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Volumn , Issue , 2007, Pages 23-70

The methodologies of systems biology

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EID: 84882515392     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-044452085-2/50004-8     Document Type: Chapter
Times cited : (37)

References (112)
  • 2
    • 0037435030 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics
    • Aebersold R, Mann M Mass spectrometry-based proteomics. Nature 2003, 422:198-207.
    • (2003) Nature , vol.422 , pp. 198-207
    • Aebersold, R.1    Mann, M.2
  • 5
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: understanding the cell's functional organization
    • Barabási A-L, Oltvai ZN Network biology: understanding the cell's functional organization. Nature Reviews Genetics 2004, 5:101-113.
    • (2004) Nature Reviews Genetics , vol.5 , pp. 101-113
    • Barabási, A.-L.1    Oltvai, Z.N.2
  • 8
    • 23144442824 scopus 로고    scopus 로고
    • Multiplexed absolute quantification in pro- teomics using artificial QCAT proteins of concatenated signature peptides
    • Beynon RJ, Doherty MK, Pratt JM, Gaskell SJ Multiplexed absolute quantification in pro- teomics using artificial QCAT proteins of concatenated signature peptides. Nature Methods 2005, 2:587-589.
    • (2005) Nature Methods , vol.2 , pp. 587-589
    • Beynon, R.J.1    Doherty, M.K.2    Pratt, J.M.3    Gaskell, S.J.4
  • 11
    • 0000245743 scopus 로고    scopus 로고
    • Statistical modeling: The two cultures
    • Breiman L Statistical modeling: The two cultures. Statistical Science 2001, 16:199-215.
    • (2001) Statistical Science , vol.16 , pp. 199-215
    • Breiman, L.1
  • 13
    • 0033528999 scopus 로고    scopus 로고
    • Functional genomics: Learning to think about gene expression data
    • Brent R Functional genomics: Learning to think about gene expression data. Current Biology 1999, 9:R338-R341.
    • (1999) Current Biology , vol.9
    • Brent, R.1
  • 16
    • 0029927663 scopus 로고    scopus 로고
    • Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically-controlled yeast cultures
    • Davey HM, Davey CL, Woodward AM, Edmonds AN, Lee AW, Kell DB Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically-controlled yeast cultures. Biosystems 1996, 39:43-61.
    • (1996) Biosystems , vol.39 , pp. 43-61
    • Davey, H.M.1    Davey, C.L.2    Woodward, A.M.3    Edmonds, A.N.4    Lee, A.W.5    Kell, D.B.6
  • 17
    • 0029832083 scopus 로고    scopus 로고
    • Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analysis
    • Davey HM, Kell DB Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analysis. Microbiological Reviews 1996, 60:641-696.
    • (1996) Microbiological Reviews , vol.60 , pp. 641-696
    • Davey, H.M.1    Kell, D.B.2
  • 19
    • 18844406001 scopus 로고    scopus 로고
    • Measuring the metabolome: current analytical technologies
    • Dunn WB, Bailey NJC, Johnson HE Measuring the metabolome: current analytical technologies. Analyst 2005, 130:606-625.
    • (2005) Analyst , vol.130 , pp. 606-625
    • Dunn, W.B.1    Bailey, N.J.C.2    Johnson, H.E.3
  • 20
    • 16244402990 scopus 로고    scopus 로고
    • Metabolomics: current analytical platforms and methodologies
    • Dunn WB, Ellis DI Metabolomics: current analytical platforms and methodologies. Trends in Analytical Chemistry 2005, 24:285-294.
    • (2005) Trends in Analytical Chemistry , vol.24 , pp. 285-294
    • Dunn, W.B.1    Ellis, D.I.2
  • 23
    • 0034811140 scopus 로고    scopus 로고
    • Relaxations and fluctuations in myoglobin
    • Frauenfelder H, McMahon BH Relaxations and fluctuations in myoglobin. Biosystems 2001, 62:3-8.
    • (2001) Biosystems , vol.62 , pp. 3-8
    • Frauenfelder, H.1    McMahon, B.H.2
  • 28
    • 0008849269 scopus 로고    scopus 로고
    • From simple to complex oscillatory behaviour in metabolic and genetic control networks
    • Goldbeter A, Gonze D, Houart G, Leloup JC, Halloy J, Dupont G From simple to complex oscillatory behaviour in metabolic and genetic control networks. Chaos 2001, 11:247-260.
    • (2001) Chaos , vol.11 , pp. 247-260
    • Goldbeter, A.1    Gonze, D.2    Houart, G.3    Leloup, J.C.4    Halloy, J.5    Dupont, G.6
  • 33
    • 0037288767 scopus 로고    scopus 로고
    • Systems biology: integrating technology, biology, and computation
    • Hood L Systems biology: integrating technology, biology, and computation. Mechanisms of Ageing and Development 2003, 124:9-16.
