Microfluidic technology for molecular diagnostics

Advances in Biochemical Engineering/Biotechnology

Volumn 133, Issue , 2013, Pages 89-114

  Robinson, Tom ^a   Dittrich, Petra S ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Detection; Immunoassays; Lab on a chip; Label free; Lensless; Microfluidics; Paper microfluidics; Pre treatment

Indexed keywords

ARTICLE; EQUIPMENT; HOSPITAL INFORMATION SYSTEM; HUMAN; METHODOLOGY; MICROFLUIDIC ANALYSIS; MOLECULAR PATHOLOGY;

HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; PATHOLOGY, MOLECULAR; POINT-OF-CARE SYSTEMS;

EID: 84882977273     PISSN: 07246145     EISSN: None     Source Type: Book Series    
DOI: 10.1007/10_2012_139     Document Type: Article

References (127)

1. Agresti JJ, Antipov E, et al (2010) "Ultrahigh-throughput screening in drop-based microfluidics for directed evolution (vol 170, pg 4004, 2010). " Proc Natl Acad Sci U S A 107(14):6550-6550
2. Baker CA, Duong CT et al (2009) Recent advances in microfluidic detection systems. Bioanalysis 1(5):967-975
3. Ballerini DR, Li X, et al (2011) "Flow control concepts for thread-based microfluidic devices. " Biomicrofluidics 5(1)
4. Banjanovic A (2009) Special Report: towards universal global mobile phone coverage. Euromonitor Intern
5. Bhandari P, Narahari T et al (2011) 'Fab-Chips': a versatile, fabric-based platform for lowcost, rapid and multiplexed diagnostics. Lab Chip 11(15):2493-2499
6. Blow N (2007) Microfluidics: in search of a killer application. Nat Methods 4(8):665-668
7. Bornhop DJ, Latham JC et al (2007) Free-solution, label-free molecular interactions studied by back-scattering interferometry. Science 317(5845):1732-1736
8. Brassard D, Malic L et al (2011) Advanced EWOD-based digital microfluidic system for multiplexed analysis of biomolecular interactions. IEEE 24th international conference on micro electro mechanical systems
9. Brennan D, Justice J et al (2009) Emerging optofluidic technologies for point-of-care genetic analysis systems: a review. Anal Bioanal Chem 395(3):621-636
10. Brody JP, Yager P (1997) Diffusion-based extraction in a microfabricated device. Sens Actuators A: Phys 58(1):13-18
11. Carrilho E, Phillips ST et al (2009) Paper microzone plates. Anal Chem 81(15):5990-5998
12. Cheng CM, Martinez AW et al (2010) Paper-based ELISA. Angew Chem Int Ed 49(28):4771-4774
13. Cherukat P, Mclaughlin JB (1994) The inertial lift on a rigid sphere in a linear shear flow field near a flat wall. J Fluid Mech 263:1-18
14. Chin CD, Laksanasopin T et al (2011) Microfluidics-based diagnostics of infectious diseases in the developing world. Nat Med 17(8):1015-1019
15. Chin CD, Linder V et al (2012) "Commercialization of microfluidic point-of-care diagnostic devices. " Lab Chip
16. Chou HP, Spence C et al (1999) "A microfabricated device for sizing and sorting DNA molecules. " Proc Natl Acad Sci U S A 96(1):11-13
17. Colyer CL, Mangru SD et al (1997) Microchip-based capillary electrophoresis of human serum proteins. J Chromatogr A 781(1-2):271-276
18. Cui X, Lee LM et al (2008) "Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imaging. " Proc Natl Acad Sci U S A 105(31):10670-10675
19. Delamarche E, Bernard A et al (1997) Patterned delivery of immunoglobulins to surfaces using microfluidic networks. Science 276(5313):779-781
20. Delaney JL, Hogan CF et al (2011) Electrogenerated chemiluminescence detection in paperbased microfluidic sensors. Anal Chem 83(4):1300-1306
21. Delehanty JB, Ligler FS (2002) A microarray immunoassay for simultaneous detection of proteins and bacteria. Anal Chem 74(21):5681-5687
