High doses of dexamethasone induce increased β-cell proliferation in pancreatic rat islets

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 4, 2009, Pages

  Rafacho, Alex ^a,e   Cestari, Tânia M ^b   Taboga, Sebastião R ^c   Boschero, Antonio C ^a   Bosqueiro, José R ^d  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Institute of Biosciences Humanities and Exact Sciences   (Brazil)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^e IB   (Brazil)

Author keywords

Glucocorticoid; Hyperglycemia; Hyperinsulinemia; Insulin resistance; cell growth

Indexed keywords

DEXAMETHASONE; GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; S6 KINASE;

ADULT; ARTICLE; CELL GROWTH; CELL HYPERPLASIA; CELL PROLIFERATION; CELL SIZE; CONTROLLED STUDY; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INDUCED RESISTANCE; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MORPHOMETRICS; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; ANIMAL; CELL CYCLE; CELL DEATH; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; HISTOLOGY; METABOLIC SYNDROME X; ORGAN SIZE; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; METABOLIC SYNDROME X; ORGAN SIZE; RATS; RATS, WISTAR;

EID: 65649099155     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90931.2008     Document Type: Article

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