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Volumn 25, Issue 10, 2013, Pages 610-616

Biomarkers of radiation exposure: Can they predict normal tissue radiosensitivity?

Author keywords

Chromosome aberrations; DNA damage response; Gamma H2AX foci; Normal tissue damage; Radiosensitivity; Radiotherapy

Indexed keywords

BIOLOGICAL MARKER;

EID: 84883275812     PISSN: 09366555     EISSN: 14332981     Source Type: Journal    
DOI: 10.1016/j.clon.2013.06.010     Document Type: Article
Times cited : (45)

References (73)
  • 1
    • 0029928295 scopus 로고    scopus 로고
    • Normal tissue radiosensitivity - how important is it?
    • Burnet N.G., Wurm R., Nyman J., Peacock J.H. Normal tissue radiosensitivity - how important is it?. Clin Oncol 1996, 8:25-34.
    • (1996) Clin Oncol , vol.8 , pp. 25-34
    • Burnet, N.G.1    Wurm, R.2    Nyman, J.3    Peacock, J.H.4
  • 2
    • 0020580592 scopus 로고
    • Ataxia telangiectasia with cancer. An indication for reduced radiotherapy and chemotherapy doses
    • Abadir R., Hakami N. Ataxia telangiectasia with cancer. An indication for reduced radiotherapy and chemotherapy doses. Br J Radiol 1983, 56(665):343-345.
    • (1983) Br J Radiol , vol.56 , Issue.665 , pp. 343-345
    • Abadir, R.1    Hakami, N.2
  • 3
    • 0023387494 scopus 로고
    • Radiotherapeutic management of medulloblastoma in a pediatric patient with ataxia telangiectasia
    • Hart R.M., Kimler B.F., Evans R.G., Park C.H. Radiotherapeutic management of medulloblastoma in a pediatric patient with ataxia telangiectasia. Int J Radiat Oncol Biol Phys 1987, 13:1237-1240.
    • (1987) Int J Radiat Oncol Biol Phys , vol.13 , pp. 1237-1240
    • Hart, R.M.1    Kimler, B.F.2    Evans, R.G.3    Park, C.H.4
  • 4
    • 0030045139 scopus 로고    scopus 로고
    • How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?
    • Tucker S.L., Geara F.B., Peters L.J., Brock W.A. How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?. Radiother Oncol 1996, 38:103-113.
    • (1996) Radiother Oncol , vol.38 , pp. 103-113
    • Tucker, S.L.1    Geara, F.B.2    Peters, L.J.3    Brock, W.A.4
  • 5
    • 0026708350 scopus 로고
    • Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity
    • Burnet N.G., Nyman J., Turesson I., Wurm R., Yarnold J.R., Peacock J.H. Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity. Lancet 1992, 339(8809):1570-1571.
    • (1992) Lancet , vol.339 , Issue.8809 , pp. 1570-1571
    • Burnet, N.G.1    Nyman, J.2    Turesson, I.3    Wurm, R.4    Yarnold, J.R.5    Peacock, J.H.6
  • 6
    • 0028584219 scopus 로고
    • The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules
    • Burnet N.G., Nyman J., Turesson I., Wurm R., Yarnold J.R., Peacock J.H. The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules. Radiother Oncol 1994, 33:228-238.
    • (1994) Radiother Oncol , vol.33 , pp. 228-238
    • Burnet, N.G.1    Nyman, J.2    Turesson, I.3    Wurm, R.4    Yarnold, J.R.5    Peacock, J.H.6
  • 7
    • 0029840089 scopus 로고    scopus 로고
    • Low dose-rate fibroblast radiosensitivity and the prediction of patient response to radiotherapy
    • Burnet N.G., Wurm R., Peacock J.H. Low dose-rate fibroblast radiosensitivity and the prediction of patient response to radiotherapy. Int J Radiat Biol 1996, 70:289-300.
    • (1996) Int J Radiat Biol , vol.70 , pp. 289-300
    • Burnet, N.G.1    Wurm, R.2    Peacock, J.H.3
  • 8
    • 0027376513 scopus 로고
    • Prospective comparison of invitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients
    • Geara F.B., Peters L.J., Ang K.K., Wike J.L., Brock W.A. Prospective comparison of invitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys 1993, 27:1173-1179.