22. Dittrich PS, Manz A (2005) Single-molecule fluorescence detection in microfluidic channels-the Holy Grail in lTAS? Anal Bioanal Chem 382(8):1771-1782
23. Dittrich PS, Muller B et al (2004) Studying reaction kinetics by simultaneous FRET and cross-correlation analysis in a miniaturized continuous flow reactor. Phys Chem Chem Phys 6(18):4416-4420
24. Dittrich PS, Schwille P (2003) An integrated microfluidic system for reaction, highsensitivity detection, and sorting of fluorescent cells and particles. Anal Chem 75(21): 5767-5774
25. Dittrich PS, Tachikawa K et al (2006) Micro total analysis systems. Latest advancements and trends. Anal Chem 78(12):3887-3907
26. Dodge A, Brunet E et al (2006) PDMS-based microfluidics for proteomic analysis. Analyst 131(10):1122-1128
27. Dungchai W, Chailapakul O et al (2009) Electrochemical detection for paper-based microfluidics. Anal Chem 81(14):5821-5826
28. Einav S, Gerber D et al (2008) Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol 26(9):1019-1027
29. El-Ali J, Sorger PK et al (2006) Cells on chips. Nature 442(7101):403-411
30. Estmer Nilsson C, Abbas S et al (2010) A novel assay for influenza virus quantification using surface plasmon resonance. Vaccine 28(3):759-766
31. Floris A, Staal S et al (2010) A prefilled, ready-to-use electrophoresis based lab-on-a-chip device for monitoring lithium in blood. Lab Chip 10(14):1799-1806
32. Fu AY, Spence C et al (1999) A microfabricated fluorescence-activated cell sorter. Nat Biotechnol 17(11):1109-1111
33. Fu E, Kauffman P et al (2010) Chemical signal amplification in two-dimensional paper networks. Sens Actuators B-Chem 149(1):325-328
34. Gervais L, de Rooij N et al (2011) Microfluidic chips for point-of-care immunodiagnostics. Adv Mater 23(24):H151-H176
35. Gervais L, Delamarche E (2009) Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates. Lab Chip 9(23):3330-3337
36. Ghosh KK, Burns LD, et al (2011) "Miniaturized integration of a fluorescence microscope. " Nat Methods 8(10):871-U147
37. Gorkin R, Park J et al (2010) Centrifugal microfluidics for biomedical applications. Lab Chip 10(14):1758-1773
38. Gubala V, Harris LF et al (2012) Point of care diagnostics: status and future. Anal Chem 84(2):487-515
39. Gurkan UA, Moon S et al (2011) Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing. Biotechnol J 6(2):138-149
40. Haeberle S, Brenner T et al (2006) Centrifugal extraction of plasma from whole blood on a rotating disk. Lab Chip 6(6):776-781
41. Hatch A, Garcia E et al (2004) Diffusion-based analysis of molecular interactions in microfluidic devices. Proc IEEE 92(1):126-139
42. Hatch A, Kamholz AE et al (2001) A rapid diffusion immunoassay in a T-sensor. Nat Biotechnol 19(5):461-465
43. Helton KL, Nelson KE et al (2008) Conditioning saliva for use in a microfluidic biosensor. Lab Chip 8(11):1847-1851
44. Herr AE, Hatch AV, et al (2007) "Microfluidic immunoassays as rapid saliva-based clinical diagnostics. " Proc Natl Acad Sci U S A 104(13):5268-5273
45. Hosokawa K, Omata M et al (2007) Immunoassay on a power-free microchip with laminar flow-assisted dendritic amplification. Anal Chem 79(15):6000-6004
46. Janasek D, Franzke J et al (2006) Scaling and the design of miniaturized chemical-analysis systems. Nature 442(7101):374-380
47. Jebrail MJ, Yang H et al (2011) A digital microfluidic method for dried blood spot analysis. Lab Chip 11(19):3218-3224
48. Jiang H, Weng X et al (2011) Microfluidic whole-blood immunoassays. Microfluid Nanofluid 10(5):941-964
49. Kamholz AE (2004) Proliferation of microfluidics in literature and intellectual property. Lab Chip 4(2):16n-20n
