-
1
-
-
26444448463
-
The survival kinases Akt and Pim as potential pharmacological targets
-
Amaravadi R., Thompson C.B. The survival kinases Akt and Pim as potential pharmacological targets. Journal of Clinical Investigation 2005, 115:2618-2624.
-
(2005)
Journal of Clinical Investigation
, vol.115
, pp. 2618-2624
-
-
Amaravadi, R.1
Thompson, C.B.2
-
3
-
-
0036289544
-
Down-regulation of Mcl-1 by inhibition of the PI3-K/Akt pathway is required for cell shrinkage-dependent cell death
-
Araki T., Hayashi M., Watanabe N., Kanuka H., Yoshino J., Miura M., Saruta T. Down-regulation of Mcl-1 by inhibition of the PI3-K/Akt pathway is required for cell shrinkage-dependent cell death. Biochemical and Biophysical Research Communications 2002, 290:1275-1281.
-
(2002)
Biochemical and Biophysical Research Communications
, vol.290
, pp. 1275-1281
-
-
Araki, T.1
Hayashi, M.2
Watanabe, N.3
Kanuka, H.4
Yoshino, J.5
Miura, M.6
Saruta, T.7
-
4
-
-
16944362939
-
Dopaminergic neurons intrinsic to the primate striatum
-
Betarbet R., Turner R., Chockkan V., DeLong M.R., Allers K.A., Walters J., Levey A.I., Greenamyre J.T. Dopaminergic neurons intrinsic to the primate striatum. Journal of Neuroscience 1997, 17:6761-6768.
-
(1997)
Journal of Neuroscience
, vol.17
, pp. 6761-6768
-
-
Betarbet, R.1
Turner, R.2
Chockkan, V.3
DeLong, M.R.4
Allers, K.A.5
Walters, J.6
Levey, A.I.7
Greenamyre, J.T.8
-
6
-
-
0035813212
-
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3β
-
Bijur G.N., Jope R.S. Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3β. Journal of Biological Chemistry 2001, 276:37436-37442.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 37436-37442
-
-
Bijur, G.N.1
Jope, R.S.2
-
7
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E., Frisch S., Reed J.C. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282:1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
Frisch, S.7
Reed, J.C.8
-
8
-
-
33845517069
-
Phosphatidylinositol transfer protein expression altered by aging and parkinson disease
-
Chalimoniuk M., Snoek G., Adamczyk A., Małecki A., Strosznajder J. Phosphatidylinositol transfer protein expression altered by aging and parkinson disease. Cellular and Molecular Neurobiology 2006, 26:1151-1164.
-
(2006)
Cellular and Molecular Neurobiology
, vol.26
, pp. 1151-1164
-
-
Chalimoniuk, M.1
Snoek, G.2
Adamczyk, A.3
Małecki, A.4
Strosznajder, J.5
-
9
-
-
0036977912
-
Beneficial effects of different Polygonum multiflorum Thunb. Extracts on memory and hippocampus morphology
-
Chan Y.C., Cheng F.C., Wang M.F. Beneficial effects of different Polygonum multiflorum Thunb. Extracts on memory and hippocampus morphology. Journal of Nutritional Science and Vitaminology 2002, 48:491-497.
-
(2002)
Journal of Nutritional Science and Vitaminology
, vol.48
, pp. 491-497
-
-
Chan, Y.C.1
Cheng, F.C.2
Wang, M.F.3
-
10
-
-
0041317800
-
Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice
-
Chan Y.C., Wang M.F., Chang H.C. Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice. The American Journal of Chinese Medicine 2003, 31:171-179.
-
(2003)
The American Journal of Chinese Medicine
, vol.31
, pp. 171-179
-
-
Chan, Y.C.1
Wang, M.F.2
Chang, H.C.3
-
11
-
-
0034730180
-
Insulin-like growth factor 1 regulates developing brain glucose metabolism
-
Cheng C.M., Reinhardt R.R., Lee W.-H., Joncas G., Patel S.C., Bondy C.A. Insulin-like growth factor 1 regulates developing brain glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:10236-10241.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 10236-10241
-
-
Cheng, C.M.1
Reinhardt, R.R.2
Lee, W.-H.3
Joncas, G.4
Patel, S.C.5
Bondy, C.A.6
-
13
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross D.A.E., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
14
-
-
18244394308
-
IGF-1 in the brain as a regulator of reproductive neuroendocrine function
-
Daftary S.S., Gore A.C. IGF-1 in the brain as a regulator of reproductive neuroendocrine function. Experimental Biology and Medicine 2005, 230:292-306.
