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Volumn 6, Issue 1, 2013, Pages 45-55

Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the Mptp mouse model of Parkinson's disease: Focus on endogenous neurorestoration

Author keywords

Astrocytes; Dopaminergic neurons; Neurodegeneration; Neurogenesis; Neuroprotection; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA TOCOPHEROL; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AROMATASE; ASCORBIC ACID; BETA CATENIN; CHEMOKINE; CYCLOOXYGENASE 2; DOPAMINE; FLURBIPROFEN 4 NITROXYBUTYL ESTER; GAMMA INTERFERON; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOCORTICOID RECEPTOR; GLUTATHIONE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MYELOPEROXIDASE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXYNITRITE; PROTEIN S 100; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN; WNT1 PROTEIN;

EID: 84882779971     PISSN: 18746098     EISSN: 18746128     Source Type: Journal    
DOI: 10.2174/1874609811306010007     Document Type: Article
Times cited : (58)

References (72)
  • 1
    • 0242681988 scopus 로고
    • Idiopathic and 1-methyl-4phenyl- 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
    • Oxford University Press, Chapter 65
    • Di Monte DA, Langston JW. Idiopathic and 1-methyl-4phenyl- 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism. In: H Kettenmann and BR Ransom, eds, Neuroglia. Oxford University Press, 1995; Chapter 65: pp.989-97.
    • (1995) Neuroglia , pp. 989-997
    • Di Monte, D.A.1    Langston, J.W.2
  • 2
    • 0027354220 scopus 로고
    • Parkinson's disease and the adaptive capacity of the nigrostriatal dopamine system: Possible neurochemical mechanisms
    • Hornykiewicz O. Parkinson's disease and the adaptive capacity of the nigrostriatal dopamine system: Possible neurochemical mechanisms. Adv Neurol 1993; 60: 140-7.
    • (1993) Adv Neurol , vol.60 , pp. 140-147
    • Hornykiewicz, O.1
  • 3
    • 0037378912 scopus 로고    scopus 로고
    • Neurodegeneration and prospects for neuroprotection and rescue in Parkinson's disease
    • Olanow CW, Shapira AHV, Agid Y. Neurodegeneration and prospects for neuroprotection and rescue in Parkinson's disease. Ann Neurol 2003; 53(Suppl 3): S1-2.
    • (2003) Ann Neurol , vol.53 , Issue.SUPPL. 3
    • Olanow, C.W.1    Shapira, A.H.V.2    Agid, Y.3
  • 4
    • 33745612296 scopus 로고    scopus 로고
    • Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitinproteasome system
    • Betarbet R, Canet-Aviles RM, Sherer TB, et al. Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitinproteasome system. Neurobiol Dis 2006; 22: 404-20.
    • (2006) Neurobiol Dis , vol.22 , pp. 404-420
    • Betarbet, R.1    Canet-Aviles, R.M.2    Sherer, T.B.3
  • 5
    • 0037208691 scopus 로고    scopus 로고
    • Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies
    • Tanner CM. Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies. Adv Neurol 2003; 91: 133-42.
    • (2003) Adv Neurol , vol.91 , pp. 133-142
    • Tanner, C.M.1
  • 7
    • 25844493093 scopus 로고    scopus 로고
    • The role of early life environmental risk factors in Parkinson's disease. What is the evidence?
    • Logroscino G. The role of early life environmental risk factors in Parkinson's disease. What is the evidence? Environ Health Perspectives 2005; 113: 1234-8.
    • (2005) Environ Health Perspectives , vol.113 , pp. 1234-1238
    • Logroscino, G.1
  • 8
    • 32244434803 scopus 로고    scopus 로고
    • Hormones are key actors in gene X environment interactions programming the vulnerability to Parkinson's disease: Glia as a common final pathway
    • Marchetti B, Serra PA, L'Episcopo F, et al. Hormones are key actors in gene X environment interactions programming the vulnerability to Parkinson's disease: Glia as a common final pathway. Ann NY Acad Sci 2005; 1057: 296-318.
