No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: Results from the RAPPER study

Radiotherapy and Oncology

Volumn 97, Issue 1, 2010, Pages 9-14

  Barnett, Gillian C ^a,d   Coles, Charlotte E ^b   Burnet, Neil G ^a   Pharoah, Paul D P ^a   Wilkinson, Jennifer ^b   West, Catharine M L ^c   Elliott, Rebecca M ^c   Baynes, Caroline ^a   Dunning, Alison M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Breast; Breast cancer; Genetics; Radiotherapy; TGFB1

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST DISEASE; BREAST EDEMA; BREAST FIBROSIS; BREAST SHRINKAGE; CLINICAL ASSESSMENT; EDEMA; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MASTALGIA; MEDICAL PHOTOGRAPHY; PIGMENT DISORDER; PRIORITY JOURNAL; PROTEIN SECRETION; QUESTIONNAIRE; RADIATION INJURY; RADIOSENSITIVITY; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN INDURATION; TELANGIECTASIA;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CHI-SQUARE DISTRIBUTION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FIBROSIS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LOGISTIC MODELS; MIDDLE AGED; PHOTOGRAPHY; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; RADIATION INJURIES; RADIATION TOLERANCE; RADIOTHERAPY; TRANSFORMING GROWTH FACTOR BETA1; TUMOR MARKERS, BIOLOGICAL;

EID: 77957872526     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2009.12.006     Document Type: Article

References (43)

