Cellular radiosensitivity and complication risk after curative radiotherapy

Radiotherapy and Oncology

Volumn 55, Issue 2, 2000, Pages 173-178

  Peacock, John ^a   Ashton, Anita ^b   Bliss, Judith ^a   Bush, Cyd ^a   Eady, John ^a   Jackson, Caroline ^a   Owen, Roger ^b   Regan, Jane ^a   Yarnold, John ^a,c  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b CHELTENHAM GENERAL HOSPITAL   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Breast cancer; Cellular radiosensitivity; Ionizing radiation; Predictive tests

Indexed keywords

ARTICLE; BREAST CANCER; CLONOGENIC ASSAY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; PREDICTION; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIOSENSITIVITY; TISSUE INJURY; TISSUE REACTION;

CASE-CONTROL STUDIES; DNA DAMAGE; FIBROBLASTS; HUMANS; RADIATION TOLERANCE; RADIOTHERAPY;

EID: 0034194449     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(00)00173-0     Document Type: Article

References (27)

1. Anscher MS, Peters WP, Reisenbichler H, et al. Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer. N. Engl. J. Med. 1993;328:1592-1598.
2. Bentzen SM. Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiother. Oncol. 1997;43:121-131.
3. Bentzen SM, Overgaard J. Patient-to-patient variability in the expression of radiation-induced normal tissue injury. Semin. Radiat. Oncol. 1994;4:68-80.
4. Borger J, Kemperman H, Hart A, et al. Risk factors in breast-conservation therapy (see comments). J. Clin. Oncol. 1994;12:653-660.
5. Burnet NG, Nyman J, Turesson I, et al. Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity. Lancet 1992;339:1570-1571.
6. Dearnaley DP, Khoo VS, Norman AR, et al. Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial. Lancet 1999;353:267-272.
7. Early Breast Cancer Trialists' Collaborative Group. Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials published erratum appears in N. Engl. J. Med. 1996; 334(15): 1003. N. Engl. J. Med. 1995;333:1444-1455.
8. Fisher B, Anderson S, Redmond CK, et al. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer (see comments). N. Engl. J. Med. 1995;333:1456-1461.
9. Geara FB, Peters LJ, Ang KK, et al. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int. J. Radiat. Oncol. Biol. Phys. 1993;27:1173-1179.
10. Houghton J, Baum M, Haybittle JL. Role of radiotherapy following total mastectomy in patients with early breast cancer. The Closed Trials Working Party of the CRC Breast Cancer Trials Group. World J. Surg. 1994;18:117-122.
11. Johansen J, Bentzen SM, Overgaard J, et al. Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiother. Oncol. 1996;40:101-109.
12. Kiltie AE, Ryan AJ, Swindell R, et al. A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients. Radiother. Oncol. 1999;51:55-65.
13. MacKay RI, Niemierko A, Goitein M, et al. Potential clinical impact of normal-tissue intrinsic radiosensitivity testing (letter). Radiother. Oncol. 1998;46:215-216.
14. Moody AM, Mayles WP, Bliss JM, et al. The influence of breast size on late radiation effects and association with radiotherapy dose inhomogeneity. Radiother. Oncol. 1994;33:106-112.
15. Overgaard M, Hansen PS, Overgaard J, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial (see comments). N. Engl. J. Med. 1997;337:949-955.
16. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Co-operative Group DBCG 82c randomised trial. Lancet 1999;353:1641-1648.
17. Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N. Engl. J. Med. 1997;337:956-962.
18. Rudat V, Dietz A, Conradt C, et al. In vitro radiosensitivity of primary human fibroblasts. Lack of correlation with acute radiation toxicity in patients with head and neck cancer. Radiother. Oncol. 1997;43:181-188.
19. Russell NS, Grummels A, Hart AA, et al. Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer. Int. J. Radiat. Biol. 1998;73:661-670.
20. Sikora K. Enraged about radiotherapy. Br. Med. J. 1994;308:188-189.
21. Sneeuw KC, Aaronson NK, Yarnold JR, et al. Cosmetic and functional outcomes of breast conserving treatment for early stage breast cancer. 1. Comparison of patients' ratings, observers' ratings, and objective assessments. Radiother. Oncol. 1992;25:153-159.
22. Sneeuw KC, Aaronson NK, Yarnold JR, et al. Cosmetic and functional outcomes of breast conserving treatment for early stage breast cancer. 2. Relationship with psychosocial functioning. Radiother. Oncol. 1992;25:160-166.
23. Tucker SL, Turesson I, Thames HD. Evidence for individual differences in the radiosensitivity of human skin. Eur. J. Cancer 1992;11:1783-1791.
24. Turesson I. Individual variation and dose dependency in the progression rate of skin telangiectasia. Int. J. Radiat. Oncol. Biol. Phys. 1990;19:1569-1574.
25. Turesson I, Nyman J, Holmberg E, et al. Prognostic factors for acute and late skin reactions in radiotherapy patients. Int. J. Radiat. Oncol. Biol. Phys. 1996;36:1065-1075.
26. West CM, Davidson SE, Elyan SA, et al. The intrinsic radiosensitivity of normal and tumour cells. Int. J. Radiat. Biol. 1998;73:409-413.
27. Yarnold JR, Owen JR, Bliss JM, et al. Randomized comparison of a 13 fraction schedule with a conventional 25 fraction schedule of radiotherapy after local excision of early breast cancer: preliminary analysis (Meeting abstract). Br. J. Cancer 1994;70(Suppl 22).