    • (2005) Ann NY Acad Sci , vol.1057 , pp. 296-318
    • Marchetti, B.1    Serra, P.A.2    L'episcopo, F.3
  • 9
    • 0037379324 scopus 로고    scopus 로고
    • Genetic and environmental factors in the cause of Parkinson's disease
    • Warner TT, Schapira AHV. Genetic and environmental factors in the cause of Parkinson's disease. Ann Neurol 2003; 53: S16-25.
    • (2003) Ann Neurol , vol.53
    • Warner, T.T.1    Schapira, A.H.V.2
  • 10
    • 33644526277 scopus 로고    scopus 로고
    • Estrogen, neuroinflammation and neuroprotection in Parkinson's disease: Glia dictates resistance versus vulnerability to neurodegeneration
    • Morale MC, Serra PA, L'Episcopo F, et al. Estrogen, neuroinflammation and neuroprotection in Parkinson's disease: glia dictates resistance versus vulnerability to neurodegeneration. Neuroscience 2006; 138: 869-78.
    • (2006) Neuroscience , vol.138 , pp. 869-878
    • Morale, M.C.1    Serra, P.A.2    L'episcopo, F.3
  • 11
    • 40849111916 scopus 로고    scopus 로고
    • Loss of Aromatase Cytochrome P450 function as a risk factor for Parkinson's disease?
    • Morale MC, L'Episcopo F, Tirolo C, et al. Loss of Aromatase Cytochrome P450 function as a risk factor for Parkinson's disease? Brain Res Rev 2008; 57(2): 431-43.
    • (2008) Brain Res Rev , vol.57 , Issue.2 , pp. 431-443
    • Morale, M.C.1    L'episcopo, F.2    Tirolo, C.3
  • 12
    • 47849098033 scopus 로고    scopus 로고
    • Estrogen and SERM neuroprotection in animal models of Parkinson's disease
    • Morissette M, Al Swedi S, Callier S, Di Paolo T. Estrogen and SERM neuroprotection in animal models of Parkinson's disease. Mol Cell Endocrinol 2008; 290: 60-9.
    • (2008) Mol Cell Endocrinol , vol.290 , pp. 60-69
    • Morissette, M.1    Al Swedi, S.2    Callier, S.3    Di Paolo, T.4
  • 14
    • 0041653249 scopus 로고    scopus 로고
    • Non steroidal antiinflammatory drugs and the risk of Parkinson's disease
    • Chen H, Zhang SM, Herman MA, et al. Non steroidal antiinflammatory drugs and the risk of Parkinson's disease. Arch Neurol 2003; 60:1059-64.
    • (2003) Arch Neurol , vol.60 , pp. 1059-1064
    • Chen, H.1    Zhang, S.M.2    Herman, M.A.3
  • 15
    • 0041522790 scopus 로고    scopus 로고
    • Non steroidal anti-inflammatory drugs protect against Parkinson neurodegeneration: Can an NSAID a day keep Parkinson disease away?
    • Schiess M. Non steroidal anti-inflammatory drugs protect against Parkinson neurodegeneration: can an NSAID a day keep Parkinson disease away? Arc Neurol 2003; 60: 1043-44.
    • (2003) Arc Neurol , vol.60 , pp. 1043-1044
    • Schiess, M.1
  • 16
    • 78549263421 scopus 로고    scopus 로고
    • Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • L'Episcopo F, Tirolo C, Caniglia S, et al. Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Neuroinflamm 2010; 7: 83.
    • (2010) J Neuroinflamm , vol.7 , pp. 83
    • L'episcopo, F.1    Tirolo, C.2    Caniglia, S.3
  • 17
    • 80051993172 scopus 로고    scopus 로고
    • Switching microglial harmful phenotype promotes life-long restoration of Substantia Nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice
    • L'Episcopo F, Tirolo C, Testa N, et al. Switching microglial harmful phenotype promotes life-long restoration of Substantia Nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice. Rejuvenation Res 2011; 14: 411-24.