-
(2005)
Experimental Biology and Medicine
, vol.230
, pp. 292-306
-
-
Daftary, S.S.1
Gore, A.C.2
-
15
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
16
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H., Datta S.R., Franke T.F., Birnbaum M.J., Yao R., Cooper G.M., Segal R.A., Kaplan D.R., Greenberg M.E. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997, 275:661-665.
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
17
-
-
33645102888
-
Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice
-
D'Astous M., Mendez P., Morissette M., Garcia-Segura L.M., Di Paolo T. Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Molecular Pharmacology 2006, 69:1492-1498.
-
(2006)
Molecular Pharmacology
, vol.69
, pp. 1492-1498
-
-
D'Astous, M.1
Mendez, P.2
Morissette, M.3
Garcia-Segura, L.M.4
Di Paolo, T.5
-
19
-
-
12944250922
-
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
-
Fang X., Yu S.X., Lu Y., Bast R.C., Woodgett J.R., Mills G.B. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:11960-11965.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 11960-11965
-
-
Fang, X.1
Yu, S.X.2
Lu, Y.3
Bast, R.C.4
Woodgett, J.R.5
Mills, G.B.6
-
20
-
-
1642471831
-
PI3K/Akt and apoptosis: size matters
-
Franke T.F., Hornik C.P., Segev L., Shostak G.A., Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene 2003, 22:8983-8998.
-
(2003)
Oncogene
, vol.22
, pp. 8983-8998
-
-
Franke, T.F.1
Hornik, C.P.2
Segev, L.3
Shostak, G.A.4
Sugimoto, C.5
-
22
-
-
77955096088
-
Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death
-
Fukui M., Choi H.J., Zhu B.T. Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radical Biology & Medicine 2010, 49:800-813.
-
(2010)
Free Radical Biology & Medicine
, vol.49
, pp. 800-813
-
-
Fukui, M.1
Choi, H.J.2
Zhu, B.T.3
-
23
-
-
0034050672
-
MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies
-
Grünblatt E., Mandel S., Youdim M.B.H. MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies. Journal of Neurology 2000, 247:II95-II102.
-
(2000)
Journal of Neurology
, vol.247
-
-
Grünblatt, E.1
Mandel, S.2
Youdim, M.B.H.3
-
24
-
-
0034522342
-
Caspases: key players in programmed cell death
-
Grütter M.G. Caspases: key players in programmed cell death. Current Opinion in Structural Biology 2000, 10:649-655.
-
(2000)
Current Opinion in Structural Biology
, vol.10
, pp. 649-655
-
-
Grütter, M.G.1
-
25
-
-
0021224694
-
Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors
-
Heikkila R.E., Manzino L., Cabbat F.S., Duvoisin R.C. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 1984, 311:467-469.
-
(1984)
Nature
, vol.311
, pp. 467-469
-
-
Heikkila, R.E.1
Manzino, L.2
Cabbat, F.S.3
Duvoisin, R.C.4
-
26
-
-
10644221251
-
Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons
-
Huang T.-J., Verkhratsky A., Fernyhough P. Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons. Molecular and Cellular Neuroscience 2005, 28:42-54.
-
(2005)
Molecular and Cellular Neuroscience
, vol.28
, pp. 42-54
-
-
Huang, T.-J.1
Verkhratsky, A.2
Fernyhough, P.3
-
27
-
-
0028784523
-
Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
Jackson-Lewis V., Jakowec M., Burke R.E., Przedborsk S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 1995, 4:257-269.
-
(1995)
Neurodegeneration
, vol.4
, pp. 257-269
-
-
Jackson-Lewis, V.1
Jakowec, M.2
Burke, R.E.3
Przedborsk, S.4
-
28
-
-
34347259269
-
Protocol for the MPTP mouse model of Parkinson's disease
-
Jackson-Lewis V., Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nature Protocols 2007, 2:141-151.
-
(2007)
Nature Protocols
, vol.2
, pp. 141-151
-
-
Jackson-Lewis, V.1
Przedborski, S.2
-
29
-
-
2342503324
-
Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway
-
Jakowec M.W., Nixon K., Hogg E., McNeill T., Petzinger G.M. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of Neuroscience Research 2004, 76:539-550.
