Anti-proliferative effects of new staurosporine derivatives isolated from a marine ascidian and its predatory flatworm

Cancer Letters

Volumn 174, Issue 2, 2001, Pages 165-172

  Schupp, P ^a   Steube, K ^b   Meyer, C ^b   Proksch, P ^c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b LEIBNIZ INSTITUTE DSMZ GERMAN COLLECTION OF MICROORGANISMS AND CELL CULTURES   (Germany)

^c Institut Pharmazeutische Technologie   (Germany)

Author keywords

Anticancer drug; Human leukemia cell lines; Inhibition of cell proliferation; Staurosporines; Structure activity relationships

Indexed keywords

11 HYDROXY 4' N DEMETHYLSTAUROSPORINE; 11 HYDROXYSTAUROSPORINE; 3 HYDROXY 3' DEMETHOXY 3' HYDROXYSTAUROSPORINE; 3 HYDROXY 4' N METHYLSTAUROSPORINE; 3 HYDROXYSTAUROSPORINE; 3' DEMETHOXY 3' HYDROXYSTAUROSPORINE; 4' N DEMETHYLSTAUROSPORINE; 4' N METHYLSTAUROSPORINE; 7 HYDROXYSTAUROSPORINE; CARBAZOLE DERIVATIVE; CARBON 11; DNA; MIDOSTAURIN; RNA; STAUROSPORINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASCIDIACEA; CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DNA SYNTHESIS; DRUG EFFECT; DRUG INHIBITION; DRUG ISOLATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROXYLATION; IC 50; LEUKEMIA; LEUKEMIA CELL LINE; MACROMOLECULE; MEDICAL ASSESSMENT; NONHUMAN; PREDATOR; PRIORITY JOURNAL; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WORM;

ANIMALS; CELL DIVISION; CELL SURVIVAL; DNA REPLICATION; DNA, NEOPLASM; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PLATYHELMINTHS; STAUROSPORINE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; UROCHORDATA;

ASCIDIA; MYCOBACTERIUM AVIUM COMPLEX (MAC); PLATYHELMINTHES;

EID: 0035965944     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00694-2     Document Type: Article

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