50. Khandurina J, McKnight TE et al (2000) Integrated system for rapid PCR-based DNA analysis in microfluidic devices. Anal Chem 72(13):2995-3000
51. Kim N, Kim D-K et al (2009) Development of indirect-competitive quartz crystal microbalance immunosensor for C-reactive protein. Sens Actuators B: Chem 143(1):444-448
52. Kopp MU, de Mello AJ et al (1998) Chemical amplification: continuous-flow PCR on a chip. Science 280(5366):1046-1048
53. Krishnamoorthy G, Carlen ET et al (2009) Integrated electrokinetic sample focusing and surface plasmon resonance imaging system for measuring biomolecular interactions. Anal Chem 81(5):1957-1963
54. Kuhn P, Eyer K et al (2011) A Microfluidic vesicle screening platform: monitoring the lipid membrane permeability of tetracyclines. Anal Chem 83(23):8877-8885
55. Lee BS, Lee J-N et al (2009) A fully automated immunoassay from whole blood on a disc. Lab Chip 9(11):1548-1555
56. Li X, Tian JF et al (2010) Thread as a versatile material for low-cost microfluidic diagnostics. Acs Appl Mater Interfaces 2(1):1-6
57. Liu H, Crooks RM (2011) Three-dimensional paper microfluidic devices assembled using the principles of origami. J Am Chem Soc 133(44):17564-17566
58. Liu XY, Cheng CM, et al (2011) A portable microfluidic paper-based device for ELISA. IEEE 24th international conference on micro electro mechanical systems
59. Lombardi D, Dittrich PS (2010) Advances in microfluidics for drug discovery. Expert Opin Drug Discov 5(11):1081-1094
60. Madou M (1997) Fundamentals of Microfabrication. CRC Press, New York
61. Madou MJ, Lee LJ et al (2001) Design and fabrication of CD-like microfluidic platforms for diagnostics: microfluidic functions. Biomed Microdevices 3(3):245-254
62. Madou M, Zoval J et al (2006) Lab on a CD. Annu Rev Biomed Eng 8:601-628
63. Manz A, Graber N et al (1990) Miniaturized total chemical-analysis systems-a novel concept for chemical sensing. Sens Actuators B-Chem 1(1-6):244-248
64. Mark D, Haeberle S et al (2010) Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. Chem Soc Rev 39(3):1153-1182
65. Martinez AW, Phillips ST et al (2007) Patterned paper as a platform for inexpensive, lowvolume, portable bioassays. Angew Chem Int Ed 46(8):1318-1320
66. Martinez AW, Phillips ST, et al (2008) "Three-dimensional microfluidic devices fabricated in layered paper and tape. " Proc Natl Acad Sci 105(50):19606-19611
67. Martinez AW, Phillips ST et al (2009) Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal Chem 82(1):3-10
68. McDonald JC, Duffy DC et al (2000) Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21(1):27-40
69. Miller E, Ng A et al (2011) A digital microfluidic approach to heterogeneous immunoassays. Anal Bioanal Chem 399(1):337-345
70. Moon S, Keles HO et al (2009) Integrating microfluidics and lensless imaging for point-ofcare testing. Biosens Bioelectron 24(11):3208-3214
71. Myers FB, Lee LP (2008) Innovations in optical microfluidic technologies for point-of-care diagnostics. Lab Chip 8(12):2015-2031
72. Nagrath S, Sequist LV et al (2007) "Isolation of rare circulating tumour cells in cancer patients by microchip technology. " Nature 450(7173):1235-U1210
73. Ng AHC, Uddayasankar U et al (2010) Immunoassays in microfluidic systems. Anal Bioanal Chem 397(3):991-1007
74. Olthuis W, Van Der Schoot BH et al (1989) A dipstick sensor for coulometric acid-base titrations. Sens Actuators 17(1-2):279-283
75. Osborn JL, Lutz B et al (2010) Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks. Lab Chip 10(20):2659-2665