    • (1993) Int J Radiat Oncol Biol Phys , vol.27 , pp. 1173-1179
    • Geara, F.B.1    Peters, L.J.2    Ang, K.K.3    Wike, J.L.4    Brock, W.A.5
  • 9
    • 0027932166 scopus 로고
    • Evidence for a positive correlation between invitro radiosensitivity of normal human skin fibroblasts and the occurrence of subcutaneous fibrosis after radiotherapy
    • Johansen J., Bentzen S.M., Overgaard J., Overgaard M. Evidence for a positive correlation between invitro radiosensitivity of normal human skin fibroblasts and the occurrence of subcutaneous fibrosis after radiotherapy. Int J Radiat Biol 1994, 66:407-412.
    • (1994) Int J Radiat Biol , vol.66 , pp. 407-412
    • Johansen, J.1    Bentzen, S.M.2    Overgaard, J.3    Overgaard, M.4
  • 10
    • 0029166901 scopus 로고
    • Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer
    • Brock W.A., Tucker S.L., Geara F.B., et al. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. Int J Radiat Oncol Biol Phys 1995, 32:1371-1379.
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , pp. 1371-1379
    • Brock, W.A.1    Tucker, S.L.2    Geara, F.B.3
  • 11
    • 0029145291 scopus 로고
    • Acomparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T heterozygotes
    • West C.M., Elyan S.A., Berry P., Cowan R., Scott D. Acomparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T heterozygotes. Int J Radiat Biol 1995, 68:197-203.
    • (1995) Int J Radiat Biol , vol.68 , pp. 197-203
    • West, C.M.1    Elyan, S.A.2    Berry, P.3    Cowan, R.4    Scott, D.5
  • 12
    • 0019456036 scopus 로고
    • Observations of radiation-induced chromosome fragment loss in live mammalian cells in culture, and its effect on colony-forming ability
    • Grote S.J., Joshi G.P., Revell S.H., Shaw C.A. Observations of radiation-induced chromosome fragment loss in live mammalian cells in culture, and its effect on colony-forming ability. Int J Radiat Biol 1981, 39:395-408.
    • (1981) Int J Radiat Biol , vol.39 , pp. 395-408
    • Grote, S.J.1    Joshi, G.P.2    Revell, S.H.3    Shaw, C.A.4
  • 13
    • 0020064209 scopus 로고
    • X-ray-induced chromosome damage in live mammalian cells, and improved measurements of its effects on their colony-forming ability
    • Joshi G.P., Nelson W.J., Revell S.H., Shaw C.A. X-ray-induced chromosome damage in live mammalian cells, and improved measurements of its effects on their colony-forming ability. Int J Radiat Biol 1982, 41:161-181.
    • (1982) Int J Radiat Biol , vol.41 , pp. 161-181
    • Joshi, G.P.1    Nelson, W.J.2    Revell, S.H.3    Shaw, C.A.4
  • 14
    • 0036669349 scopus 로고    scopus 로고
    • Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations
    • Borgmann K., Röper B., El-Awady R., et al. Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol 2002, 64:141-152.
    • (2002) Radiother Oncol , vol.64 , pp. 141-152
    • Borgmann, K.1    Röper, B.2    El-Awady, R.3
  • 15
    • 41749104006 scopus 로고    scopus 로고
    • Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy
    • Borgmann K., Hoeller U., Nowack S., et al. Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy. Int J Radiat Oncol Biol Phys 2008, 71:256-264.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 256-264
    • Borgmann, K.1    Hoeller, U.2    Nowack, S.3
  • 16
    • 0344873101 scopus 로고    scopus 로고
    • Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer
    • Hoeller U., Borgmann K., Bonacker M., et al. Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiother Oncol 2003, 69:137-144.
    • (2003) Radiother Oncol , vol.69 , pp. 137-144
    • Hoeller, U.1    Borgmann, K.2    Bonacker, M.3
  • 17
    • 1642556817 scopus 로고    scopus 로고
    • Adouble-strand break repair defect in ATM-deficient cells contributes to radiosensitivity
    • Kühne M., Riballo E., Rief N., Rothkamm K., Jeggo P.A., Löbrich M. Adouble-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res 2004, 64:500-508.
