DNA repair alterations in children with pediatric malignancies: Novel opportunities to identify patients at risk for high-grade toxicities

International Journal of Radiation Oncology Biology Physics

Volumn 78, Issue 2, 2010, Pages 359-369

  Rübe, Claudia E ^a   Fricke, Andreas ^a   Schneider, Ruth ^a   Simon, Karin ^a   Kühne, Martin ^a   Fleckenstein, Jochen ^a   Gräber, Stefan ^a   Graf, Norbert ^a   Rübe, Christian ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Childhood cancer; DNA double strand breaks; DNA repair; Normal tissue toxicity; Predictive assay

Indexed keywords

AGE-MATCHED CONTROLS; BLOOD LYMPHOCYTES; BLOOD SAMPLES; CANCER THERAPY; CHILDHOOD CANCERS; DNA REPAIR; DNA REPAIR PATHWAYS; DOUBLE STRAND BREAK REPAIR; GENETIC ALTERATIONS; HEALTHY CONTROLS; NORMAL-TISSUE TOXICITY; PILOT STUDIES; PREDICTIVE ASSAY; REGULATORY FACTORS; REPAIR FUNCTIONS; SOLID CANCER; TIME POINTS; TISSUE RESPONSE;

BLOOD; DNA; GENES; HANDICAPPED PERSONS; PHOSPHORYLATION; TOXICITY; TUMORS;

REPAIR;

BLEOMYCIN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; HISTONE H2AX; IDARUBICIN; IFOSFAMIDE; LOMUSTINE; MELPHALAN; METHOTREXATE; PROCARBAZINE; TEMOZOLOMIDE; TOPOTECAN; TROFOSFAMIDE; BIOLOGICAL MARKER; H2AFX PROTEIN, HUMAN; HISTONE; SIGNAL PEPTIDE; TP53BP1 PROTEIN, HUMAN;

ADOLESCENT; ADULT; APLASIA; ARTICLE; ASTROCYTOMA; BLOOD SAMPLING; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHILD; CHILDHOOD CANCER; CHONDROSARCOMA; CLEAR CELL SARCOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DESMOPLASTIC SMALL ROUND CELL TUMOR; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; FEVER; GASTROINTESTINAL SYMPTOM; GENE MUTATION; GLIOBLASTOMA; GRANULOSA CELL TUMOR; HODGKIN DISEASE; HUMAN; KIDNEY DISEASE; LYMPHOCYTE; MALE; MALIGNANT TERATOMA; MEDULLOBLASTOMA; NECROSIS; NEPHROBLASTOMA; NEUROBLASTOMA; OSTEOSARCOMA; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; RADIATION PNEUMONIA; REGULATORY MECHANISM; SCHOOL CHILD; SEPSIS; SKIN MANIFESTATION; SPINAL CORD DISEASE; SYNOVIAL SARCOMA; TOXICITY; ATAXIA TELANGIECTASIA; BLOOD; CASE CONTROL STUDY; FEASIBILITY STUDY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HETEROZYGOTE; HOMOZYGOTE; NEOPLASMS; NONPARAMETRIC TEST; PHYSIOLOGY; PROCEDURES; RADIATION DOSE; RADIATION INJURY; RADIATION RESPONSE; TIME; YOUNG ADULT;

ADOLESCENT; ATAXIA TELANGIECTASIA; BIOLOGICAL MARKERS; BLOOD; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; FEASIBILITY STUDIES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HETEROZYGOTE; HISTONES; HOMOZYGOTE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTES; MALE; NEOPLASMS; PILOT PROJECTS; RADIATION INJURIES; RADIATION TOLERANCE; STATISTICS, NONPARAMETRIC; TIME FACTORS; YOUNG ADULT;

EID: 78650166256     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.08.052     Document Type: Article

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