76. Ozcan A, Demirci U (2008) Ultra wide-field lens-free monitoring of cells on-chip. Lab Chip 8(1):98-106
77. Pang S, Han C et al (2011) Fluorescence microscopy imaging with a fresnel zone plate array based optofluidic microscope. Lab Chip 11(21):3698-3702
78. Pang W, Zhao H, et al (2012) "Piezoelectric microelectromechanical resonant sensors for chemical and biological detection. " Lab Chip 12(1):29-44
79. Peeling RW, Holmes KK et al (2006) Rapid tests for sexually transmitted infections (STIs): the way forward. Sex Transm Infect 82(suppl 5):v1-v6
80. Piiav L (2005) "Point-of-care immunotesting: approaching the analytical performance of central laboratory methods. " Clin Biochem 38(7):591-606
81. Pipper J, Inoue M, Ng LFP, Neuzil P, Zhang Y, Novak L (2007) Catching bird flu in a droplet. Nature Medicine 13(10):1259-1263
82. Pollack MG, Shenderov AD et al (2002) Electrowetting-based actuation of droplets for integrated microfluidics. Lab Chip 2(2):96-101
83. Posthuma-Trumpie G, Korf J et al (2009) Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey. Anal Bioanal Chem 393(2):569-582
84. Psaltis D, Quake SR et al (2006) Developing optofluidic technology through the fusion of microfluidics and optics. Nature 442(7101):381-386
85. Safavieh R, Mirzaei M, Qasaimeh MA, Juncker D (2009). Proceedings of MicroTAS 2009, the 13th international conference on miniaturized systems for chemistry and life sciences, ICC Jeju, Jeju, South Korea
86. Reches M, Mirica KA et al (2010) Thread as a matrix for biomedical assays. Acs Appl Mater Interfaces 2(6):1722-1728
87. Rezk AR, Qi A et al (2012) Uniform mixing in paper-based microfluidic systems using surface acoustic waves. Lab Chip 12(4):773-779
88. Robinson T, Valluri P et al (2008) Three-dimensional molecular mapping in a microfluidic mixing device using fluorescence lifetime imaging. Opt Lett 33(16):1887-1889
89. Schmid A, Kortmann H et al (2010) Chemical and biological single cell analysis. Curr Opin Biotechnol 21(1):12-20
90. Schulte TH, Bardell RL et al (2002) Microfluidic technologies in clinical diagnostics. Clin Chim Acta 321(1-2):1-10
91. Seo S, Isikman SO et al (2010) High-throughput lens-free blood analysis on a chip. Anal Chem 82(11):4621-4627
92. Seo S, Su TW et al (2008) Multi-color LUCAS: lensfree on-chip cytometry using tunable monochromatic illumination and digital noise reduction. Cell Mol Bioeng 1(2-3):146-156
93. Seo S, Su TW et al (2009) Lensfree holographic imaging for on-chip cytometry and diagnostics. Lab Chip 9(6):777-787
94. Shalom D, Wootton RCR et al (2007) Synthesis of thiol functionalized gold nanoparticles using a continuous flow microfluidic reactor. Mater Lett 61(4-5):1146-1150
95. Shankaran DR, Gobi KVA et al (2007) Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest. Sens Actuators B-Chem 121(1):158-177
96. Shoji S, Esashi M et al (1988) Prototype miniature blood-gas analyzer fabricated on a silicon-wafer. Sens Actuators 14(2):101-107
97. Sia SK, Linder V et al (2004) An integrated approach to a portable and low-cost immunoassay for resource-poor settings. Angew Chem Int Ed 43(4):498-502
98. Sims CE, Allbritton NL (2007) Analysis of single mammalian cells on-chip. Lab Chip 7(4):423-440
99. Srinivasan V, Pamula VK et al (2004) An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids. Lab Chip 4(4):310-315
100. Steigert J, Grumann M et al (2006) Fully integrated whole blood testing by real-time absorption measurement on a centrifugal platform. Lab Chip 6(8):1040-1044
101. Stern E, Vacic A et al (2010) Label-free biomarker detection from whole blood. Nat Nanotechnol 5(2):138-142
