메뉴 건너뛰기




Volumn , Issue , 2013, Pages 53-76

Natural or Synthetic Therapeutics That Block PAKs

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84882571121     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-407198-8.00003-5     Document Type: Chapter
Times cited : (1)

References (102)
  • 1
    • 0028464349 scopus 로고
    • Regulation of the Ras signalling network
    • Maruta H, Burgess AW Regulation of the Ras signalling network. Bioessays 1994, 16:489-496.
    • (1994) Bioessays , vol.16 , pp. 489-496
    • Maruta, H.1    Burgess, A.W.2
  • 2
    • 0030811528 scopus 로고    scopus 로고
    • Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts
    • Tang Y, Chen Z, Ambrose D, Liu J, et al. Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol 1997, 17:4454-4464.
    • (1997) Mol Cell Biol , vol.17 , pp. 4454-4464
    • Tang, Y.1    Chen, Z.2    Ambrose, D.3    Liu, J.4
  • 3
    • 0031610579 scopus 로고    scopus 로고
    • PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
    • Manser E, Loo T, Koh C, Zhao Z, et al. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol Cell 1998, 1:183-192.
    • (1998) Mol Cell , vol.1 , pp. 183-192
    • Manser, E.1    Loo, T.2    Koh, C.3    Zhao, Z.4
  • 4
    • 0032479975 scopus 로고    scopus 로고
    • PAK promotes morphological changes by acting upstream of Rac
    • Obermeier A, Ahmed S, Manser E, Ye SC, et al. PAK promotes morphological changes by acting upstream of Rac. EMBO J 1998, 17:4328-4339.
    • (1998) EMBO J , vol.17 , pp. 4328-4339
    • Obermeier, A.1    Ahmed, S.2    Manser, E.3    Ye, S.C.4
  • 5
    • 0033576673 scopus 로고    scopus 로고
    • The CDC42-specific inhibitor derived from ACK blocks the v-Ha-RAS-induced transformation
    • Nur-E-Kamal MSA, Kamal JM, Quresh MM, Maruta H The CDC42-specific inhibitor derived from ACK blocks the v-Ha-RAS-induced transformation. Oncogene 1999, 18:7787-7793.
    • (1999) Oncogene , vol.18 , pp. 7787-7793
    • Nur-E-Kamal, M.S.A.1    Kamal, J.M.2    Quresh, M.M.3    Maruta, H.4
  • 6
    • 0035716159 scopus 로고    scopus 로고
    • Signal therapy for RAS induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation
    • He H, Hirokawa Y, Manser E, Lim L, et al. Signal therapy for RAS induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation. Cancer J 2001, 7:191-202.
    • (2001) Cancer J , vol.7 , pp. 191-202
    • He, H.1    Hirokawa, Y.2    Manser, E.3    Lim, L.4
  • 7
    • 31544476561 scopus 로고    scopus 로고
    • Role of PAK pathway defects in the cognitive deficits of Alzheimer's disease
    • Zhao L, Ma QL, Calon F, Harris-White M, et al. Role of PAK pathway defects in the cognitive deficits of Alzheimer's disease. Nat Neurosci 2006, 9:234-242.
    • (2006) Nat Neurosci , vol.9 , pp. 234-242
    • Zhao, L.1    Ma, Q.L.2    Calon, F.3    Harris-White, M.4
  • 8
    • 70349484472 scopus 로고    scopus 로고
    • An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently
    • Viaud J, Peterson J An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther 2009, 8:2559-2565.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2559-2565
    • Viaud, J.1    Peterson, J.2
  • 9
    • 17344374130 scopus 로고    scopus 로고
    • Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
    • Maroney A, Glicksman M, Basma A, Walton K, et al. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J Neurosci 1998, 18:104-111.
    • (1998) J Neurosci , vol.18 , pp. 104-111
    • Maroney, A.1    Glicksman, M.2    Basma, A.3    Walton, K.4
  • 10
    • 0036635758 scopus 로고    scopus 로고
    • The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants
    • Nheu T, He H, Hirokawa Y, Tamaki K, et al. The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J 2002, 8:328-336.
    • (2002) Cancer J , vol.8 , pp. 328-336
    • Nheu, T.1    He, H.2    Hirokawa, Y.3    Tamaki, K.4
  • 11
    • 0034604338 scopus 로고    scopus 로고
    • Structure of PAK1 in an auto-inhibited conformation reveals a multistage activation switch
    • Lei M, Lu W, Meng W, et al. Structure of PAK1 in an auto-inhibited conformation reveals a multistage activation switch. Cell 2000, 102:387-397.
    • (2000) Cell , vol.102 , pp. 387-397
    • Lei, M.1    Lu, W.2    Meng, W.3
  • 12
    • 27744463434 scopus 로고    scopus 로고
    • Signal therapy of breast cancer xenograft in mice by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance
    • Hirokawa Y, Arnold M, Nakajima H, Zalcberg J, et al. Signal therapy of breast cancer xenograft in mice by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance. Cancer Biol Ther 2005, 4:956-960.
    • (2005) Cancer Biol Ther , vol.4 , pp. 956-960
    • Hirokawa, Y.1    Arnold, M.2    Nakajima, H.3    Zalcberg, J.4
  • 13
    • 0035965944 scopus 로고    scopus 로고
    • Anti-proliferative effects of a new staurosporine derivative isolated from a marine ascidian and its predatory flat worm
    • Schupp P, Steube K, Meyer C, et al. Anti-proliferative effects of a new staurosporine derivative isolated from a marine ascidian and its predatory flat worm. Cancer Lett 2001, 174:165-172.