    • (2003) Mechanisms of Ageing and Development , vol.124 , pp. 9-16
    • Hood, L.1
  • 36
    • 17644427530 scopus 로고    scopus 로고
    • Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kB pathway: the roles of IKK and IkBa
    • Ihekwaba A, Broomhead DS, Grimley R, Benson N, Kell DB Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kB pathway: the roles of IKK and IkBa. Systems Biology 2004, 1:93-103.
    • (2004) Systems Biology , vol.1 , pp. 93-103
    • Ihekwaba, A.1    Broomhead, D.S.2    Grimley, R.3    Benson, N.4    Kell, D.B.5
  • 40
    • 0003071825 scopus 로고
    • Protonmotive energy-transducing systems: some physical principles and experimental approaches
    • Academic Press, London, C.J. Anthony (Ed.)
    • Kell DB Protonmotive energy-transducing systems: some physical principles and experimental approaches. Bacterial Energy Transduction 1988, 429-490. Academic Press, London. C.J. Anthony (Ed.).
    • (1988) Bacterial Energy Transduction , pp. 429-490
    • Kell, D.B.1
  • 41
    • 2942676743 scopus 로고    scopus 로고
    • Metabolomics and systems biology: making sense of the soup
    • Kell DB Metabolomics and systems biology: making sense of the soup. Current Opinions in Microbiology 2004, 7:296-307.
    • (2004) Current Opinions in Microbiology , vol.7 , pp. 296-307
    • Kell, D.B.1
  • 42
    • 21144442700 scopus 로고    scopus 로고
    • Metabolomics, machine learning and modelling: towards an understanding of the language of cells
    • Kell DB Metabolomics, machine learning and modelling: towards an understanding of the language of cells. Biochemical Society Transactions 2005, 33:520-524.
    • (2005) Biochemical Society Transactions , vol.33 , pp. 520-524
    • Kell, D.B.1
  • 43
    • 33644959172 scopus 로고    scopus 로고
    • Metabolomics, modelling and machine learning in systems biology: towards an under- standing of the languages of cells. The 2005 Theodor Bücher lecture
    • Kell DB Metabolomics, modelling and machine learning in systems biology: towards an under- standing of the languages of cells. The 2005 Theodor Bücher lecture. FEBS Journal 2006, 273:873-894.
    • (2006) FEBS Journal , vol.273 , pp. 873-894
    • Kell, D.B.1
  • 45
    • 0034160040 scopus 로고    scopus 로고
    • On the optimization of classes for the assignment of unidentified read- ing frames in functional genomics programmes: the need for machine learning
    • Kell DB, King RD On the optimization of classes for the assignment of unidentified read- ing frames in functional genomics programmes: the need for machine learning. Trends in Biotechnology 2000, 18:93-98.
    • (2000) Trends in Biotechnology , vol.18 , pp. 93-98
    • Kell, D.B.1    King, R.D.2
  • 47
    • 0002459646 scopus 로고    scopus 로고
    • Snapshots of systems: metabolic control analysis and biotech- nology in the post-genomic era
    • Kluwer Academic Publishers, Dor- drecht, A. Cornish-Bowden, M.L. Cárdenas (Eds.)
    • Kell DB, Mendes P Snapshots of systems: metabolic control analysis and biotech- nology in the post-genomic era. Technological and Medical Implications of Metabolic Control Analysis 2000, 3-25. Kluwer Academic Publishers, Dor- drecht. http://dbk.ch.umist.ac.uk/WhitePapers/mcabio.htm, A. Cornish-Bowden, M.L. Cárdenas (Eds.).
    • (2000) Technological and Medical Implications of Metabolic Control Analysis , pp. 3-25
    • Kell, D.B.1    Mendes, P.2
  • 48
    • 0345743608 scopus 로고    scopus 로고
    • Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era
    • Kell DB, Oliver SG Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. Bioessays 2004, 26:99-105.
    • (2004) Bioessays , vol.26 , pp. 99-105
    • Kell, D.B.1    Oliver, S.G.2
  • 52
    • 0000944264 scopus 로고
    • Metabolic control theory: its role in microbiology and biotechnology
    • Kell DB, Westerhoff HV Metabolic control theory: its role in microbiology and biotechnology. FEMS Microbiology Reviews 1986, 39:305-320.
    • (1986) FEMS Microbiology Reviews , vol.39 , pp. 305-320
    • Kell, D.B.1    Westerhoff, H.V.2
  • 54
    • 0037079054 scopus 로고    scopus 로고
    • Computational systems biology
    • Kitano H Computational systems biology. Nature 2002, 420:206-210.
