DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: Evidence in human NT2 and NT2-N cells

Journal of Neurochemistry

Volumn 88, Issue 6, 2004, Pages 1424-1430

  Zhang, Zhijing ^a,b   Chen, Chang Qing ^a   Manev, Hari ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

5 aza 2 deoxycytidine (AdC); 5 lipoxygenase; DNA methylation; Epigenetic; NT2 cell line; Valproic acid (valproate, VPA)

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ARACHIDONATE 5 LIPOXYGENASE; BISULFITE; CYTOSINE; DINUCLEOTIDE; HISTONE; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; VALPROIC ACID;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; NERVE CELL; NERVE CELL DIFFERENTIATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MODIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 1642309652     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02275.x     Document Type: Article

References (41)

1. Andrews P. W. (1987) Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol. 103, 285-293.
2. Boado R. J., Pardridge W. M., Vinters H. V. and Blak K. L. (1992) Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multi-transcript family. Proc. Natl Acad. Sci. USA 89, 9044-9048.
3. Cervoni N. and Szyf M. (2001) Demethylase activity is directed by histone acetylation. J. Biol. Chem. 276, 40778-40787.
4. Chen R. Z., Akbarian S., Tudor M. and Jaenisch R. (2001) Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat. Genet. 27, 327-331.
5. Chen Y., Sharma R. P., Costa R. H., Costa E. and Grayson D. R. (2002) On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res. 30, 2930-2939.
6. Christman J. K. (2002) 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21, 5483-5495.
7. Creusot F., Acs G. and Christman J. K. (1982) Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2′deoxycytidine. J. Biol. Chem. 257, 2041-2048.
8. Detich N., Bovenzi V. and Szyf M. (2003) Valproate induces replication independent active DNA demethylation. J. Biol. Chem. 278, 27586-27592.
9. Francis D. D., Szegeda K., Campbell G., Martin W. D. and Insel T. R. (2003) Epigenetic sources of behavioral differences in mice. Nat. Neurosci. 6, 445-446.
10. Frommer M., McDonald L. E., Millar D. S., Collies C. M., Watt F., Grigg G. W., Molloy P. L. and Paul C. L. (1992) A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl Acad. Sci. USA 89, 1827-1831.
11. Funk C. D. (2001) Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294, 1871-1875.
12. Golubic M., Prayson R. A., Vargo L., Bondar J. and Barnett G. H. (2003) Increased expression of 5-lipoxygenase in glioblastoma multiforme. Adv. Exp. Med. Biol. 525, 205-208.
13. Grunau C., Schattevoy R., Mache N. and Rosenthal A. (2000) Meth-Tools - a toolbox to visualize and analyze DNA methylation data. Nucleic Acids Res. 28, 1053-1058.
14. Guan Z., Giustetto M., Lomvardas S., Kim J.-H., Miniaci M. C., Schwartz J. H., Thanos D. and Kandel E. R. (2002) Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Cell 111, 483-493.
15. Hoshiko S., Radmark O. and Samuelsson B. (1990) Characterization of the human 5-lipoxygenase promoter. Proc. Natl Acad. Sci. USA 87, 9073-9077.
16. Huang Y., Doherty J. J. and Dingledine R. (2002) Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes in an early event triggered by status epilepticus. J. Neurosci. 22, 8422-8428.
17. Jones P. A. and Takai D. (2001) The role of DNA methylation in mammalian epigenetics. Science 293, 1068-1070.
18. Klan N., Seuter S., Schnur N., Jung M. and Steinhilber D. (2003) Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. Biol. Chem. 384, 777-785.
19. Lammers C. H., Schweitzer P., Facchinetti P., Arrang J. M., Madamba S. G., Siggins G. R. and Piomelli D. (1996) Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling. J. Neurochem. 66, 147-152.
