-
1
-
-
0037155837
-
Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
-
Aoki, H., Kang, P. M., Hampe, A., Yoshimura, K., Noma, T., Matsuzaki, M., and Izumo, S. (2002) Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes, Biol. Chem. 277, 10244-10250
-
(2002)
Biol. Chem.
, vol.277
, pp. 10244-10250
-
-
Aoki, H.1
Kang, P.M.2
Hampe, A.3
Yoshimura, K.4
Noma, T.5
Matsuzaki, M.6
Izumo, S.7
-
2
-
-
46649084880
-
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury
-
Hanawa, N., Shinohara, M., Saberi, B., Gaarde, W. A., Han, D., and Ka-plowitz, N. (2008) Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. Biol. Chem. 283, 13565-13577
-
(2008)
Biol. Chem.
, vol.283
, pp. 13565-13577
-
-
Hanawa, N.1
Shinohara, M.2
Saberi, B.3
Gaarde, W.A.4
Han, D.5
Ka-Plowitz, N.6
-
3
-
-
67349094513
-
Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria
-
Zhao, Y., and Herdegen, T. (2009) Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria. Mol. Cell. Neurosci. 41, 186-195
-
(2009)
Mol. Cell. Neurosci.
, vol.41
, pp. 186-195
-
-
Zhao, Y.1
Herdegen, T.2
-
4
-
-
37349081929
-
C-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons
-
Zhou, Q., Lam, P. Y., Han, D., and Cadenas, E. (2008) c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons, Neurochem. 104, 325-335
-
(2008)
Neurochem.
, vol.104
, pp. 325-335
-
-
Zhou, Q.1
Lam, P.Y.2
Han, D.3
Cadenas, E.4
-
5
-
-
62849111251
-
Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging
-
Zhou, Q., Lam, P. Y., Han, D., and Cadenas, E. (2009) Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. FEBS Lett. 583, 1132-1140
-
(2009)
FEBS Lett.
, vol.583
, pp. 1132-1140
-
-
Zhou, Q.1
Lam, P.Y.2
Han, D.3
Cadenas, E.4
-
6
-
-
79955544880
-
Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation
-
Chambers, J. W., and LoGrasso, P. V. (2011) Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation, J. Biol. Chem. 286, 16052-16062
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16052-16062
-
-
Chambers, J.W.1
Lograsso, P.V.2
-
8
-
-
0036269755
-
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase
-
Lei, IC, Nimnual, A., Zong, W. X., Kennedy, N. J., Flavell, R. A., Thompson, C. B., Bar-Sagi, D., and Davis, R. J. (2002) The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol. Cell. Biol. 22, 4929-4942
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 4929-4942
-
-
Lei, I.C.1
Nimnual, A.2
Zong, W.X.3
Kennedy, N.J.4
Flavell, R.A.5
Thompson, C.B.6
Bar-Sagi, D.7
Davis, R.J.8
-
9
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
Tournier, C, Hess, P., Yang, D. D., Xu, J., Turner, T. IC, Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., and Davis, R. J. (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288, 870-874
-
(2000)
Science
, vol.288
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
Turner, T.I.C.5
Nimnual, A.6
Bar-Sagi, D.7
Jones, S.N.8
Flavell, R.A.9
Davis, R.J.10
-
10
-
-
10044265209
-
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
-
Ventura, J. J., Coqswell, P., Flavell, R. A., Baldwin, A. S., Jr., and Davis, R. J. (2004) JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev. 18, 2905-2915
-
(2004)
Genes Dev.
, vol.18
, pp. 2905-2915
-
-
Ventura, J.J.1
Coqswell, P.2
Flavell, R.A.3
Baldwin Jr., A.S.4
Davis, R.J.5
-
11
-
-
3843090683
-
Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats
-
Ferrandi, C, Ballerio, R., Gaillard, P., Giachetti, C, Carboni, S., Vitte, P. A., Gotteland, J. P., and Cirillo, R. (2004) Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats. Br. J. Pharmacol. 142, 953-960
-
(2004)
Br. J. Pharmacol.
