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Volumn 19, Issue 2, 2010, Pages 551-557

Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from Northern Italy: Implication for pharmacogenomics

Author keywords

5 LO; Alzheimer's disease; COX 2; Pharmacogenomics

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 2;

EID: 77049112046     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-1260     Document Type: Article
Times cited : (24)

References (51)
  • 5
    • 56449106689 scopus 로고    scopus 로고
    • Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease
    • Ikonomovic MD, Abrahamson EE, Uz T, Manev H, Dekosky ST (2008) Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease. J Histochem Cytochem 56, 1065-1073.
    • (2008) J Histochem Cytochem , vol.56 , pp. 1065-1073
    • Ikonomovic, M.D.1    Abrahamson, E.E.2    Uz, T.3    Manev, H.4    Dekosky, S.T.5
  • 7
    • 0033178889 scopus 로고    scopus 로고
    • Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease
    • Ho L, Pieroni C, Winger D, Purohit DP, Aisen PS, Pasinetti GM (1999) Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease. J Neurosci Res 57, 295-303.
    • (1999) J Neurosci Res , vol.57 , pp. 295-303
    • Ho, L.1    Pieroni, C.2    Winger, D.3    Purohit, D.P.4    Aisen, P.S.5    Pasinetti, G.M.6
  • 9
    • 0030951257 scopus 로고    scopus 로고
    • Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: Specific localization in affected neurones and axons
    • Oka A, Takashima S (1997) Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons. Neuroreport 8, 1161-1164.
    • (1997) Neuroreport , vol.8 , pp. 1161-1164
    • Oka, A.1    Takashima, S.2
  • 10
    • 0030909616 scopus 로고    scopus 로고
    • Cyclooxygenase-2 gene expression in neurons contributes to ischemic brain damage
    • Nogawa S, Zhang F, Ross ME, Iadecola C (1997) Cyclooxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17, 2746-2755.
    • (1997) J Neurosci , vol.17 , pp. 2746-2755
    • Nogawa, S.1    Zhang, F.2    Ross, M.E.3    Iadecola, C.4
  • 11
    • 34547492807 scopus 로고    scopus 로고
    • Roles of prostaglandin synthesis in excitotoxic brain diseases
    • Takemiya T, Matsumura K, Yamagata K (2007) Roles of prostaglandin synthesis in excitotoxic brain diseases. Neurochem Int 51, 112-120.
    • (2007) Neurochem Int , vol.51 , pp. 112-120
    • Takemiya, T.1    Matsumura, K.2    Yamagata, K.3
  • 12
    • 0031826073 scopus 로고    scopus 로고
    • Strong nuclear factor-κB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex
    • Lukiw WJ, Bazan NG (1998) Strong nuclear factor-κB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J Neurosci Res 53, 583-592.
    • (1998) J Neurosci Res , vol.53 , pp. 583-592
    • Lukiw, W.J.1    Bazan, N.G.2
  • 13
    • 0030608878 scopus 로고    scopus 로고
    • Involvement of NF-κBin the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages
    • D'Acquisto F, Iuvone T, Rombola L, Sautebin L, Di Rosa M, Carnuccio R (1997) Involvement of NF-κBin the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett 418, 175-178.
    • (1997) FEBS Lett , vol.418 , pp. 175-178
    • D'Acquisto, F.1    Iuvone, T.2    Rombola, L.3    Sautebin, L.4    Di Rosa, M.5    Carnuccio, R.6
  • 15
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal antiinflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies
    • Etminan M, Gill S, SamiiA(2003) Effect of non-steroidal antiinflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 327, 128.
    • (2003) BMJ , vol.327 , pp. 128
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 16
    • 19944363180 scopus 로고    scopus 로고
    • The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs
    • Hoozemans JJ, O'Banion MK (2005) The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs. Curr Drug Targets CNS Neurol Disord 4, 307-315.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 307-315
    • Hoozemans, J.J.1    O'Banion, M.K.2
  • 17
    • 0038064189 scopus 로고    scopus 로고
    • Pharmacologic agents associated with a preventive effect on Alzheimer's disease: A review of the epidemiologic evidence
    • Veld BA, Launer LJ, Breteler MM, Hofman A, Stricker BH (2002) Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence. Epidemiol Rev 24, 248-268.
    • (2002) Epidemiol Rev , vol.24 , pp. 248-268
    • Veld, B.A.1    Launer, L.J.2    Breteler, M.M.3    Hofman, A.4    Stricker, B.H.5
  • 18
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • Martin BK, Szekely C, Brandt J, Piantadosi S, Breitner JC, Craft S, Evans D, Green R, Mullan M (2009) Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol 65, 896-905.
    • (2009) Arch Neurol , vol.65 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.5    Craft, S.6    Evans, D.7    Green, R.8    Mullan, M.9
  • 19
    • 65249154212 scopus 로고    scopus 로고
    • Can treatment with nonsteroidal anti-inflammatory drugs protect from dementia?
    • Bregman N, Karni A, Korczyn AD (2009) Can treatment with nonsteroidal anti-inflammatory drugs protect from dementia? Arch Neurol 66, 539-540.
    • (2009) Arch Neurol , vol.66 , pp. 539-540
    • Bregman, N.1    Karni, A.2    Korczyn, A.D.3
  • 20
    • 9144219644 scopus 로고    scopus 로고
    • Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    • Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM (2003) Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. J Biol Chem 278, 50970-50977.
    • (2003) J Biol Chem , vol.278 , pp. 50970-50977
    • Qin, W.1    Ho, L.2    Pompl, P.N.3    Peng, Y.4    Zhao, Z.5    Xiang, Z.6    Robakis, N.K.7    Shioi, J.8    Suh, J.9    Pasinetti, G.M.10
  • 21
    • 31544445520 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141l presenilin-2 familial Alzheimer's disease
    • Qin W, Peng Y, Ksiezak-Reding H, Ho L, Stetka B, Lovati E, Pasinetti GM (2006) Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141l presenilin-2 familial Alzheimer's disease. Mol Psychiatry 11, 172-181.
    • (2006) Mol Psychiatry , vol.11 , pp. 172-181
    • Qin, W.1    Peng, Y.2    Ksiezak-Reding, H.3    Ho, L.4    Stetka, B.5    Lovati, E.6    Pasinetti, G.M.7
  • 22
    • 0036231413 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity
    • Mirjany M, Ho L, Pasinetti GM (2002) Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity. J Pharmacol Exp Ther 301, 494-500.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 494-500
    • Mirjany, M.1    Ho, L.2    Pasinetti, G.M.3
  • 25
    • 42649138585 scopus 로고    scopus 로고
    • Association of prostaglandinendoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese
    • Ma L, Tang NLS, Zhang YP, Ji L, Tam CWC, Lui VWC, Chiu HF, Lam LC (2008) Association of prostaglandinendoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese. Neurobiol Aging 29, 856-860.
    • (2008) Neurobiol Aging , vol.29 , pp. 856-860
    • Ma, L.1    Tang, N.L.S.2    Zhang, Y.P.3    Ji, L.4    Tam, C.W.C.5    Lui, V.W.C.6    Chiu, H.F.7    Lam, L.C.8
  • 26
    • 30044446862 scopus 로고    scopus 로고
    • 5-Lipoxygenase activating protein homodimer in human neutrophils. Evidence for a role in leukotriene synthesis
    • Plante H, Picard S, Mancini J, Borgeat P (2006) 5-Lipoxygenase activating protein homodimer in human neutrophils. Evidence for a role in leukotriene synthesis. Biochem J 393, 211-218.
    • (2006) Biochem J , vol.393 , pp. 211-218
    • Plante, H.1    Picard, S.2    Mancini, J.3    Borgeat, P.4
  • 27
    • 30344484832 scopus 로고    scopus 로고