    • (2004) Cancer Res , vol.64 , pp. 500-508
    • Kühne, M.1    Riballo, E.2    Rief, N.3    Rothkamm, K.4    Jeggo, P.A.5    Löbrich, M.6
  • 19
    • 0030659063 scopus 로고    scopus 로고
    • Acorrelation between residual DNA double-strand breaks and clonogenic measurements of radiosensitivity in fibroblasts from preradiotherapy cervix cancer patients
    • Kiltie A.E., Orton C.J., Ryan A.J., et al. Acorrelation between residual DNA double-strand breaks and clonogenic measurements of radiosensitivity in fibroblasts from preradiotherapy cervix cancer patients. Int J Radiat Oncol Biol Phys 1997, 39:1137-1144.
    • (1997) Int J Radiat Oncol Biol Phys , vol.39 , pp. 1137-1144
    • Kiltie, A.E.1    Orton, C.J.2    Ryan, A.J.3
  • 20
    • 0031777393 scopus 로고    scopus 로고
    • The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks
    • Zhou P.K., Sproston A.R., Marples B., West C.M., Margison G.P., Hendry J.H. The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks. Radiother Oncol 1998, 47:271-276.
    • (1998) Radiother Oncol , vol.47 , pp. 271-276
    • Zhou, P.K.1    Sproston, A.R.2    Marples, B.3    West, C.M.4    Margison, G.P.5    Hendry, J.H.6
  • 21
    • 0034129412 scopus 로고    scopus 로고
    • Relationship between cellular radiosensitivity and non-repaired double-strand breaks studied for different growth states, dose rates and plating conditions in a normal human fibroblast line
    • Dikomey E., Brammer I. Relationship between cellular radiosensitivity and non-repaired double-strand breaks studied for different growth states, dose rates and plating conditions in a normal human fibroblast line. Int J Radiat Biol 2000, 76:773-781.
    • (2000) Int J Radiat Biol , vol.76 , pp. 773-781
    • Dikomey, E.1    Brammer, I.2
  • 22
    • 0033022149 scopus 로고    scopus 로고
    • Acorrelation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients
    • Kiltie A.E., Ryan A.J., Swindell R., et al. Acorrelation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients. Radiother Oncol 1999, 51:55-65.
    • (1999) Radiother Oncol , vol.51 , pp. 55-65
    • Kiltie, A.E.1    Ryan, A.J.2    Swindell, R.3
  • 23
    • 78650166256 scopus 로고    scopus 로고
    • DNA repair alterations in children with pediatric malignancies: novel opportunities to identify patients at risk for high-grade toxicities
    • Rübe C.E., Fricke A., Schneider R., et al. DNA repair alterations in children with pediatric malignancies: novel opportunities to identify patients at risk for high-grade toxicities. Int J Radiat Oncol Biol Phys 2010, 78:359-369.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , pp. 359-369
    • Rübe, C.E.1    Fricke, A.2    Schneider, R.3
  • 24
    • 77952116482 scopus 로고    scopus 로고
    • H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype
    • Vasireddy R.S., Sprung C.N., Cempaka N.L., Chao M., McKay M.J. H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype. Br J Cancer 2010, 102:1511-1518.
    • (2010) Br J Cancer , vol.102 , pp. 1511-1518
    • Vasireddy, R.S.1    Sprung, C.N.2    Cempaka, N.L.3    Chao, M.4    McKay, M.J.5
  • 25
    • 58149180926 scopus 로고    scopus 로고
    • DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing
    • Rübe C.E., Grudzenski S., Kühne M., et al. DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing. Clin Cancer Res 2008, 14:6546-6555.
    • (2008) Clin Cancer Res , vol.14 , pp. 6546-6555
    • Rübe, C.E.1    Grudzenski, S.2    Kühne, M.3
  • 26
    • 73349090920 scopus 로고    scopus 로고
    • Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity invivo
    • Bhogal N., Kaspler P., Jalali F., et al. Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity invivo. Radiat Res 2010, 173:1-9.
    • (2010) Radiat Res , vol.173 , pp. 1-9
    • Bhogal, N.1    Kaspler, P.2    Jalali, F.3
  • 27
    • 84855169068 scopus 로고    scopus 로고
    • Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment
    • Bourton E.C., Plowman P.N., Smith D., Arlett C.F., Parris C.N. Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment. Int J Cancer 2011, 129:2928-2934.