20. Manev H. and Uz T. (2002a) 5-Lipoxygenase in the central nervous system: therapeutic implications. Curr. Med. Chem. Anti-Inflammatory Anti-Allergy Agents 1, 115-121.
21. Manev H. and Uz T. (2002b) DNA hypomethylating agents 5-aza-2′-deoxycytidine and valproate increase neuronal 5-lipoxygenase mRNA. Eur. J. Pharmacol. 445, 149-150.
22. Manev H. and Uz T. (2003) The eicosanoid pathway and brain aging, in Membrane Lipid Signaling in Aging and Age-Related Disease (Mattson, M. P., ed.), Vol. 12, pp. 117-136. Advances in Cell Aging and Gerontology, Elsevier, Amsterdam.
23. Manev H., Uz T., Manev R. and Zhang Z. (2001) Neurogenesis and neuroprotection in the adult brain: a putative role for 5-lipoxygenase? Ann. NY Acad. Sci. 939, 45-51.
24. Petronis A. (2001) Human morbid genetics revisited: relevance of epigenetics. Trends Genet. 17, 142-146.
25. Qu T., Uz T. and Manev H. (2000) Inflammatory 5-LOX mRNA and protein are increased in brain of aging rats. Neurobiol. Aging 21, 647-652.
26. Ramsahoye B. H., Biniszkiewicz D., Lyko F., Clark V., Bird A. P. and Jaenisch R. (2000) Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc. Natl Acad. Sci. USA 97, 5237-5242.
27. Robertson K. D., Uzvolgyi E., Liang G., Talmadge C., Sumegi J., Gonzales F. A. and Jones P. A. (1999) The human DNA methyl-transferases (DNMTs) 1, 3a, and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 27, 2291-2298.
28. Shahbazian M. D. and Zoghbi H. Y. (2002) Rett syndrome and MeCP2: linking epigenetics and neuronal function. Am. J. Hum. Genet. 71, 1259-1272.
29. Silverman E. S., Du J., De Sanctis G. T., Radmark O., Samuelsson B., Drazen J. M. and Collins T. (1998) Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants. Am. J. Respir. Cell Mol. Biol. 19, 316-323.
30. The Editor (2003) Definitions in epigenetics. Ann. NY Acad. Sci. 983, 321-328.
31. Tomimoto H., Shibata M., Ihara M., Akiguchi I., Ohtani R. and Budka H. (2002) A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans. Acta Neuropathol. (Berl.) 104, 601-607.
32. Tremolizzo L., Carboni G., Ruzicka W. B., Mitchell C. P., Sugaya I., Tueting P., Sharma R., Grayson D. R., Costa E. and Guidotti A. (2002) An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc. Natl Acad. Sci. USA 99, 17095-17100.
33. Tucker K. L. (2001) Methylated cytosine and the brain: a new base for neuroscience. Neuron 30, 649-652.
34. Uhl J., Klan N., Rose M., Entian K. D., Werz O. and Steinhilber D. (2002) The 5-lipoxygenase promotoer is regulated by DNA methylation. J. Biol. Chem. 277, 4374-4379.
35. Uz T., Pesold C., Longone P. and Manev H. (1998) Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability. FASEB J. 12, 439-449.
36. Uz T., Manev R. and Manev H. (2001) 5-Lipoxygenase is required for proliferation of immature cerebellar granule neurons in vitro. Eur. J. Pharmacol. 418, 15-22.
37. Vermaak D., Ahmad K. and Henikoff S. (2003) Maintenance of chromatin states: an open-and-shut case. Curr. Opin. Cell Biol. 15, 266-274.
38. Warnecke P. M., Stirzaker C., Song J., Grunau C., Melki J. R. and Clark S. J. (2002) Identification and resolution of artifacts in bisulfite sequencing. Methods 27, 101-107.
39. Weaver I. C., Szyf M. and Meaney M. J. (2002) From maternal care to gene expression: DNA methylation and the maternal programming of stress responses. Endocr. Res. 28, 699.
40. Whitney L. W., Ludwin S. K., McFarland H. F. and Biddison W. E. (2001) Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions. J. Neuroimmunol. 121, 40-48.
41. Zhao X., Ueba T., Christie B. R., Barkho B., McConnell M. J., Nakashima K., Lein E. S., Eadie B. D., Willhoite A. R., Muotri A. R. et al. (2003) Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl Acad. Sci. USA 100, 6777-6782.