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Volumn 37, Issue 1, 2013, Pages 3-8

Involvement of 5-lipoxygenase in Alzheimer's disease: A role for DNA methylation

Author keywords

5 lipoxygenase; Alzheimer's disease; biomarker; DNA methylation; fatty acid amide hydrolase; peripheral blood mononuclear cells

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; BIOLOGICAL MARKER; LEUKOTRIENE B4; PROTEIN;

EID: 84883142421     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130506     Document Type: Article
Times cited : (41)

References (48)
  • 1
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148, 1204-1222.
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 2
    • 56349145099 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease: A reappraisal
    • Pratic̀o D (2008) Oxidative stress hypothesis in Alzheimer's disease: A reappraisal. Trends Pharmacol Sci 29, 609-615.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 609-615
    • Pratic̀o, D.1
  • 4
    • 27544477825 scopus 로고    scopus 로고
    • Structural biology of mammalian lipoxygenases: Enzymatic consequences of targeted alterations of the protein structure
    • DOI 10.1016/j.bbrc.2005.08.238, PII S0006291X05019406
    • Kuhn H, Saam J, Eibach S, Holzhutter HG, Ivanov I,Walther M (2005) Structural biology of mammalian lipoxygenases: Enzymatic consequences of targeted alterations of the protein structure. Biochem Biophys Res Commun 338, 93-101. (Pubitemid 41540542)
    • (2005) Biochemical and Biophysical Research Communications , vol.338 , Issue.1 , pp. 93-101
    • Kuhn, H.1    Saam, J.2    Eibach, S.3    Holzhutter, H.-G.4    Ivanov, I.5    Walther, M.6
  • 5
    • 80054052917 scopus 로고    scopus 로고
    • Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease
    • Haeggstr̈om JZ, Funk CD (2011) Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease. Chem Rev 111, 5866-5898.
    • (2011) Chem Rev , vol.111 , pp. 5866-5898
    • Haeggstr̈om, J.Z.1    Funk, C.D.2
  • 6
    • 0034101592 scopus 로고    scopus 로고
    • New anti-inflammatory treatment strategy in Alzheimer's disease
    • DOI 10.1254/jjp.82.85
    • Sugaya K, Uz T, Kumar V, Manev H (2000) New antiinflammatory treatment strategy in Alzheimer's disease. Jpn J Pharmacol 82, 85-94. (Pubitemid 30153588)
    • (2000) Japanese Journal of Pharmacology , vol.82 , Issue.2 , pp. 85-94
    • Sugaya, K.1    Uz, T.2    Kumar, V.3    Manev, H.4
  • 7
    • 0036753450 scopus 로고    scopus 로고
    • Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
    • DOI 10.1016/S0197-4580(02)00021-0, PII S0197458002000210
    • Klegeris A, McGeer PL (2002) Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. Neurobiol Aging 23, 787-794. (Pubitemid 35217703)
    • (2002) Neurobiology of Aging , vol.23 , Issue.5 , pp. 787-794
    • Klegeris, A.1    McGeer, P.L.2
  • 8
    • 84882256181 scopus 로고    scopus 로고
    • The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: In vivo and in vitro evidence
    • doi: 10.1016/j.biopsych.2012.12.012
    • Chu J, Li JG, Ceballos-Diaz C, Golde T, Pratic̀o D (2013) The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: In vivo and in vitro evidence. Biol Psychiatry. doi: 10.1016/j.biopsych.2012.12.012
    • (2013) Biol Psychiatry
    • Chu, J.1    Li, J.G.2    Ceballos-Diaz, C.3    Golde, T.4    Pratic̀o, D.5
  • 9
    • 34347397335 scopus 로고    scopus 로고
    • 5-Lipoxygenase: Regulation of expression and enzyme activity
    • DOI 10.1016/j.tibs.2007.06.002, PII S0968000407001442
    • R°admark O, Werz O, Steinhilber D, Samuelsson B (2007) 5-Lipoxygenase: Regulation of expression and enzyme activity. Trends Biochem Sci 32, 332-341. (Pubitemid 47021417)
    • (2007) Trends in Biochemical Sciences , vol.32 , Issue.7 , pp. 332-341
    • Radmark, O.1    Werz, O.2    Steinhilber, D.3    Samuelsson, B.4
  • 10
    • 33747885659 scopus 로고    scopus 로고
    • Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders
    • DOI 10.1016/j.brainresrev.2006.02.002, PII S0165017306000117
    • Phillis JW, Horrocks LA, Farooqui AA (2006) Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders. Brain Res Rev 52, 201-243. (Pubitemid 44291802)
    • (2006) Brain Research Reviews , vol.52 , Issue.2 , pp. 201-243
    • Phillis, J.W.1    Horrocks, L.A.2    Farooqui, A.A.3
