Normal tissue radiosensitivity - how important is it?

Clinical Oncology

Volumn 8, Issue 1, 1996, Pages 25-34

  Burnet, N G ^a,c   Wurm, R ^a   Nyman, J ^b   Peacock, J H ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c VELINDRE CANCER CENTRE   (United Kingdom)

Author keywords

Individualized radiotherapy; Normal tissue radiosensitivity testing

Indexed keywords

ARTICLE; CANCER RADIOTHERAPY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIOSENSITIVITY;

EID: 0029928295     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0936-6555(05)80035-4     Document Type: Article

References (88)

1. Deacon J, Peckham MJ, Steel GG. The radioresponsiveness of human tumours and the initial slope of the survival curve. Radiother Oncol 1984;2:317-23.
2. Fertil B, Malaise EP. Inherent cellular radiosensitivity as a basic concept for human tumour radiotherapy. Int J Radiat Oncol Biol Phys 1981;7:621-9.
3. Fletcher GH. Elective irradiation of sub-clinical disease in cancers of the head and neck. Cancer 1972:29;1450-4.
4. Steel GG, Peacock JH. Why are some tumours more radiosensitive than others? Radiother Oncol 1989;15:63-72.
5. Suit H. Potential for improving survival rates for the cancer patient by increasing the efficacy of treatment to the primary lesion. Cancer 1982;50:1227-34.
6. Withers HR. Biologic basis of radiation therapy. In: Perez CA, Brady LW, editors. Principles and practice of radiation oncology. 2nd ed. Philadelphia: Lippincott, 1992:64-98.
7. Hellman S. Principles of radiation therapy. In: Cancer: principles and practice of oncology. DeVita VT, Hellman S, Rosenberg SA, editors. Philadelphia: Lippincott, 1985:227-55.
8. Horwich A. The future of radiotherapy. Radiother Oncol 1990;19:353-6.
9. Wheldon TE. Mathematical models in cancer research. Bristol: Hilger, 1988.
10. Norman A, Kagan AR, Chan SL. The importance of genetics for the optimisation of radiation therapy. Am J Clin Oncol 1988;11:84-8.
11. Arlett CF. Human cellular radiosensitivity: the search for the diagnostic Holy Grail or a poisoned chalice. Adv Radiat Biol 1992;16:273-92.
12. Emami B, Lyman J, Brown A, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991;21:109-22.
13. Marks LB, Prosnitz LR. Estimation of normal tissue complication probabilities with three-dimensional technology. Int J Radiat Oncol Biol Phys 1994;28:777-9.
14. Withers HR. Predicting late normal tissue responses. Int J Radiat Oncol Biol Phys 1986;12:693-8.
15. Turesson I, Thames H. Repair capacity and kinetics of human skin during fractionated radiotherapy: Erythema, desquamation and telangiectasia after 3 and 5 years follow-up. Radiother Oncol 1989;15:169-88.
16. Turesson I. The progression rate of late radiation effects in normal tissue and its impact on dose-response relationships. Radiother Oncol 1989;15:217-26.
17. Turesson I. Individual variation and dose dependency in the progression rate of skin telangiectasia. Int J Radiat Oncol Biol Phys 1990;19:1569-74.
18. West CML, Hendry JH, Scott D, et al. 25th Paterson Symposium: Is there a future for radiosensitivity testing? Br J Cancer 1991;64:197-9.
19. Bentzen SM, Overgaard J. Patient-to-patient variability in the expression of radiation-induced normal tissue injury. Semin Radiat Oncol 1994;4:68-80.
20. West CML, Scott D, Peacock JP. The Association for Radiation Research first workshop report: Normal cell radiosensitivity: Clinical application in predicting response to radiotherapy and cancer predisposition. Int J Radiat Biol 1994;66:231-4.
21. Tucker SL, Turesson I, Thames HD. Evidence of individual differences in the radiosensitivity of human skin. Euro J Cancer 1992;28A:1783-91.
22. Bentzen SM, Overgaard M, Overgaard J. Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity. Eur J Cancer 1993;29A:1373-6.
