5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells

Neuroscience

Volumn 164, Issue 4, 2009, Pages 1531-1537

  Imbesi, M ^a   Dzitoyeva, S ^a   Ng, L W ^a   Manev, H ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

5 Lipoxygenase; aging; cerebellar granule; DNMT1; DNMT3a; epigenetic

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CPG OLIGODEOXYNUCLEOTIDE; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; MESSENGER RNA; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ANIMAL CELL; ARTICLE; CELL AGING; CELL MATURATION; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GRANULE CELL; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

5' UNTRANSLATED REGIONS; ANIMALS; ANIMALS, NEWBORN; ARACHIDONATE 5-LIPOXYGENASE; BASE SEQUENCE; CELL AGING; CELL DIFFERENTIATION; CELLS, CULTURED; CEREBELLUM; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

EID: 70449523239     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.09.039     Document Type: Article

References (34)

1. Barrachina M., and Ferrer I. DNA methylation of Alzheimer's disease and tauopathy-related genes in postmortem brain. J Neuropathol Exp Neurol 68 (2009) 880-891
2. Chinnici C.M., Yao Y., and Praticò D. The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old. Neurobiol Aging 28 (2007) 1457-1462
3. Chu J., and Praticò D. The 5-lipoxygenase as a common pathway for pathological brain and vascular aging. Cardiovasc Psychiatry Neuro (2009) article ID 174657; doi:10.1155/2009/174657
4. Costa E., Dong E., Grayson D.R., Guidotti A., Ruzicka W., and Veldic M. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics 2 (2007) 29-36
5. Favaron M., Manev H., Alho H., Bertolino M., Ferret B., Guidotti A., and Costa E. Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc Natl Acad Sci U S A 85 (1988) 7351-7355
6. Feng J., Chang H., Li E., and Fan G. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res 79 (2005) 734-746
7. Firuzi O., Zhuo J., Chinnici C.M., Wisniewski T., and Praticò D. 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease. FASEB J 22 (2008) 1169-1178
8. Hamm S., Just G., Lacoste N., Moitessier N., Szyf M., and Mamer O. On the mechanism of demethylation of 5-methylcytosine in DNA. Bioorg Med Chem Lett 18 (2008) 1046-1049
9. Ikonomovic M.D., Abrahamson E.E., Uz T., Manev H., and Dekosky S.T. Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease. J Histochem Cytochem 56 (2008) 1065-1073
10. MacDonald J.L., and Roskams A.J. Epigenetic regulation of nervous system development by DNA methylation and histone deacetylation. Prog Neurobiol 88 (2009) 170-183
11. Manev H., and Manev R. 5-lipoxygenase as a possible biological link between depressive symptoms and atherosclerosis. Arch Gen Psychiatry 64 (2007) 1333
12. Manev H., and Uz T. Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression. Ann N Y Acad Sci 890 (1999) 183-190
13. Manev H., Dzitoyeva S., Imbesi M., and Uz T. DNA methylation-related sites in the mouse 5-lipoxygenase gene. Program no. 144.25/V12. Neuroscience Meeting Planner (2008), Society for Neuroscience, Washington, DC
14. Mohammadi G., and Saberivand A. Simple method to extract DNA from mammalian whole blood. J Mol Genet 1 (2009) 7-10
15. Morrison L.D., Smith D.D., and Kish S.J. Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. J Neurochem 67 (1996) 1328-1331
16. Ono T., Uehara Y., Kurishita A., Tawa R., and Sakurai H. Biological significance of DNA methylation in the ageing process. Age Ageing 22 (1993) S34-S43
17. Rådmark O., Werz O., Steinhilber D., and Samuelsson B. 5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem Sci 32 (2007) 332-341
18. Rath P.C., and Kanungo M.S. Methylation of repetitive DNA sequences in the brain during aging of the rat. FEBS Lett 244 (1989) 193-198
19. Scarpa S., Fuso A., D'Anselmi F., and Cavallaro R.A. Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?. FEBS Lett 541 (2003) 145-148
20. Schmittgen T.D., and Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3 (2008) 1101-1108
21. Serhan C.N., Yacoubian Y., and Yang R. Anti-inflammatory and proresolving lipid mediators. Annu Rev Pathol 3 (2008) 279-312
22. Sharma R.P., Tun N., and Grayson D.R. Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical cultures. Epigenetics 3 (2008) 74-80
23. Siegmund K.D., Connor C.M., Campan M., Long T.I., Weisenberger D.J., Biniszkiewicz D., Jaenisch R., Laird P.W., and Akbarian S. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One 2 9 (2007) e895
24. Tohgi H., Utsugisawa K., Nagane Y., Yoshimura M., Genda Y., and Ukitsu M. Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex. Brain Res Mol Brain Res 70 (1999) 288-292
25. Tsunoda T., and Takagi T. Estimating transcription factor bindability on DNA. Bioinformatics 15 (1999) 622-630
26. Uhl J., Klan N., Rose M., Entian K.D., Werz O., and Steinhilber D. The 5-lipoxygenase promoter is regulated by DNA methylation. J Biol Chem 277 (2002) 4374-4379
27. Uhl J., Klan N., Rose M., Entian K.D., Werz O., and Steinhilber D. DNA methylation regulates 5-lipoxygenase promoter activity. Adv Exp Med Biol 525 (2003) 169-172
28. Uz T., Pesold C., Longone P., and Manev H. Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability. FASEB J 12 (1998) 439-449
29. Uz T., Manev R., and Manev H. 5-Lipoxygenase is required for proliferation of immature cerebellar granule neurons in vitro. Eur J Pharmacol 418 (2001) 15-22
30. 4 are regulatory signals for neural stem cell proliferation and differentiation. FASEB J 20 (2006) 1785-1792
31. Watanabe D., Uchiyama K., and Hanaoka K. Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development. Neuroscience 142 (2006) 727-737
32. Wen S., Li H., and Liu J. Epigenetic background of neuronal fate determination. Prog Neurobiol 87 (2009) 98-117
33. i signalling in rat cerebellar granule neurones aged in vitro. Neurobiol Aging 25 (2004) 349-359
34. Zhang Z., Chen C.Q., and Manev H. DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells. J Neurochem 88 (2004) 1424-1430