, vol.142
, pp. 953-960
-
-
Ferrandi, C.1
Ballerio, R.2
Gaillard, P.3
Giachetti, C.4
Carboni, S.5
Vitte, P.A.6
Gotteland, J.P.7
Cirillo, R.8
-
12
-
-
0032757190
-
Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia
-
He, H, Li, H. L., Lin, A., and Gottlieb, R. A. (1999) Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia. Cell Death Differ. 6, 987-991
-
(1999)
Cell Death Differ.
, vol.6
, pp. 987-991
-
-
He, H.1
Li, H.L.2
Lin, A.3
Gottlieb, R.A.4
-
13
-
-
25444482606
-
Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusi on-induced cell death in vivo
-
Kaiser, R. A., Liang, Q., Bueno, O., Huang, Y., Lackey, T., Klevitsky, R., Hewett, T. E., and Molkentin, J. D. (2005) Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusi on-induced cell death in vivo. J. Biol. Chem. 280, 32602-32608
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 32602-32608
-
-
Kaiser, R.A.1
Liang, Q.2
Bueno, O.3
Huang, Y.4
Lackey, T.5
Klevitsky, R.6
Hewett, T.E.7
Molkentin, J.D.8
-
14
-
-
80051999961
-
Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase-interacting motif-1 (KIM1)
-
Chambers, J. W., Cherry, L., Laughlin, J. D., Figuera-Losada, M., and Lograsso, P. V. (2011) Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase-interacting motif-1 (KIM1). ACS Chem. Biol. 6, 808-818
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 808-818
-
-
Chambers, J.W.1
Cherry, L.2
Laughlin, J.D.3
Figuera-Losada, M.4
Lograsso, P.V.5
-
15
-
-
0036845859
-
A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria
-
Wiltshire, C, Matsushita, M., Tsukada, S., Gillespie, D. A., and May, G. H. (2002) A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria. Biochem. J. 367, 577-585
-
(2002)
Biochem. J.
, vol.367
, pp. 577-585
-
-
Wiltshire, C.1
Matsushita, M.2
Tsukada, S.3
Gillespie, D.A.4
May, G.H.5
-
16
-
-
34147143391
-
Isolation and subfractionation of mitochondria from animal cells and tissue culture lines
-
Pallotti, F., and Lenaz, G. (2007) Isolation and subfractionation of mitochondria from animal cells and tissue culture lines. Methods Cell Biol. 80, 3-44
-
(2007)
Methods Cell Biol.
, vol.80
, pp. 3-44
-
-
Pallotti, F.1
Lenaz, G.2
-
17
-
-
0014068230
-
The submitochondrial localization of monoamine oxidase. An enzymatic marker for the outer membrane of rat liver mitochondria
-
Schnaitman, C, Erwin, V. G., and Greenawalt, J. W. (1967) The submitochondrial localization of monoamine oxidase. An enzymatic marker for the outer membrane of rat liver mitochondria. Cell Biol. 32, 719-735
-
(1967)
Cell Biol.
, vol.32
, pp. 719-735
-
-
Schnaitman, C.1
Erwin, V.G.2
Greenawalt, J.W.3
-
18
-
-
38349158077
-
Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy
-
Mukhopadhyay, P., Rajesh, M., Haskó, G., Hawkins, B. J., Madesh, M., and Pacher, P. (2007) Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Wat Protoc. 2, 2295-2301
-
(2007)
Wat Protoc.
, vol.2
, pp. 2295-2301
-
-
Mukhopadhyay, P.1
Rajesh, M.2
Haskó, G.3
Hawkins, B.J.4
Madesh, M.5
Pacher, P.6
-
19
-
-
79955111737
-
Small molecule c-/αH-N-terminal kinase (JNK) inhibitors protect dopaminergic neurons in a model of Parkinson's disease
-
Chambers, J. W., Pachori, A., Howard, S., Ganno, M., Hansen, D., Jr., Kamenecka, T., Song, X., Duckett, D., Chen, W., Ling, Y. Y., Cherry, L., Cameron, M. D., Lin, L., Ruiz, C. H., and Lograsso, P. (2011) Small molecule c-/αH-N-terminal kinase (JNK) inhibitors protect dopaminergic neurons in a model of Parkinson's disease. ACS Chem. Neurosci. 2, 198-206
-
(2011)
ACS Chem. Neurosci.