    • (2011) Rejuvenation Res , vol.14 , pp. 411-424
    • L'episcopo, F.1    Tirolo, C.2    Testa, N.3
  • 18
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine exposure
    • Langston JW, Forno LS Tetrud J, Reevers AG, Kaplan JA, Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine exposure. Ann Neurol 1999; 46: 598-605.
    • (1999) Ann Neurol , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reevers, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 19
    • 0032425283 scopus 로고    scopus 로고
    • Novel alpha-synuclein-immunoreactive proteins in brain samples from the Contursi kindred, Parkinson's, and Alzheimer's disease
    • Langston JW, Sastry S, Chan P, Forno LS, Bolin LM, Di Monte DA. Novel alpha-synuclein-immunoreactive proteins in brain samples from the Contursi kindred, Parkinson's, and Alzheimer's disease. Exp Neurol 1998; 154(2): 684-90.
    • (1998) Exp Neurol , vol.154 , Issue.2 , pp. 684-690
    • Langston, J.W.1    Sastry, S.2    Chan, P.3    Forno, L.S.4    Bolin, L.M.5    Di Monte, D.A.6
  • 20
    • 0031930771 scopus 로고    scopus 로고
    • Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease
    • Banati RB, Daniel SE, Blunt SB. Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease. Mov Disord 1998; 13(2): 221-7.
    • (1998) Mov Disord , vol.13 , Issue.2 , pp. 221-227
    • Banati, R.B.1    Daniel, S.E.2    Blunt, S.B.3
  • 22
    • 47749126515 scopus 로고    scopus 로고
    • Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression
    • Gao HM, Hong JS. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol 2008; 29(8): 357-65.
    • (2008) Trends Immunol , vol.29 , Issue.8 , pp. 357-365
    • Gao, H.M.1    Hong, J.S.2
  • 23
    • 0033835748 scopus 로고    scopus 로고
    • The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system
    • Herrera J, Castano A, Venero JL, Cano J, Machado A. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiol Dis 2000; 7: 429-47.
    • (2000) Neurobiol Dis , vol.7 , pp. 429-447
    • Herrera, J.1    Castano, A.2    Venero, J.L.3    Cano, J.4    Machado, A.5
  • 24
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: A target for neuroprotection?
    • Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol 2009; 8: 382-97.
    • (2009) Lancet Neurol , vol.8 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 25
    • 69249208792 scopus 로고    scopus 로고
    • Neuronal NOS and ciyclooxygenase- 2 contribute to DNA damage in a mouse model of Parkinson Disease
    • Hoang T, Choi DK, Nagai M, et al. Neuronal NOS and ciyclooxygenase- 2 contribute to DNA damage in a mouse model of Parkinson Disease. Free Radic Biol Med 2009; 47: 1049-56.
    • (2009) Free Radic Biol Med , vol.47 , pp. 1049-1056
    • Hoang, T.1    Choi, D.K.2    Nagai, M.3
  • 27
    • 25144468525 scopus 로고    scopus 로고
    • To be or not to be (inflammed) is that the question in anti-inflammatory drug therapy of neurodegenerative diseases?
    • Marchetti B, Abbracchio MP. To be or not to be (inflammed) is that the question in anti-inflammatory drug therapy of neurodegenerative diseases? Trends Pharmacol Sci 2005; 26: 517-25.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 517-525
    • Marchetti, B.1    Abbracchio, M.P.2
  • 28
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • McGeer PL, McGeer EG. Glial reactions in Parkinson's disease. Mov Disord 2008; 23: 474-83.
    • (2008) Mov Disord , vol.23 , pp. 474-483
    • McGeer, P.L.1    McGeer, E.G.2
  • 29
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988; 38(8): 1285-91.