    • (2001) Cancer Lett , vol.174 , pp. 165-172
    • Schupp, P.1    Steube, K.2    Meyer, C.3
  • 14
    • 0036952785 scopus 로고    scopus 로고
    • Cloning of the staurosporine biosynthetic gene cluster from Streptomyces, sp. TP-ao274 and its heterologous expression in Streptomyces lividans
    • Onaka H, Taniguchi S, Igarashi Y, Furumai T Cloning of the staurosporine biosynthetic gene cluster from Streptomyces, sp. TP-ao274 and its heterologous expression in Streptomyces lividans. J Antibiot (Tokyo) 2002, 55:1063-1071.
    • (2002) J Antibiot (Tokyo) , vol.55 , pp. 1063-1071
    • Onaka, H.1    Taniguchi, S.2    Igarashi, Y.3    Furumai, T.4
  • 15
    • 0028037550 scopus 로고
    • Cloning and expression of rabbit and human tryptophan hydroxylase cDNA in E. coli
    • Tipper J, Citron B, Ribeiro P, Kaufmann S Cloning and expression of rabbit and human tryptophan hydroxylase cDNA in E. coli. Arch Biochem Biophys 1994, 315:445-453.
    • (1994) Arch Biochem Biophys , vol.315 , pp. 445-453
    • Tipper, J.1    Citron, B.2    Ribeiro, P.3    Kaufmann, S.4
  • 16
    • 0033794165 scopus 로고    scopus 로고
    • An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies
    • He H, Hirokawa Y, Levitzki A, Maruta H An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies. Cancer J 2000, 6:243-248.
    • (2000) Cancer J , vol.6 , pp. 243-248
    • He, H.1    Hirokawa, Y.2    Levitzki, A.3    Maruta, H.4
  • 17
    • 84855470323 scopus 로고    scopus 로고
    • Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration
    • Wu W, Sun Z, Wu J, Peng X, et al. Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. PLoS One 2012, 7:e29920.
    • (2012) PLoS One , vol.7
    • Wu, W.1    Sun, Z.2    Wu, J.3    Peng, X.4
  • 18
    • 3142520112 scopus 로고    scopus 로고
    • The Tyr kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation
    • He H, Hirokawa Y, Gazit A, Yamashita Y, et al. The Tyr kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol Ther 2004, 3:96-101.
    • (2004) Cancer Biol Ther , vol.3 , pp. 96-101
    • He, H.1    Hirokawa, Y.2    Gazit, A.3    Yamashita, Y.4
  • 19
    • 33845630173 scopus 로고    scopus 로고
    • Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr kinase inhibitors)
    • Hirokawa Y, Levitzki A, Lessene G, Baell J, et al. Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr kinase inhibitors). Cancer Lett 2007, 245:242-251.
    • (2007) Cancer Lett , vol.245 , pp. 242-251
    • Hirokawa, Y.1    Levitzki, A.2    Lessene, G.3    Baell, J.4
  • 20
    • 0033063429 scopus 로고    scopus 로고
    • Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
    • Schindler T, Sicheri F, Pico A, Gazit A, Levitzki A, Kuriyan J Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol Cell 1999, 3:639-648.
    • (1999) Mol Cell , vol.3 , pp. 639-648
    • Schindler, T.1    Sicheri, F.2    Pico, A.3    Gazit, A.4    Levitzki, A.5    Kuriyan, J.6
  • 21
    • 79953792348 scopus 로고    scopus 로고
    • Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration
    • Yadav V, Denning MF Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Mol Carcinog 2011, 50:346-352.
    • (2011) Mol Carcinog , vol.50 , pp. 346-352
    • Yadav, V.1    Denning, M.F.2
  • 22
    • 77952720804 scopus 로고    scopus 로고
    • Small-molecule PAK inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
    • Murray B, Guo CX, Piraino J, Westwick J, et al. Small-molecule PAK inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Cad Sci USA 2010, 107:9446-9451.
    • (2010) Proc Natl Cad Sci USA , vol.107 , pp. 9446-9451
    • Murray, B.1    Guo, C.X.2    Piraino, J.3    Westwick, J.4
  • 23
    • 0141819123 scopus 로고    scopus 로고
    • PAK4 kinase is essential for embryonic viability and for proper neuronal development
    • Qu J, Li X, Novitch B, Zheng Y, et al. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol 2003, 23:7122-7133.
    • (2003) Mol Cell Biol , vol.23 , pp. 7122-7133
    • Qu, J.1    Li, X.2    Novitch, B.3    Zheng, Y.4
  • 24
    • 0028258610 scopus 로고
    • FK228, a novel antitumor bicyclic depsipeptide, I. Taxonomy, fermentation, isolation, physicochemical and biological properties, and antitumor activity
    • Ueda H, Nakajima H, Hori Y, Fujita T, et al. FK228, a novel antitumor bicyclic depsipeptide, I. Taxonomy, fermentation, isolation, physicochemical and biological properties, and antitumor activity. J Antibiot 1994, 47:301-310.
    • (1994) J Antibiot , vol.47 , pp. 301-310
    • Ueda, H.1    Nakajima, H.2    Hori, Y.3    Fujita, T.4
  • 25
    • 0344431240 scopus 로고    scopus 로고
    • FK228, a potent anti-tumor antibiotic, is a novel histone deacetylase inhibitor
    • Nakajima H, Kim YB, Terano H, Yoshida M, et al. FK228, a potent anti-tumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res 1998, 241:126-133.
    • (1998) Exp Cell Res , vol.241 , pp. 126-133
    • Nakajima, H.1    Kim, Y.B.2    Terano, H.3    Yoshida, M.4
  • 26
    • 31544455853 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma
    • Kobayashi Y, Ohtsuki M, Murakami T, Kobayashi T, et al. Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma. Oncogene 2006, 25:512-524.