-
(2004)
Journal of Neuroscience Research
, vol.76
, pp. 539-550
-
-
Jakowec, M.W.1
Nixon, K.2
Hogg, E.3
McNeill, T.4
Petzinger, G.M.5
-
30
-
-
0000340348
-
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
-
Javitch J.A., D'Amato R.J., Strittmatter S.M., Snyder S.H. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings of the National Academy of Sciences of the United States of America 1985, 82:2173-2177.
-
(1985)
Proceedings of the National Academy of Sciences of the United States of America
, vol.82
, pp. 2173-2177
-
-
Javitch, J.A.1
D'Amato, R.J.2
Strittmatter, S.M.3
Snyder, S.H.4
-
31
-
-
11844260672
-
Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3β and its upstream regulators
-
Jiang H., Guo W., Liang X., Rao Y. Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3β and its upstream regulators. Cell 2005, 120:123-135.
-
(2005)
Cell
, vol.120
, pp. 123-135
-
-
Jiang, H.1
Guo, W.2
Liang, X.3
Rao, Y.4
-
33
-
-
0030717621
-
Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease
-
Joyce J.N., Smutzer G., Whitty C.J., Myers A., Bannon M.J. Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease. Movement Disorders 1997, 12:885-897.
-
(1997)
Movement Disorders
, vol.12
, pp. 885-897
-
-
Joyce, J.N.1
Smutzer, G.2
Whitty, C.J.3
Myers, A.4
Bannon, M.J.5
-
35
-
-
0023911192
-
MPTP toxicity: implications for research in Parkinson's disease
-
Kopin I.J., Markey S.P. MPTP toxicity: implications for research in Parkinson's disease. Annual Review of Neuroscience 1988, 11:81-96.
-
(1988)
Annual Review of Neuroscience
, vol.11
, pp. 81-96
-
-
Kopin, I.J.1
Markey, S.P.2
-
36
-
-
0029751103
-
The etiology of Parkinson's disease with emphasis on the MPTP story
-
Langston J.W. The etiology of Parkinson's disease with emphasis on the MPTP story. Neurology 1996, 47:153S-160S.
-
(1996)
Neurology
, vol.47
-
-
Langston, J.W.1
-
38
-
-
62449129138
-
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps
-
Levy O., Malagelada C., Greene L. Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis 2009, 14:478-500.
-
(2009)
Apoptosis
, vol.14
, pp. 478-500
-
-
Levy, O.1
Malagelada, C.2
Greene, L.3
-
39
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin M.T., Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443:787-795.
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
40
-
-
28444474253
-
Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice
-
Li X., Matsumoto K., Murakami Y., Tezuka Y., Wu Y., Kadota S. Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice. Pharmacology Biochemistry and Behavior 2005, 82:345-352.
-
(2005)
Pharmacology Biochemistry and Behavior
, vol.82
, pp. 345-352
-
-
Li, X.1
Matsumoto, K.2
Murakami, Y.3
Tezuka, Y.4
Wu, Y.5
Kadota, S.6
-
41
-
-
78049290400
-
Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway
-
Li C., Cai F., Yang Y., Zhao X., Wang C., Li J., Jia Y., Tang J., liu Q. Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway. European Journal of Pharmacology 2010, 649:382-389.
-
(2010)
European Journal of Pharmacology
, vol.649
, pp. 382-389
-
-
Li, C.1
Cai, F.2
Yang, Y.3
Zhao, X.4
Wang, C.5
Li, J.6
Jia, Y.7
Tang, J.8
Liu, Q.9
-
42
-
-
65349142455
-
Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway
-
Liu J.H., Yin F., Guo L.X., Deng X.H., Hu Y.H. Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway. Acta Pharmacologica Sinica 2009, 30:159-165.
-
(2009)
Acta Pharmacologica Sinica
, vol.30
, pp. 159-165
-
-
Liu, J.H.1
Yin, F.2
Guo, L.X.3
Deng, X.H.4
Hu, Y.H.5
-
43
-
-
58149395816
-
RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation
-
Malagelada C., Jin Z.H., Greene L.A. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. Journal of Neuroscience 2008, 28:14363-14371.
-
(2008)
Journal of Neuroscience
, vol.28
, pp. 14363-14371
-
-
Malagelada, C.1
Jin, Z.H.2
Greene, L.A.3
-
44
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
45
-
-
0037075791
-
First non-ATP competitive glycogen synthase kinase 3β (GSK3β) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease
-
Martinez A., Alonso M., Castro A., Pérez C., Moreno F.J. First non-ATP competitive glycogen synthase kinase 3β (GSK3β) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. Journal of Medicinal Chemistry 2002, 45:1292-1299.