23. Bentzen SM, Overgaard M. Relationship between early and late normal tissue injury after post-mastectomy radiotherapy. Radiother Oncol 1991;20:159-65.
24. Bourne RG, Kearsley JH, Grove W.D, et al. The relationship between early and late gastrointestinal complications of radiation therapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys 1983;9:1445-50.
25. Hopewell JW, van den Aardweg GJMJ. Current concepts of dose fractionation in radiotherapy: Normal tissue tolerance. Br J Radiol 1988;suppl 22:88-94.
26. Turesson I, Notter G. The influence of the overall treatment time in radiotherapy on the acute reaction: Comparison of the effects of daily and twice-a-week fractionation on human skin. Int J Radiat Oncol Biol Phys 1984;10:607-18.
27. Turesson I, Nyman J, Holmberg E, et al. Prognostic factors for acute and late skin reactions in radiotherapy patients. Int J Radiat Biol Oncol Phys, Submitted 1995.
28. Plowman PN, Bridges BA, Arlett CF, et al. An instance of clinical morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasia. Br J Radiol 1990;63:624-8.
29. Strandqvist M. Studien über die kumulative Wirkung der Röntgenstrahlen bei Fractionierung. Acta Radiol 1944;55 (suppl):1-300.
30. Perez CA, Brady LW. Overview. In: Perez CA, Brady LW, editors. Principles and practice of radiation oncology. 2nd ed. Philadelphia: Lippincott, 1992:1-63.
31. Nyman J, Turesson I. Basal cell density in human skin for various fractionation schedules in radiotherapy. Radiother Oncol 1994;33:117-24.
32. Nyman J, Turesson I. Does the interval between fractions matter in the range 4-8 hours in radiotherapy? A study of acute and late human skin reactions. Radiother Oncol 1995;34:171-8.
33. Bentzen SM, Thames HD, Overgaard M. Latent-time estimation for late cutaneous and subcutaneous radiation reactions in a single follow up clinical study. Radiother Oncol 1989;15:267-74.
34. Bentzen SM, Overgaard M, Thames HD. Fractionation sensitivity of a functional endpoint: Impaired shoulder movement after post-mastectomy radiotherapy. Int J Radiat Oncol Biol Phys 1989;17:531-7.
35. Arlett CF, Harcourt SA. Survey of radiosensitivity in a variety of human cell strains. Cancer Res 1980;40:926-32.
36. Arlett CF, Green MHL, Priestley A, et al. Comparative human cellular radiosensitivity. I: The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes. Int J Radiat Oncol Biol Phys 1988;54:911-28.
37. Burnet NG, Nyman J, Turesson I, et al. Improving radiotherapy cure rates by predicting normal tissue tolerance from in vitro cellular radiation sensitivity. Lancet 1992;339;1570-1.
38. Burnet NG. The relationship between cellular radiation sensitivity and normal tissue response to radiotherapy: prospects for individualising radiotherapy prescriptions [thesis]. Cambridge: Cambridge University, 1993.
39. Burnet NG, Wurm R, Tait DM, et al. Cellular sensitivity and low dose-rate recovery in Fanconi anaemia fibroblasts. Br J Radiol 1994;67:579-83.
40. Burnet NG, Nyman J, Turesson I, et al. The relationship between cellular radiation sensitivity and tissue response to radiotherapy may provide the basis for individualising radiotherapy schedules. Radiother Oncol 1994;33:228-38.
41. Cox R, Masson WK. Radiosensitivity in cultured human fibroblasts. Int J Radiat Biol 1980;38:575-6.
42. Deschavanne PJ, Debieu D, Fertil B, et al. Re-evaluation of in vitro radiosensitivity of human fibroblasts of different genetic origins. Int J Radiat Biol 1986;50:279-93.
43. Dritschilo A, Brennan T, Weichselbaum RR, et al. Response of human fibroblasts to low dose rate gamma irradiation. Radiat Res 1984;100:387-95.
44. Little JB, Nove J, Strong LC, et al. Survival of human diploid skin fibroblasts from normal individuals after X-irradiation. Int J Radiat Biol 1988;54:899-910.