    • (2006) Oncogene , vol.25 , pp. 512-524
    • Kobayashi, Y.1    Ohtsuki, M.2    Murakami, T.3    Kobayashi, T.4
  • 27
    • 15044343269 scopus 로고    scopus 로고
    • Suppression of PI 3-kinase/AKT signaling pathway is a determinant of the sensitivity to a novel HDAC inhibitor, FK228, in lung adenocarcinoma cells
    • Kodani M, Igishi T, Matsumoto S, Chikumi H, et al. Suppression of PI 3-kinase/AKT signaling pathway is a determinant of the sensitivity to a novel HDAC inhibitor, FK228, in lung adenocarcinoma cells. Oncol Rep 2005, 13:477-483.
    • (2005) Oncol Rep , vol.13 , pp. 477-483
    • Kodani, M.1    Igishi, T.2    Matsumoto, S.3    Chikumi, H.4
  • 28
    • 77749309291 scopus 로고    scopus 로고
    • Romidepsin (FK228) for the treatment of CTCL
    • Campas-Moya C Romidepsin (FK228) for the treatment of CTCL. Drugs Today 2009, 45:787.
    • (2009) Drugs Today , vol.45 , pp. 787
    • Campas-Moya, C.1
  • 30
    • 3442880458 scopus 로고    scopus 로고
    • A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor
    • Hirokawa Y, Tikoo A, Huynh J, Utermark T, et al. A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor. Cancer J 2004, 10:20-26.
    • (2004) Cancer J , vol.10 , pp. 20-26
    • Hirokawa, Y.1    Tikoo, A.2    Huynh, J.3    Utermark, T.4
  • 31
    • 0027491616 scopus 로고
    • The GTPase-activating NF1 fragment of 91 amino acids reverses the v-Ha-RAS-induced malignant phenotype
    • Nur-E-Kmal MSA, Varga M, Maruta H The GTPase-activating NF1 fragment of 91 amino acids reverses the v-Ha-RAS-induced malignant phenotype. J Biol Chem 1993, 268:22331-22337.
    • (1993) J Biol Chem , vol.268 , pp. 22331-22337
    • Nur-E-Kmal, M.S.A.1    Varga, M.2    Maruta, H.3
  • 32
    • 0028168361 scopus 로고
    • An anti-RAS function of neurofibromatosis type 2 gene product (NF2/Merlin)
    • Tikoo A, Varga M, Ramesh V, Gusella J, et al. An anti-RAS function of neurofibromatosis type 2 gene product (NF2/Merlin). J Biol Chem 1994, 269:23387-23390.
    • (1994) J Biol Chem , vol.269 , pp. 23387-23390
    • Tikoo, A.1    Varga, M.2    Ramesh, V.3    Gusella, J.4
  • 33
    • 0037023648 scopus 로고    scopus 로고
    • A dominant-negative p65 PAK peptide inhibits angiogenesis
    • Kiosses W, Hood J, Yang S, Gerritsen M, et al. A dominant-negative p65 PAK peptide inhibits angiogenesis. Circ Res 2002, 90:697-702.
    • (2002) Circ Res , vol.90 , pp. 697-702
    • Kiosses, W.1    Hood, J.2    Yang, S.3    Gerritsen, M.4
  • 34
    • 63849230362 scopus 로고    scopus 로고
    • PAK1 regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
    • Allen J, Jaffer Z, Park S, Burgin S, et al. PAK1 regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood 2009, 113:2695-2705.
    • (2009) Blood , vol.113 , pp. 2695-2705
    • Allen, J.1    Jaffer, Z.2    Park, S.3    Burgin, S.4
  • 36
    • 0023838394 scopus 로고
    • Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis
    • Grunberger D, Banerjee R, Eisinger K, Oltz E, et al. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 1988, 44:230-232.
    • (1988) Experientia , vol.44 , pp. 230-232
    • Grunberger, D.1    Banerjee, R.2    Eisinger, K.3    Oltz, E.4
  • 37
    • 0030730661 scopus 로고    scopus 로고
    • Preferential cytotoxicity to tumor cells of artepillin C isolated from propolis
    • Matsuno T, Jung SK, Matsumoto Y, Saito M, et al. Preferential cytotoxicity to tumor cells of artepillin C isolated from propolis. Anticancer Res 1997, 17:3565-3568.
    • (1997) Anticancer Res , vol.17 , pp. 3565-3568
    • Matsuno, T.1    Jung, S.K.2    Matsumoto, Y.3    Saito, M.4
  • 38
    • 38049034385 scopus 로고    scopus 로고
    • Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition
    • Awale S, Li F, Onozuka H, Esumi H, et al. Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorg Med Chem 2008, 16:181-189.
    • (2008) Bioorg Med Chem , vol.16 , pp. 181-189
    • Awale, S.1    Li, F.2    Onozuka, H.3    Esumi, H.4
  • 39
    • 16244414339 scopus 로고    scopus 로고
    • Down-regulation of Rac1 activation by caffeic acid in aortic smooth muscle cells
    • Xu JW, Ikeda K, Kobayakawa A, Ikami T, et al. Down-regulation of Rac1 activation by caffeic acid in aortic smooth muscle cells. Life Sci 2005, 76:2861-2872.
    • (2005) Life Sci , vol.76 , pp. 2861-2872
    • Xu, J.W.1    Ikeda, K.2    Kobayakawa, A.3    Ikami, T.4
  • 40
    • 61449164799 scopus 로고    scopus 로고
    • Artepillin C (ARC) in Brazilian green propolis selectively blocks the oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice
    • Messerli S, Ahn MR, Kunimasa K, Yanagihara M, et al. Artepillin C (ARC) in Brazilian green propolis selectively blocks the oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice. Phytother Res 2009, 23:423-427.