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, pp. 1292-1299
-
-
Martinez, A.1
Alonso, M.2
Castro, A.3
Pérez, C.4
Moreno, F.J.5
-
46
-
-
0343052652
-
Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion
-
Matsuura K., Kabuto H., Makino H., Ogawa N. Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion. Journal of Neuroscience Methods 1997, 73:45-48.
-
(1997)
Journal of Neuroscience Methods
, vol.73
, pp. 45-48
-
-
Matsuura, K.1
Kabuto, H.2
Makino, H.3
Ogawa, N.4
-
48
-
-
20744435383
-
Molecular pathophysiology of Parkinson's disease
-
Moore D.J., West A.B., Dawson V.L., Dawson T.M. Molecular pathophysiology of Parkinson's disease. Annual Review of Neuroscience 2005, 28:57-87.
-
(2005)
Annual Review of Neuroscience
, vol.28
, pp. 57-87
-
-
Moore, D.J.1
West, A.B.2
Dawson, V.L.3
Dawson, T.M.4
-
49
-
-
13844269035
-
Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL/6 mice
-
Mori A., Ohashi S., Nakai M., Moriizumi T., Mitsumoto Y. Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL/6 mice. Neuroscience Research 2005, 51:265-274.
-
(2005)
Neuroscience Research
, vol.51
, pp. 265-274
-
-
Mori, A.1
Ohashi, S.2
Nakai, M.3
Moriizumi, T.4
Mitsumoto, Y.5
-
50
-
-
37749047236
-
Glycogen synthase kinase-3β, or a link between amyloid and tau pathology?
-
Muyllaert D., Kremer A., Jaworski T., Borghgraef P., Devijver H., Croes S., Dewachter I., Van Leuven F. Glycogen synthase kinase-3β, or a link between amyloid and tau pathology?. Genes, Brain and Behavior 2008, 7:57-66.
-
(2008)
Genes, Brain and Behavior
, vol.7
, pp. 57-66
-
-
Muyllaert, D.1
Kremer, A.2
Jaworski, T.3
Borghgraef, P.4
Devijver, H.5
Croes, S.6
Dewachter, I.7
Van Leuven, F.8
-
51
-
-
47249083512
-
Differential modulation of Akt/glycogen synthase kinase-3β pathway regulates apoptotic and cytoprotective signaling responses
-
Nair V.D., Olanow C.W. Differential modulation of Akt/glycogen synthase kinase-3β pathway regulates apoptotic and cytoprotective signaling responses. Journal of Biological Chemistry 2008, 283:15469-15478.
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 15469-15478
-
-
Nair, V.D.1
Olanow, C.W.2
-
53
-
-
0032493729
-
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
-
Pap M., Cooper G.M. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. Journal of Biological Chemistry 1998, 273:19929-19932.
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 19929-19932
-
-
Pap, M.1
Cooper, G.M.2
-
54
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
Peso L.d., González-García M., Page C., Herrera R., Nuñez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997, 278:687-689.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Peso, L.1
González-García, M.2
Page, C.3
Herrera, R.4
Nuñez, G.5
-
55
-
-
0034646644
-
Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein
-
Pugazhenthi S., Nesterova A., Sable C., Heidenreich K.A., Boxer L.M., Heasley L.E., Reusch J.E.-B. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. Journal of Biological Chemistry 2000, 275:10761-10766.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 10761-10766
-
-
Pugazhenthi, S.1
Nesterova, A.2
Sable, C.3
Heidenreich, K.A.4
Boxer, L.M.5
Heasley, L.E.6
Reusch, J.E.-B.7
-
56
-
-
79952036901
-
+: the involvement of PI3K/Akt pathway activation
-
+: the involvement of PI3K/Akt pathway activation. Toxicology Letters 2011, 202:1-7.
-
(2011)
Toxicology Letters
, vol.202
, pp. 1-7
-
-
Qin, R.1
Li, X.2
Li, G.3
Tao, L.4
Li, Y.5
Sun, J.6
Kang, X.7
Chen, J.8
-
57
-
-
33845507061
-
Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease
-
Ries V., Henchcliffe C., Kareva T., Rzhetskaya M., Bland R., During M.J., Kholodilov N., Burke R.E. Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:18757-18762.