45. Weichselbaum RR, Nove J, Little JB. X-ray sensitivity of fifty three human diploid fibroblast cell strains from patients with characterised genetic disorders. Cancer Res 1980;40:920-5.
46. Woods WG, Byrne TD. In vitro sensitivity of normal and hereditary retinoblastoma fibroblasts to DNA-damaging agents. Cancer Res 1986;46:6305-10.
47. Little JB, Nove J. Sensitivity of human diploid fibroblast cell strains from various genetic disorders to acute and protracted radiation exposure. Radiat Res 1990;123:87-92.
48. Arlett CF. The radiosensitivity of cultured human cells. In: Fielden EM, Fowler JF, Hendry JH, et al., editors. Proceedings of the 8th International Congress of Radiation Research. London: Taylor & Francis, 1987:424-30.
49. Duckworth-Rysiecki G, Taylor AMR. Effects of ionising radiation on cells from Fanconi's anaemia patients. Cancer Res 1985;45:416-20.
50. Gluckman E. Radiosensitivity in Fanconi anaemia: Application to the conditioning for bone marrow transplantation. Radiother Oncol 1990;(suppl 1):88-93.
51. Peacock JH, Cassoni AM, McMillan TJ, et al. Radiosensitive human tumour cells may not be recovery deficient. Int J Radiat Biol 1988;54:945-53.
52. Steel GG, Deacon JM, Duchesne GM, et al. The dose-rate effect in human tumour cells. Radiother Oncol 1987;9:299-310.
53. Steel GG, Kelland LR, Peacock JP. The radiobiological basis for low dose-rate radiotherapy. In: Mould RF, editor. Brachytherapy 2. Proceedings of the 5th International Selectron Users Meeting 1988. Leersum:Nucletron, 1989:15-25.
54. Steel GG. Cellular sensitivity to low dose-rate irradiation focuses the problem of tumour radioresistance. Radiother Oncol 1991;20;71-83.
55. Smith KC, Hahn GM, Hoppe RT, et al. Radiosensitivity in vitro of human fibroblasts derived from patients with a severe skin reaction to radiation therapy. Int J Radiat Oncol Biol Phys 1980;6:1573-5.
56. Weichselbaum RR, Epstein J, Little JB. In vitro radiosensitivity of human diploid fibroblasts derived from patients with unusual clinical responses to radiation. Radiology, 1976; 121:479-82.
57. Woods WG, Byrne TD, Kim TH. Sensitivity of cultured cells to gamma radiation in a patient exhibiting marked in vivo radiation sensitivity. Cancer 1988;62:2341-5.
58. Loeffler JS, Harris JR, Dahlberg WK, et al. In vitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy from breast cancer. Radiat Res 1990; 121:227-31.
59. Johansen J, Bentzen SM, Overgaard J, et al. Evidence for a positive correlation between in vitro radiosensitivity of normal human skin fibroblasts and the occurrence of subcutaneous fibrosis after radiotherapy. Int J Radiat Biol 1994;66:407-12.
60. Geara FB, Peters LJ, Ang KK, et al. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys, 1993;27:1173-9.
61. Brock WA, Tucker SL, Geara FB, et al. fibroblast sensitivity versus acute and late normal skin response in patients treated for breast cancer. Int J Radiat Oncol Biol Phys 1995;32:1371-9.
62. Begg AC, Russell NS, Knaken H, et al. Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy. Int J Radiat Biol 1993;64:393-405.
63. Wurm R, Burnet NG, Nyman J, et al. DNA damage and cell survival to predict normal tissue response to radiotherapy. Radiother Oncol 1992; (suppl 24):S89.
64. Wurm R, Burnet NG, Duggal N, et al. Cellular radiosensitivity and DNA damage in primary human fibroblasts. Int J Radiat Oncol Biol Phys 1994;30:625-33.
65. McIlwrath AJ, Vasey PA, Ross GM, et al. Cell cycle arrests and radiosensitivity of human tumour cell lines: Dependence on wild type p53 for radiosensitivity. Cancer Res 1994; 54:3718-22.
66. Horwich A. Cancer Research Campaign review of radiobiology research: Meeting report. Br J Cancer 1993;67:198-201.
