Neurogenesis after ischaemic brain insults

Current Opinion in Neurobiology

Volumn 13, Issue 1, 2003, Pages 127-132

  Kokaia, Zaal ^a   Lindvall, Olle ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN PROTEIN; CALBINDIN; EPIDERMAL GROWTH FACTOR; ERYTHROPOIETIN; FIBROBLAST GROWTH FACTOR 2; PROTEIN MEIS 2; PROTEIN PBX; STEM CELL FACTOR; UNCLASSIFIED DRUG;

BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CONVALESCENCE; CORPUS STRIATUM; HIPPOCAMPUS; LATERAL BRAIN VENTRICLE; MAZE TEST; NERVE CELL; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; REVIEW; STEM CELL; THALAMUS;

EID: 0037319033     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(03)00017-5     Document Type: Review

References (44)

1. Gage F.H. Mammalian neural stem cells. Science. 287:2000;1433-1438.
2. Reynolds B.A., Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 255:1992;1707-1717.
3. Kuhn H.G., Dickinson-Anson H., Gage F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16:1996;2027-2033.
4. Seki T., Arai Y. Age-related production of new granule cells in the adult dentate gyrus. Neuroreport. 6:1995;2479-2482.
5. van Praag H., Kempermann G., Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2:1999;266-270.
6. Gould E., Beylin A., Tanapat P., Reeves A., Shors T.J. Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 2:1999;260-265.
7. Kempermann G., Kuhn H.G., Gage F.H. Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc. Natl. Acad. Sci. USA. 94:1997;10409-10414.
8. Bengzon J., Kokaia Z., Elmer E., Nanobashvili A., Kokaia M., Lindvall O. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc. Natl. Acad. Sci. USA. 94:1997;10432-10437.
9. Parent J.M., Yu T.W., Leibowitz R.T., Geschwind D.H., Sloviter R.S., Lowenstein D.H. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 17:1997;3727-3738.
10. Parent J.M., Valentin V.V., Lowenstein D.H. Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway. J. Neurosci. 22:2002;3174-3188.
11. Liu J., Solway K., Messing R.O., Sharp F.R. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosci. 18:1998;7768-7778.
12. Takagi Y., Nozaki K., Takahashi J., Yodoi J., Ishikawa M., Hashimoto N. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice. Brain Res. 831:1999;283-287.
13. Kee N.J., Preston E., Wojtowicz J.M. Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat. Exp. Brain Res. 136:2001;313-320.
14. Iwai M., Hayashi T., Zhang W.R., Sato K., Manabe Y., Abe K. Induction of highly polysialylated neural cell adhesion molecule (PSA-NCAM) in postischemic gerbil hippocampus mainly dissociated with neural stem cell proliferation. Brain Res. 902:2001;288-293.
15. Yagita Y., Kitagawa K., Ohtsuki T., Takasawa K., Miyata T., Okano H., Hori M., Matsumoto M. Neurogenesis by progenitor cells in the ischemic adult rat hippocampus. Stroke. 32:2001;1890-1896.
16. Arvidsson A., Kokaia Z., Lindvall O. N-methyl-D-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke. Eur. J. Neurosci. 14:2001;10-18 In this study, we demonstrate that MCAO leads to a marked increase of neurogenesis in the ipsilateral dentate subgranular zone. This effect is not dependent on the occurrence of cell death in the hippocampus. The stroke-induced neurogenesis is mediated through glutamatergic mechanisms acting on NMDA receptors.
17. Komitova M., Perfilieva E., Mattsson B., Eriksson P.S., Johansson B.B. Effects of cortical ischemia and postischemic environmental enrichment on hippocampal cell genesis and differentiation in the adult rat. J. Cereb. Blood Flow Metab. 22:2002;852-860.
18. Takasawa K., Kitagawa K., Yagita Y., Sasaki T., Tanaka S., Matsushita K., Ohstuki T., Miyata T., Okano H., Hori M., Matsumoto M. Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 22:2002;299-307.
19. Nakatomi H., Kuriu T., Okabe S., Yamamoto S., Hatano O., Kawahara N., Tamura A., Kirino T., Nakafuku M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell. 110:2002;429-441 Intraventricular infusion of the growth factors FGF-2 and EGF after global ischaemia in rats leads to marked regeneration of hippocampal CA1 pyramidal neurons. The new neurons originate from proliferating progenitors localised in the posterior periventricle close to the hippocampus. Some of the regenerated neurons receive synaptic inputs and project to subiculum. The growth factor-treated animals show partial recovery of CA1 synaptic responses and water-maze performance.
20. Jin K., Minami M., Lan J.Q., Mao X.O., Batteur S., Simon R.P., Greenberg D.A. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc. Natl. Acad. Sci. USA. 98:2001;4710-4715 The authors report stroke-induced cell proliferation in the dentate subgranular zone and the rostral subventricular zone. The proliferated cells coexpressed markers for immature neurons.
21. Zhang R.L., Zhang Z.G., Zhang L., Chopp M. Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience. 105:2001;33-41.
