Chromosome damage and cell proliferation rates in In vitro irradiated whole blood as markers of late radiation toxicity after radiation therapy to the prostate

International Journal of Radiation Oncology Biology Physics

Volumn 85, Issue 5, 2013, Pages 1346-1352

  Beaton, Lindsay A ^a   Ferrarotto, Catherine ^a   Marro, Leonora ^a   Samiee, Sara ^b   Malone, Shawn ^b   Grimes, Scott ^b   Malone, Kyle ^b   Wilkins, Ruth C ^a  

^a HEALTH CANADA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN DEPRIVATION THERAPY; CELL PROLIFERATION RATE; CHROMOSOMAL ABERRATION; DICENTRIC CHROMOSOMES; LATE RADIATION TOXICITIES; LYMPHOCYTE PROLIFERATION; METHODS AND MATERIALS; STATISTICALLY SIGNIFICANT DIFFERENCE;

BLOOD; CELL PROLIFERATION; CYTOLOGY; RADIOTHERAPY; TISSUE;

CHROMOSOMES;

ADULT; AGED; ANDROGEN DEPRIVATION THERAPY; ARTICLE; BLOOD RADIATION; BLOOD SAMPLING; CANCER HORMONE THERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CHROMOSOME DAMAGE; COHORT ANALYSIS; CONTROLLED STUDY; DICENTRIC CHROMOSOME; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; METAPHASE; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PROCTITIS; PROSPECTIVE STUDY; PROSTATE CANCER; RADIATION DOSE ESCALATION; RADIOSENSITIVITY; RANDOMIZED CONTROLLED TRIAL; SHORT COURSE THERAPY; TISSUE INJURY;

AGED; CELL PROLIFERATION; CHROMOSOME ABERRATIONS; GENETIC MARKERS; HUMANS; LYMPHOCYTES; MALE; METAPHASE; MIDDLE AGED; PROCTITIS; PROSPECTIVE STUDIES; PROSTATIC NEOPLASMS; RADIATION DOSAGE; RADIATION INJURIES; RADIATION TOLERANCE;

EID: 84875263768     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.09.026     Document Type: Article

References (20)

1. M. Roach III Reducing the toxicity associated with the use of radiotherapy in men with localized prostate cancer Urol Clin North Am 31 2004 353 366
2. S.M. Bentzen, W. Dorr, and M.S. Anscher Normal tissue effects: reporting and analysis Semin Radiat Oncol 13 2003 189 202
3. S.M. Bentzen, M. Overgaard, and J. Overgaard Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity Eur J Cancer 29A 1993 1373 1376
4. B. Emami, J. Lyman, and A. Brown Tolerance of normal tissue to therapeutic irradiation Int J Radiat Oncol Biol Phys 21 1991 109 122
5. L.B. Marks, E.D. Yorke, and A. Jackson Use of normal tissue complication probability models in the clinic Int J Radiat Oncol Biol Phys 76 2010 S10 S19
6. S.M. Bentzen, and J. Overgaard Patient-to-patient variability in the expression of radiation-induced normal tissue injury Semin Radiat Oncol 4 1994 68 80
7. N.G. Burnet, J. Nyman, and I. Turesson The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules Radiother Oncol 33 1994 228 238
8. W.A. Brock, S.L. Tucker, and F.B. Geara Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer Int J Radiat Oncol Biol Phys 32 1995 1371 1379
9. F.B. Geara, L.J. Peters, and K.K. Ang Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients Int J Radiat Oncol Biol Phys 27 1993 1173 1179
10. S. Neubauer, J. Dunst, and E. Gebhart The impact of complex chromosomal rearrangements on the detection of radiosensitivity in cancer patients Radiother Oncol 43 1997 189 195
11. K. Borgmann, B. Roper, and R. El-Awady Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations Radiother Oncol 64 2002 141 152
12. C.N. Andreassen Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles? Acta Oncol 44 2005 801 815
13. C.M. West, S.A. Elyan, and P. Berry A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T heterozygotes Int J Radiat Biol 68 1995 197 203
14. U. Hoeller, K. Borgmann, and M. Bonacker Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer Radiother Oncol 69 2003 137 144
15. K. Borgmann, U. Hoeller, and S. Nowack Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy Int J Radiat Oncol Biol Phys 71 2008 256 264
16. J.D. Cox, J. Stetz, and T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
17. International Atomic Energy Agency. Cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies. A Manual, IAEA, Vienna; 2011.
18. D.C. Lloyd, R.J. Purrott, and E.J. Reeder The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people Mutat Res 72 1980 523 532
19. P. Vodicka, Z. Polivkova, and S. Sytarova Chromosomal damage in peripheral blood lymphocytes of newly diagnosed cancer patients and healthy controls Carcinogenesis 31 2010 1238 1241
20. M.L. Chua, N. Somaiah, and R. A'Hern Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy Radiother Oncol 99 2011 362 366