    • (2011) Int J Cancer , vol.129 , pp. 2928-2934
    • Bourton, E.C.1    Plowman, P.N.2    Smith, D.3    Arlett, C.F.4    Parris, C.N.5
  • 28
    • 79960367184 scopus 로고    scopus 로고
    • Residual DNA and chromosomal damage in exvivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy
    • Chua M.L., Somaiah N., A'Hern R., et al. Residual DNA and chromosomal damage in exvivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy. Radiother Oncol 2011, 99:362-366.
    • (2011) Radiother Oncol , vol.99 , pp. 362-366
    • Chua, M.L.1    Somaiah, N.2    A'Hern, R.3
  • 29
    • 0030220359 scopus 로고    scopus 로고
    • Relationship between the invitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy
    • Johansen J., Bentzen S.M., Overgaard J., Overgaard M. Relationship between the invitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiother Oncol 1996, 40:101-109.
    • (1996) Radiother Oncol , vol.40 , pp. 101-109
    • Johansen, J.1    Bentzen, S.M.2    Overgaard, J.3    Overgaard, M.4
  • 30
    • 0034194449 scopus 로고    scopus 로고
    • Cellular radiosensitivity and complication risk after curative radiotherapy
    • Peacock J., Ashton A., Bliss J., et al. Cellular radiosensitivity and complication risk after curative radiotherapy. Radiother Oncol 2000, 55:173-178.
    • (2000) Radiother Oncol , vol.55 , pp. 173-178
    • Peacock, J.1    Ashton, A.2    Bliss, J.3
  • 31
    • 0032972485 scopus 로고    scopus 로고
    • Lack of correlation between residual radiation-induced DNA damage in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients
    • Kiltie A.E., Barber J.B., Swindell R., et al. Lack of correlation between residual radiation-induced DNA damage in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients. Int J Radiat Oncol Biol Phys 1999, 43:481-487.
    • (1999) Int J Radiat Oncol Biol Phys , vol.43 , pp. 481-487
    • Kiltie, A.E.1    Barber, J.B.2    Swindell, R.3
  • 32
    • 40249086612 scopus 로고    scopus 로고
    • Residual gammaH2AX after irradiation of human lymphocytes and monocytes invitro and its relation to late effects after prostate brachytherapy
    • Olive P.L., Banáth J.P., Keyes M. Residual gammaH2AX after irradiation of human lymphocytes and monocytes invitro and its relation to late effects after prostate brachytherapy. Radiother Oncol 2008, 86:336-346.
    • (2008) Radiother Oncol , vol.86 , pp. 336-346
    • Olive, P.L.1    Banáth, J.P.2    Keyes, M.3
  • 33
    • 0036669225 scopus 로고    scopus 로고
    • Editorial radiotherapy and oncology 2002: predictive assays for normal tissue damage
    • Russell N.S., Begg A.C. Editorial radiotherapy and oncology 2002: predictive assays for normal tissue damage. Radiother Oncol 2002, 64:125-129.
    • (2002) Radiother Oncol , vol.64 , pp. 125-129
    • Russell, N.S.1    Begg, A.C.2
  • 35
    • 0031737611 scopus 로고    scopus 로고
    • Describing patients'* normal tissue reactions: concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity. Steering Committee of the BioMed2 European Union Concerted Action Programme on the Development of Predictive Tests of Normal Tissue Response to Radiation Therapy
    • Burnet N.G., Johansen J., Turesson I., Nyman J., Peacock J.H. Describing patients'* normal tissue reactions: concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity. Steering Committee of the BioMed2 European Union Concerted Action Programme on the Development of Predictive Tests of Normal Tissue Response to Radiation Therapy. Int J Cancer 1998, 79:606-613.
    • (1998) Int J Cancer , vol.79 , pp. 606-613
    • Burnet, N.G.1    Johansen, J.2    Turesson, I.3    Nyman, J.4    Peacock, J.H.5
  • 36
    • 0038386480 scopus 로고    scopus 로고
    • Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed
    • Dikomey E., Borgmann K., Peacock J., Jung H. Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed. Int J Radiat Oncol Biol Phys 2003, 56:1194-1200.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 1194-1200
    • Dikomey, E.1    Borgmann, K.2    Peacock, J.3    Jung, H.4
  • 37
    • 0019208703 scopus 로고
    • Radiosensitivity invitro of human fibroblasts derived from patients with a severe skin reaction to radiation therapy
    • Smith K.C., Hahn G.M., Hoppe R.T., Earle J.D. Radiosensitivity invitro of human fibroblasts derived from patients with a severe skin reaction to radiation therapy. Int J Radiat Oncol Biol Phys 1980, 6:1573-1575.