    • (2009) Phytother Res , vol.23 , pp. 423-427
    • Messerli, S.1    Ahn, M.R.2    Kunimasa, K.3    Yanagihara, M.4
  • 41
    • 85008741692 scopus 로고    scopus 로고
    • An innovated approach to in vivo screening for the major anti-cancer drugs
    • Nova Science Publishers, pp. 249-59
    • Maruta H An innovated approach to in vivo screening for the major anti-cancer drugs. Horizons in cancer research 2010, 41. Nova Science Publishers, pp. 249-59.
    • (2010) Horizons in cancer research , vol.41
    • Maruta, H.1
  • 42
    • 59449102431 scopus 로고    scopus 로고
    • CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice
    • Demestre M, Messerli S, Celli N, Shahhossini M, et al. CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice. Phytother Res 2009, 23:226-230.
    • (2009) Phytother Res , vol.23 , pp. 226-230
    • Demestre, M.1    Messerli, S.2    Celli, N.3    Shahhossini, M.4
  • 43
    • 79955966556 scopus 로고    scopus 로고
    • Activation of PAK-MEK signaling pathway in malaria parasite-infected erythrocytes
    • Sicard A, Semblat JP, Doerig C, Hamelin R, et al. Activation of PAK-MEK signaling pathway in malaria parasite-infected erythrocytes. Cell Microbiol 2011, 13:836-845.
    • (2011) Cell Microbiol , vol.13 , pp. 836-845
    • Sicard, A.1    Semblat, J.P.2    Doerig, C.3    Hamelin, R.4
  • 44
    • 33847646688 scopus 로고    scopus 로고
    • Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation
    • Wang JX, Tang W, Shi LP, Wan J, et al. Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation. Brit J Pharmacol 2007, 150:652-661.
    • (2007) Brit J Pharmacol , vol.150 , pp. 652-661
    • Wang, J.X.1    Tang, W.2    Shi, L.P.3    Wan, J.4
  • 45
    • 77649189381 scopus 로고    scopus 로고
    • Artesunate induces oncosis-like cell death in vitro and has anti-tumor activity against pancreatic cancer xenografts in vivo
    • Du JH, Zhang HD, Ma ZJ, Ji KM Artesunate induces oncosis-like cell death in vitro and has anti-tumor activity against pancreatic cancer xenografts in vivo. Cancer Chemother Pharmacol 2010, 65:895-902.
    • (2010) Cancer Chemother Pharmacol , vol.65 , pp. 895-902
    • Du, J.H.1    Zhang, H.D.2    Ma, Z.J.3    Ji, K.M.4
  • 46
    • 0019448342 scopus 로고
    • The antimalaria activity of Quassinoids against chloroquine-resistant P. falciparum in vitro
    • Trager W, Polonsky J The antimalaria activity of Quassinoids against chloroquine-resistant P. falciparum in vitro. Am J Trop Med Hyg 1981, 30:531-537.
    • (1981) Am J Trop Med Hyg , vol.30 , pp. 531-537
    • Trager, W.1    Polonsky, J.2
  • 47
    • 0017509714 scopus 로고
    • Antitumor plants. IV. Constituents of S. versicolor
    • Ghosh P, Larrahond J, LeQuesne P, Raffauf R Antitumor plants. IV. Constituents of S. versicolor. Lloydia 1977, 40:364-369.
    • (1977) Lloydia , vol.40 , pp. 364-369
    • Ghosh, P.1    Larrahond, J.2    LeQuesne, P.3    Raffauf, R.4
  • 48
    • 0031610121 scopus 로고    scopus 로고
    • Anticancer activity of glaucarubinone analogues
    • Valeriote F, Corbett T, Grieco P, Moher E, et al. Anticancer activity of glaucarubinone analogues. Oncol Res 1998, 10:201-208.
    • (1998) Oncol Res , vol.10 , pp. 201-208
    • Valeriote, F.1    Corbett, T.2    Grieco, P.3    Moher, E.4
  • 49
    • 65249093662 scopus 로고    scopus 로고
    • Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition
    • Beutler J, Kang MI, Robert F, Clement J, et al. Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. J Nat Prod 2009, 72:503-506.
    • (2009) J Nat Prod , vol.72 , pp. 503-506
    • Beutler, J.1    Kang, M.I.2    Robert, F.3    Clement, J.4
  • 50
    • 0034697303 scopus 로고    scopus 로고
    • Regulation of microfilament organization and invasiveness of breast cancer cells by kinase dead PAK1
    • Adam L, Vadlamudi R, Mandal M, Chernoff J, et al. Regulation of microfilament organization and invasiveness of breast cancer cells by kinase dead PAK1. J Biol Chem 2000, 275:12041-12050.
    • (2000) J Biol Chem , vol.275 , pp. 12041-12050
    • Adam, L.1    Vadlamudi, R.2    Mandal, M.3    Chernoff, J.4
  • 51
    • 16644375433 scopus 로고    scopus 로고
    • The HER2/Grb2/Akt pathway regulates DNA binding activity of AP-1 in breast cancer cells
    • Mendora-Gamboa E, Siwak D, Tari A The HER2/Grb2/Akt pathway regulates DNA binding activity of AP-1 in breast cancer cells. Oncol Rep 2004, 12:904-908.
    • (2004) Oncol Rep , vol.12 , pp. 904-908
    • Mendora-Gamboa, E.1    Siwak, D.2    Tari, A.3
  • 52
    • 79953292298 scopus 로고    scopus 로고
    • The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat and extends the life span of C. elegans
    • Zarse K, Bossecker A, Mueller-Kuhrt L, Siems K, et al. The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat and extends the life span of C. elegans. Horm Metab Res 2011, 43:241-243.
    • (2011) Horm Metab Res , vol.43 , pp. 241-243
    • Zarse, K.1    Bossecker, A.2    Mueller-Kuhrt, L.3    Siems, K.4
  • 53
    • 78650496926 scopus 로고    scopus 로고
    • The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors
    • Castelletti D, Fiaschetti G, Di Dato V, Ziegler U, et al. The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors. Mol Cancer Ther 2010, 9:3145-3157.
    • (2010) Mol Cancer Ther , vol.9 , pp. 3145-3157
    • Castelletti, D.1    Fiaschetti, G.2    Di Dato, V.3    Ziegler, U.4
  • 54
    • 79952229430 scopus 로고    scopus 로고
    • Pancreatic cancers require autophagy for their growth
    • Yang SH, Wang X, Contino G, Leasa M, et al. Pancreatic cancers require autophagy for their growth. Gene Develop 2011, 25:717-729.
    • (2011) Gene Develop , vol.25 , pp. 717-729
    • Yang, S.H.1    Wang, X.2    Contino, G.3    Leasa, M.4
  • 55
    • 33646418727 scopus 로고    scopus 로고
    • Sichuan pepper extracts block the PAK1/cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice
    • Hirokawa Y, Nheu T, Grimm K, Mautner V, et al. Sichuan pepper extracts block the PAK1/cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice. Cancer Biol Ther 2006, 5:305-309.
    • (2006) Cancer Biol Ther , vol.5 , pp. 305-309
    • Hirokawa, Y.1    Nheu, T.2    Grimm, K.3    Mautner, V.4
  • 56
    • 76249092901 scopus 로고    scopus 로고
    • Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression
    • Cai XZ, Wang J, Li XD, Wang GL, et al. Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression. Cancer Biol Ther 2009, 8:1360-1368.
    • (2009) Cancer Biol Ther , vol.8 , pp. 1360-1368
    • Cai, X.Z.1    Wang, J.2    Li, X.D.3    Wang, G.L.4
  • 57
    • 34547945472 scopus 로고    scopus 로고
    • CAPE stimulates glucose uptake through AMPK activation in skeletal muscle cells
    • Lee ES, Uhm KO, Lee YM, Han M, et al. CAPE stimulates glucose uptake through AMPK activation in skeletal muscle cells. Biochem Biophys Res Commun 2007, 361:854-858.
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 854-858
    • Lee, E.S.1    Uhm, K.O.2    Lee, Y.M.3    Han, M.4
  • 58
    • 59249092573 scopus 로고    scopus 로고
    • AMPK mediates curcumin-induced cell death of CaOV3 ovarian cancer cells
    • Pan W, Yang C, Cao C, Song X, et al. AMPK mediates curcumin-induced cell death of CaOV3 ovarian cancer cells. Oncol Rep 2008, 20:1553-1559.
    • (2008) Oncol Rep , vol.20 , pp. 1553-1559
    • Pan, W.1    Yang, C.2    Cao, C.3    Song, X.4
  • 59
    • 24644508916 scopus 로고    scopus 로고
    • Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis
    • Li L, Braiteh FS, Kurzrock R Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 2005, 104:1322-1331.
    • (2005) Cancer , vol.104 , pp. 1322-1331
    • Li, L.1    Braiteh, F.S.2    Kurzrock, R.3
  • 60
    • 67650882757 scopus 로고    scopus 로고
    • Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model
    • Mach C, Mathew L, Mosley S, Kurzrock R, et al. Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model. Anticancer Res 2009, 29:1895-1899.
    • (2009) Anticancer Res , vol.29 , pp. 1895-1899
    • Mach, C.1    Mathew, L.2    Mosley, S.3    Kurzrock, R.4
  • 61
    • 70449520196 scopus 로고    scopus 로고
    • Effect of cyclodextrin complexation of curcumin on its solubility and anti-angiogenic and anti-inflammatory activity in Rat colitis model
    • Yadav V, Suresh S, Devi K, Yadav S Effect of cyclodextrin complexation of curcumin on its solubility and anti-angiogenic and anti-inflammatory activity in Rat colitis model. AAPS Pharm Sci Tech 2009, 10:752-762.
    • (2009) AAPS Pharm Sci Tech , vol.10 , pp. 752-762
    • Yadav, V.1    Suresh, S.2    Devi, K.3    Yadav, S.4
  • 62
    • 0033049036 scopus 로고    scopus 로고
    • Tyr kinase inhibitor emodin suppresses the growth ErbB2-overexpressing breast cancer cells in athymic mice
    • Zhang L, Lao YK, Xia W, Hortbagyi G, et al. Tyr kinase inhibitor emodin suppresses the growth ErbB2-overexpressing breast cancer cells in athymic mice. Clin Cancer Res 1999, 5:343-353.
    • (1999) Clin Cancer Res , vol.5 , pp. 343-353
    • Zhang, L.1    Lao, Y.K.2    Xia, W.3    Hortbagyi, G.4
  • 63
    • 75849147916 scopus 로고    scopus 로고
    • Anti-diabetic effects of emodin involved in the activation of PPARgamma in high-fat diet-fed and low dose of streptozotocin-induced diabetic mice
    • Xue J, Ding W, Liu Y Anti-diabetic effects of emodin involved in the activation of PPARgamma in high-fat diet-fed and low dose of streptozotocin-induced diabetic mice. Fitoterapia 2010, 81:173-177.
    • (2010) Fitoterapia , vol.81 , pp. 173-177
    • Xue, J.1    Ding, W.2    Liu, Y.3
  • 64
    • 0025600993 scopus 로고
    • Berberine-induced morphologic differentiation and down-regulation of c-Ki-ras2 protooncogene expression in human teratocarcinoma cells
    • Chang KS, Gao C, Wang LC Berberine-induced morphologic differentiation and down-regulation of c-Ki-ras2 protooncogene expression in human teratocarcinoma cells. Cancer Lett 1990, 55:103-108.
