메뉴 건너뛰기




Volumn 86, Issue 1-2, 2013, Pages 48-56

Dynamics of Akt activation during mouse embryo development: Distinct subcellular patterns distinguish proliferating versus differentiating cells

Author keywords

3D reconstruction; Akt; Confocal imaging; Differentiation; Mouse embryo; Proliferation

Indexed keywords

PROTEIN KINASE B; THREONINE;

EID: 84882788269     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1016/j.diff.2013.07.001     Document Type: Article
Times cited : (7)

References (66)
  • 2
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi D.R., James S.R., Downes C.P., Holmes A.B., Gaffney P.R., Reese C.B., Cohen P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Current Biology 1997, 7:261-269.
    • (1997) Current Biology , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 3
    • 4544245817 scopus 로고    scopus 로고
    • Integrins in the mouse myotome: developmental changes and differences between the epaxial and hypaxial lineage
    • Bajanca F., Luz M., Duxson M.J., Thorsteinsdóttir S. Integrins in the mouse myotome: developmental changes and differences between the epaxial and hypaxial lineage. Developmental Dynamics 2004, 231:402-415.
    • (2004) Developmental Dynamics , vol.231 , pp. 402-415
    • Bajanca, F.1    Luz, M.2    Duxson, M.J.3    Thorsteinsdóttir, S.4
  • 4
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • Bellacosa A., Testa J.R., Staal S.P., Tsichlis P.N. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 1991, 254:274-277.
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 9
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: a hard Akt to follow
    • Brazil D.P., Hemmings B.A. Ten years of protein kinase B signalling: a hard Akt to follow. Trends in Biochemical Sciences 2001, 26:657-664.
    • (2001) Trends in Biochemical Sciences , vol.26 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 12
    • 33748419667 scopus 로고    scopus 로고
    • Myogenic progenitor cells and skeletal myogenesis in vertebrates
    • Buckingham M. Myogenic progenitor cells and skeletal myogenesis in vertebrates. Current Opinion in Genetics & Development 2006, 16:525-532.
    • (2006) Current Opinion in Genetics & Development , vol.16 , pp. 525-532
    • Buckingham, M.1
  • 13
    • 9444225533 scopus 로고    scopus 로고
    • Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition
    • Burstyn-Cohen T., Stanleigh J., Sela-Donenfeld D., Kalcheim C. Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition. Development 2004, 131:5327-5339.
    • (2004) Development , vol.131 , pp. 5327-5339
    • Burstyn-Cohen, T.1    Stanleigh, J.2    Sela-Donenfeld, D.3    Kalcheim, C.4
  • 14
    • 50849127509 scopus 로고    scopus 로고
    • PI3-K and GSK-3: Akt-ing together with microtubules
    • Buttrick G.J., Wakefield J.G. PI3-K and GSK-3: Akt-ing together with microtubules. Cell Cycle 2008, 7:2621-2625.
    • (2008) Cell Cycle , vol.7 , pp. 2621-2625
    • Buttrick, G.J.1    Wakefield, J.G.2
  • 17
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 20
    • 33746579821 scopus 로고    scopus 로고
    • Regulation of phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappa B signaling pathways in dystrophin-deficient skeletal muscle in response to mechanical stretch
    • Dogra C., Changotra H., Wergedal J.E., Kumar A. Regulation of phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappa B signaling pathways in dystrophin-deficient skeletal muscle in response to mechanical stretch. Journal of Cellular Physiology 2006, 208:575-585.
    • (2006) Journal of Cellular Physiology , vol.208 , pp. 575-585
    • Dogra, C.1    Changotra, H.2    Wergedal, J.E.3    Kumar, A.4
  • 22
    • 34247116441 scopus 로고    scopus 로고
    • Physiological roles of PKB/Akt isoforms in development and disease
    • Dummler B., Hemmings B.A. Physiological roles of PKB/Akt isoforms in development and disease. Biochemical Society Transactions 2007, 35:231-235.
    • (2007) Biochemical Society Transactions , vol.35 , pp. 231-235
    • Dummler, B.1    Hemmings, B.A.2
  • 27
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 29
    • 0037318822 scopus 로고    scopus 로고
    • Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
    • Glass D.J. Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nature Cell Biology 2003, 5:87-90.
    • (2003) Nature Cell Biology , vol.5 , pp. 87-90
    • Glass, D.J.1
  • 30
    • 0037728809 scopus 로고    scopus 로고
    • The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    • Grille S.J., Bellacosa A., Upson J., Klein-Szanto A.J., Van Roy F., Lee-Kwon W., Donowitz M., Tsichlis P.N., Larue L. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Research 2003, 63:2172-2178.
    • (2003) Cancer Research , vol.63 , pp. 2172-2178
    • Grille, S.J.1    Bellacosa, A.2    Upson, J.3    Klein-Szanto, A.J.4    Van Roy, F.5    Lee-Kwon, W.6    Donowitz, M.7    Tsichlis, P.N.8    Larue, L.9
  • 31
    • 67651160305 scopus 로고    scopus 로고
    • PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase
    • Gupta A., Dey C.S. PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase. Molecular and Cellular Endocrinology 2009, 309:55-62.
    • (2009) Molecular and Cellular Endocrinology , vol.309 , pp. 55-62
    • Gupta, A.1    Dey, C.S.2
  • 32
    • 33644928412 scopus 로고    scopus 로고
    • Asymmetric localization of numb in the chick somite and the influence of myogenic signals
    • Holowacz T., Zeng L., Lassar A.B. Asymmetric localization of numb in the chick somite and the influence of myogenic signals. Developmental Dynamics 2006, 235:633-645.
    • (2006) Developmental Dynamics , vol.235 , pp. 633-645
    • Holowacz, T.1    Zeng, L.2    Lassar, A.B.3
  • 34
    • 11844260672 scopus 로고    scopus 로고
    • Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3β and its upstream regulators
    • Jiang H., Guo W., Liang X., Rao Y. Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3β and its upstream regulators. Cell 2005, 120:123-135.
    • (2005) Cell , vol.120 , pp. 123-135
    • Jiang, H.1    Guo, W.2    Liang, X.3    Rao, Y.4
  • 35
    • 22144444102 scopus 로고    scopus 로고
    • Cell rearrangements during development of the somite and its derivatives
    • Kalcheim C., Ben-Yair R. Cell rearrangements during development of the somite and its derivatives. Current Opinion in Genetics & Development 2005, 15:371-380.
    • (2005) Current Opinion in Genetics & Development , vol.15 , pp. 371-380
    • Kalcheim, C.1    Ben-Yair, R.2
  • 37
    • 0029908016 scopus 로고    scopus 로고
    • Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
    • Kohn A.D., Summers S.a, Birnbaum M.J., Roth R.A. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. The Journal of Biological Chemistry 1996, 271:31372-31378.
    • (1996) The Journal of Biological Chemistry , vol.271 , pp. 31372-31378
    • Kohn, A.D.1    Summers, S.A.2    Birnbaum, M.J.3    Roth, R.A.4
  • 38
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    • Larue L., Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 2005, 24:7443-7454.
    • (2005) Oncogene , vol.24 , pp. 7443-7454
    • Larue, L.1    Bellacosa, A.2
  • 40
    • 84865839326 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: insights from development
    • Lim J., Thiery J.P. Epithelial-mesenchymal transitions: insights from development. Development 2012, 139:3471-3486.
    • (2012) Development , vol.139 , pp. 3471-3486
    • Lim, J.1    Thiery, J.P.2
  • 41
    • 75749136013 scopus 로고    scopus 로고
    • The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling
    • Luther P.K. The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling. Journal of Muscle Research and Cell Motility 2009, 30:171-185.
    • (2009) Journal of Muscle Research and Cell Motility , vol.30 , pp. 171-185
    • Luther, P.K.1
  • 42
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 43
    • 33744457653 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
    • Martelli A.M., Nyåkern M., Tabellini G., Bortul R., Tazzari P.L., Evangelisti C., Cocco L. Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 2006, 20:911-928.
    • (2006) Leukemia , vol.20 , pp. 911-928
    • Martelli, A.M.1    Nyåkern, M.2    Tabellini, G.3    Bortul, R.4    Tazzari, P.L.5    Evangelisti, C.6    Cocco, L.7
  • 44
