Mitotic activation of Akt signalling pathway in Han:SPRD rats with polycystic kidney disease

Nephrology

Volumn 12, Issue 4, 2007, Pages 357-363

  Wahl, Patricia R ^a   Hir, Michel Le ^a   Vogetseder, Alexander ^a   Arcaro, Alexandre ^b   Starke, Astrid ^a   Waeckerle Men, Ying ^a   Serra, Andreas L ^a,c   Wuthrich, Rudolf P ^a,c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

ADPKD; Akt kinase; Cell proliferation; Han:SPRD rat; Mitosis; MTOR

Indexed keywords

AKT 3 PROTEIN; BROXURIDINE; KI 67 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN KINASE B BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELL ACTIVATION; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; EPITHELIUM; EPITHELIUM CELL; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; INTERPHASE; KIDNEY POLYCYSTIC DISEASE; MALE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROPHASE; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; MITOSIS; POLYCYSTIC KIDNEY DISEASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

EID: 34447566918     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2007.00811.x     Document Type: Article

References (26)

1. Sutters M, Germino GG. Autosomal dominant polycystic kidney disease: Molecular genetics and pathophysiology. J. Lab. Clin. Med. 2003 141 : 91 101.
2. Wilson PD. Polycystic kidney disease. N. Engl. J. Med. 2004 350 : 151 64.
3. Comperat E, Ferlicot S, Camparo P et al. Expression of epidermal growth factor receptor and proliferative activity of cyst epithelium in human renal cystic diseases. Urol. Int. 2006 76 : 269 73.
4. Yamaguchi T, Hempson SJ, Reif GA, Hedge AM, Wallace DP. Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells. J. Am. Soc. Nephrol. 2006 17 : 178 87.
5. Yamaguchi T, Wallace DP, Magenheimer BS, Hempson SJ, Grantham JJ, Calvet JP. Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. J. Biol. Chem. 2004 279 : 40419 30.
6. Lee JE, Park MH, Park JH. The gene expression profile of cyst epithelial cells in autosomal dominant polycystic kidney disease patients. J. Biochem. Mol. Biol. 2004 37 : 612 17.
7. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000 103 : 253 62.
8. Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004 18 : 1926 45.
9. Scott PH, Brunn GJ, Kohn AD, Roth RA, Lawrence JC Jr. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 1998 95 : 7772 7.
10. Navé BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem. J. 1999 344 : 427 31.
11. Sekulic A, Hudson CC, Homme JL et al. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000 60 : 3504 13.
12. Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 2002 4 : 648 57.
13. Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 2002 10 : 151 62.
14. Wahl PR, Serra AL, Le Hir M, Molle KD, Hall MN, Wuthrich RP. Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrol. Dial. Transplant. 2006 21 : 598 604.
15. Dawson CA, Bongard RD, Rickaby DA, Linehan JH, Roerig DL. Effect of transit time on metabolism of a pulmonary endothelial enzyme substrate. Am. J. Physiol. 1989 257 : H853 65.
16. Tsurutani J, Fukuoka J, Tsurutani H et al. Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors. J. Clin. Oncol. 2006 24 : 306 14.
17. Dangi S, Cha H, Shapiro P. Requirement for phosphatidylinositol-3 kinase activity during progression through S-phase and entry into mitosis. Cell. Signal. 2003 15 : 667 75.
18. Huang C, Li J, Ke Q et al. Ultraviolet-induced phosphorylation of p70(S6K) at Thr (389) and Thr (421)/Ser (424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C. Cancer Res. 2002 62 : 5689 97.
19. Le XF, Hittelman WN, Liu J et al. Paclitaxel induces inactivation of p70, S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Oncogene 2003 22 : 484 97.
20. Tao Y, Kim J, Schrier RW, Edelstein CL. Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease. J. Am. Soc. Nephrol. 2005 16 : 46 51.
21. Shillingford JM, Murcia NS, Larson CH et al. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc. Natl. Acad. Sci. USA 2006 103 : 5466 71.
22. Munemura C, Uemasu J, Kawasaki H. Epidermal growth factor and endothelin in cyst fluid from autosomal dominant polycystic kidney disease cases: Possible evidence of heterogeneity in cystogenesis. Am. J. Kidney Dis. 1994 24 : 561 8.
23. Moskowitz DW, Bonar SL, Liu W, Sirgi CF, Marcus MD, Clayman RV. Epidermal growth factor precursor is present in a variety of human renal cyst fluids. J. Urol. 1995 153 : 578 83.
24. Lakshmanan J, Eysselein V. Hereditary error in epidermal growth factor prohormone metabolism in a rat model of autosomal dominant polycystic kidney disease. Biochem. Biophys. Res. Commun. 1993 197 : 1083 93.
25. Pugh JL, Sweeney WE Avner ED. Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture. Kidney Int. 1995 47 : 774 8.
26. Torres VE, Sweeney WE Wang X et al. EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats. Kidney Int. 2003 64 : 1573 9.