An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids

Lab on a Chip

Volumn 4, Issue 4, 2004, Pages 310-315

  Srinivasan, Vijay ^a   Pamula, Vamsee K ^a   Fair, Richard B ^a  

^a Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

URIC ACID;

ARTICLE; AUTOANALYSIS; BIOASSAY; BLOOD; COLORIMETRY; CONTINUOUS FLOW REACTOR; DEVICE; DIAGNOSTIC PROCEDURE; ENZYMATIC ASSAY; FLUID TRANSPORT; HUMAN; LACRIMAL FLUID; LIQUID; MICROCIRCULATION; MICROFLUIDIC LAB ON CHIP; PHYSIOLOGY; PLASMA; PRIORITY JOURNAL; SALIVA; SERUM; SWEAT; TECHNIQUE; URINE;

EID: 4344632455     PISSN: 14730197     EISSN: None     Source Type: Journal    
DOI: 10.1039/b403341h     Document Type: Article

References (21)

1. D. R. Reyes, D. Iossifidis, P-A. Auroux and A. Manz, Micro total analysis systems. I. Introduction, theory, and technology, Anal. Chem., 2002, 74(2), 2623-2636.
2. A. J. Tüdõs, G. A. J. Besselink and R. B. M. Schasfoort, Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry, Lab Chip, 2001, 1(2), 83-95.
3. E. Verpoorte, Microfluidic chips for clinical and forensic analysis, Electrophoresis, 2002, 23(5), 677-712.
4. G. J. M. Bruin, Recent developments in electrokinetically driven analysis on microfabricated devices, Electrophoresis, 2000, 21, 3931-3951.
5. D. C. Duffy, H. L. Gillis, J. Lin, N. F. Sheppard, Jr and G. J. Kellogg, Microfabricated centrifugal microfluidic systems: characterization and Multiple Enzymatic Assays, Anal. Chem., 1999, 71, 4669-4678.
6. J. V. Zoval and M. J. Madou, Centrifuge-based fluidic platforms, Proc. IEEE, 2004, 92(1), 140-153.
7. C. H. Ahn, J. W. Choi, G. Beaucage, J. H. Nevin, J. B. Lee, A. Puntambekar and J. Y. Lee, Disposable smart lab on a chip for point-of-care clinical diagnostics, Proc. IEEE, 2004, 92(1), 154-173.
8. Micronics Inc, http://www.micronics.net.
9. Biosite Inc, http://www.biosite.com.
10. I-STAT Corporation, http://www.istat.com.
11. M. G. Pollack, A. D. Shenderov and R. B. Fair, Electrowetting-based actuation of droplets for integrated microfluidics, Lab Chip, 2002, 2(1), 96-101.
12. J. A. Schwartz, J. V. Vykoukal and P. R. C. Gascoyne, Droplet-based chemistry on a programmable micro-chip, Lab Chip, 2004, 4, 11-17.
13. H. Ren, V. Srinivasan and R. B. Fair, Automated electrowetting-based droplet dispensing with good reproducibility, Proceedings of MicroTAS 2003, 2003, 993-996.
14. P. Paik, V. K. Pamula, M. G. Pollack and R. B. Fair, Electrowetting-based droplet mixers for microfluidic systems, Lab Chip, 2003, 3(1), 28-33.
15. P. Paik, V. K. Pamula and R. B. Fair, Rapid droplet mixers for digital microfluidic systems, Lab Chip, 2003, 3, 253-259.
16. V. Srinivasan, V. K. Pamula and R. B. Fair, A droplet-based microfluidic lab-on-a-chip for glucose detection, Anal. Chim. Acta, 2004, 507(1), 145-150.
17. V. Srinivasan, V. K. Pamula, M. G. Pollack and R. B. Fair, Clinical diagnostics on human whole blood, plasma, serum, urine, saliva, sweat, and tears on a digital microfluidic platform, Proceedings of MicroTAS 2003, 2003, 1287-1290.
18. R. B. Fair, V. Srinivasan, H. Ren, P. Paik, V. K. Pamula and M. G. Pollack, Electrowetting-based on-chip sample processing for integrated microfluidics, IEEE International Electron Devices Meeting (IEDM), 2003.
19. S-K. Cho, H. Moon and C-J. Kim, Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits, J. Microelectromech. Syst., 2003, 12(1), 70-80.
20. J-Y. Yoon and R. L. Garrell, Preventing biomolecular adsorption in electrowetting-based biofluidic chips, Anal. Chem., 2003, 75, 5097-5102.
21. Tietz Textbook of Clinical Chemistry, ed. C. A. Burtis and E. R. Ashwood, W.B. Saunders Company, Philadelphia, USA, 3rd edn., 1999.