Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 46, 2008, Pages 17772-17777

  Mittag, Tanja ^a   Orlicky, Stephen ^b   Choy, Wing Yiu ^c,e   Tang, Xiaojing ^b   Lin, Hong ^a   Sicheri, Frank ^b,c   Kay, Lewis E ^c,d   Tyers, Mike ^b,c,f   Forman Kay, Julie D ^a,c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF WESTERN ONTARIO   (Canada)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Disorder; Dynamic complex; Multisite phosphorylation; NMR; Protein interaction

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN CDC4; PROTEIN SIC1; UNCLASSIFIED DRUG;

ARTICLE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION;

BINDING SITES; CELL CYCLE PROTEINS; F-BOX PROTEINS; ISOMERISM; LIGANDS; PHOSPHORYLATION; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 56649112976     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809222105     Document Type: Article

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