, vol.2
, pp. 198-206
-
-
Chambers, J.W.1
Pachori, A.2
Howard, S.3
Ganno, M.4
Hansen Jr., D.5
Kamenecka, T.6
Song, X.7
Duckett, D.8
Chen, W.9
Ling, Y.Y.10
Cherry, L.11
Cameron, M.D.12
Lin, L.13
Ruiz, C.H.14
Lograsso, P.15
-
20
-
-
74849136062
-
Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-/αH-N-terminal kinase (JNK) inhibitors
-
Kamenecka, T., Jiang, R., Song, X., Duckett, D., Chen, W., Ling, Y. Y., Habel, J., Laughlin, J. D., Chambers, J., Figuera-Losada, M., Cameron, M. D., Lin, L., Ruiz, C. H., and LoGrasso, P. V (2010) Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-/αH-N-terminal kinase (JNK) inhibitors. Med. Chem. 53, 419-431
-
(2010)
Med. Chem.
, vol.53
, pp. 419-431
-
-
Kamenecka, T.1
Jiang, R.2
Song, X.3
Duckett, D.4
Chen, W.5
Ling, Y.Y.6
Habel, J.7
Laughlin, J.D.8
Chambers, J.9
Figuera-Losada, M.10
Cameron, M.D.11
Lin, L.12
Ruiz, C.H.13
Lograsso, P.V.14
-
21
-
-
4544255383
-
The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia
-
Okuno, S., Saito, A., Hayashi, T., and Chan, P. H. (2004) The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. Neurosci. 24, 7879-7887
-
(2004)
Neurosci.
, vol.24
, pp. 7879-7887
-
-
Okuno, S.1
Saito, A.2
Hayashi, T.3
Chan, P.H.4
-
22
-
-
3042818863
-
Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation
-
Dougherty, C. J., Kubasiak, L. A., Frazier, D. P., Li, H., Xiong, W. C, Bishopric, N. H, and Webster, IC A. (2004) Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation. FASEBJ. 18, 1060-1070
-
(2004)
FASEBJ
, vol.18
, pp. 1060-1070
-
-
Dougherty, C.J.1
Kubasiak, L.A.2
Frazier, D.P.3
Li, H.4
Xiong, W.C.5
Bishopric, N.H.6
Webster, I.C.A.7
-
23
-
-
0037086678
-
Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress
-
Dougherty, C. J., Kubasiak, L. A., Prentice, H., Andreka, P., Bishopric, N. H, and Webster, IC A. (2002) Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress. Biochem. J. 362, 561-571
-
(2002)
Biochem. J.
, vol.362
, pp. 561-571
-
-
Dougherty, C.J.1
Kubasiak, L.A.2
Prentice, H.3
Andreka, P.4
Bishopric, N.H.5
Webster, I.C.A.6
-
24
-
-
0028329953
-
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
Dérijard, B., Hibi, M., Wu, I. H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R. J. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Dérijard, B.1
Hibi, M.2
Wu, I.H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
25
-
-
34548478108
-
-
Yu, J., Novgorodov, S. A., Chudakova, D., Zhu, H., Bielawska, A., Bie-lawska, J., Obeid, L. M., Kindy, M. S., and Gudz, T. I. (2007) J. Biol. Chem. 282, 25940-25949
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 25940-25949
-
-
Yu, J.1
Novgorodov, S.A.2
Chudakova, D.3
Zhu, H.4
Bielawska, A.5
Bie-Lawska, J.6
Obeid, L.M.7
Kindy, M.S.8
Gudz, T.I.9
-
26
-
-
0028984151
-
P493Fl 2 kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous system
-
Mohit, A. A., Martin, J. H, and Miller, C. A. (1995) p493Fl 2 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron 14, 67-78
-
(1995)
Neuron
, vol.14
, pp. 67-78
-
-
Mohit, A.A.1
Martin, J.H.2
Miller, C.A.3
-
27
-
-
66549126199
-
Identification of small-molecule inhibitors of the JIP-JNK interaction
-
Chen, T., Kablaoui, N., Little, J., Timofeevski, S., Tschantz, W. R., Chen, P., Feng, J., Charlton, M., Stanton, R., and Bauer, P. (2009) Identification of small-molecule inhibitors of the JIP-JNK interaction. Biochem. J. 420, 283-294
-
(2009)
Biochem. J.