102. Stevens DY, Petri CR et al (2008) Enabling a microfluidic immunoassay for the developing world by integration of on-card dry reagent storage. Lab Chip 8(12):2038-2045
103. Su T-W, Seo S et al (2009) High-throughput lensfree imaging and characterization of a heterogeneous cell solution on a chip. Biotechnol Bioeng 102(3):856-868
104. Tachi T, Kaji N et al (2009) Microchip-based homogeneous immunoassay using fluorescence polarization spectroscopy. Lab Chip 9(7):966-971
105. Terry M (2011) Telemicroscopes and point-of-care diagnostics team up with smartphones. Telemed J e-health: Off J Am Telemed Assoc 17(5):320-323
106. Tourovskaia A, Figueroa-Masot X et al (2005) Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies. Lab Chip 5(1):14-19
107. Tseng D, Mudanyali O et al (2010) Lensfree microscopy on a cellphone. Lab Chip 10(14):1787-1792
108. Uludaǧ Y, Tothill IE (2010) Development of a sensitive detection method of cancer biomarkers in human serum (75%) using a quartz crystal microbalance sensor and nanoparticles amplification system. Talanta 82(1):277-282
109. Wang H, Meng S et al (2008) Microfluidic immunosensor based on stable antibodypatterned surface in PMMA microchip. Electrochem Commun 10(3):447-450
110. Wang J, Ahmad H et al (2010) A self-powered, one-step chip for rapid, quantitative and multiplexed detection of proteins from pinpricks of whole blood. Lab Chip 10(22):3157-3162
111. Wang S, Ge L et al (2012) Paper-based chemiluminescence ELISA: Lab-on-paper based on chitosan modified paper device and wax-screen-printing. Biosens Bioelectron 31(1):212-218
112. Weibel DB, Whitesides GM (2006) Applications of microfluidics in chemical biology. Curr Opin Chem Biology 10(6):584-591
113. Weigl BH, Yager P (1999) Microfluidic diffusion-based separation and detection. Science 283(5400):346-347
114. Wen X, He H et al (2009) Specific antibody immobilization with biotin-poly(L-lysine)-gpoly(ethylene glycol) and protein A on microfluidic chips. ". J Immunol Methods 350(1-2): 97-105
115. West J, Becker M et al (2008) Micro total analysis systems: latest achievements. Anal Chem 80(12):4403-4419
116. Wheeler AR (2008) Putting electrowetting to work. Science 322(5901):539-540
117. Whitesides GM, Ostuni E et al (2001) Soft lithography in biology and biochemistry. Ann Rev Biomed Eng 3:335-373
118. WHO (2008) CD4 + T-Cell enumeration technologies; Technical Information. WHO, Geneva
119. Wilding P, Shoffner MA et al (1994) PCR in a silicon microstructure. Clin Chem 40(9): 1815-1818
120. Woolley AT, Lao KQ et al (1998) Capillary electrophoresis chips with integrated electrochemical detection. Anal Chem 70(4):684-688
121. Yager P, Edwards T et al (2006) Microfluidic diagnostic technologies for global public health. Nature 442(7101):412-418
122. Yamada M, Nakashima M, et al (2004) "Pinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel. " Anal Chem 76(18):5465-5471
123. Yao CY, Zhu TY et al (2010) Development of a quartz crystal microbalance biosensor with aptamers as bio-recognition element. Sensors 10(6):5859-5871
124. Ymeti A, Greve J et al (2006) Fast, ultrasensitive virus detection using a young interferometer sensor. Nano Lett 7(2):394-397
125. Zheng G, Patolsky F et al (2005) Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat Biotech 23(10):1294-1301
126. Zheng GA, Lee SA et al (2010) Sub-pixel resolving optofluidic microscope for on-chip cell imaging. Lab Chip 10(22):3125-3129
127. Zhu HY, Mavandadi S et al (2011) Optofluidic fluorescent imaging cytometry on a cell phone. Anal Chem 83(17):6641-6647