1. N.G. Burnet, R.M. Elliott, A. Dunning, and C.M. West Radiosensitivity, radiogenomics and RAPPER Clin Oncol (R Coll Radiol) 18 2006 525 528
2. G.C. Barnett, J. Wilkinson, and A.M. Moody A randomised controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: baseline characteristics and dosimetry results Radiother Oncol 92 2009 34 41
3. S.M. Bentzen Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology Nat Rev 6 2006 702 713
4. L.M. Wakefield, J.J. Letterio, and T. Chen Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer Clin Cancer Res 1 1995 129 136
5. E.J. Ehrhart, P. Segarini, M.L. Tsang, A.G. Carroll, and M.H. Barcellos-Hoff Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation FASEB J 11 1997 991 1002
6. K. Randall, and J.E. Coggle Expression of transforming growth factor-beta 1 in mouse skin during the acute phase of radiation damage Int J Radiat Biol 68 1995 301 309
7. M. Martin, M.C. Vozenin, N. Gault, F. Crechet, C.M. Pfarr, and J.L. Lefaix Coactivation of AP-1 activity and TGF-beta1 gene expression in the stress response of normal skin cells to ionizing radiation Oncogene 15 1997 981 989
8. K.B. Ewan, R.L. Henshall-Powell, and S.A. Ravani Transforming growth factor-beta1 mediates cellular response to DNA damage in situ Cancer Res 62 2002 5627 5631
9. S. Delanian, and J.L. Lefaix The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway Radiother Oncol 73 2004 119 131
10. Z. Vujaskovic, M.S. Anscher, and Q.F. Feng Radiation-induced hypoxia may perpetuate late normal tissue injury Int J Radiat Oncol Biol Phys 50 2001 851 855
11. M.S. Anscher, L. Chen, and Z. Rabbani Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy Int J Radiat Oncol Biol Phys 62 2005 255 259
12. K.L. Andarawewa, A.C. Erickson, and W.S. Chou Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition Cancer Res 67 2007 8662 8670
13. M.H. Barcellos-Hoff Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage Semin Cancer Biol 15 2005 138 148
14. M.S. Anscher, F.M. Kong, L.B. Marks, G.C. Bentel, and R.L. Jirtle Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis Int J Radiat Oncol Biol Phys 37 1997 253 258
15. A. Novakova-Jiresova, M.M. Van Gameren, R.P. Coppes, H.H. Kampinga, and H.J. Groen Transforming growth factor-beta plasma dynamics and post-irradiation lung injury in lung cancer patients Radiother Oncol 71 2004 183 189
16. X.L. Fu, H. Huang, and G. Bentel Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta Int J Radiat Oncol Biol Phys 50 2001 899 908
17. E.S. Evans, Z. Kocak, and S.M. Zhou Does transforming growth factor-beta1 predict for radiation-induced pneumonitis in patients treated for lung cancer? Cytokine 35 2006 186 192
18. C. Li, P.B. Wilson, E. Levine, J. Barber, A.L. Stewart, and S. Kumar TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis Int J Cancer 84 1999 155 159
19. Z. Kahan, M. Csenki, and Z. Varga The risk of early and late lung sequelae after conformal radiotherapy in breast cancer patients Int J Radiat Oncol Biol Phys 68 2007 673 681
20. S. Quarmby, H. Fakhoury, and E. Levine Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients Int J Radiat Biol 79 2003 137 143
21. C.N. Andreassen, J. Alsner, M. Overgaard, and J. Overgaard Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes Radiother Oncol 69 2003 127 135
22. G. Giotopoulos, R.P. Symonds, and K. Foweraker The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes Br J Cancer 96 2007 1001 1007
23. C.A. Peters, R.G. Stock, and J.A. Cesaretti TGFB1 single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapy Int J Radiat Oncol Biol Phys 70 2008 752 759
24. K. De Ruyck, M. Van Eijkeren, and K. Claes TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors Int J Radiat Oncol Biol Phys 65 2006 1240 1248
25. C.N. Andreassen, and J. Alsner Genetic variants and normal tissue toxicity after radiotherapy: a systematic review Radiother Oncol 92 2009 299 309
26. G.C. Barnett, C.M. West, and A.M. Dunning Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype Nat Rev 9 2009 134 142
27. S.M. Bentzen, R.K. Agrawal, and E.G. Aird The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial Lancet Oncol 9 2008 331 341
28. S.M. Bentzen, R.K. Agrawal, and E.G. Aird The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial Lancet 371 2008 1098 1107
29. J.S. Haviland, A. Ashton, and B. Broad Evaluation of a method for grading late photographic change in breast appearance after radiotherapy for early breast cancer Clin Oncol (R Coll Radiol) 20 2008 497 501
30. LENT SOMA tables Radiother Oncol 35 1995 17 60
31. LENT SOMA scales for all anatomic sites Int J Radiat Oncol Biol Phys 31 1995 1049 1091
32. M.A. Sprangers, M. Groenvold, and J.I. Arraras The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study J Clin Oncol 14 1996 2756 2768
33. R. Shah, C.K. Hurley, and P.E. Posch A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T) Hum Genet 120 2006 461 469
34. A.M. Dunning, P.D. Ellis, and S. McBride A transforming growth factor beta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer Cancer Res 63 2003 2610 2615
35. D.J. Grainger, K. Heathcote, and M. Chiano Genetic control of the circulating concentration of transforming growth factor type beta1 Human Mol Genet 8 1999 93 97
36. M. Yokota, S. Ichihara, T.L. Lin, N. Nakashima, and Y. Yamada Association of a T29→C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese Circulation 101 2000 2783 2787
37. B.S. Saltzman, J.F. Yamamoto, and R. Decker Association of genetic variation in the transforming growth factor beta-1 gene with serum levels and risk of colorectal neoplasia Cancer Res 68 2008 1236 1244
38. C.N. Andreassen, J. Alsner, and J. Overgaard TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer Radiother Oncol 75 2005 18 21
39. C.N. Andreassen, J. Alsner, M. Overgaard, F.B. Sorensen, and J. Overgaard Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM-a study based on DNA from formalin fixed paraffin embedded tissue samples Int J Radiat Biol 82 2006 577 586
40. S.M. Bentzen, H.D. Thames, and M. Overgaard Latent-time estimation for late cutaneous and subcutaneous radiation reactions in a single-follow-up clinical study Radiother Oncol 15 1989 267 274
41. E. Dikomey, K. Borgmann, J. Peacock, and H. Jung Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed Int J Radiat Oncol Biol Phys 56 2003 1194 1200
42. I. Turesson Individual variation and dose dependency in the progression rate of skin telangiectasia Int J Radiat Oncol Biol Phys 19 1990 1569 1574
43. I. Turesson, J. Nyman, E. Holmberg, and A. Oden Prognostic factors for acute and late skin reactions in radiotherapy patients Int J Radiat Oncol Biol Phys 36 1996 1065 1075