DNA methylation regulates 5-lipoxygenase promoter activity

Advances in Experimental Medicine and Biology

Volumn 525, Issue , 2003, Pages 169-172

  Uhl, Johannes ^b   Klan, Niko ^b   Rose, Matthias ^b   Entian, Karl Dieter ^b   Werz, Oliver ^a   Steinhilber, Dieter ^a  

^a GOETHE UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CELL DNA; DNA METHYLTRANSFERASE; MESSENGER RNA; METHYLTRANSFERASE;

CELL DIFFERENTIATION; CELL FREE SYSTEM; CELL STRAIN HL 60; CELL STRAIN U937; CONFERENCE PAPER; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0037530213     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-9194-2_35     Document Type: Conference Paper

References (6)

1. Funk CD, Hoshiko S, Matsumoto T, Rådmark O, Samuelsson B. Characterization of the human 5-lipoxygenase gene. Proc Natl Acad Sci USA 1989; 86:2587-2591.
2. Uhl J, Klan N, Rose M, Entian KD, Werz O, Steinhilber D. The 5-lipoxygenase promoter is regulated by DNA methylation. J Biol Chem 2002; 277:4374-4379.
3. Claesson H-E, Jakobsson P-J, Steinhilber D, Odlander B, Samuelsson B. Expression of 5-lipoxygenase and biosynthesis of leukotriene B4 in human monomorphonuclear leukocytes. J Lipid Med 1993; 6:15-22.
4. Steinhilber D, Hoshiko S, Grunewald J, Rådmark O, Samuelsson B. Serum factors regulate 5-lipoxygenase activity in maturating HL-60 cells. Biochim Biophys Acta 1993; 1178:1-8.
5. Detich N, Theberge J, Szyf M. Promoter-specific activation and demethylation by MBD2/demethylase. J Biol Chem 2002; 277:35791-35794.
6. Kim GD, Ni J, Kelesoglu N, Roberts RJ, Pradhan S. Cooperation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. Embo J 2002; 21:4183-4195.