    • (1980) Int J Radiat Oncol Biol Phys , vol.6 , pp. 1573-1575
    • Smith, K.C.1    Hahn, G.M.2    Hoppe, R.T.3    Earle, J.D.4
  • 38
    • 0025381093 scopus 로고
    • Invitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer
    • Loeffler J.S., Harris J.R., Dahlberg W.K., Little J.B. Invitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer. Radiat Res 1990, 121:227-231.
    • (1990) Radiat Res , vol.121 , pp. 227-231
    • Loeffler, J.S.1    Harris, J.R.2    Dahlberg, W.K.3    Little, J.B.4
  • 39
    • 0030909643 scopus 로고    scopus 로고
    • Potential clinical impact of normal-tissue intrinsic radiosensitivity testing
    • Bentzen S.M. Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiother Oncol 1997, 43:121-131.
    • (1997) Radiother Oncol , vol.43 , pp. 121-131
    • Bentzen, S.M.1
  • 40
    • 76449112804 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects
    • Bentzen S.M., Parliament M., Deasy J.O., et al. Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects. Int J Radiat Oncol Biol Phys 2010, 76:S145-S150.
    • (2010) Int J Radiat Oncol Biol Phys , vol.76
    • Bentzen, S.M.1    Parliament, M.2    Deasy, J.O.3
  • 41
    • 0027267258 scopus 로고
    • Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity
    • Bentzen S.M., Overgaard M., Overgaard J. Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity. Eur J Cancer 1993, 29A:1373-1376.
    • (1993) Eur J Cancer , vol.29 A , pp. 1373-1376
    • Bentzen, S.M.1    Overgaard, M.2    Overgaard, J.3
  • 42
    • 0026656388 scopus 로고
    • Evidence for individual differences in radiosensitivity of human skin
    • Tucker S.L., Turesson I., Thames H.D. Evidence for individual differences in radiosensitivity of human skin. Eur J Cancer 1992, 28A:1783-1791.
    • (1992) Eur J Cancer , vol.28 A , pp. 1783-1791
    • Tucker, S.L.1    Turesson, I.2    Thames, H.D.3
  • 43
    • 0026801976 scopus 로고
    • Radiosensitivity measurement of keratinocytes and fibroblasts from radiotherapy patients
    • Geara F.B., Peters L.J., Ang K.K., Wike J.L., Brock W.A. Radiosensitivity measurement of keratinocytes and fibroblasts from radiotherapy patients. Int J Radiat Oncol Biol Phys 1992, 24:287-293.
    • (1992) Int J Radiat Oncol Biol Phys , vol.24 , pp. 287-293
    • Geara, F.B.1    Peters, L.J.2    Ang, K.K.3    Wike, J.L.4    Brock, W.A.5
  • 45
    • 0026448469 scopus 로고
    • Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose rate irradiation
    • Geara F.B., Peters L.J., Ang K.K., et al. Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose rate irradiation. Cancer Res 1992, 52:6348-6352.
    • (1992) Cancer Res , vol.52 , pp. 6348-6352
    • Geara, F.B.1    Peters, L.J.2    Ang, K.K.3
  • 46
    • 32644433401 scopus 로고    scopus 로고
    • How to model the events in cutaneous fibrosis?
    • Vozenin-Brotons M.C., Mauviel A. How to model the events in cutaneous fibrosis?. Med Sci (Paris) 2006, 22:172-177.
    • (2006) Med Sci (Paris) , vol.22 , pp. 172-177
    • Vozenin-Brotons, M.C.1    Mauviel, A.2
  • 47
    • 0842328507 scopus 로고    scopus 로고
    • Development and evaluation of a skin organ model for the analysis of radiation effects
    • Meineke V., Müller K., Ridi R., et al. Development and evaluation of a skin organ model for the analysis of radiation effects. Strahlenther Onkol 2004, 180:102-108.