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, pp. 18757-18762
-
-
Ries, V.1
Henchcliffe, C.2
Kareva, T.3
Rzhetskaya, M.4
Bland, R.5
During, M.J.6
Kholodilov, N.7
Burke, R.E.8
-
58
-
-
0036782149
-
The radical scavenging effects of stilbene glucosides from Polygonum multiflorum
-
Ryu G., Ju J., Park Y., Ryu S., Choi B., Lee B. The radical scavenging effects of stilbene glucosides from Polygonum multiflorum. Archives of Pharmacal Research 2002, 25:636-639.
-
(2002)
Archives of Pharmacal Research
, vol.25
, pp. 636-639
-
-
Ryu, G.1
Ju, J.2
Park, Y.3
Ryu, S.4
Choi, B.5
Lee, B.6
-
59
-
-
58149347052
-
Neuroprotective effects of (±)catechin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mice
-
Ruan H., Yang Y., Zhu X., Wang X., Chen R. Neuroprotective effects of (±)catechin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mice. Neuroscience Letters 2009, 450:152-157.
-
(2009)
Neuroscience Letters
, vol.450
, pp. 152-157
-
-
Ruan, H.1
Yang, Y.2
Zhu, X.3
Wang, X.4
Chen, R.5
-
60
-
-
33751078859
-
Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism
-
Sagi Y., Mandel S., Amit T., Youdim M.B.H. Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism. Neurobiology of Disease 2007, 25:35-44.
-
(2007)
Neurobiology of Disease
, vol.25
, pp. 35-44
-
-
Sagi, Y.1
Mandel, S.2
Amit, T.3
Youdim, M.B.H.4
-
62
-
-
0027504297
-
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
-
Tipton K.F., Singer T.P. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. Journal of Neurochemistry 1993, 61:1191-1206.
-
(1993)
Journal of Neurochemistry
, vol.61
, pp. 1191-1206
-
-
Tipton, K.F.1
Singer, T.P.2
-
63
-
-
70350347175
-
Akt signal transduction dysfunction in Parkinson's disease
-
Timmons S., Coakley M.F., Moloney A.M., Neill C.O'. Akt signal transduction dysfunction in Parkinson's disease. Neuroscience Letters 2009, 467:30-35.
-
(2009)
Neuroscience Letters
, vol.467
, pp. 30-35
-
-
Timmons, S.1
Coakley, M.F.2
Moloney, A.M.3
Neill, C.O'.4
-
64
-
-
48349136909
-
Progress in Parkinson's disease's-Where do we stand?
-
Toulouse A., Sullivan A.M. Progress in Parkinson's disease's-Where do we stand?. Progress in Neurobiology 2008, 85:376-392.
-
(2008)
Progress in Neurobiology
, vol.85
, pp. 376-392
-
-
Toulouse, A.1
Sullivan, A.M.2
-
65
-
-
32544448671
-
Protective effect of Polygonum multiflorum Thunb on amyloid β-peptide 25-35 induced cognitive deficits in mice
-
Um M.-Y., Choi W.-H., Aan J.-Y., Kim S.-R., Ha T.-Y. Protective effect of Polygonum multiflorum Thunb on amyloid β-peptide 25-35 induced cognitive deficits in mice. Journal of Ethnopharmacology 2006, 104:144-148.
-
(2006)
Journal of Ethnopharmacology
, vol.104
, pp. 144-148
-
-
Um, M.-Y.1
Choi, W.-H.2
Aan, J.-Y.3
Kim, S.-R.4
Ha, T.-Y.5
-
66
-
-
39749196233
-
Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice
-
Wakamatsu M., Ishii A., Iwata S., Sakagami J., Ukai Y., Ono M., Kanbe D., Muramatsu S.-i., Kobayashi K., Iwatsubo T., Yoshimoto M. Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice. Neurobiology of Aging 2008, 29:574-585.
-
(2008)
Neurobiology of Aging
, vol.29
, pp. 574-585
-
-
Wakamatsu, M.1
Ishii, A.2
Iwata, S.3
Sakagami, J.4
Ukai, Y.5
Ono, M.6
Kanbe, D.7
Muramatsu, S.-I.8
Kobayashi, K.9
Iwatsubo, T.10
Yoshimoto, M.11
-
67
-
-
34249689633
-
Inhibition of glycogen synthase kinase-3β protects dopaminergic neurons from MPTP toxicity
-
Wang W., Yang Y., Ying C., Li W., Ruan H., Zhu X., You Y., Han Y., Chen R., Wang Y., Li M. Inhibition of glycogen synthase kinase-3β protects dopaminergic neurons from MPTP toxicity. Neuropharmacology 2007, 52:1678-1684.
