A dominant-negative p65 PAK peptide inhibits angiogenesis

Circulation Research

Volumn 90, Issue 6, 2002, Pages 697-702

  Kiosses, William B ^a   Hood, John ^a   Yang, Suya ^b   Gerritsen, Mary E ^b   Cheresh, David A ^a   Alderson, Nazilla ^a   Schwartz, Martin Alexander ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENENTECH INC   (United States)

Author keywords

Cell contractility; Endothelial cells; Endothelial tube forming assay; p21 activated kinase

Indexed keywords

ADAPTOR PROTEIN; P21 ACTIVATED KINASE; PROTEIN KINASE; PROTEIN NCK; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CHORIOALLANTOIS; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE PRODUCTS, TAT; HUMANS; MUTATION; NEOVASCULARIZATION, PHYSIOLOGIC; ONCOGENE PROTEINS; PEPTIDES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS;

EID: 0037023648     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000014227.76102.5D     Document Type: Article

References (16)

1. Angiogenesis: Regulators and clinical applications
2. Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis
3. A role for p21-activated kinase in endothelial cell migration
4. The p21Rac/Cdc42-activated kinases (PAKs)
5. Activation of Pak by membrane localization mediated by an SH3 domain from the adapter protein Nck
6. In vivo protein transduction: Delivery of a biologically active protein into the mouse
7. HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
8. Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium
9. Stimulation of the Na/H exchanger in human endothelial cells activated by granulocyte and granulocyte-macrophage colony stimulating factor
10. Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels
11. Integrin avb3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
12. Silicone rubber substrata: A new wrinkle in the study of cell locomotion
13. Cell migration: May the force be with you
14. Regulation of endothelial cell morphogenesis by integrins, mechanical forces and matrix guidance pathways
15. A conserved negative regulatory region in αPAK: Inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1
16. Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity