Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation

Free Radical Biology and Medicine

Volumn 47, Issue 3, 2009, Pages 229-240

  Wang, Ting ^a   Gu, Jun ^a   Wu, Peng Fei ^a   Wang, Fang ^a,b,c   Xiong, Zhe ^a   Yang, Yuan Jian ^a   Wu, Wen Ning ^a   Dong, Ling Dan ^a   Chen, Jian Guo ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Free radicals; Middle cerebral artery occlusion; Oxygen glucose deprivation; Reactive oxygen nitrogen species; Tetrahydroxystilbene glucoside

Indexed keywords

2,3,5,4' TETRAHYDROXYSTILBENE 2 O BETA DEXTRO GLUCOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; POLYPHENOL DERIVATIVE; PROTEIN BCL 2; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN; CELLS, CULTURED; CYTOPROTECTION; DOWN-REGULATION; DRUGS, CHINESE HERBAL; GLUCOSIDES; INFARCTION, MIDDLE CEREBRAL ARTERY; MAP KINASE KINASE 4; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; POLYGONUM; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RHIZOME; SIGNAL TRANSDUCTION; SIRTUIN 1; STILBENES;

POLYGONUM MULTIFLORUM;

EID: 67349106386     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.02.027     Document Type: Article

References (61)

1. Doyle K.P., Simon R.P., and Stenzel-Poore M.P. Mechanisms of ischemic brain damage. Neuropharmacology 55 (2008) 310-318
2. Crack P.J., and Taylor J.M. Reactive oxygen species and the modulation of stroke. Free Radic. Biol. Med. 38 (2005) 1433-1444
3. Mehta S.L., Manhas N., and Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res. Rev. 54 (2007) 34-66
4. Sugawara T., Fujimura M., Noshita N., Kim G.W., Saito A., Hayashi T., Narasimhan P., Maier C.M., and Chan P.H. Neuronal death/survival signaling pathways in cerebral ischemia. NeuroRx 1 (2004) 17-25
5. Shen H.M., and Liu Z.G. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic. Biol. Med. 40 (2006) 928-939
6. Slemmer J.E., Shacka J.J., Sweeney M.I., and Weber J.T. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr. Med. Chem. 15 (2008) 404-414
7. Sekhon B., Sekhon C., Khan M., Patel S.J., Singh I., and Singh A.K. N-acetyl cysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res. 971 (2003) 1-8
8. Jiang H., Koubi D., Zhang L., Kuo J., Rodriguez A.I., Hunter T.J., Gautam S.C., and Levine R.A. Inhibitors of iNOS protect PC12 cells against the apoptosis induced by oxygen and glucose deprivation. Neurosci. Lett. 375 (2005) 59-63
9. Cai F., Li C., Wu J., Min Q., Ouyang C., Zheng M., Ma S., Yu W., and Lin F. Modulation of the oxidative stress and nuclear factor kappaB activation by theaflavin 3,3′-gallate in the rats exposed to cerebral ischemia-reperfusion. Folia Biol. (Prague) 53 (2007) 164-172
10. Warner D.S., Sheng H., and Batinic-Haberle I. Oxidants, antioxidants and the ischemic brain. J. Exp. Biol. 207 (2004) 3221-3231
11. Scalbert A., and Williamson G. Dietary intake and bioavailability of polyphenols. J. Nutr. 130 (2000) 2073S-2085S
12. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr. Rev. 56 (1998) 317-333
13. Dore S. Unique properties of polyphenol stilbenes in the brain: more than direct antioxidant actions; gene/protein regulatory activity. NeuroSignals 14 (2005) 61-70
14. Dragsted L.O. Antioxidant actions of polyphenols in humans. Int. J. Vitam. Nutr. Res. 73 (2003) 112-119
15. Sang S., Hou Z., Lambert J.D., and Yang C.S. Redox properties of tea polyphenols and related biological activities. Antioxid. Redox Signal. 7 (2005) 1704-1714
16. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., and Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 480-481 (2001) 243-268
17. Zhang H., Schools G.P., Lei T., Wang W., Kimelberg H.K., and Zhou M. Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Exp. Neurol. 212 (2008) 44-52
18. Jiang J., Wang W., Sun Y.J., Hu M., Li F., and Zhu D.Y. Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. Eur. J. Pharmacol. 561 (2007) 54-62
19. Tsai S.K., Hung L.M., Fu Y.T., Cheng H., Nien M.W., Liu H.Y., Zhang F.B., and Huang S.S. Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats. J. Vasc. Surg. 46 (2007) 346-353
20. Nagai K., Jiang M.H., Hada J., Nagata T., Yajima Y., Yamamoto S., and Nishizaki T. (-)-Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant. Brain Res. 956 (2002) 319-322
21. Xiong Z., Liu C., Wang F., Li C., Wang W., Wang J., and Chen J. Protective effects of breviscapine on ischemic vascular dementia in rats. Biol. Pharm. Bull. 29 (2006) 1880-1885
22. Liu C., Wu J., Gu J., Xiong Z., Wang F., Wang J., Wang W., and Chen J. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats. Pharmacol. Biochem. Behav. 86 (2007) 423-430
23. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., and Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 (2003) 191-196
24. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., Hu L.S., Cheng H.L., Jedrychowski M.P., Gygi S.P., Sinclair D.A., Alt F.W., and Greenberg M.E. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 (2004) 2011-2015
25. Daitoku H., Hatta M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., and Fukamizu A. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl. Acad. Sci. USA 101 (2004) 10042-10047
26. Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., and Mayo M.W. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23 (2004) 2369-2380
27. Chen Y., Wang M., Rosen R.T., and Ho C.T. 2,2-Diphenyl-1-picrylhydrazyl radical-scavenging active components from Polygonum multiflorum Thunb. J. Agric. Food Chem. 47 (1999) 2226-2228
28. Ryu G., Ju J.H., Park Y.J., Ryu S.Y., Choi B.W., and Lee B.H. The radical scavenging effects of stilbene glucosides from Polygonum multiflorum. Arch. Pharm. Res. 25 (2002) 636-639
29. Wang X., Zhao L., Han T., Chen S., and Wang J. Protective effects of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. Eur. J. Pharmacol. 578 (2008) 339-348
30. Liu Q.L., Xiao J.H., Ma R., Ban Y., and Wang J.L. Effect of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-d-glucoside on lipoprotein oxidation and proliferation of coronary arterial smooth cells. J. Asian Nat. Prod. Res. 9 (2007) 689-697
31. Zhang L., Xing Y., Ye C.F., Ai H.X., Wei H.F., and Li L. Learning-memory deficit with aging in APP transgenic mice of Alzheimer's disease and intervention by using tetrahydroxystilbene glucoside. Behav. Brain Res. 173 (2006) 246-254
32. Wang R., Tang Y., Feng B., Ye C., Fang L., Zhang L., and Li L. Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats. Neuroscience 49 (2007) 739-746
33. van Vliet E., Aronica E., Redeker S., Marchi N., Rizzi M., Vezzani A., and Gorter J. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. Epilepsy Res. 60 (2004) 203-213
34. Kunz A., Park L., Abe T., Gallo E.F., Anrather J., Zhou P., and Iadecola C. Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. J. Neurosci. 27 (2007) 7083-7093
35. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J. Cell. Mol. Med. 7 (2003) 249-257
36. Ghosh H.S., Spencer J.V., Ng B., McBurney M.W., and Robbins P.D. Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem. J. 408 (2007) 105-111
37. Peters O., Back T., Lindauer U., Busch C., Megow D., Dreier J., and Dirnagl U. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 18 (1998) 196-205
38. Sugawara T., and Chan P.H. Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid. Redox Signal. 5 (2003) 597-607
39. Yamada J., Yoshimura S., Yamakawa H., Sawada M., Nakagawa M., Hara S., Kaku Y., Iwama T., Naganawa T., Banno Y., Nakashima S., and Sakai N. Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation. Neurosci. Res. 45 (2003) 1-8
40. Desagher S., and Martinou J.C. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10 (2000) 369-377
41. Christophe M., and Nicolas S. Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion. Curr. Pharm. Des. 12 (2006) 739-757
42. Swerdlow R.H. Mitochondrial DNA-related mitochondrial dysfunction in neurodegenerative diseases. Arch. Pathol. Lab. Med. 126 (2002) 271-280
43. 2+ signals and neuronal death in brain ischemia. Stroke 38 (2007) 674-676
44. Arundine M., and Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 34 (2003) 325-337
45. Chinopoulos C., and Adam-Vizi V. Calcium, mitochondria and oxidative stress in neuronal pathology: novel aspects of an enduring theme. FEBS J. 273 (2006) 433-450
46. Sato M., Bagchi D., Tosaki A., and Das D.K. Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN. Free Radic. Biol. Med. 31 (2001) 729-737
47. Yoshizumi M., Kogame T., Suzaki Y., Fujita Y., Kyaw M., Kirima K., Ishizawa K., Tsuchiya K., Kagami S., and Tamaki T. Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells. Br. J. Pharmacol. 136 (2002) 1023-1032
48. Cazevieille C., Muller A., Meynier F., and Bonne C. Superoxide and nitric oxide cooperation in hypoxia/reoxygenation-induced neuron injury. Free Radic. Biol. Med. 14 (1993) 389-395
49. Brown G.C., and Borutaite V. Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. Biochim. Biophys. Acta 1658 (2004) 44-49
50. Iadecola C., Zhang F., Casey R., Nagayama M., and Ross M.E. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J. Neurosci. 17 (1997) 9157-9164
51. Mori K., Togashi H., Ueno K.I., Matsumoto M., and Yoshioka M. Aminoguanidine prevented the impairment of learning behavior and hippocampal long-term potentiation following transient cerebral ischemia. Behav. Brain Res. 120 (2001) 159-168
52. Cardenas A., De Alba J., Moro M.A., Leza J.C., Lorenzo P., and Lizasoain I. Protective effect of N-(3-(aminomethyl)benzyl) acetamidine, an inducible nitric oxide synthase inhibitor, in brain slices exposed to oxygen-glucose deprivation. Eur. J. Pharmacol. 354 (1998) 161-165
53. Kaltschmidt B., Heinrich M., and Kaltschmidt C. Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells. Neuromol. Med. 2 (2002) 299-309
54. Kleinert H., Pautz A., Linker K., and Schwarz P.M. Regulation of the expression of inducible nitric oxide synthase. Eur. J. Pharmacol. 500 (2004) 255-266
55. Ahn K.S., and Aggarwal B.B. Transcription factor NF-kappaB: a sensor for smoke and stress signals. Ann. N.Y. Acad. Sci. 1056 (2005) 218-233
56. Caccamo D., Campisi A., Curro M., Bramanti V., Tringali M., Li Volti G., Vanella A., and Ientile R. Antioxidant treatment inhibited glutamate-evoked NF-kappaB activation in primary astroglial cell cultures. Neurotoxicology 26 (2005) 915-921
57. Li H.L., Huang Y., Zhang C.N., Liu G., Wei Y.S., Wang A.B., Liu Y.Q., Hui R.T., Wei C., Williams G.M., Liu D.P., and Liang C.C. Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways. Free Radic. Biol. Med. 40 (2006) 1756-1775
58. Hou D.X., Luo D., Tanigawa S., Hashimoto F., Uto T., Masuzaki S., Fujii M., and Sakata Y. Prodelphinidin B-4 3′-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Biochem. Pharmacol. 74 (2007) 742-751
59. Chen L., Fischle W., Verdin E., and Greene W.C. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 293 (2001) 1653-1657
60. Laing R.J., Jakubowski J., and Laing R.W. Middle cerebral artery occlusion without craniectomy in rats: which method works best?. Stroke 24 (1993) 294-297
61. Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989) 84-91