    • (1988) Neurology , vol.38 , Issue.8 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 30
    • 34247366072 scopus 로고    scopus 로고
    • Inflammation as a causative factor in the aetiology of Parkinson's disease
    • Whitton PS. Inflammation as a causative factor in the aetiology of Parkinson's disease. Brit J Pharmacol 2007; 150: 963-76.
    • (2007) Brit J Pharmacol , vol.150 , pp. 963-976
    • Whitton, P.S.1
  • 32
    • 0033040497 scopus 로고    scopus 로고
    • Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
    • Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 1999; 97: 703-11.
    • (1999) Cell , vol.97 , pp. 703-711
    • Doetsch, F.1    Caillé, I.2    Lim, D.A.3    García-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 33
    • 33644507720 scopus 로고    scopus 로고
    • Adult neurogenesis and functional plasticity in neuronal circuits
    • Lledo PM, Alonso M, Grubb MS. Adult neurogenesis and functional plasticity in neuronal circuits. Nature Neurosci 2006; 7: 179-222.
    • (2006) Nature Neurosci , vol.7 , pp. 179-222
    • Lledo, P.M.1    Alonso, M.2    Grubb, M.S.3
  • 36
    • 70350148423 scopus 로고    scopus 로고
    • The role of astroglia in neuroprotection
    • Bélanger M, Magistretti PJ. The role of astroglia in neuroprotection. Dialog. Clin Neurosci 2009; 11(3): 281-95.
    • (2009) Dialog. Clin Neurosci , vol.11 , Issue.3 , pp. 281-295
    • Bélanger, M.1    Magistretti, P.J.2
  • 37
    • 70349134701 scopus 로고    scopus 로고
    • Astrocyte function and role in motor neuron disease: A future therapeutic target?
    • Blakburn D, Sargsyan S, Monk PN, Shaw PJ. Astrocyte function and role in motor neuron disease: a future therapeutic target? Glia 2009; 57: 1251-64.
    • (2009) Glia , vol.57 , pp. 1251-1264
    • Blakburn, D.1    Sargsyan, S.2    Monk, P.N.3    Shaw, P.J.4
  • 39
    • 1342332143 scopus 로고    scopus 로고
    • Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: Critical role of glial nitric oxide
    • Morale MC, Serra PA, Delogu MR, et al. Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide. FASEB J 2004; 18: 164-6.
    • (2004) FASEB J , vol.18 , pp. 164-166
    • Morale, M.C.1    Serra, P.A.2    Delogu, M.R.3
  • 40
    • 20244369883 scopus 로고    scopus 로고
    • Glucocorticoid receptornitric oxide crosstalk and vulnerability to experimental Parkinsonism: Pivotal role for glia-neuron interactions
    • Marchetti B, Serra PA, Tirolo C, et al. Glucocorticoid receptornitric oxide crosstalk and vulnerability to experimental Parkinsonism: pivotal role for glia-neuron interactions. Brain Res Rev 2005; 48(2): 302-21.
    • (2005) Brain Res Rev , vol.48 , Issue.2 , pp. 302-321
    • Marchetti, B.1    Serra, P.A.2    Tirolo, C.3
  • 41
    • 77954329712 scopus 로고    scopus 로고
    • Glia-neuron crosstalk in neuroinflammation, neurodegeneration and neuroprotection
    • Marchetti B, Kettenmann H, Streit WJ. Glia-neuron crosstalk in neuroinflammation, neurodegeneration and neuroprotection. Brain Res Review Special Issue 2005; 482(2): 129-489.
    • (2005) Brain Res Review Special Issue , vol.482 , Issue.2 , pp. 129-489
    • Marchetti, B.1    Kettenmann, H.2    Streit, W.J.3
  • 42
    • 0004175524 scopus 로고
    • Kettenmann H, Ransom BR, eds, Oxford University Press
    • Kettenmann H, Ransom BR. Neuroglia. Kettenmann H, Ransom BR, eds, Oxford University Press 1995.