-
(2007)
Neuropharmacology
, vol.52
, pp. 1678-1684
-
-
Wang, W.1
Yang, Y.2
Ying, C.3
Li, W.4
Ruan, H.5
Zhu, X.6
You, Y.7
Han, Y.8
Chen, R.9
Wang, Y.10
Li, M.11
-
68
-
-
37349124150
-
Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice
-
Wang X., Zhao L., Han T., Chen S., Wang J. Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. European Journal of Pharmacology 2008, 578:339-348.
-
(2008)
European Journal of Pharmacology
, vol.578
, pp. 339-348
-
-
Wang, X.1
Zhao, L.2
Han, T.3
Chen, S.4
Wang, J.5
-
69
-
-
67349106386
-
Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation
-
Wang T., Gu J., Wu P.-F., Wang F., Xiong Z., Yang Y.-J., Wu W.-N., Dong L.-D., Chen J.-G. Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radical Biology & Medicine 2009, 47:229-240.
-
(2009)
Free Radical Biology & Medicine
, vol.47
, pp. 229-240
-
-
Wang, T.1
Gu, J.2
Wu, P.-F.3
Wang, F.4
Xiong, Z.5
Yang, Y.-J.6
Wu, W.-N.7
Dong, L.-D.8
Chen, J.-G.9
-
70
-
-
57749108326
-
Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs
-
Weinreb O., Mandel S., Bar-Am O., Yogev-Falach M., Avramovich-Tirosh Y., Amit T., Youdim M.B.H. Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs. Neurotherapeutics 2009, 6:163-174.
-
(2009)
Neurotherapeutics
, vol.6
, pp. 163-174
-
-
Weinreb, O.1
Mandel, S.2
Bar-Am, O.3
Yogev-Falach, M.4
Avramovich-Tirosh, Y.5
Amit, T.6
Youdim, M.B.H.7
-
71
-
-
0033083082
-
Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias
-
West M.J. Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends in Neurosciences 1999, 22:51-61.
-
(1999)
Trends in Neurosciences
, vol.22
, pp. 51-61
-
-
West, M.J.1
-
72
-
-
0025286104
-
Molecular cloning and expression of glycogen synthase kinase-3/factor A
-
Woodgett J.R. Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO Journal 1990, 9:2431-2438.
-
(1990)
EMBO Journal
, vol.9
, pp. 2431-2438
-
-
Woodgett, J.R.1
-
73
-
-
0034704134
-
Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells
-
Wu W., Lee W.-L., Wu Y.Y., Chen D., Liu T.-J., Jang A., Sharma P.M., Wang P.H. Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells. Journal of Biological Chemistry 2000, 275:40113-40119.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 40113-40119
-
-
Wu, W.1
Lee, W.-L.2
Wu, Y.Y.3
Chen, D.4
Liu, T.-J.5
Jang, A.6
Sharma, P.M.7
Wang, P.H.8
-
74
-
-
42049096551
-
Association between AKT1 gene and Parkinson's disease: a protective haplotype
-
Xiromerisiou G., Hadjigeorgiou G.M., Papadimitriou A., Katsarogiannis E., Gourbali V., Singleton A.B. Association between AKT1 gene and Parkinson's disease: a protective haplotype. Neuroscience Letters 2008, 436:232-234.
-
(2008)
Neuroscience Letters
, vol.436
, pp. 232-234
-
-
Xiromerisiou, G.1
Hadjigeorgiou, G.M.2
Papadimitriou, A.3
Katsarogiannis, E.4
Gourbali, V.5
Singleton, A.B.6
-
76
-
-
0028963084
-
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
-
Yao R., Cooper G. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 1995, 267:2003-2006.
-
(1995)
Science
, vol.267
, pp. 2003-2006
-
-
Yao, R.1
Cooper, G.2
-
77
-
-
38549147516
-
Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3β and a receptor-independent anti-oxidative action
-
Yu Y., Wang J.-R., Sun P.-H., Guo Y., Zhang Z.-J., Jin G.-Z., Zhen X. Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3β and a receptor-independent anti-oxidative action. Journal of Neurochemistry 2008, 104:946-956.
-
(2008)
Journal of Neurochemistry
, vol.104
, pp. 946-956
-
-
Yu, Y.1
Wang, J.-R.2
Sun, P.-H.3
Guo, Y.4
Zhang, Z.-J.5
Jin, G.-Z.6
Zhen, X.7
|