Exogenous glucocorticoids and a high-fat diet cause severe hyperglycemia and hyperinsulinemia and limit islet glucose responsiveness in young male Sprague-Dawley rats

Endocrinology

Volumn 154, Issue 9, 2013, Pages 3197-3208

  Beaudry, Jacqueline L ^a   D'souza, Anna M ^a   Teich, Trevor ^a   Tsushima, Robert ^b   Riddell, Michael C ^a  

^a York University   (Canada)

^b YORK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; PLACEBO; PROTEIN KINASE C ALPHA;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CIRCADIAN RHYTHM; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTROPHY; INSULIN RESISTANCE; INSULIN RESPONSE; LIPID DIET; MALE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PRIORITY JOURNAL; RAT;

ANIMALS; CIRCADIAN RHYTHM; CORTICOSTERONE; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DRUG IMPLANTS; ENZYME INDUCTION; GLUCOCORTICOIDS; HYPERGLYCEMIA; HYPERINSULINISM; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX;

EID: 84883137033     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-2114     Document Type: Article

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