    • (1995) Neuroglia
    • Kettenmann, H.1    Ransom, B.R.2
  • 43
    • 45749101293 scopus 로고    scopus 로고
    • MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology
    • Mallajosyula JK, Kaur D, Chinta SJ, et al. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PLoS One 2008; 3(2): e1616.
    • (2008) PLoS One , vol.3 , Issue.2
    • Mallajosyula, J.K.1    Kaur, D.2    Chinta, S.J.3
  • 44
    • 10744221309 scopus 로고    scopus 로고
    • Bilirubin protects astrocytes from its own toxicity inducing up-regulation and translocation of multigrug resistance-associated protein 1 (Mrp 1)
    • Gennuso F, Fernetti C, Tirolo C, et al. Bilirubin protects astrocytes from its own toxicity inducing up-regulation and translocation of multigrug resistance-associated protein 1 (Mrp 1). Proc Natl Acad Sci USA 2004; 101: 2470-5.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2470-2475
    • Gennuso, F.1    Fernetti, C.2    Tirolo, C.3
  • 45
    • 62449132771 scopus 로고    scopus 로고
    • Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
    • Chen PC, Vargas MR, Pani AK, et al. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. Proc Natl Acad Sci USA 2009; 106(8): 2933-8.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.8 , pp. 2933-2938
    • Chen, P.C.1    Vargas, M.R.2    Pani, A.K.3
  • 48
    • 0033103571 scopus 로고    scopus 로고
    • Aromatase expression by astrocytes after brain injury: Implications for local estrogen formation and brain repair
    • Garcia-Segura LM, Wozniak A, Azcoitia I. Aromatase expression by astrocytes after brain injury: implications for local estrogen formation and brain repair. Neuroscience 1999; 89: 567-78.
    • (1999) Neuroscience , vol.89 , pp. 567-578
    • Garcia-Segura, L.M.1    Wozniak, A.2    Azcoitia, I.3
  • 49
    • 0029801365 scopus 로고    scopus 로고
    • Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways
    • Engele J, Franke B. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell Tissue Res 1996; 286: 235-40.
    • (1996) Cell Tissue Res , vol.286 , pp. 235-240
    • Engele, J.1    Franke, B.2
  • 50
    • 0026042368 scopus 로고
    • The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia
    • Engele J, Bohn MC. The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia. J Neurosci 1991; 11(10): 3070-8.
    • (1991) J Neurosci , vol.11 , Issue.10 , pp. 3070-3078
    • Engele, J.1    Bohn, M.C.2
  • 51
    • 0034659602 scopus 로고    scopus 로고
    • Basic fibroblast growth factor (bFGF) acts on both neurons and glia to mediate the neurotrophic effects of astrocytes on LHRH neurons in culture
    • Gallo F, Morale MC, Spina-Purrello V, et al. Basic fibroblast growth factor (bFGF) acts on both neurons and glia to mediate the neurotrophic effects of astrocytes on LHRH neurons in culture. Synapse 2000; 36: 233-53.
    • (2000) Synapse , vol.36 , pp. 233-253
    • Gallo, F.1    Morale, M.C.2    Spina-Purrello, V.3
  • 52
    • 68049127516 scopus 로고    scopus 로고
    • Mesencephalic astrocytederived neurotrophic factor is neurorestorative in rat model of Parkinson's disease
    • Voutilainen MH, Back S, Porsti E, et al. Mesencephalic astrocytederived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. J Neurosci 2009; 29: 9651-9.
    • (2009) J Neurosci , vol.29 , pp. 9651-9659
    • Voutilainen, M.H.1    Back, S.2    Porsti, E.3
  • 53
    • 32244442041 scopus 로고    scopus 로고
    • Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion
    • Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol Cell Neurosci 2006; 31(2): 251-62.