22. Arvidsson A., Collin T., Kirik D., Kokaia Z., Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8:2002;963-970 In this study, we show that stroke caused by MCAO in adult rats leads to marked increase of cell proliferation in the subventricular zone. Stroke-generated new neurons and possibly also neuroblasts formed before the insult migrate into the severely damaged area of the striatum. There, they express markers of developing and mature striatal medium-sized spiny neurons.
23. Parent J.M., Vexler Z.S., Gong C., Derugin N., Ferriero D.M. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann. Neurol. 52:2002;802-813 Here, the authors report striatal neurogenesis following middle cerebral artery occlusion in adult rats. Cell proliferation is increased in the subventricular zone, and newly generated neuroblasts migrate into the peri-infarct striatum. The new neurons express markers of striatal medium-sized spiny neurons.
24. Toresson H., Parmar M., Campbell K. Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation. Mech. Dev. 94:2000;183-187.
25. Magavi S.S., Leavitt B.R., Macklis J.D. Induction of neurogenesis in the neocortex of adult mice. Nature. 405:2000;951-955.
26. Gu W., Brännström T., Wester P. Cortical neurogenesis in adult rats after reversible photothrombotic stroke. J. Cereb. Blood Flow Metab. 20:2000;1166-1173.
27. Jiang W., Gu W., Brannstrom T., Rosqvist R., Wester P. Cortical neurogenesis in adult rats after transient middle cerebral artery occlusion. Stroke. 32:2001;1201-1207.
28. Jin K., Mao X.O., Sun Y., Xie L., Greenberg D.A. Stem cell factor stimulates neurogenesis in vitro and in vivo. J. Clin. Invest. 110:2002;311-319 The authors provide in vitro and in vivo evidence that stem cell factor (SCF), which is synthesised in response to hypoxia, stimulates neurogenesis in the SVZ and SGZ through its receptor c-kit. The expression of this receptor is increased after MCAO.
29. Yoshimura S., Takagi Y., Harada J., Teramoto T., Thomas S.S., Waeber C., Bakowska J.C., Breakefield X.O., Moskowitz M.A. FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc. Natl. Acad. Sci. USA. 98:2001;5874-5879 The authors report attenuation of cell proliferation and neurogenesis in the dentate subgranular zone in FGF-2 knockout mice subjected to middle cerebral artery occlusion or kainic acid-evoked seizures. Injecting the knockout mice intraventricularly with the herpes simplex virus carrying the FGF-2 gene restored cell proliferation after seizures to normal levels.
30. Zigova T., Pencea V., Wiegand S.J., Luskin M.B. Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol. Cell. Neurosci. 11:1998;234-245.
31. Pencea V., Bingaman K.D., Wiegand S.J., Luskin M.B. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J. Neurosci. 21:2001;6706-6717.
32. Benraiss A., Chmielnicki E., Lerner K., Roh D., Goldman S.A. Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J. Neurosci. 21:2001;6718-6731.
33. Larsson E., Mandel R.J., Klein R.L., Muzycczka N., Lindvall O., Kokaia Z. Suppression of insult-induced neurogenesis an adult rat brain by brain-derived neurotrophic factor. Exp. Neurol. 177:2002;1-8.
34. Shingo T., Sorokan S.T., Shimazaki T., Weiss S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J. Neurosci. 21:2001;9733-9743 The authors show that the cytokine erythropoietin (EPO), which is produced in response to hypoxia, stimulates neurogenesis. Intraventricular EPO infusion increased the numbers of both cells migrating to the olfactory bulb and new olfactory bulb interneurons.
35. Bernabeu R., Sharp F.R. NMDA and AMPA/kainate glutamate receptors modulate dentate neurogenesis and CA3 synapsin-I in normal and ischemic hippocampus. J. Cereb. Blood Flow Metab. 20:2000;1669-1680.
36. Aboody K.S., Brown A., Rainov N.G., Bower K.A., Liu S., Yang W., Small J.E., Herrlinger U., Ourednik V., Black P.M.et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc. Natl. Acad. Sci. USA. 97:2000;12846-12851.
37. Veizovic T., Beech J.S., Stroemer R.P., Watson W.P., Hodges H. Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells. Stroke. 32:2001;1012-1019.
38. Mason H.A., Ito S., Corfas G. Extracellular signals that regulate the tangential migration of olfactory bulb neuronal precursors: inducers, inhibitors, and repellents. J. Neurosci. 21:2001;7654-7663.
39. Stoll G., Jander S., Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 56:1998;149-171.
40. Hamasaki T., Goto S., Nishikawa S., Ushio Y. A role of netrin-1 in the formation of the subcortical structure striatum: repulsive action on the migration of late-born striatal neurons. J. Neurosci. 21:2001;4272-4280.
41. Ekdahl C.T., Mohapel P., Elmer E., Lindvall O. Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus. Eur. J. Neurosci. 14:2001;937-945.
42. Ekdahl C.T., Mohapel P., Weber E., Bahr B., Blomgren K., Lindvall O. Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus. Eur. J. Neurosci. 16:2002;1463-1471.
43. van Praag H., Schinder A.F., Christie B.R., Toni N., Palmer T.D., Gage F.H. Functional neurogenesis in the adult hippocampus. Nature. 415:2002;1030-1034.
44. Carlen M., Cassidy R.M., Brismar H., Smith G.A., Enquist L.W., Frisen J. Functional integration of adult-born neurons. Curr. Biol. 12:2002;606-608.