    • (1990) Cancer Lett , vol.55 , pp. 103-108
    • Chang, K.S.1    Gao, C.2    Wang, L.C.3
  • 65
    • 33744804815 scopus 로고    scopus 로고
    • Inhibition of lipid synthesis through activation of AMPK: an additional mechanism for the hypolipidemic effects of berberine
    • Brusq JM, Ancellin N, Grondin P, Guillard R, et al. Inhibition of lipid synthesis through activation of AMPK: an additional mechanism for the hypolipidemic effects of berberine. J Lipid Res 2006, 47:1281-1288.
    • (2006) J Lipid Res , vol.47 , pp. 1281-1288
    • Brusq, J.M.1    Ancellin, N.2    Grondin, P.3    Guillard, R.4
  • 66
    • 67649515350 scopus 로고    scopus 로고
    • Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells
    • Tsang CM, Lau EP, Di K, Cheung PY, et al. Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells. Int J Mol Med 2009, 24:131-138.
    • (2009) Int J Mol Med , vol.24 , pp. 131-138
    • Tsang, C.M.1    Lau, E.P.2    Di, K.3    Cheung, P.Y.4
  • 67
    • 79955460123 scopus 로고    scopus 로고
    • Potent anti-protozoan activity of a novel semi-synthetic berberine derivative
    • Bahar M, Deng Y, Zhu XH, He SS, et al. Potent anti-protozoan activity of a novel semi-synthetic berberine derivative. Bioorg Med Chem Lett 2011, 21:2606-2610.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 2606-2610
    • Bahar, M.1    Deng, Y.2    Zhu, X.H.3    He, S.S.4
  • 68
    • 9444230640 scopus 로고    scopus 로고
    • The life and times of ivermectin: a success story
    • Omura S, Crump A The life and times of ivermectin: a success story. Nat Rev Microbiol 2004, 2:894-899.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 894-899
    • Omura, S.1    Crump, A.2
  • 69
    • 84882595949 scopus 로고    scopus 로고
    • Ivermectin inactivates the kinase PAK1 and block the PAK1-dependent growth of human ovarian cancer and NF2 tumor cell lines
    • Hashimoto H, Messerli S, Sudo T, Maruta H Ivermectin inactivates the kinase PAK1 and block the PAK1-dependent growth of human ovarian cancer and NF2 tumor cell lines. Drug Discov Ther 2009, 3:243-246.
    • (2009) Drug Discov Ther , vol.3 , pp. 243-246
    • Hashimoto, H.1    Messerli, S.2    Sudo, T.3    Maruta, H.4
  • 71
    • 44649103221 scopus 로고    scopus 로고
    • Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMPK
    • Li HB, Ge YK, Zheng XX, Zhang L Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMPK. Eur J Pharmacol 2008, 588:165-169.
    • (2008) Eur J Pharmacol , vol.588 , pp. 165-169
    • Li, H.B.1    Ge, Y.K.2    Zheng, X.X.3    Zhang, L.4
  • 72
    • 58149287975 scopus 로고    scopus 로고
    • Plant adaptogens increase lifespan and stress resistance in C. elegans
    • Wiegant F, Surinova S, Ytsma E, Langelaar-Makkinje M, et al. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 2009, 10:27-42.
    • (2009) Biogerontology , vol.10 , pp. 27-42
    • Wiegant, F.1    Surinova, S.2    Ytsma, E.3    Langelaar-Makkinje, M.4
  • 73
    • 44449116049 scopus 로고    scopus 로고
    • The influence of Rhodiola quadrifida 50% hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice
    • Skopin'ska-Rozewska E, Malinowski M, Wasiutyn'ski A, Sommer E, et al. The influence of Rhodiola quadrifida 50% hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice. Pol J Vet Sci 2008, 11:97-104.
    • (2008) Pol J Vet Sci , vol.11 , pp. 97-104
    • Skopin'ska-Rozewska, E.1    Malinowski, M.2    Wasiutyn'ski, A.3    Sommer, E.4
  • 74
    • 84867735113 scopus 로고    scopus 로고
    • Coffee polyphenol caffeic acid but not chlorogenic acid increases AMPK and insulin-independent glucose transport in rat skeletal muscle
    • Tsuda S, Egawa T, Ma X, Oshima R, et al. Coffee polyphenol caffeic acid but not chlorogenic acid increases AMPK and insulin-independent glucose transport in rat skeletal muscle. J Nutr Biochem 2012, 23:1403-1409.
    • (2012) J Nutr Biochem , vol.23 , pp. 1403-1409
    • Tsuda, S.1    Egawa, T.2    Ma, X.3    Oshima, R.4
  • 75
    • 20444443930 scopus 로고    scopus 로고
    • Phytoestrogen exposure elevates PTEN levels
    • Waite KA, Sinden MR, Eng C Phytoestrogen exposure elevates PTEN levels. Hum Mol Genet 2005, 14:1457-1463.
    • (2005) Hum Mol Genet , vol.14 , pp. 1457-1463
    • Waite, K.A.1    Sinden, M.R.2    Eng, C.3
  • 76
    • 57149123016 scopus 로고    scopus 로고
    • Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
    • Penumathsa SV, Thirunavukkarasu M, Zhan L, Maulik G, et al. Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium. J Cell Mol Med 2008, 12:2350-2361.
    • (2008) J Cell Mol Med , vol.12 , pp. 2350-2361
    • Penumathsa, S.V.1    Thirunavukkarasu, M.2    Zhan, L.3    Maulik, G.4
  • 77
    • 77953305755 scopus 로고    scopus 로고
    • LKB1 inactivates PAK1 by phosphorylation of Thr 109 in the p21-binding domain
    • Deguchi A, Miyashi H, Kojima Y, Okawa K, et al. LKB1 inactivates PAK1 by phosphorylation of Thr 109 in the p21-binding domain. J Biol Chem 2010, 285:18283-18290.