    • 70449369840 scopus 로고    scopus 로고
    • Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis
    • PLoS One
    • Martins, G.G., Rifes, P., Amândio, R., Rodrigues, G., Palmeirim, I., Thorsteinsdóttir, S., 2009. Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis. PLoS One 4, e7429.
    • (2009) , vol.4
    • Martins, G.G.1    Rifes, P.2    Amândio, R.3    Rodrigues, G.4    Palmeirim, I.5    Thorsteinsdóttir, S.6
  • 47
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • Nieto M.A. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annual Review of Cell and Developmental Biology 2011, 27:347-376.
    • (2011) Annual Review of Cell and Developmental Biology , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 52
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: insights into a complex relationship
    • Sabatini D.M. mTOR and cancer: insights into a complex relationship. Nature Reviews. Cancer 2006, 6:729-734.
    • (2006) Nature Reviews. Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 53
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 54
    • 83455215759 scopus 로고    scopus 로고
    • Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
    • Schiaffino S., Mammucari C. Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. Skeletal Muscle 2011, 1:4.
    • (2011) Skeletal Muscle , vol.1 , pp. 4
    • Schiaffino, S.1    Mammucari, C.2
  • 55
    • 0037428076 scopus 로고    scopus 로고
    • Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity
    • Shi S.-H., Jan L.Y., Jan Y.-N. Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell 2003, 112:63-75.
    • (2003) Cell , vol.112 , pp. 63-75
    • Shi, S.-H.1    Jan, L.Y.2    Jan, Y.-N.3
  • 56
    • 0037018847 scopus 로고    scopus 로고
    • A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle
    • Shtivelman E., Sussman J., Stokoe D. A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle. Current Biology 2002, 12:919-924.
    • (2002) Current Biology , vol.12 , pp. 919-924
    • Shtivelman, E.1    Sussman, J.2    Stokoe, D.3
  • 58
    • 20944442241 scopus 로고    scopus 로고
    • Asymmetric cell divisions are concentrated in the dermomyotome dorsomedial lip during epaxial primary myotome morphogenesis
    • Venters S.J., Ordahl C.P. Asymmetric cell divisions are concentrated in the dermomyotome dorsomedial lip during epaxial primary myotome morphogenesis. Anatomy and Embryology 2005, 209:449-460.
    • (2005) Anatomy and Embryology , vol.209 , pp. 449-460
    • Venters, S.J.1    Ordahl, C.P.2
  • 59
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos C.J., Matter W.F., Hui K.Y., Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). The Journal of Biological Chemistry 1994, 269:5241-52418.
    • (1994) The Journal of Biological Chemistry , vol.269 , pp. 5241-52418
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 61
    • 0037442990 scopus 로고    scopus 로고
    • A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment
    • Wakefield J.G., Stephens D.J., Tavaré J.M. A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment. Journal of Cell Science 2003, 116:637-646.
    • (2003) Journal of Cell Science , vol.116 , pp. 637-646
    • Wakefield, J.G.1    Stephens, D.J.2    Tavaré, J.M.3
  • 63
    • 84865830634 scopus 로고    scopus 로고
    • Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes
    • Xue G., Restuccia D.F., Lan Q., Hynx D., Dirnhofer S., Hess D., Rüegg C., Hemmings B.A. Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes. Cancer Discovery 2012, 2:248-259.
    • (2012) Cancer Discovery , vol.2 , pp. 248-259
    • Xue, G.1    Restuccia, D.F.2    Lan, Q.3    Hynx, D.4    Dirnhofer, S.5    Hess, D.6    Rüegg, C.7    Hemmings, B.A.8
  • 66
    • 33846044650 scopus 로고    scopus 로고
    • Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation
    • Yoshizaki H., Mochizuki N., Gotoh Y., Matsuda M. Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation. Molecular Biology of the Cell 2007, 18:119-128.
    • (2007) Molecular Biology of the Cell , vol.18 , pp. 119-128
    • Yoshizaki, H.1    Mochizuki, N.2    Gotoh, Y.3    Matsuda, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.