    • 5-Lipoxygenase (ALOX5) and FLAP(ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease
    • Manev H, Manev R (2006) 5-Lipoxygenase (ALOX5) and FLAP(ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease. Med Hypotheses 66, 501-503.
    • (2006) Med Hypotheses , vol.66 , pp. 501-503
    • Manev, H.1    Manev, R.2
  • 28
    • 25444475777 scopus 로고    scopus 로고
    • Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment
    • Yao Y, Clark CM, Trojanowski JQ, Lee VM, Pratic̀o D (2005) Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment. Ann Neurol 58, 623-626.
    • (2005) Ann Neurol , vol.58 , pp. 623-626
    • Yao, Y.1    Clark, C.M.2    Trojanowski, J.Q.3    Lee, V.M.4    Pratic̀o, D.5
  • 33
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) " Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer's Disease". Neurology 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 34
    • 0004235298 scopus 로고
    • American Psychiatric Association. 3rd revised ed. Washington (DC), American Psychiatric Association
    • American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders: DSM-III-R, 3rd revised ed. Washington (DC), American Psychiatric Association.
    • (1987) Diagnostic and Statistical Manual of Mental Disorders: DSM-III-R
  • 35
    • 0024284028 scopus 로고    scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller SA, Dykes DD, Polesky HF (1998) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16, 1215.
    • (1998) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 36
    • 34548532090 scopus 로고    scopus 로고
    • Genetic risk profiles for Alzheimer's disease: Integration of APOE genotype and variants that up-regulate inflammation
    • Licastro F, Porcellini E, Caruso C, Lio D, Corder EH (2007) Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation. Neurobiol Aging 28, 1637-1643.
    • (2007) Neurobiol Aging , vol.28 , pp. 1637-1643
    • Licastro, F.1    Porcellini, E.2    Caruso, C.3    Lio, D.4    Corder, E.H.5
  • 37
    • 0032542897 scopus 로고    scopus 로고
    • What's wrong with Bonferroni adjustments?
    • Perneger TV (1998) What's wrong with Bonferroni adjustments? Br Med J 316, 1236-1238.
    • (1998) Br Med J , vol.316 , pp. 1236-1238
    • Perneger, T.V.1
  • 39
    • 0025215247 scopus 로고
    • Power and sample size calculations. A review and a computer program
    • Dupont WD, Plummer WD Jr. (1990) Power and sample size calculations. A review and a computer program. Control Clin. Trials 11, 116-128.
    • (1990) Control Clin. Trials , vol.11 , pp. 116-128
    • Dupont, W.D.1    Plummer Jr., W.D.2
  • 41
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database
    • Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 39, 17-23.
    • (2007) Nat Genet , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 42
    • 16844364790 scopus 로고    scopus 로고
    • PTGS2 (COX-2)-765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs
    • Ulrich CM, Whitton J, Yu JH, Sibert J, Sparks R, Potter JD, Bigler J (2005) PTGS2 (COX-2)-765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. Cancer Epidemiol Biomarkers Prev 14, 616-619.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 616-619
    • Ulrich, C.M.1    Whitton, J.2    Yu, J.H.3    Sibert, J.4    Sparks, R.5    Potter, J.D.6    Bigler, J.7
  • 48
    • 77049122653 scopus 로고    scopus 로고
    • accessed June 8, 2009
    • http://www.alzforum.org/res/com/gen/alzgene/largescale.asp; accessed June 8, 2009
  • 49
    • 14544286348 scopus 로고    scopus 로고
    • Genetic factors in Alzheimer's disease
    • Bird TD (2005) Genetic factors in Alzheimer's disease. N Engl J Med 352, 862-864.
    • (2005) N Engl J Med , vol.352 , pp. 862-864
    • Bird, T.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.