Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment

International Journal of Cancer

Volumn 129, Issue 12, 2011, Pages 2928-2934

  Bourton, Emma C ^a   Plowman, Piers N ^b   Smith, Daniel ^b   Arlett, Colin F ^c   Parris, Christopher N ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

H2AX; DNA repair; normal tissue toxicity; predictive testing; radiotherapy

Indexed keywords

BIOLOGICAL MARKER; HISTONE H2AX; H2AFX PROTEIN, HUMAN; HISTONE;

ACUTE TOXICITY; ADULT; AGED; ARTICLE; BLOOD SAMPLING; BRAIN ARTERIOVENOUS MALFORMATION; BREAST ADENOCARCINOMA; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; CHRONIC TOXICITY; CLINICAL ARTICLE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DIAGNOSTIC TEST; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DYSURIA; FATIGUE; FEMALE; FLOW CYTOMETRY; GAMMA RADIATION; HUMAN; HUMAN CELL; HYPOPHYSIS ADENOMA; IMMUNOCYTOCHEMISTRY; INTESTINAL FIBROSIS; INTESTINE STENOSIS; INTRADUCTAL CARCINOMA; MALE; PERIPHERAL LYMPHOCYTE; PREDICTION; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION NECROSIS; SKIN FIBROSIS; SKIN INJURY; TELANGIECTASIA; THORAX MALFORMATION; THYROID PAPILLARY CARCINOMA; URINARY FREQUENCY; UTERINE CERVIX CARCINOMA; DOUBLE STRANDED DNA BREAK; LYMPHOCYTE; METABOLISM; MIDDLE AGED; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOTHERAPY;

ADULT; BIOLOGICAL MARKERS; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; HISTONES; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; RADIOTHERAPY;

EID: 84855169068     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25953     Document Type: Article

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