, vol.420
, pp. 283-294
-
-
Chen, T.1
Kablaoui, N.2
Little, J.3
Timofeevski, S.4
Tschantz, W.R.5
Chen, P.6
Feng, J.7
Charlton, M.8
Stanton, R.9
Bauer, P.10
-
28
-
-
76449090858
-
Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors
-
De, S. K., Chen, V, Stebbins, J. L., Chen, L. H, Cellitti, J. F., Machleidt, T., Barile, E., Riel-Mehan, M., Dahl, R., Yang, L., Emdadi, A., Murphy, R., and Pellecchia, M. (2010) Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. Bioorg. Med. Chem. 18, 590-596
-
(2010)
Bioorg. Med. Chem.
, vol.18
, pp. 590-596
-
-
De, S.K.1
Chen, V.2
Stebbins, J.L.3
Chen, L.H.4
Cellitti, J.F.5
MacHleidt, T.6
Barile, E.7
Riel-Mehan, M.8
Dahl, R.9
Yang, L.10
Emdadi, A.11
Murphy, R.12
Pellecchia, M.13
-
29
-
-
62949201723
-
Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[t/]thiazoles as novel c-Jun N-terminal kinase inhibitors
-
De, S. IC, Chen, L. H., Stebbins, J. L., Machleidt, T., Riel-Mehan, M., Dahl, R., Chen, V., Yuan, H., Barile, E., Emdadi, A., Murphy, R., and Pellecchia, M. (2009) Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[t/]thiazoles as novel c-Jun N-terminal kinase inhibitors. Bioorg. Med. Chem. 17, 2712-2717
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 2712-2717
-
-
De, S.I.C.1
Chen, L.H.2
Stebbins, J.L.3
MacHleidt, T.4
Riel-Mehan, M.5
Dahl, R.6
Chen, V.7
Yuan, H.8
Barile, E.9
Emdadi, A.10
Murphy, R.11
Pellecchia, M.12
-
30
-
-
64549143360
-
Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase
-
De, S. IC, Stebbins, J. L., Chen, L. H., Riel-Mehan, M., Machleidt, T., Dahl, R., Yuan, H., Emdadi, A., Barile, E., Chen, V., Murphy, R., and Pellecchia, M. (2009) Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase. Med. Chem. 52, 1943-1952
-
(2009)
Med. Chem.
, vol.52
, pp. 1943-1952
-
-
De, S.I.C.1
Stebbins, J.L.2
Chen, L.H.3
Riel-Mehan, M.4
MacHleidt, T.5
Dahl, R.6
Yuan, H.7
Emdadi, A.8
Barile, E.9
Chen, V.10
Murphy, R.11
Pellecchia, M.12
-
31
-
-
55949100580
-
Identification of a newJNK inhibitor targeting the JNK-JIP interaction site
-
Stebbins, J. L., De, S. IC, Machleidt, T., Becattini, B., Vazquez, J., Kuntzen, C, Chen, L. H., Cellitti, I. F., Riel-Mehan, M., Emdadi, A., Solinas, G., Karin, M., and Pellecchia, M. (2008) Identification of a newJNK inhibitor targeting the JNK-JIP interaction site. Proc. Natl. Acad. Sei. U.S.A. 105, 16809-16813
-
(2008)
Proc. Natl. Acad. Sei. U.S.A.
, vol.105
, pp. 16809-16813
-
-
Stebbins, J.L.1
De, S.I.C.2
MacHleidt, T.3
Becattini, B.4
Vazquez, J.5
Kuntzen, C.6
Chen, L.H.7
Cellitti, I.F.8
Riel-Mehan, M.9
Emdadi, A.10
Solinas, G.11
Karin, M.12
Pellecchia, M.13
|