  • 12
    • 0033937951 scopus 로고    scopus 로고
    • Putative role of neuronal 5-lipoxygenase in an aging brain
    • Manev H, Uz T, Sukaya K, Sugaya K, Qu T (2000) Putative role of neuronal 5-lipoxygenase in an aging brain. FASEB J 14, 1464-1469. (Pubitemid 30439756)
    • (2000) FASEB Journal , vol.14 , Issue.10 , pp. 1464-1469
    • Manev, H.1    Uz, T.2    Sugaya, K.3    Qu, T.4
  • 13
    • 0036938594 scopus 로고    scopus 로고
    • A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans
    • Tomimoto H, Shibata M, Ihara M, Akiguchi I, Ohtani R, Budka H (2002) A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans. Acta Neuropathol 104, 601-607. (Pubitemid 36075425)
    • (2002) Acta Neuropathologica , vol.104 , Issue.6 , pp. 601-607
    • Tomimoto, H.1    Shibata, M.2    Ihara, M.3    Akiguchi, I.4    Ohtani, R.5    Budka, H.6
  • 15
    • 34447565153 scopus 로고    scopus 로고
    • The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old
    • DOI 10.1016/j.neurobiolaging.2006.06.007, PII S0197458006002193
    • Chinnici CM, Yao Y, Pratic̀o D (2007) The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old. Neurobiol Aging 28, 1457-1462. (Pubitemid 47081230)
    • (2007) Neurobiology of Aging , vol.28 , Issue.9 , pp. 1457-1462
    • Chinnici, C.M.1    Yao, Y.2    Pratico, D.3
  • 17
    • 2642693710 scopus 로고    scopus 로고
    • Aging-associated up-regulation of neuronal 5-lipoxygenase expression: Putative role in neuronal vulnerability
    • UzT, Pesold C, Longone P, ManevH(1998) Aging-associated up-regulation of neuronal 5-lipoxygenase expression: Putative role in neuronal vulnerability. FASEB J 12, 439-449. (Pubitemid 28146523)
    • (1998) FASEB Journal , vol.12 , Issue.6 , pp. 439-449
    • Tolga, U.Z.1    Pesold, C.2    Longone, P.3    Manev, H.4
  • 18
    • 42049114647 scopus 로고    scopus 로고
    • 5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease
    • DOI 10.1096/fj.07-9131.com
    • Firuzi O, Zhuo J, Chinnici CM, Wisniewski T, Pratic̀o D (2008) 5-Lipoxygenase gene disruption reduces Amyloid-pathology in a mouse model of Alzheimer's disease. FASEB J 22, 1169-1178. (Pubitemid 351519971)
    • (2008) FASEB Journal , vol.22 , Issue.4 , pp. 1169-1178
    • Firuzi, O.1    Zhuo, J.2    Chinnici, C.M.3    Wisniewski, T.4    Pratico, D.5
  • 19
    • 52949125632 scopus 로고    scopus 로고
    • The endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases
    • Centonze D, Battistini L, Maccarrone M (2008) The endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases. Curr Pharm Des 14, 2370-2382.
    • (2008) Curr Pharm des , vol.14 , pp. 2370-2382
    • Centonze, D.1    Battistini, L.2    MacCarrone, M.3
  • 20
    • 34248663955 scopus 로고    scopus 로고
    • The single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction: Twenty-something years on
    • Chomczynski P, Sacchi N (2006) The single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction: Twenty-something years on. Nat Protoc 1, 581-585.
    • (2006) Nat Protoc , vol.1 , pp. 581-585
    • Chomczynski, P.1    Sacchi, N.2
  • 21
    • 0024284028 scopus 로고
    • Asimple salting out procedure for extracting DNA from human nucleated cells
    • Miller SA, Dykes DD, PoleskyHF (1988)Asimple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16, 1215.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 23
    • 77049112046 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy: Implication for pharmacogenomics
    • List̀ F, Caruso C, Lio D, Colonna-Romano G, Chiappelli M, Licastro F, Candore G (2010) Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy: Implication for pharmacogenomics. J Alzheimers Dis 19, 551-557.
    • (2010) J Alzheimers Dis , vol.19 , pp. 551-557
    • List̀, F.1    Caruso, C.2    Lio, D.3    Colonna-Romano, G.4    Chiappelli, M.5    Licastro, F.6    Candore, G.7
  • 24
    • 0034991806 scopus 로고    scopus 로고
    • 5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's disease [4]
    • DOI 10.1176/appi.neuropsych.13.2.304
    • Qu T, Manev R, Manev H (2001) 5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and lateonset Alzheimer's disease. J Neuropsychiatry Clin Neurosci 13, 304-305. (Pubitemid 32499684)
    • (2001) Journal of Neuropsychiatry and Clinical Neurosciences , vol.13 , Issue.2 , pp. 304-305
