Individual Radiosensitivity Measured With Lymphocytes May Predict the Risk of Acute Reaction After Radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 71, Issue 1, 2008, Pages 256-264

  Borgmann, Kerstin ^a   Hoeller, Ulrike ^b   Nowack, Sven ^a   Bernhard, Michael ^a   Röper, Barbara ^c   Brackrock, Sophie ^d   Petersen, Cordula ^e   Szymczak, Silke ^f   Ziegler, Andreas ^f   Feyer, Petra ^b   Alberti, Winfried ^a   Dikomey, Ekkehard ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b VIVANTES KLINIKUM NEUKÖLLN   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Friedrich Ebert Krankenhaus   (Germany)

^e UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^f UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Acute reaction; Breast volume; Chromosomal radiosensitivity; Individual radiosensitivity; Prediction

Indexed keywords

CHROMOSOMES; DOSIMETRY; ONCOLOGY; PATIENT MONITORING; RISK ANALYSIS;

ACUTE REACTION; BREAST VOLUME; CHROMOSOMAL RADIOSENSITIVITY; INDIVIDUAL RADIOSENSITIVITY;

RADIOTHERAPY;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CHROMOSOME DELETION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG CANCER; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION SICKNESS; RADIOSENSITIVITY; RISK FACTOR; SKIN MANIFESTATION; X RAY;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BREAST; BREAST NEOPLASMS; CARCINOMA IN SITU; CARCINOMA, DUCTAL, BREAST; CHROMOSOME DELETION; FEMALE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; NEOPLASMS; PROSPECTIVE STUDIES; RADIATION INJURIES; RADIATION TOLERANCE; RADIOTHERAPY DOSAGE; RISK ASSESSMENT;

EID: 41749104006     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.01.007     Document Type: Article

References (55)

