Indicators of late normal tissue response after radiotherapy for head and neck cancer: Fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations

Radiotherapy and Oncology

Volumn 64, Issue 2, 2002, Pages 141-152

  Borgmann, Kerstin ^a   Röper, Barbara ^a,b   El Awady, Rafaat Abd ^a,c   Brackrock, Sophie ^a   Bigalke, Maika ^d   Dörk, Tilo ^d   Alberti, Winfried ^a   Dikomey, Ekkehard ^a   Dahm Daphi, Jochen ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c CAIRO UNIVERSITY   (Egypt)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

ATM; Chromosome aberration; Double strand break; Late tissue response; Ligase IV; MRE11; Nijmegen breakage syndrome; Predictive test; RAD50; Radiosensitivity

Indexed keywords

BIOLOGICAL MARKER; DOUBLE STRANDED DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ADULT; AGED; ARTICLE; ATAXIA TELANGIECTASIA; CANCER GRADING; CANCER RADIOTHERAPY; CELL CYCLE G0 PHASE; CELL ISOLATION; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME DAMAGE; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FIBROSIS; GEL ELECTROPHORESIS; GENE MUTATION; GENE SEQUENCE; HEAD CANCER; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; LYMPHOCYTE; METAPHASE; MUCOSA INFLAMMATION; NECK CANCER; NIJMEGEN BREAKAGE SYNDROME; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREMATURE CHROMOSOME CONDENSATION; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; SKIN BIOPSY; SKIN FIBROBLAST; TELANGIECTASIA; TISSUE REACTION; XEROSTOMIA;

CARCINOMA, SQUAMOUS CELL; CELL SURVIVAL; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA REPAIR; FIBROBLASTS; FOLLOW-UP STUDIES; HEAD AND NECK NEOPLASMS; HUMANS; LYMPHOCYTES; TIME FACTORS;

EID: 0036669349     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(02)00167-6     Document Type: Article

References (70)