    • (2004) Strahlenther Onkol , vol.180 , pp. 102-108
    • Meineke, V.1    Müller, K.2    Ridi, R.3
  • 48
    • 81855185421 scopus 로고    scopus 로고
    • The impact of individual invivo repair of DNA double-strand breaks on oral mucositis in adjuvant radiotherapy of head-and-neck cancer
    • Fleckenstein J., Kühne M., Seegmüller K., et al. The impact of individual invivo repair of DNA double-strand breaks on oral mucositis in adjuvant radiotherapy of head-and-neck cancer. Int J Radiat Oncol Biol Phys 2011, 81:1465-1472.
    • (2011) Int J Radiat Oncol Biol Phys , vol.81 , pp. 1465-1472
    • Fleckenstein, J.1    Kühne, M.2    Seegmüller, K.3
  • 49
    • 84869118236 scopus 로고    scopus 로고
    • DNA double-strand break analysis by γ-H2AX foci: a useful method for determining the overreactors to radiation-induced acute reactions among head-and-neck cancer patients
    • Goutham H.V., Mumbrekar K.D., Vadhiraja B.M., et al. DNA double-strand break analysis by γ-H2AX foci: a useful method for determining the overreactors to radiation-induced acute reactions among head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 2012, 84:e607-e612.
    • (2012) Int J Radiat Oncol Biol Phys , vol.84
    • Goutham, H.V.1    Mumbrekar, K.D.2    Vadhiraja, B.M.3
  • 50
    • 0031773119 scopus 로고    scopus 로고
    • How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues
    • Barcellos-Hoff M.H. How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiat Res 1998, 150(5 Suppl.):S109-S120.
    • (1998) Radiat Res , vol.150 , Issue.5 SUPPL.
    • Barcellos-Hoff, M.H.1
  • 51
    • 0141653957 scopus 로고    scopus 로고
    • Effects of radiation on normal tissue: consequences and mechanisms
    • Stone H.B., Coleman C.N., Anscher M.S., McBride W.H. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol 2003, 4:529-536.
    • (2003) Lancet Oncol , vol.4 , pp. 529-536
    • Stone, H.B.1    Coleman, C.N.2    Anscher, M.S.3    McBride, W.H.4
  • 52
    • 33845358508 scopus 로고    scopus 로고
    • Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species
    • Jobling M.F., Mott J.D., Finnegan M.T., et al. Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species. Radiat Res 2006, 166:839-848.
    • (2006) Radiat Res , vol.166 , pp. 839-848
    • Jobling, M.F.1    Mott, J.D.2    Finnegan, M.T.3
  • 53
    • 0032589002 scopus 로고    scopus 로고
    • TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis
    • Li C., Wilson P.B., Levine E., et al. TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis. Int Cancer 1999, 84:155-159.
    • (1999) Int Cancer , vol.84 , pp. 155-159
    • Li, C.1    Wilson, P.B.2    Levine, E.3
  • 54
    • 77950688980 scopus 로고    scopus 로고
    • Predictive factors of late radiation fibrosis: a prospective study in non-small cell lung cancer
    • Mazeron R., Etienne-Mastroianni B., Pérol D., et al. Predictive factors of late radiation fibrosis: a prospective study in non-small cell lung cancer. Int Radiat Oncol Biol Phys 2010, 77:38-43.
    • (2010) Int Radiat Oncol Biol Phys , vol.77 , pp. 38-43
    • Mazeron, R.1    Etienne-Mastroianni, B.2    Pérol, D.3
  • 55
    • 84855853057 scopus 로고    scopus 로고
    • Base excision repair factors are promising prognostic and predictive markers in cancer
    • Gossage L., Perry C., Abbotts R., Madhusudan S. Base excision repair factors are promising prognostic and predictive markers in cancer. Curr Mol Pharmacol 2012, 5:115-124.
    • (2012) Curr Mol Pharmacol , vol.5 , pp. 115-124
    • Gossage, L.1    Perry, C.2    Abbotts, R.3    Madhusudan, S.4
  • 56
    • 27144513287 scopus 로고    scopus 로고
    • CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced late toxicity: a prospective study in 399 patients
    • Ozsahin M., Crompton N.E., Gourgou S., et al. CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced late toxicity: a prospective study in 399 patients. Clin Cancer Res 2005, 11:7426-7433.