1. Bentzen S.M., and Overgaard J. Patient-to-patient variability in the expression of radiation-induced normal tissue injury. Sem Radiat Oncol 4 (1994) 68-80
2. Burnet N.G., Johansen J., Turesson I., et al. Describing patients' normal tissue reactions: concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity. Int J Cancer 79 (1998) 606-613
3. Safwat A., Bentzen S.M., Turesson I., and Hendry J.H. Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy. Int J Radiat Oncol Biol Phys 52 (2002) 198-204
4. Borger J.H., Kemperman H., Smitt H.S., et al. Dose and volume effects on fibrosis after breast conservation therapy. Int J Radiat Oncol Biol Phys 30 (1994) 1073-1081
5. Russell N.S., and Begg A.C. Predictive assays for normal tissue damage. Radiother Oncol 64 (2002) 125-129
6. Tucker S.L., Turesson I., and Thames H.D. Evidence for individual differences in the radiosensitivity of human skin. Eur J Cancer 28A (1992) 1783-1791
7. Turesson I., Nyman J., Holmberg E., and Oden A. Prognostic factors for acute and late skin reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys 36 (1996) 1065-1075
8. Borgmann K., Haeberle D., Doerk T., et al. Genetic determination of chromosomal radiosensitivities in G0- and G2-phase human lymphocytes. Radiother Oncol 83 (2007) 196-202
9. Dikomey E., Borgmann K., Jung H., and Peacock J. Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed. Int J Radiat Oncol Biol Phys 56 (2003) 1194-1200
10. Hoeller U., Borgmann K., Alberti W., et al. Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiother Oncol 69 (2003) 137-144
11. West C.M.L., Davidson S.E., Elyan S.A.G., et al. Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. Int J Radiat Oncol Biol Phys 51 (2001) 10-51
12. de Ruyck K., Van Eijkeren M., Claes K., et al. Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes. Int J Radiat Oncol Biol Phys 62 (2005) 1140-1149
13. Bentzen S.M. Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiother Oncol 43 (1997) 121-131
14. Brock W.A., and Tucker S.L. In vitro radiosensitivity and normal tissue damage. Radiother Oncol 55 (2000) 93-94
15. Mackay R.I., and Hendry J.H. The modelled benefits of individualizing radiotherapy patients' dose using cellular radiosensitivity assays with inherent variability. Radiother Oncol 50 (1999) 67-75
16. Tucker S.L., Geara F.B., Peters L.J., and Brock W.A. How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?. Radiother Oncol 38 (1996) 103-113
17. Geara F.B., Peters L.J., Kian Ang K., et al. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys 27 (1993) 1173-1179
18. Jones L.A., Scott D., Cowan R., and Roberts S.A. Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation. Int J Radiat Biol 67 (1995) 519-528
19. Neubauer S., Gebhart E., Schmitt G., et al. Is chromosome in situ suppression (CISS) hybridization suited as a predictive test for intrinsic radiosensitivity in cancer patients?. Int J Oncol 8 (1996) 707-712
20. Barber J.B.P., Burril W., Spreadborough A.R., et al. Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. Radiother Oncol 55 (2000) 179-186
21. Slonina D., Klimek M., Szpytma T., and Gasinska A. Comparison of the radiosensitivity of normal-tissue cells with normal-tissue reactions after radiotherapy. Int J Radiat Biol 76 (2000) 1255-1264
22. Widel M., Jedrus S., Lukaszcyk B., et al. Radiation-induced micronucleus frequency in peripheral blood lymphocytes is correlated with normal tissue damage in patients with cervical carcinoma undergoing radiotherapy. Radiat Res 159 (2003) 713-721
23. Oppitz U., Schulte S., Stopper H., et al. In vitro radiosensitivity measured in lymphocytes and fibroblasts by colony formation and comet assay: comparison with clinical acute reactions to radiotherapy in breast cancer patients. Int J Radiat Biol 78 (2002) 611-616
24. Twardella D., Popanda O., Helmbold I., et al. Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy. Radiother Oncol 69 (2003) 145-153
25. López E., Guerrero R., Núnez M.I., et al. Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes. Breast Cancer Res 7 (2005) R690-R698
26. Burnet N.G., Nyman J., Turesson I., et al. The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules. Radiother Oncol 33 (1994) 228-238
27. Begg A.C., Russell N.S., Knaken H., and Lebesque J.V. Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy. Int J Radiat Biol 64 (1993) 393-405
28. Brock W.A., Tucker S.L., Geara F.B., et al. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. Int J Radiat Oncol Biol Phys 32 (1995) 1371-1379
29. Rudat V., Dietz A., Conradt C., et al. In vitro radiosensitivity of primary human fibroblasts. Lack of correlation with acute radiation toxicity in patients with head and neck cancer. Radiother Oncol 43 (1997) 181-188
30. Rudat V., Dietz A., Nollert J., et al. Acute and late toxicity, tumour control and intrinsic radiosensitivity of primary fibroblasts in vitro of patients with advanced head and neck cancer after concomitant boost radiochemotherapy. Radiother Oncol 53 (1999) 233-245
31. Oppitz U., Baier K., Wulf J., et al. The in vitro colony assay: a predictor of clinical outcome. Int J Radiat Biol 77 (2001) 105-110
32. -1 C ions. Int J Radiat Biol 80 (2004) 621-634
33. Borgmann K., Röper B., El-Awady R.A., et al. Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol 64 (2002) 141-152
34. Cornforth M.N., and Bedford J.S. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts. Radiat Res 111 (1987) 385-405
35. Ritter S., Nasonova E., Scholz M., and Kraft-Weyrather W. Comparison of chromosomal damage induced by x-rays and Ar ions with an LET of 1840 keV/um in G1 V79 cells. Int J Radiat Biol 69 (1996) 155-166
36. Rogers P.B., Plowman P.N., Harris S.J., and Arlett C.F. Four radiation hypersensitivity cases and their implications for clinical radiotherapy. Radiother Oncol 57 (2000) 143-154
37. Momm F., Bartelt S., Haigis K., et al. Spectrophotometric skin measurements correlate with EORTC/RTOG-common toxicity criteria. Strahlenther Onkol 6 (2004) 392-395
38. Popanda J.C.-C.O., Tan X.-L., Kropp S., et al. Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients. Clin Cancer Res 11 (2005) 4802-4809
39. Dikomey E., Dahm-Daphi J., Brammer I., et al. Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. Int J Radiat Biol 73 (1998) 269-278
40. Brammer I., Zoller M., and Dikomey E. Relationship between cellular radiosensitivity and DNA damage measured by comet assay in human normal, NBS and AT fibroblasts. Int J Radiat Biol 77 (2001) 929-938
41. Geara F.B., Peters L.J., Kian Ang K., et al. Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose-rate irradiation. Cancer Res 52 (1992) 6348-6352
42. 0 and skin fibroblasts on log phase. Radiat Res 122 (1990) 326-332
43. Bentzen S.M., and Overgaard M. Relationship between early and late normal-tissue injury after postmastectomy radiotherapy. Radiother Oncol 20 (1991) 159-165
44. Bentzen S.M., Overgaard M., and Overgaard J. Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity. Eur J Cancer 10 (1993) 1373-1376
45. Bernier J., Thames H.D., Smith C.D., and Horiot J.C. Tumor response, mucosal reactions and late effects after conventional und hyperfractionated radiotherapy. Radiother Oncol 47 (1998) 137-143
46. Jereczek-Fossa B.A., Jassem J., and Badzio A. Relationship between acute and late normal tissue injury after postoperative radiotherapy in endometrial cancer. Int J Radiat Oncol Biol Phys 52 (2002) 476-482
47. Lilla C., Ambrosone C.B., Kropp S., et al. Predictive factors for late normal tissue complications following radiotherapy for breast cancer. Breast Cancer Res Treat 106 (2007) 143-150
48. Perera F., Chisela F., Stitt L., et al. TLD skin dose measurements and acute and late effects after lumpectomy and high-dose-rate brachytherapy only for early breast cancer. Int J Radiat Oncol Biol Phys 62 (2005) 1283-1290
49. Bentzen S.M., Dörr W., Anscher M.S., et al. Normal tissue effects: reporting and analysis. Sem Radiat Oncol 13 (2003) 189-202
50. Rodemann H.P., and Blaese M.A. Responses of normal cells to ionizing radiation. Sem Radiat Oncol 17 (2007) 81-88
51. Dörr W., and Hendry J.H. Consequential late effects in normal tissues. Radiother Oncol 61 (2001) 223-231
52. Hopewell J.W., Nyman J., and Turesson I. Time factor for acute tissue reactions following fractionated irradiation: a balance between repopulation and enhanced radiosensitivity. Int J Radiat Biol 79 (2003) 513-524
53. Maclachlan T., Narayanan B., Gerlach V.L., et al. Human fibroblast growth factor 20 (FGF-20; CG53135-05): a novel cytoprotectant with radioprotective potential. Int J Radiat Biol 8 (2005) 567-579
54. Bentzen S.M. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nature Rev 6 (2006) 702-713
55. Andreassen C.N. Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?. Acta Oncol 44 (2005) 801-815