    • (2006) Mol Cell Neurosci , vol.31 , Issue.2 , pp. 251-262
    • Castelo-Branco, G.1    Sousa, K.M.2    Bryja, V.3    Pinto, L.4    Wagner, J.5    Arenas, E.6
  • 54
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: Multiple pathways, multiple receptors and multiple transcription factors
    • Gordon MD, Nusse R. Wnt signaling: Multiple pathways, multiple receptors and multiple transcription factors. J Biol Chem 281: 22429-33.
    • J Biol Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 55
    • 78650621911 scopus 로고    scopus 로고
    • Reactive astrocytes and Wnt/beta-catenin signaling link nigrostriatal injury to repair in 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • L'Episcopo F, Tirolo C, Testa N, et al. Reactive astrocytes and Wnt/beta-catenin signaling link nigrostriatal injury to repair in 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Neurobiol Dis 2011; 41: 508-27.
    • (2011) Neurobiol Dis , vol.41 , pp. 508-527
    • L'episcopo, F.1    Tirolo, C.2    Testa, N.3
  • 56
    • 79960123794 scopus 로고    scopus 로고
    • A Wnt1 regulated frizzled-1/β-catenin signalling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
    • L'Episcopo F, Serapide MF, Tirolo C, et al. A Wnt1 regulated frizzled-1/β-catenin signalling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegeneration 2011; 6: 49.
    • (2011) Mol Neurodegeneration , vol.6 , pp. 49
    • L'episcopo, F.1    Serapide, M.F.2    Tirolo, C.3
  • 57
    • 0034718896 scopus 로고    scopus 로고
    • Regenerating the damaged central nervous system
    • Horner PJ, Gage FH. Regenerating the damaged central nervous system. Nature 2000; 407(6807): 963-70.
    • (2000) Nature , vol.407 , Issue.6807 , pp. 963-970
    • Horner, P.J.1    Gage, F.H.2
  • 58
    • 0037319033 scopus 로고    scopus 로고
    • Neurogenesis after ischemic brain insults
    • Kokaia Z, Lindvall O. Neurogenesis after ischemic brain insults. Curr Opin Neurobiol 2003; 13: 127-32.
    • (2003) Curr Opin Neurobiol , vol.13 , pp. 127-132
    • Kokaia, Z.1    Lindvall, O.2
  • 59
    • 3142521479 scopus 로고    scopus 로고
    • Stem cell therapy for human degenerative disorders: How to make it work
    • Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human degenerative disorders: How to make it work. Nat Med 2004; 10: S42-50.
    • (2004) Nat Med , vol.10
    • Lindvall, O.1    Kokaia, Z.2    Martinez-Serrano, A.3
  • 60
    • 33745684551 scopus 로고    scopus 로고
    • The therapeutic potential of neural stem cells
    • Martino G, Pluchino S. The therapeutic potential of neural stem cells. Nat Rev Neurosci 2006; 7: 395-406.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 395-406
    • Martino, G.1    Pluchino, S.2
  • 61
    • 0038037721 scopus 로고    scopus 로고
    • Evidence for neurogenesis in the adult mammalian substantia nigra
    • Zhao M, Momma S, Delfani K, et al. Evidence for neurogenesis in the adult mammalian substantia nigra. Proc Natl Acad Sci USA 2003; 100: 7925-30.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7925-7930
    • Zhao, M.1    Momma, S.2    Delfani, K.3
  • 62
    • 33747342080 scopus 로고    scopus 로고
    • Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of MPTPinduced Parkinson's disease-like mice
    • Shan X, Chi L, Bishop M, et al. Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of MPTPinduced Parkinson's disease-like mice. Stem Cells 2006; 24: 1280-1287.
    • (2006) Stem Cells , vol.24 , pp. 1280-1287
    • Shan, X.1    Chi, L.2    Bishop, M.3
  • 63
    • 56249128988 scopus 로고    scopus 로고
    • Endogenous regeneration in Parkinson's disease: Do we need orthotopic dopaminergic neurogenesis?
