTERFERON RECEPTOR CHAIN 2; ALPHA INTERFERON; INTERFERON; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR 15; JANUS KINASE 1; MESSENGER RNA; PROTEIN ICP27; PROTEINASE; STAT1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; BYSTANDER EFFECT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; RNA SPLICING; SIGNAL TRANSDUCTION; THERMOSTABILITY; VIRUS REPLICATION; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BLOTTING, NORTHERN; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; CYTOKINES; FLUORESCENT ANTIBODY TECHNIQUE; HERPESVIRUS 1, HUMAN; IMMEDIATE-EARLY PROTEINS; INTERFERON TYPE I; JANUS KINASE 1; PHOSPHORYLATION; RECEPTOR, INTERFERON ALPHA-BETA; RNA SPLICING; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; UBIQUITINS; VERO CELLS;

HUMAN HERPESVIRUS 1;

EID: 70649086100     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.09.021     Document Type: Article

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