    • (2010) J Biol Chem , vol.285 , pp. 18283-18290
    • Deguchi, A.1    Miyashi, H.2    Kojima, Y.3    Okawa, K.4
  • 78
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMPK in mechanism of metformin
    • Zhou GC, Meyers R, Li Y, Chen Y, et al. Role of AMPK in mechanism of metformin. J Clin Invest 2001, 108:1167-1174.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.C.1    Meyers, R.2    Li, Y.3    Chen, Y.4
  • 79
    • 20944445254 scopus 로고    scopus 로고
    • Emodin inhibits tumor cell migration through suppression of the PI-3 kinase/CDC42/Rac pathway
    • Huang Q, Shen HM, Ong CN Emodin inhibits tumor cell migration through suppression of the PI-3 kinase/CDC42/Rac pathway. Cell Mol Life Sci 2005, 62:1167-1175.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 1167-1175
    • Huang, Q.1    Shen, H.M.2    Ong, C.N.3
  • 80
    • 57349126316 scopus 로고    scopus 로고
    • Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the PI-3 kinase/Akt/Rac1 signal pathway
    • Shin DH, Kim OK, Jun HS, Kang MK Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the PI-3 kinase/Akt/Rac1 signal pathway. Exp Mol Med 2008, 40:486-494.
    • (2008) Exp Mol Med , vol.40 , pp. 486-494
    • Shin, D.H.1    Kim, O.K.2    Jun, H.S.3    Kang, M.K.4
  • 81
    • 27744455616 scopus 로고    scopus 로고
    • Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMPK
    • Hwang JT, Park IJ, Shin JI, Lee YK, et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMPK. Biochem Biophys Res Commun 2005, 338:694-699.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 694-699
    • Hwang, J.T.1    Park, I.J.2    Shin, J.I.3    Lee, Y.K.4
  • 82
    • 1042289764 scopus 로고    scopus 로고
    • Apigenin induces apoptosis through proteosomal degradation of ErBB2 in ErBB2-overexpressing breast cancer cells via the PI3-kinase/AKT-dependent pathway
    • Way TD, Kao MC, Lin JK Apigenin induces apoptosis through proteosomal degradation of ErBB2 in ErBB2-overexpressing breast cancer cells via the PI3-kinase/AKT-dependent pathway. J Biol Chem 2004, 279:4479-4489.
    • (2004) J Biol Chem , vol.279 , pp. 4479-4489
    • Way, T.D.1    Kao, M.C.2    Lin, J.K.3
  • 83
    • 33749349202 scopus 로고    scopus 로고
    • Polyphenols stimulate AMPK, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDLR-deficient mice
    • Zang M, Xu S, Maitland-Toolan K, Zuccollo A, et al. Polyphenols stimulate AMPK, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDLR-deficient mice. Diabetes 2006, 55:2180-2191.
    • (2006) Diabetes , vol.55 , pp. 2180-2191
    • Zang, M.1    Xu, S.2    Maitland-Toolan, K.3    Zuccollo, A.4
  • 84
    • 80053522700 scopus 로고    scopus 로고
    • Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMPK in HT-29 colon cancer cells
    • Khanal P, Kang BS, Yun HJ, Cho HG, et al. Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMPK in HT-29 colon cancer cells. Biol Pharm Bull 2011, 34:1553-1559.
    • (2011) Biol Pharm Bull , vol.34 , pp. 1553-1559
    • Khanal, P.1    Kang, B.S.2    Yun, H.J.3    Cho, H.G.4
  • 85
    • 0041816087 scopus 로고    scopus 로고
    • Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo
    • Bai X, Cerimele F, Ushio-Fukai M, Waqas M, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem 2003, 278:35501-35507.
    • (2003) J Biol Chem , vol.278 , pp. 35501-35507
    • Bai, X.1    Cerimele, F.2    Ushio-Fukai, M.3    Waqas, M.4
  • 86
    • 84863470109 scopus 로고    scopus 로고
    • Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice
    • Harada S, Kishimoto M, Kobayashi M, Nakamoto K, et al. Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice. J Nat Med 2012, 66:591-599.
    • (2012) J Nat Med , vol.66 , pp. 591-599
    • Harada, S.1    Kishimoto, M.2    Kobayashi, M.3    Nakamoto, K.4
  • 87
    • 35549012934 scopus 로고    scopus 로고
    • OSU-03012, a celecoxib derivative, directly targets PAK
    • Porchia L, Guerra M, Wang YC, Zhang YL, et al. OSU-03012, a celecoxib derivative, directly targets PAK. Mol Pharmacol 2007, 72:1124-1131.
    • (2007) Mol Pharmacol , vol.72 , pp. 1124-1131
    • Porchia, L.1    Guerra, M.2    Wang, Y.C.3    Zhang, Y.L.4
  • 88
    • 84882635245 scopus 로고    scopus 로고
    • OSU-03012 sensitizes TIB-196 myeloma cells to imanitib mesylate via AMPK and STAT3 pathways
    • Bai LY, Weng JR, Tsai CH, Sargeant A, et al. OSU-03012 sensitizes TIB-196 myeloma cells to imanitib mesylate via AMPK and STAT3 pathways. Leuk Res 2010, 34:826-830.
    • (2010) Leuk Res , vol.34 , pp. 826-830
    • Bai, L.Y.1    Weng, J.R.2    Tsai, C.H.3    Sargeant, A.4
  • 89
    • 34547537264 scopus 로고    scopus 로고
    • Activation of AMPK by ErbB2/ErbB1 Tyr kinase inhibitor protects cardiac cells
    • Spector N, Yarden Y, Smith B, Lyass L, et al. Activation of AMPK by ErbB2/ErbB1 Tyr kinase inhibitor protects cardiac cells. Proc Natl Acad Sci USA 2007, 104:10607-10612.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10607-10612
    • Spector, N.1    Yarden, Y.2    Smith, B.3    Lyass, L.4
  • 90
    • 0028073143 scopus 로고
    • Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMPK
    • Sullivan J, Brocklehurst K, Marley A, Carey K, et al. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMPK. FEBBS Lett 1994, 353:33-36.