    • (2002) Nature , vol.420 , pp. 206-210
    • Kitano, H.1
  • 58
    • 0032858948 scopus 로고    scopus 로고
    • Protein folding and interactions revealed by mass spectrometry
    • Last AM, Robinson CV Protein folding and interactions revealed by mass spectrometry. Current Opinion in Chemical biology 1999, 3:564-570.
    • (1999) Current Opinion in Chemical biology , vol.3 , pp. 564-570
    • Last, A.M.1    Robinson, C.V.2
  • 60
    • 0017185443 scopus 로고
    • Simple mathematical models with very complicated dynamics
    • May RM Simple mathematical models with very complicated dynamics. Nature 1976, 261:459-467.
    • (1976) Nature , vol.261 , pp. 459-467
    • May, R.M.1
  • 61
    • 0004239941 scopus 로고
    • Oxford University Press, Oxford
    • Medawar P Pluto's republic 1982, Oxford University Press, Oxford.
    • (1982) Pluto's republic
    • Medawar, P.1
  • 62
    • 0032406131 scopus 로고    scopus 로고
    • Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation
    • Mendes P, Kell DB Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation. Bioinformatics 1998, 14:869-883.
    • (1998) Bioinformatics , vol.14 , pp. 869-883
    • Mendes, P.1    Kell, D.B.2
  • 63
    • 0029993759 scopus 로고    scopus 로고
    • Why and when channeling can decrease pool size at constant net flux in a simple dynamic channel
    • Mendes P, Kell DB, Westerhoff HV Why and when channeling can decrease pool size at constant net flux in a simple dynamic channel. Biochimica Biophysica Acta 1996, 1289:175-186.
    • (1996) Biochimica Biophysica Acta , vol.1289 , pp. 175-186
    • Mendes, P.1    Kell, D.B.2    Westerhoff, H.V.3
  • 65
    • 0347694626 scopus 로고    scopus 로고
    • SpeedScreen: label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands
    • Muckenschnabel I, Falchetto R, Mayr LM, Filipuzzi I SpeedScreen: label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands. Analytical Biochemistry 2004, 324:241-249.
    • (2004) Analytical Biochemistry , vol.324 , pp. 241-249
    • Muckenschnabel, I.1    Falchetto, R.2    Mayr, L.M.3    Filipuzzi, I.4
  • 67
    • 14044260054 scopus 로고    scopus 로고
    • Systems biology, information, disease and drug discovery
    • 5
    • Naylor S Systems biology, information, disease and drug discovery. Drug Discovery World 2004, 6:23-40. 5.
    • (2004) Drug Discovery World , vol.6 , pp. 23-40
    • Naylor, S.1
  • 70
    • 0037323878 scopus 로고    scopus 로고
    • The future: putting Humpty-Dumpty together again
    • Noble D The future: putting Humpty-Dumpty together again. Biochemical Society Transactions 2003, 31:156-158.
    • (2003) Biochemical Society Transactions , vol.31 , pp. 156-158
    • Noble, D.1
  • 71
    • 0242690927 scopus 로고    scopus 로고
    • Control of spatially heterogeneous and time- varying cellular reaction networks: a new summation law
    • Peletier MA, Westerhoff HV, Kholodenko BN Control of spatially heterogeneous and time- varying cellular reaction networks: a new summation law. Journal of Theoretical biology 2003, 225:477-487.
    • (2003) Journal of Theoretical biology , vol.225 , pp. 477-487
    • Peletier, M.A.1    Westerhoff, H.V.2    Kholodenko, B.N.3
  • 76
    • 0036038886 scopus 로고    scopus 로고
    • Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis
    • Pritchard L, Kell DB Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis. European Journal of Biochemistry 2002, 269:3894-3904.
    • (2002) European Journal of Biochemistry , vol.269 , pp. 3894-3904
    • Pritchard, L.1    Kell, D.B.2
  • 78
    • 0037406843 scopus 로고    scopus 로고
    • Thirteen years of building constraint-based in silico models of Escherichia coli
    • Reed JL, Palsson B Thirteen years of building constraint-based in silico models of Escherichia coli. Journal of Bacteriology 2003, 185:2692-2699.
    • (2003) Journal of Bacteriology , vol.185 , pp. 2692-2699
    • Reed, J.L.1    Palsson, B.2
  • 81
    • 0027446595 scopus 로고
    • Around the growth phase transition S. cerevisiae's make-up favours sustained oscillations of intracellular metabolites
    • Richard P, Teusink B, Westerhoff HV, van Dam K Around the growth phase transition S. cerevisiae's make-up favours sustained oscillations of intracellular metabolites. FEBS Letters 1993, 318:80-82.
    • (1993) FEBS Letters , vol.318 , pp. 80-82
    • Richard, P.1    Teusink, B.2    Westerhoff, H.V.3    van Dam, K.4
  • 82
    • 0004261679 scopus 로고
    • Columbia University Press, New York
    • Rosen R Life itself 1991, Columbia University Press, New York.