    • Hermann A, Storch A. Endogenous regeneration in Parkinson's disease: Do we need orthotopic dopaminergic neurogenesis? Stem Cells 2008; 26: 2749-52.
    • (2008) Stem Cells , vol.26 , pp. 2749-2752
    • Hermann, A.1    Storch, A.2
  • 64
    • 30044434850 scopus 로고    scopus 로고
    • Microglia activated by IL-4 or IFN-gamma differentiaally induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
    • Butovsky O, Ziv Y, Schwartz A, et al. Microglia activated by IL-4 or IFN-gamma differentiaally induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci 2006; 31: 49-60.
    • (2006) Mol Cell Neurosci , vol.31 , pp. 49-60
    • Butovsky, O.1    Ziv, Y.2    Schwartz, A.3
  • 65
    • 42449130907 scopus 로고    scopus 로고
    • Inflammation: A new candidate in modulating adult neurogenesis
    • Das S, Basu A. Inflammation: a new candidate in modulating adult neurogenesis. J Neurosci Res 2008; 86: 1199-208.
    • (2008) J Neurosci Res , vol.86 , pp. 1199-1208
    • Das, S.1    Basu, A.2
  • 66
    • 59349110661 scopus 로고    scopus 로고
    • Brain inflammation and adult neurogenesis: The dual role of microglia
    • Ekdahl CT, Kokaia Z, Lindvall O. Brain inflammation and adult neurogenesis: the dual role of microglia. Neurosceince 2009; 158: 1021-9.
    • (2009) Neurosceince , vol.158 , pp. 1021-1029
    • Ekdahl, C.T.1    Kokaia, Z.2    Lindvall, O.3
  • 67
    • 58149388884 scopus 로고    scopus 로고
    • Inflammation regulates functional integration of neurons born in adult brain
    • Jakubs K, Bonde S, Iosif RE, et al. Inflammation regulates functional integration of neurons born in adult brain. J Neurosci 2008; 28: 12477-88.
    • (2008) J Neurosci , vol.28 , pp. 12477-12488
    • Jakubs, K.1    Bonde, S.2    Iosif, R.E.3
  • 68
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003; 302: 1760-5.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 69
    • 33746255997 scopus 로고    scopus 로고
    • Identification of astrocyteexpressed factors that modulate neural stem/progenitor cell differentiation
    • Barkho BZ, Song H, Aimone JB, et al. Identification of astrocyteexpressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev 2006; 15: 407-21.
    • (2006) Stem Cells Dev , vol.15 , pp. 407-421
    • Barkho, B.Z.1    Song, H.2    Aimone, J.B.3
  • 70
    • 0033594892 scopus 로고    scopus 로고
    • Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis
    • Lim DA, Alvarez-Buylla A. Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis. Proc Natl Acad Sci USA 1999; 96: 7526-31.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7526-7531
    • Lim, D.A.1    Alvarez-Buylla, A.2
  • 71
    • 0037007647 scopus 로고    scopus 로고
    • Astroglia induce neurogenesis from adult neural stem cells
    • Song H, Stevens CF, Gage FH. Astroglia induce neurogenesis from adult neural stem cells. Nature 2002; 417(6884): 39-44.
    • (2002) Nature , vol.417 , Issue.6884 , pp. 39-44
    • Song, H.1    Stevens, C.F.2    Gage, F.H.3
  • 72
    • 33745509468 scopus 로고    scopus 로고
    • Multipotent neural stem cells from the adult tegmentum with dopaminergic potential develop essential properties of functional neurons
    • Hermann A, Maisel M, Wegner F, Liebau S, Kim DW, Gerlach M. Multipotent neural stem cells from the adult tegmentum with dopaminergic potential develop essential properties of functional neurons. Stem Cells 2006; 24: 949-64.
    • (2006) Stem Cells , vol.24 , pp. 949-964
    • Hermann, A.1    Maisel, M.2    Wegner, F.3    Liebau, S.4    Kim, D.W.5    Gerlach, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.