    • (1994) FEBBS Lett , vol.353 , pp. 33-36
    • Sullivan, J.1    Brocklehurst, K.2    Marley, A.3    Carey, K.4
  • 91
    • 35548999608 scopus 로고    scopus 로고
    • AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner
    • Sun Y, Connors K, Yang DQ AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Mol Cell Biochem 2007, 306:239-245.
    • (2007) Mol Cell Biochem , vol.306 , pp. 239-245
    • Sun, Y.1    Connors, K.2    Yang, D.Q.3
  • 92
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMPK and regulates apoptosis in response to energy stress
    • Shaw R, Kosmatka S, Bardeesy N, Hurley R, et al. The tumor suppressor LKB1 kinase directly activates AMPK and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004, 101:3329-3335.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3329-3335
    • Shaw, R.1    Kosmatka, S.2    Bardeesy, N.3    Hurley, R.4
  • 93
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C, Chang J, Gensch E, Rudner A, et al. A C. elegans mutant that lives twice as long as wild type. Nature 1993, 366:461-464.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4
  • 94
    • 34848850156 scopus 로고    scopus 로고
    • An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    • Greer E, Dowlatshahi D, Banko M, Villen J, et al. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 2007, 17:1646-1656.
    • (2007) Curr Biol , vol.17 , pp. 1646-1656
    • Greer, E.1    Dowlatshahi, D.2    Banko, M.3    Villen, J.4
  • 95
    • 2942662099 scopus 로고    scopus 로고
    • P21-Activated kinase 1 (PAK1): an emerging therapeutic target
    • Vadlamudi R, Kumar R p21-Activated kinase 1 (PAK1): an emerging therapeutic target. Cancer Treat Res 2004, 119:77-88.
    • (2004) Cancer Treat Res , vol.119 , pp. 77-88
    • Vadlamudi, R.1    Kumar, R.2
  • 96
    • 78650036223 scopus 로고    scopus 로고
    • Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in D. melanogaster
    • Lee KS, Lee BS, Semnani S, Avanesian A, et al. Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in D. melanogaster. Rejuven Res 2010, 13:561-570.
    • (2010) Rejuven Res , vol.13 , pp. 561-570
    • Lee, K.S.1    Lee, B.S.2    Semnani, S.3    Avanesian, A.4
  • 97
    • 85027922648 scopus 로고    scopus 로고
    • Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans
    • Pietsch K, Saul N, Shumon Chakrabarti S, Stürzenbaum S, et al. Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans. Biogerontology 2011, 12:329-347.
    • (2011) Biogerontology , vol.12 , pp. 329-347
    • Pietsch, K.1    Saul, N.2    Shumon Chakrabarti, S.3    Stürzenbaum, S.4
  • 98
    • 0034953956 scopus 로고    scopus 로고
    • Heat shock protein accumulation is upregulated in a long-lived mutant of C. elegans
    • Walker G, White T, McColl G, Jenkins N, et al. Heat shock protein accumulation is upregulated in a long-lived mutant of C. elegans. J Gerontol A Biol Sci Med Sci 2001, 56:B281-B287.
    • (2001) J Gerontol A Biol Sci Med Sci , vol.56
    • Walker, G.1    White, T.2    McColl, G.3    Jenkins, N.4
  • 99
    • 0028180628 scopus 로고
    • The yeast and mammalian RAS pathways control transcription of heat shock genes independently of heat shock transcription factor
    • Engelberg D, Zandi E, Parker C, Karin M The yeast and mammalian RAS pathways control transcription of heat shock genes independently of heat shock transcription factor. Mol Cell Biol 1994, 14:4929-4937.
    • (1994) Mol Cell Biol , vol.14 , pp. 4929-4937
    • Engelberg, D.1    Zandi, E.2    Parker, C.3    Karin, M.4
  • 100
    • 0025690737 scopus 로고
    • The heterodimerization of the ErbB1 and ErbB2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation
    • Goldman R, Levy R, Peles E, Yarden Y The heterodimerization of the ErbB1 and ErbB2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation. Biochemistry 1990, 29:11024-11028.
    • (1990) Biochemistry , vol.29 , pp. 11024-11028
    • Goldman, R.1    Levy, R.2    Peles, E.3    Yarden, Y.4
  • 101
    • 70349257239 scopus 로고    scopus 로고
    • Marine two-headed sphingolipid-like compound rhizochalin inhibits EGF-induced transformation of JB6 P+ Cl41 cells
    • Fedrov S, Makarieva T, Guzii A, Shubina L, et al. Marine two-headed sphingolipid-like compound rhizochalin inhibits EGF-induced transformation of JB6 P+ Cl41 cells. Lipids 2009, 44:777-785.
    • (2009) Lipids , vol.44 , pp. 777-785
    • Fedrov, S.1    Makarieva, T.2    Guzii, A.3    Shubina, L.4
  • 102
    • 0032478605 scopus 로고    scopus 로고
    • A GTPase-independent mechanism of PAK1 activation. Regulation by sphingosine and other biologically active lipids
    • Bokoch G, Reilly A, Daniels H, King C, et al. A GTPase-independent mechanism of PAK1 activation. Regulation by sphingosine and other biologically active lipids. J Biol Chem 1998, 273:8137-8144.
    • (1998) J Biol Chem , vol.273 , pp. 8137-8144
    • Bokoch, G.1    Reilly, A.2    Daniels, H.3    King, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.