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Volumn 226, Issue 3, 2011, Pages 822-831

Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CHLOROQUINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B INHIBITOR; TRICIRIBINE; VINCRISTINE;

EID: 78650676382     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22407     Document Type: Article
Times cited : (62)

References (43)
  • 1
    • 77957833800 scopus 로고    scopus 로고
    • The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane
    • (in press). DOI, 10.1038/cdd/2010.63.
    • Berndt N, Yang H, Trinczek B, Betzi S, Zhang Z, Wu B, Lawrence NJ, Pellecchia M, Schönbrunn E, Cheng JQ, Sebti SM. 2010. The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane. Cell Death Differ (in press). DOI: 10.1038/cdd/2010.63.
    • (2010) Cell Death Differ
    • Berndt, N.1    Yang, H.2    Trinczek, B.3    Betzi, S.4    Zhang, Z.5    Wu, B.6    Lawrence, N.J.7    Pellecchia, M.8    Schönbrunn, E.9    Cheng, J.Q.10    Sebti, S.M.11
  • 3
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • Brazil DP, Yang ZZ, Hemmings BA. 2004. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29: 233-242.
    • (2004) Trends Biochem Sci , vol.29 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 4
    • 33750570212 scopus 로고    scopus 로고
    • The minimal instrumentation requirements for Hoechst side population analysis: Stem cell analysis on low-cost flow cytometry platforms
    • Cabana R, Frolova EG, Kapoor V, Thomas RA, Krishan A, Telford WG. 2006. The minimal instrumentation requirements for Hoechst side population analysis: Stem cell analysis on low-cost flow cytometry platforms. Stem Cells 24: 2573-2581.
    • (2006) Stem Cells , vol.24 , pp. 2573-2581
    • Cabana, R.1    Frolova, E.G.2    Kapoor, V.3    Thomas, R.A.4    Krishan, A.5    Telford, W.G.6
  • 6
  • 7
    • 45149121372 scopus 로고    scopus 로고
    • The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism
    • Chiarini F, Del Sole M, Mongiorgi S, Gaboardi GC, Cappellini A, Mantovani I, Follo MY, McCubrey JA, Martelli AM. 2008. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. Leukemia 22: 1106-1116.
    • (2008) Leukemia , vol.22 , pp. 1106-1116
    • Chiarini, F.1    Del Sole, M.2    Mongiorgi, S.3    Gaboardi, G.C.4    Cappellini, A.5    Mantovani, I.6    Follo, M.Y.7    McCubrey, J.A.8    Martelli, A.M.9
  • 8
    • 65949088837 scopus 로고    scopus 로고
    • Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
    • Chiarini F, Fala F, Tazzari PL, Ricci F, Astolfi A, Pession A, Pagliaro P, McCubrey JA, Martelli AM. 2009. Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia. Cancer Res 69: 3520-3528.
    • (2009) Cancer Res , vol.69 , pp. 3520-3528
    • Chiarini, F.1    Fala, F.2    Tazzari, P.L.3    Ricci, F.4    Astolfi, A.5    Pession, A.6    Pagliaro, P.7    McCubrey, J.A.8    Martelli, A.M.9
  • 9
    • 62449266454 scopus 로고    scopus 로고
    • TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): Phospho-Ser 2481 is a marker for intact mTOR signaling complex 2
    • Copp J, Manning G, Hunter T. 2009. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): Phospho-Ser 2481 is a marker for intact mTOR signaling complex 2. Cancer Res 69: 1821-1827.
    • (2009) Cancer Res , vol.69 , pp. 1821-1827
    • Copp, J.1    Manning, G.2    Hunter, T.3
  • 12
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. 2009. Targeting PI3K signalling in cancer: Opportunities, challenges and limitations. Nat Rev Cancer 9: 550-562.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 13
    • 71549161146 scopus 로고    scopus 로고
    • Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
    • Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, Khuri FR, Sun SY. 2009. Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res 69: 8967-8976.
    • (2009) Cancer Res , vol.69 , pp. 8967-8976
    • Fu, L.1    Kim, Y.A.2    Wang, X.3    Wu, X.4    Yue, P.5    Lonial, S.6    Khuri, F.R.7    Sun, S.Y.8
  • 14
    • 60349088457 scopus 로고    scopus 로고
    • Perifosine: Update on a novel Akt inhibitor
    • Gills JJ, Dennis PA. 2009. Perifosine: Update on a novel Akt inhibitor. Curr Oncol Rep 11: 102-110.
    • (2009) Curr Oncol Rep , vol.11 , pp. 102-110
    • Gills, J.J.1    Dennis, P.A.2
  • 16
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • Ho MM, Ng AV, Lam S, Hung JY. 2007. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 67: 4827-4833.
    • (2007) Cancer Res , vol.67 , pp. 4827-4833
    • Ho, M.M.1    Ng, A.V.2    Lam, S.3    Hung, J.Y.4
  • 17
    • 8844258034 scopus 로고    scopus 로고
    • Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle
    • Horn S, Endl E, Fehse B, Weck MM, Mayr GW, Jucker M. 2004. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle. Leukemia 18: 1839-1849.
    • (2004) Leukemia , vol.18 , pp. 1839-1849
    • Horn, S.1    Endl, E.2    Fehse, B.3    Weck, M.M.4    Mayr, G.W.5    Jucker, M.6
  • 20
    • 10044259800 scopus 로고    scopus 로고
    • Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia
    • Kantarjian H, Thomas D, O'Brien S, Cortes J, Giles F, Jeha S, Bueso-Ramos CE, Pierce S, Shan J, Koller C, Beran M, Keating M, Freireich EJ. 2004. Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. Cancer 101: 2788-2801.
    • (2004) Cancer , vol.101 , pp. 2788-2801
    • Kantarjian, H.1    Thomas, D.2    O'Brien, S.3    Cortes, J.4    Giles, F.5    Jeha, S.6    Bueso-Ramos, C.E.7    Pierce, S.8    Shan, J.9    Koller, C.10    Beran, M.11    Keating, M.12    Freireich, E.J.13
  • 21
    • 68749109333 scopus 로고    scopus 로고
    • The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: A report from the Children's Oncology Group
    • Larson Gedman A, Chen Q, Kugel Desmoulin S, Ge Y, LaFiura K, Haska CL, Cherian C, Devidas M, Linda SB, Taub JW, Matherly LH. 2009. The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: A report from the Children's Oncology Group. Leukemia 23: 1417-1425.
    • (2009) Leukemia , vol.23 , pp. 1417-1425
    • Larson Gedman, A.1    Chen, Q.2    Kugel Desmoulin, S.3    Ge, Y.4    LaFiura, K.5    Haska, C.L.6    Cherian, C.7    Devidas, M.8    Linda, S.B.9    Taub, J.W.10    Matherly, L.H.11
  • 22
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. 2008. Autophagy in the pathogenesis of disease. Cell 132: 27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 23
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu P, Cheng H, Roberts TM, Zhao JJ. 2009. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 8: 627-644.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 24
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
    • LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA. 2008. Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations. Drug Resist Update 11: 32-50.
    • (2008) Drug Resist Update , vol.11 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 30
    • 77649270350 scopus 로고    scopus 로고
    • Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling
    • Nakanishi T, Chumsri S, Khakpour N, Brodie AH, Leyland-Jones B, Hamburger AW, Ross DD, Burger AM. 2010. Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling. Br J Cancer 102: 815-826.
    • (2010) Br J Cancer , vol.102 , pp. 815-826
    • Nakanishi, T.1    Chumsri, S.2    Khakpour, N.3    Brodie, A.H.4    Leyland-Jones, B.5    Hamburger, A.W.6    Ross, D.D.7    Burger, A.M.8
  • 31
    • 33746046785 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways
    • Nyakern M, Cappellini A, Mantovani I, Martelli AM. 2006. Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways. Mol Cancer Ther 5: 1559-1570.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1559-1570
    • Nyakern, M.1    Cappellini, A.2    Mantovani, I.3    Martelli, A.M.4
  • 34
    • 40749150603 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • Pui CH, Robison LL, Look AT. 2008. Acute lymphoblastic leukaemia. Lancet 371: 1030-1043.
    • (2008) Lancet , vol.371 , pp. 1030-1043
    • Pui, C.H.1    Robison, L.L.2    Look, A.T.3
  • 37
    • 77349109478 scopus 로고    scopus 로고
    • Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression and targeted therapy
    • Sullivan JP, Minna JD, Shay JW. 2010. Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression and targeted therapy. Cancer Metastasis Rev 29: 61-72.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 61-72
    • Sullivan, J.P.1    Minna, J.D.2    Shay, J.W.3
  • 38
    • 12344288380 scopus 로고    scopus 로고
    • Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin
    • VanderWeele DJ, Zhou R, Rudin CM. 2004. Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin. Mol Cancer Ther 3: 1605-1613.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1605-1613
    • VanderWeele, D.J.1    Zhou, R.2    Rudin, C.M.3
  • 42
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL, Cantley LC. 2008. PI3K pathway alterations in cancer: Variations on a theme. Oncogene 27: 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 43
    • 74249106880 scopus 로고    scopus 로고
    • Targeted therapy in T-cell malignancies: Dysregulation of the cellular signaling pathways
    • Zhao WL. 2010. Targeted therapy in T-cell malignancies: Dysregulation of the cellular signaling pathways. Leukemia 24: 13-21.
    • (2010) Leukemia , vol.24 , pp. 13-21
    • Zhao, W.L.1


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