The neurosurvival factor Humanin inhibits β-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice

Metabolism: Clinical and Experimental

Volumn 59, Issue 3, 2010, Pages 343-349

  Hoang, Phuong T ^a   Park, Patricia ^a   Cobb, Laura J ^a   Paharkova Vatchkova, Valdislava ^a   Hakimi, Michael ^a   Cohen, Pinchas ^a   Lee, Kuk Wha ^a  

^a MATTEL CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; GAMMA INTERFERON; HUMANIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE TOLERANCE; IN VITRO STUDY; LYMPHOCYTIC INFILTRATION; METABOLIC INHIBITION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CASPASES; DIABETES MELLITUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GLUCOSE TOLERANCE TEST; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED NOD; NEURONS; NEUROSECRETORY SYSTEMS; STAT3 TRANSCRIPTION FACTOR;

EID: 76249131322     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.08.001     Document Type: Article

References (39)

1. Eizirik D.L., and Mandrup-Poulsen T. A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44 (2001) 2115-2133
2. O'Brien B.A., Harmon B.V., Cameron D.P., and Allan D.J. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46 (1997) 750-757
3. Paraskevas S., Aikin R., Maysinger D., et al. Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival. FEBS Lett 455 (1999) 203-208
4. Tobiasch E., Gunther L., and Bach F.H. Heme oxygenase-1 protects pancreatic beta cells from apoptosis caused by various stimuli. J Investig Med 49 (2001) 566-571
5. Bodzioch M., Lapicka-Bodzioch K., Zapala B., et al. Evidence for potential functionality of nuclearly-encoded humanin isoforms. Genomics (2009)
6. Hashimoto Y., Niikura T., Tajima H., et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A 98 (2001) 6336-6341
7. Guo B., Zhai D., Cabezas E., et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 423 (2003) 456-461
8. Ikonen M., Liu B., Hashimoto Y., et al. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proc Natl Acad Sci U S A 100 (2003) 13042-13047
9. Arakawa T., Kita Y., and Niikura T. A rescue factor for Alzheimer's diseases: discovery, activity, structure, and mechanism. Curr Med Chem 15 (2008) 2086-2098
10. Hamaguchi K., Gaskins H.R., and Leiter E.H. NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes 40 (1991) 842-849
11. Kariya S., Takahashi N., Ooba N., et al. Humanin inhibits cell death of serum-deprived PC12h cells. Neuroreport 13 (2002) 903-907
12. Stephens L.A., Thomas H.E., Ming L., et al. Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells. Endocrinology 140 (1999) 3219-3227
13. Zumsteg U., Frigerio S., and Hollander G.A. Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage. Diabetes 49 (2000) 39-47
14. Hashimoto Y., Suzuki H., Aiso S., et al. Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection. Life Sci 77 (2005) 3092-3104
15. Xu X., Chua C.C., Gao J., et al. Humanin is a novel neuroprotective agent against stroke. Stroke 37 (2006) 2613-2619
16. Xu J., Cole D.C., Chang C.P., et al. Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem 51 (2008) 4115-4121
17. Ying G., Iribarren P., Zhou Y., et al. Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J Immunol 172 (2004) 7078-7085
18. Harada M., Habata Y., Hosoya M., et al. N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem Biophys Res Commun 324 (2004) 255-261
19. Luciano F., Zhai D., Zhu X., et al. Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL. J Biol Chem 280 (2005) 15825-15835
20. Zhai D., Luciano F., Zhu X., et al. Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak. J Biol Chem 280 (2005) 15815-15824
21. Wang D., Li H., Yuan H., et al. Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase. Apoptosis 10 (2005) 963-971
22. Hashimoto Y., Kurita M., Aiso S., et al. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor {alpha}/WSX-1/gp130. Mol Biol Cell (2009)
23. Heinrich P.C., Behrmann I., Muller-Newen G., et al. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 334 Pt 2 (1998) 297-314
24. Taga T., and Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15 (1997) 797-819
25. Garcia-Ocana A., Vasavada R.C., Cebrian A., et al. Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes 50 (2001) 2752-2762
26. Garcia-Ocana A., Takane K.K., Syed M.A., et al. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem 275 (2000) 1226-1232
27. Watada H., Kajimoto Y., Miyagawa J., et al. PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes 45 (1996) 1826-1831
28. De Breuck S., Baeyens L., and Bouwens L. Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas. Diabetologia 49 (2006) 108-116
29. Kaneto H., Miyagawa J., Kajimoto Y., et al. Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation. J Biol Chem 272 (1997) 29137-29143
30. Baeyens L., and Bouwens L. Can beta-cells be derived from exocrine pancreas?. Diabetes Obes Metab 10 Suppl 4 (2008) 170-178
31. Mori H., Shichita T., Yu Q., et al. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochem Biophys Res Commun 359 (2007) 952-958
32. Mziaut H., Kersting S., Knoch K.P., et al. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci U S A 105 (2008) 674-679
33. Tsukiyama S., Matsushita M., Matsumoto S., et al. Transduction of exogenous constitutively activated Stat3 into dispersed islets induces proliferation of rat pancreatic beta-cells. Tissue Eng 12 (2006) 131-140
34. Costes S., Broca C., Bertrand G., et al. ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival. Diabetes 55 (2006) 2220-2230
35. Fei H., Zhao B., Zhao S., and Wang Q. Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis. Mol Cell Biochem 315 (2008) 75-84
36. Thomas D., Yang H., Boffa D.J., et al. Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2. Transplantation 74 (2002) 1489-1496
37. McKenzie M.D., Carrington E.M., Kaufmann T., et al. Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells. Diabetes 57 (2008) 1284-1292
38. Shim M.L., Levitt Katz L.E., Davis J., et al. Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells. Growth Horm IGF Res 14 (2004) 216-225
39. Portis A.J., Warnock G.L., Finegood D.T., et al. Glucoregulatory response to moderate exercise in long-term islet cell autografted dogs. Can J Physiol Pharmacol 68 (1990) 1308-1312