1. Antoccia A., Stumm M., Saar K., Ricordy R., Maraschio P., Tanzarella C. Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines. Int J Radiat Biol. 75:1999;583-591.
2. Appleby J.M., Barber J.B.P., Levine E., et al. Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy. Br J Cancer. 76:1997;1546-1549.
3. Barber J.B.P., Burril W., Spreadborough A.R., et al. Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. Radiother Oncol. 55:2000;179-186.
4. Barber J.B.P., West C.M.L., Kiltie A.E., Roberts S.A., Scott D. Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy. Radiat Res. 153:2000;570-578.
5. Baria K., Warren C., Roberts S.A., West C.M., Scott D. Chromosomal radiosensitivity as a marker of predisposition to common cancers? Br J Cancer. 84:2001;892-896.
6. Baria K., Warren C., Eden O.B., Roberts S., West C.N., Scott D. Chromosomal radiosensitivity in young cancer patients: possible evidence of genetic predisposition. Int J Radiat Biol. 78:2002;341-346.
7. Begg A.C., Russell N.S., Knaken H., Lebesque J.V. Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy. Int J Radiat Biol. 64:1993;393-405.
8. Bentzen S.M. Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiother Oncol. 43:1997;121-131.
9. Bentzen S.M., Overgaard J. Patient-to-patient variability in the expression of radiation-induced normal tissue injury. Semin Radiat Oncol. 4:1994;68-80.
10. Bonassi S., Abbondandolo A., Camurri L., et al. Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an italian cohort study. Cancer Genet Cytogenet. 79:1995;133-135.
11. Bonassi S., Hagmar L., Strömberg U., et al. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. Cancer Res. 60:2000;1619-1625.
12. Brammer I., Dikomey E., Johansen J., Bentzen S.M., Overgaard J. Residuale DNA-Doppelstrangbrüche und zelluläre Strahlenempfindlichkeit von normalen humanen Fibroblasten. Strahlenther Onkol. 172:1996;33.
13. Brock W.A., Tucker S.L., Geara F.B., et al. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. Int J Radiat Oncol Biol Phys. 32:1995;1371-1379.
14. Burnet N.G., Nyman J., Turesson I., Wurm R., Yarnold J.R., Peacock J.H. The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules. Radiother Oncol. 33:1994;228-238.
15. Burnet N.G., Wurm R., Peacock J.H. Low dose-rate fibroblast radiosensitivity and the prediction of patient response to radiotherapy. Int J Radiat Biol. 70:1996;289-300.
16. Dahm-Daphi J., Dikomey E. Separation of DNA fragments induced by ionizing irradiation using a graded-field gel electrophoresis. Int J Radiat Biol. 67:1995;161-168.
17. Dahm-Daphi J., Dikomey E. Rejoining of DNA double-strand breaks in X-irradiated CHO cells studied by constant- and graded-field gel electrophoresis. Int J Radiat Biol. 69:1996;615-621.
18. Dikomey E., Dahm-Daphi J., Brammer I., Martensen R., Kaina B. Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. Int J Radiat Biol. 73:1998;269-278.
19. Dikomey E., Brammer I., Johansen J., Bentzen S.M., Overgaard J. Relationship between DNA double-strand breaks, cell killing, and fibrosis studied in confluent skin fibroblasts derived from breast cancer patients. Int J Radiat Oncol Biol Phys. 46:2000;481-490.
20. Fertil B., Dertinger H., Courdi A., Malaise E.P. Mean inactivation dose: a useful concept for intercomparison of human cell survival curves. Radiat Res. 99:1984;73-84.
21. Geara F.B., Peters L.J., Kian Ang K., et al. Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose-rate irradiation. Cancer Res. 52:1992;6348-6352.
22. Geara F.B., Peters L.J., Kian Ang K., Wike J.L., Brock W.A. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys. 27:1993;1173-1179.
23. Geara F.B., Peters L.J., Kian Ang K., Wike J.L., Brock W.A. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys. 27:1993;1173-1179.
24. Grawunder U., Zimmer D., Kulesza P., Lieber M.R. Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo. J Biol Chem. 273:1998;24708-24714.
25. Hagmar L., Brogger A., Hansteen I.-L., et al. Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: nordic study group on the health risk of chromosome damage. Cancer Res. 54:1994;2919-2922.
26. Hendrickson E.A. Insights from model systems. Cell cycle regulation of mammalian DNA double-strand break repair. Am J Hum Genet. 61:1997;795-800.
27. Iliakis G.E., Metzger L., Denko N., Stamato T.D. Detection of DNA double-strand breaks in synchronous cultures of CHO cells by means of asymmetric field inversion gel electrophoresis. Int J Radiat Biol. 59:1991;321-341.
28. Johansen J., Bentzen S.M., Overgaard J., Overgaard M. Evidence for a positive correlation between in vitro radiosensitivity of normal human skin fibroblasts and the occurrence of subcutaneous after radiotherapy. Int J Radiat Biol. 66:1994;407-412.
29. Johansen J., Bentzen S.M., Overgaard J., Overgaard M. Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiother Oncol. 40:1996;101-109.
30. Jones L.A., Scott D., Cowan R., Roberts S.A. Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation. Int J Radiat Biol. 67:1995;519-528.
31. Jorgensen T.J., Shiloh Y. The ATM gene and the radiobiology of ataxia-telangiectasia. Int J Radiat Biol. 69:1996;527-537.
32. Jung H., Beck-Bornholdt H.P., Svoboda V., Alberti W., Hermann T. Quantification of late complications after radiation therapy. Radiother Oncol. 61:2001;233-246.
33. Kasten U., Plottner N., Johansen J., Overgaard J., Dikomey E. Ku70/80 gene expression and DNA-dependent protein kinase (DNA-PK) activity do not correlate with double-strand break (dsb) repair capacity and cellular radiosensitivity in normal human fibroblasts. Br J Cancer. 79:1999;1037-1041.
34. Kiltie A.E., Ryan A.J., Swindell R., et al. A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients. Radiother Oncol. 51:1999;55-65.
35. Kondrashova T.V., Ivanova T.I., Katsalap S.N. Chromosome aberrations in cultured peripheral lymphocytes from persons with elevated skin radiosensitivity. Environ Health Perspect. 105:(6):1997;1437-1439.