    • Qu, T.1    Manev, R.2    Manev, H.3
  • 26
    • 1642309652 scopus 로고    scopus 로고
    • DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: Evidence in human NT2 and NT2-N cells
    • Zhang Z, Chen CQ, Manev H (2004) DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: Evidence in human NT2 and NT2-N cells. J Neurochem 88, 1424-1430. (Pubitemid 38366918)
    • (2004) Journal of Neurochemistry , vol.88 , Issue.6 , pp. 1424-1430
    • Zhang, Z.1    Chen, C.-Q.2    Manev, H.3
  • 29
    • 77954552201 scopus 로고    scopus 로고
    • Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer's disease
    • Copped̀e F, Migliore L (2010) Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer's disease. J Alzheimers Dis 20, 953-966.
    • (2010) J Alzheimers Dis , vol.20 , pp. 953-966
    • Copped̀e, F.1    Migliore, L.2
  • 31
    • 84858195896 scopus 로고    scopus 로고
    • New pharmacological strategies for treatment of Alzheimer's disease: Focus on disease modifying drugs
    • Salomone S, Caraci F, Leggio GM, Fedotova J, Drago F (2012) New pharmacological strategies for treatment of Alzheimer's disease: Focus on disease modifying drugs. Br J Clin Pharmacol 73, 504-517.
    • (2012) Br J Clin Pharmacol , vol.73 , pp. 504-517
    • Salomone, S.1    Caraci, F.2    Leggio, G.M.3    Fedotova, J.4    Drago, F.5
  • 32
    • 0032577868 scopus 로고    scopus 로고
    • Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by Trichostatin A and butyrate
    • DOI 10.1006/bbrc.1998.8891
    • Dangond F, Gullans SR (1998) Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. Biochem Biophys Res Commun 247, 833-837. (Pubitemid 28418477)
    • (1998) Biochemical and Biophysical Research Communications , vol.247 , Issue.3 , pp. 833-837
    • Dangond, F.1    Gullans, S.R.2
  • 36
    • 70449523239 scopus 로고    scopus 로고
    • 5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells
    • Imbesi M, Dzitoyeva S, Ng LW, Manev H (2009) 5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells. Neuroscience 164, 1531-1537.
    • (2009) Neuroscience , vol.164 , pp. 1531-1537
    • Imbesi, M.1    Dzitoyeva, S.2    Ng, L.W.3    Manev, H.4
  • 37
    • 77649247703 scopus 로고    scopus 로고
    • 5-lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice
    • Dzitoyeva S, Imbesi M, Ng LW, Manev H (2009) 5-lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice. Neural Plas 2009, 209-596.
    • (2009) Neural Plas , vol.2009 , pp. 209-596
    • Dzitoyeva, S.1    Imbesi, M.2    Ng, L.W.3    Manev, H.4
  • 42
    • 80054080661 scopus 로고    scopus 로고
    • Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: Cross-talk between the eicosanoid and endocannabinoid signaling pathways
    • Rouzer CA, Marnett LJ (2011) Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: Cross-talk between the eicosanoid and endocannabinoid signaling pathways. Chem Rev 111, 5899-5921.
    • (2011) Chem Rev , vol.111 , pp. 5899-5921
    • Rouzer, C.A.1    Marnett, L.J.2
  • 43
  • 45
    • 81755181762 scopus 로고    scopus 로고
    • Non-steroidal antiinflammatory drugs and cognitive function: Are prostaglandins at the heart of cognitive impairment in dementia and delirium?
    • Cunningham C, Skelly DT (2012) Non-steroidal antiinflammatory drugs and cognitive function: Are prostaglandins at the heart of cognitive impairment in dementia and delirium? J Neuroimmune Pharmacol 7, 60-73.
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 60-73
    • Cunningham, C.1    Skelly, D.T.2
  • 46
    • 84899519009 scopus 로고    scopus 로고
    • Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?
    • doi: 10.3389/fnagi.2010.00019
    • Imbimbo BP, Solfrizzi V, Panza F (2010) Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment? Front Aging Neurosci. doi: 10.3389/fnagi.2010.00019
    • (2010) Front Aging Neurosci
    • Imbimbo, B.P.1    Solfrizzi, V.2    Panza, F.3
  • 47
    • 77958484639 scopus 로고    scopus 로고
    • NSAID-induced gastrointestinal and cardiovascular injury
    • Ng SC, Chan FK (2010) NSAID-induced gastrointestinal and cardiovascular injury. Curr Opin Gastroenterol 26, 611-617.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 611-617
    • Ng, S.C.1    Chan, F.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.