    • (2005) Clin Cancer Res , vol.11 , pp. 7426-7433
    • Ozsahin, M.1    Crompton, N.E.2    Gourgou, S.3
  • 57
    • 67651087086 scopus 로고    scopus 로고
    • Radiation-induced lymphocyte apoptosis to predict radiation therapy late toxicity in prostate cancer patients
    • Schnarr K., Boreham D., Sathya J., Julian J., Dayes I.S. Radiation-induced lymphocyte apoptosis to predict radiation therapy late toxicity in prostate cancer patients. Int J Radiat Oncol Biol Phys 2009, 74:1424-1430.
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , pp. 1424-1430
    • Schnarr, K.1    Boreham, D.2    Sathya, J.3    Julian, J.4    Dayes, I.S.5
  • 58
    • 84871195184 scopus 로고    scopus 로고
    • Correlation of invitro lymphocyte radiosensitivity and gene expression with late normal tissue reactions following curative radiotherapy for breast cancer
    • Finnon P., Kabacik S., MacKay A., et al. Correlation of invitro lymphocyte radiosensitivity and gene expression with late normal tissue reactions following curative radiotherapy for breast cancer. Radiother Oncol 2012, 105:329-336.
    • (2012) Radiother Oncol , vol.105 , pp. 329-336
    • Finnon, P.1    Kabacik, S.2    MacKay, A.3
  • 59
    • 79958137942 scopus 로고    scopus 로고
    • Inter-individual and inter-cell type variation in residual DNA damage after invivo irradiation of human skin
    • Chua M.L., Somaiah N., Bourne S., et al. Inter-individual and inter-cell type variation in residual DNA damage after invivo irradiation of human skin. Radiother Oncol 2011, 99:225-230.
    • (2011) Radiother Oncol , vol.99 , pp. 225-230
    • Chua, M.L.1    Somaiah, N.2    Bourne, S.3
  • 60
    • 84883285782 scopus 로고    scopus 로고
    • Comparison of in vivo skin and in vitro blood lymphocyte models for the prediction of late normal tissue responses in breast radiotherapy patients
    • abstr 11116
    • Chua M.L.K., Somaiah N., Davies S., et al. Comparison of in vivo skin and in vitro blood lymphocyte models for the prediction of late normal tissue responses in breast radiotherapy patients. J Clin Oncol 2013, 31(suppl; abstr 11116).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Chua, M.L.K.1    Somaiah, N.2    Davies, S.3
  • 61
    • 84875263768 scopus 로고    scopus 로고
    • Chromosome damage and cell proliferation rates in invitro irradiated whole blood as markers of late radiation toxicity after radiation therapy to the prostate
    • Beaton L.A., Ferrarotto C., Marro L., et al. Chromosome damage and cell proliferation rates in invitro irradiated whole blood as markers of late radiation toxicity after radiation therapy to the prostate. Int J Radiat Oncol Biol Phys 2013, 85:1346-1352.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , pp. 1346-1352
    • Beaton, L.A.1    Ferrarotto, C.2    Marro, L.3
  • 62
    • 21244472962 scopus 로고    scopus 로고
    • Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and invitro chromosomal radiosensitivity in lymphocytes
    • De Ruyck K., Van Eijkeren M., Claes K., et al. Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and invitro chromosomal radiosensitivity in lymphocytes. Int J Radiat Oncol Biol Phys 2005, 62:1140-1149.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 1140-1149
    • De Ruyck, K.1    Van Eijkeren, M.2    Claes, K.3
  • 63
    • 80655133070 scopus 로고    scopus 로고
    • Astandardized G2-assay for the prediction of individual radiosensitivity
    • Pantelias G.E., Terzoudi G.I. Astandardized G2-assay for the prediction of individual radiosensitivity. Radiother Oncol 2011, 101:28-34.
    • (2011) Radiother Oncol , vol.101 , pp. 28-34
    • Pantelias, G.E.1    Terzoudi, G.I.2
  • 64
    • 77953334158 scopus 로고    scopus 로고
    • A5-fraction regimen of adjuvant radiotherapy for women with early breast cancer: first analysis of the randomised UK FAST trial (ISRCTN62488883, CRUKE/04/015). EJC Supplements. Presidential sessions late breaking and best of ECCO 15-ESMO 34
    • Brunt A.M., Sydenham M., Bliss J., et al. A5-fraction regimen of adjuvant radiotherapy for women with early breast cancer: first analysis of the randomised UK FAST trial (ISRCTN62488883, CRUKE/04/015). EJC Supplements. Presidential sessions late breaking and best of ECCO 15-ESMO 34. Abstracts 2009, 7:2.