36. 0 and skin fibroblasts on log phase. Radiat Res. 122:1990;326-332.
37. Lees-Miller S.P., Godbout R., et al. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science. 267:1995;1183-1185.
38. Loeffler J.S., Harris J.R., Dahlberg W.K., Little J.B. In vitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer. Radiat Res. 121:1990;227-231.
39. Mackay R.I., Hendry J.H. The modelled benefits of individualizing radiotherapy patients' dose using cellular radiosensitivity assays with inherent variability. Radiother Oncol. 50:1999;67-75.
40. Marcou Y., D'Andrea D., Jeggo P.A., Plowman P.N. Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity. Radiother Oncol. 60:2001;75-79.
41. Neitzel H. A routine method for the establishment of permanent growing lymphoblastoid cell lines. Hum Genet. 73:1986;320-326.
42. Neubauer S., Gebhart E., Schmitt G., Birkenhake S., Dunst J. Is chromosome in situ suppression (CISS) hybridization suited as a predictive test for intrinsic radiosensitivity in cancer patients? Int J Oncol. 8:1996;707-712.
43. Neubauer S., Dunst J., Gebhart E. The impact of complex chromosomal rearrangements on the detection of radiosensitivity in cancer patients. Radiother Oncol. 43:1997;189-195.
44. Oppitz U., Baier K., Wulf J., Schakowski R., Flentje M. The invitro colony assay: a predictor of clinical outcome. Int J Radiat Biol. 77:2001;105-110.
45. Pantelias G.E., Maillie H.D. Direct analysis of radiation-induced chromosome fragments and rings in unstimulated human peripheral blood lymphocytes by means of the premature chromosome condensation technique. Mutat Res. 149:1985;67-72.
46. Papworth R., Slevin N., Roberts S.A., Scott D. Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients. Br J Cancer. 84:2001;776-782.
47. Parshad R., Price F.M., Bohr V.A., Cowans K.H., Zujewski J.A., Sanford K.K. Deficient DNA repair capacity, a predisposing factor in breast cancer. Br J Cancer. 74:1996;1-5.
48. Peacock J., Ashton A., Bliss J., et al. Cellular radiosensitivity and complication risk after curative radiotherapy. Radiother Oncol. 55:2000;173-178.
49. Plowman P.N., Bridges B.A., Arlett C.F., Hinney A., Kingston J.E. An instance of clinical radiation morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasia. Br J Radiol. 63:1990;624-628.
50. Ramsay J., Birrell G. Normal tissue radiosensitivity in breast cancer patients. Int J Radiat Oncol Biol Phys. 32:1995;339-344.
51. Riballo E., Critchlow S.E., Teo S.-H., et al. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr Biol. 9:(13):1999;699-702.
52. Rogers P.B., Plowman P.N., Harris S.J., Arlett C.F. Four radiation hypersensitivity cases and their implications for clinical radiotherapy. Radiother Oncol. 57:2000;143-154.
53. Rudat V., Dietz A., Conradt C., Weber K.-J., Flentje M. In vitro radiosensitivity of primary human fibroblasts. Lack of correlation with acute radiation toxicity in patients with head and neck cancer. Radiother Oncol. 43:1997;181-188.
54. Rudat V., Dietz A., Nollert J., et al. Acute and late toxicity, tumour control and intrinsic radiosensitivity of primary fibroblasts in vitro of patients with advanced head and neck cancer after concomitant boost radiochemotherapy. Radiother Oncol. 53:1999;233-245.
55. Russell N.S., Grummels A., Hart A.A.M., et al. Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer. Int J Radiat Biol. 73:1998;661-670.
56. Sandoval N., Platzer M., Rosenthal Adörk T., et al. Characterization of ATM mutations in 66 ataxia telangiectasia families. Hum Mol Genet. 8:1999;69-79.
57. Sanford K.K., Parshad R., Price F.M., et al. Enhanced chromatid damage in blood lymphocytes after G2 phase X-irradiation, a marker of the ataxia-telangiectasia gene. J Natl Cancer Inst. 82:1990;1050-1054.
58. Scott D., Spreadbouough A.R., Roberts L.A., Moore C.J. Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition. Radiat Res. 1996;3-16.
59. Scott D., Barber J.B.P., Spreadborough A.R., Burrill W., Roberts S.A. Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. Int J Radiat Biol. 75:1999;1-10.
60. Smith K.C., Hahn G.M., Hoppe R.T., Earle J.D. Radiosensitivity in vitro of human fibroblasts derived from patients with a severe skin reaction to radiation therapy. Int J Radiat Oncol Biol Phys. 6:1980;1573-1575.
61. Svoboda V., Beck-Bornholdt H.-P., Herrmann T., Alberti W., Jung H. Late complications after a combined pre and postoperative (sandwich) radiotherapy for rectal cancer. Radiother Oncol. 53:1999;177-187.
62. Teebor G.W., Boorstein R.J., Cadet J. The repairability of oxidative free radical mediated damage to DNA: a review. Int J Radiat Biol. 54:(2):1988;131-150.
63. Tucker S.L., Turesson I., Thames H.D. Evidence for individual differences in the radiosensitivity of human skin. Eur J Cancer. 28A:1992;1783-1791.
64. Tucker S.L., Geara F.B., Peters L.J., Brock W.A. How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity? Radiother Oncol. 38:1996;103-113.
65. Tupler R., Marseglia G.L., Stefanini M., et al. A variant of the Nijmegen breakage syndrome with unusual cytogenetic features and intermediate cellular radiosensitivity. J Med Genet. 34:1997;169-202.
66. Turesson I. Individual variation and dose dependency in the progression rate of skin telangiectasia. Int J Radiat Oncol Biol Phys. 19:1990;1569-1574.
67. Turesson I., Nyman J., Holmberg E., Oden A. Prognostic factors for acute and late skin reactions in radiotheraphy patients. Int J Radiat Oncol Biol Phys. 36:1996;1065-1075.
68. Weichselbaum R.R., Epstein J., Little J.B. In vitro radiosensitivity of human diploid fibroblasts derived from patients with unusual clinical responses to radiation. Radiology. 121:1976;479-482.
69. West C.M.L., Elyan S.A.G., Berry P., Cowan R., Scott D. A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T heterozygotes. Int J Radiat Biol. 68:1995;197-203.
70. Woods W.G., Byrne T.D., Kim T.H. Sensitivity of cultured cells to gamma radiation in a patient exhibiting marked in vivo radiation sensitivity. Cancer. 62:1988;2341-2345.