67. Elyan SAG, West CML, Roberts SA, et al. Use of an internal standard in comparative measurements of the intrinsic radiosensitivity of human T-lymphocytes. Int J Radiat Biol 1993; 64:385-91.
68. Floyd DN, Cassoni AM. Intrinsic radiosensitivity of adult and cord blood lymphocytes as determined by the micronucleus assay. Eur J Cancer 1994;30A:615-20.
69. Geara FB, Peters LJ, Ang KK, et al. Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose irradiation. Cancer Res 1992;52:6348-52.
70. Nakamura N, Sposto R, Kushiro J, et al. Is inter-individual variation of cellular radiosensitivity real or artifactual? Radiat Res 1991;125:326-30.
71. Cole J, Arlett CF, Green MHL, et al. Comparative human cellular radiosensitivity. II: The survival following gamma-irradiation of unstimulated (GO) T-lymphocytes, T-lymphocyte lines, lymphoblastoid cell lines and fibroblasts from normal donors, from ataxia-telangiectasia patients and from ataxia-telangiectasia heterozygotes. Int J Radiat Biol 1988; 54:929-43.
72. Ågren A, Brahme A, Turesson I. Optimisation of uncomplicated control for head and neck tumours. Int J Radiat Oncol Biol Phys 1990;19:1077-85.
73. Williams MV, Denekamp J, Fowler JF. Dose-response relationships for human tumours: Implications for clinical trials of dose modifying agents. Int J Radiat Oncol Biol Phys 1984;10:1703-7.
74. Suit HD, Baumann M, Skates S, et al. Clinical interest in determinations of cellular radiation sensitivity. Int J Radiat Biol 1989;56:725-37.
75. Brahme A. Dosimetric precision requirements in radiation therapy. Acta Radiol Oncol 1984;23:379-91.
76. Henk JM. Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: A rationale for hypoxic cell sensitisers? Int J Radiat Oncol Biol Phys 1986;12:1339-41.
77. 125I implantation. Int J Radiat Oncol Biol Phys 1991;21:537-47.
78. Saunders MI, Dische S, Grosch EJ, et al. Experience with CHART. Int J Radiat Oncol Biol and Phys 1991;21:871-8.
79. Horiot JC, on behalf of the EORTC Cooperative Group of Radiotherapy. Present status and updated results of the trials on hyperfractionation (HF) and/or accelerated fractionation (AF). Eur J Cancer 1993;29A(suppl 6):S43.
80. Nyman J. Normal skin reactions in radiotherapy: Proliferation, progression and prognostic factors [thesis]. Gothenburg: University of Gothenburg, 1995.
81. Peters LJ. Inherent radiosensitivity of tumour and normal tissue cells as a predictor of human tumour response. Radiother Oncol 1990;7:177-90.
82. West CML, Hendry JH. Intrinsic radiosensitivity as a predictor of patient response to radiotherapy. Br J Radiol 1992; (suppl 24):146-52.
83. Hart RM, Kimler BF, Evans RG, et al. Radiotherapeutic management of medulloblastoma in a pediatric patient with ataxia telangiectasia. Int J Radiat Biol Oncol Phys 1987;13:1237-40.
84. Dahlberg WK, Little JB, Fletcher JA, et al. Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patient. Int J Radiat Biol 1993;63:191-8.
85. Sklar MD. The ras oncogene increases the intrinsic resistance of NIH 3T3 cells to ionising radiation. Science 1988;239:645-7.
86. Lee JM, and Bernstein A. P53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci USA 1993;90:5742-6.
87. West CML, Davidson SE, Hunter RD. Surviving fraction at 2 Gy versus control of human cervical carcinoma: Update of the Manchester study. In: Dewey WC, Edington M, Fry RJM, et al. editors. Radiation research: A twentieth century perspective, volume II. Proceedings of the Ninth International Congress on Radiation Research. San Diego: Academic Press, 1992:706-11.
88. Brock WA, Baker FL, and Peters LJ. Radiosensitivity of human head and neck squamous cell carcinomas in primary culture and its potential as a predictive assay of tumour radiocurability. Int J Radiat Biol 1989;56:751-60.