    • (2009) Abstracts , vol.7 , pp. 2
    • Brunt, A.M.1    Sydenham, M.2    Bliss, J.3
  • 65
    • 38149102436 scopus 로고    scopus 로고
    • Question of dose, fractionation and technique: ingredients for testing hypofractionation in prostate cancer - the CHHiP trial
    • Khoo V.S., Dearnaley D.P. Question of dose, fractionation and technique: ingredients for testing hypofractionation in prostate cancer - the CHHiP trial. Clin Oncol (R Coll Radiol) 2008, 20:12-14.
    • (2008) Clin Oncol (R Coll Radiol) , vol.20 , pp. 12-14
    • Khoo, V.S.1    Dearnaley, D.P.2
  • 66
    • 0344676392 scopus 로고    scopus 로고
    • Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes
    • Andreassen C.N., Alsner J., Overgaard M., Overgaard J. Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol 2003, 69:127-135.
    • (2003) Radiother Oncol , vol.69 , pp. 127-135
    • Andreassen, C.N.1    Alsner, J.2    Overgaard, M.3    Overgaard, J.4
  • 67
    • 72049089840 scopus 로고    scopus 로고
    • Cellular radiosensitivity: how much better do we understand it?
    • Jeggo P., Lavin M.F. Cellular radiosensitivity: how much better do we understand it?. Int J Radiat Biol 2009, 85:1061-1081.
    • (2009) Int J Radiat Biol , vol.85 , pp. 1061-1081
    • Jeggo, P.1    Lavin, M.F.2
  • 68
    • 74549176997 scopus 로고    scopus 로고
    • Establishment of a radiogenomics consortium
    • West C., Rosenstein B.S. Establishment of a radiogenomics consortium. Radiother Oncol 2010, 94:117-118.
    • (2010) Radiother Oncol , vol.94 , pp. 117-118
    • West, C.1    Rosenstein, B.S.2
  • 69
    • 77957864864 scopus 로고    scopus 로고
    • Searching for genetic determinants of normal tissue radiosensitivity -are we on the right track?
    • Andreassen C.N. Searching for genetic determinants of normal tissue radiosensitivity -are we on the right track?. Radiother Oncol 2010, 97:1-8.
    • (2010) Radiother Oncol , vol.97 , pp. 1-8
    • Andreassen, C.N.1
  • 70
    • 33646914155 scopus 로고    scopus 로고
    • Genetic predictors of adverse radiotherapy effects: the Gene-PARE project
    • Ho A.Y., Atencio D.P., Peters S., et al. Genetic predictors of adverse radiotherapy effects: the Gene-PARE project. Int J Radiat Oncol Biol Phys 2006, 65:646-655.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 646-655
    • Ho, A.Y.1    Atencio, D.P.2    Peters, S.3
  • 71
    • 77957872526 scopus 로고    scopus 로고
    • No association between SNPs regulating TGF-beta1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study
    • Barnett G.C., Coles C.E., Burnet N.G., et al. No association between SNPs regulating TGF-beta1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study. Radiother Oncol 2010, 97:9-14.
    • (2010) Radiother Oncol , vol.97 , pp. 9-14
    • Barnett, G.C.1    Coles, C.E.2    Burnet, N.G.3
  • 72
    • 84864868856 scopus 로고    scopus 로고
    • Areplicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy
    • Talbot C.J., Tanteles G.A., Barnett G.C., et al. Areplicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy. Br J Cancer 2012, 107:748-753.
    • (2012) Br J Cancer , vol.107 , pp. 748-753
    • Talbot, C.J.1    Tanteles, G.A.2    Barnett, G.C.3
  • 73
    • 0025305031 scopus 로고
    • The ESTRO Regaud lecture. Inherent radiosensitivity of tumor and normal tissue cells as a predictor of human tumor response
    • Peters L.J. The ESTRO Regaud lecture. Inherent radiosensitivity of tumor and normal tissue cells as a predictor of human tumor response. Radiother Oncol 1990, 17:177-190.
    • (1990) Radiother Oncol , vol.17 , pp. 177-190
    • Peters, L.J.1


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