    • (1991) Life itself
    • Rosen, R.1
  • 83
    • 0344861965 scopus 로고    scopus 로고
    • Model selection methodology in supervised learning with evolutionary computation
    • Rowland JJ Model selection methodology in supervised learning with evolutionary computation. Biosystems 2003, 72:187-196.
    • (2003) Biosystems , vol.72 , pp. 187-196
    • Rowland, J.J.1
  • 85
    • 0004146634 scopus 로고
    • Cambridge University Press, Cambridge
    • Schrödinger E What is life? 1944, Cambridge University Press, Cambridge.
    • (1944) What is life?
    • Schrödinger, E.1
  • 86
    • 0033568523 scopus 로고    scopus 로고
    • New insights into enzyme catalysis - Ground state tunnelling driven by protein dynamics
    • Scrutton NS, Basran J, Sutcliffe MJ New insights into enzyme catalysis - Ground state tunnelling driven by protein dynamics. European Journal of Biochemistry 1999, 264:666-671.
    • (1999) European Journal of Biochemistry , vol.264 , pp. 666-671
    • Scrutton, N.S.1    Basran, J.2    Sutcliffe, M.J.3
  • 88
    • 0036227648 scopus 로고    scopus 로고
    • DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I gyrase
    • Snoep JL, van der Weijden CC, Andersen HW, Westerhoff HV, Jensen PR DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I gyrase. European Journal of Biochemistry 2002, 269:1662-1669.
    • (2002) European Journal of Biochemistry , vol.269 , pp. 1662-1669
    • Snoep, J.L.1    van der Weijden, C.C.2    Andersen, H.W.3    Westerhoff, H.V.4    Jensen, P.R.5
  • 89
    • 84882465211 scopus 로고    scopus 로고
    • Silicon cells
    • Springer, Berlin, L. Alberghina, H.V. Westerhoff (Eds.)
    • Snoep JL, Westerhoff HV Silicon cells. Systems biology 2005, Springer, Berlin. L. Alberghina, H.V. Westerhoff (Eds.).
    • (2005) Systems biology
    • Snoep, J.L.1    Westerhoff, H.V.2
  • 98
    • 0034877874 scopus 로고    scopus 로고
    • The silicon cell, not dead but live!
    • Westerhoff HV The silicon cell, not dead but live!. Metabolic Engineering 2001, 3:207-210.
    • (2001) Metabolic Engineering , vol.3 , pp. 207-210
    • Westerhoff, H.V.1
  • 100
    • 80053609751 scopus 로고    scopus 로고
    • What is Systems Biology? From genes to function and back
    • Springer, Berlin, L. Alberghina, H.V. Westerhoff (Eds.)
    • Westerhoff HV, Hofmeyr JH-S What is Systems Biology? From genes to function and back. Systems biology 2005, Springer, Berlin. L. Alberghina, H.V. Westerhoff (Eds.).
    • (2005) Systems biology
    • Westerhoff, H.V.1    Hofmeyr, J.H.-S.2
  • 101
    • 0023385129 scopus 로고
    • Matrix method for determining the steps most rate-limiting to metabolic fluxes in biotechnological processes
    • Westerhoff HV, Kell DB Matrix method for determining the steps most rate-limiting to metabolic fluxes in biotechnological processes. Biotechnology Bioengineering 1987, 30:101-107.
    • (1987) Biotechnology Bioengineering , vol.30 , pp. 101-107
    • Westerhoff, H.V.1    Kell, D.B.2
  • 102
  • 105
    • 5044227742 scopus 로고    scopus 로고
    • The evolution of molecular biology into systems biology
    • Westerhoff HV, Palsson BO The evolution of molecular biology into systems biology. Nature Biotechnology 2004, 22:1249-1252.
    • (2004) Nature Biotechnology , vol.22 , pp. 1249-1252
    • Westerhoff, H.V.1    Palsson, B.O.2
  • 107
    • 0026323101 scopus 로고
    • Quantitative approaches to the analy- sis of the control and regulation of microbial metabolism
    • Westerhoff HV, van Heeswijk W, Kahn D, Kell DB Quantitative approaches to the analy- sis of the control and regulation of microbial metabolism. Antonie van Leeuwenhoek 1991, 60:193-207.
    • (1991) Antonie van Leeuwenhoek , vol.60 , pp. 193-207
    • Westerhoff, H.V.1    van Heeswijk, W.2    Kahn, D.3    Kell, D.B.4
  • 108
    • 0033780562 scopus 로고    scopus 로고
    • Infrared spectroscopy of enzyme reaction intermediates
    • Wharton CW Infrared spectroscopy of enzyme reaction intermediates. Natural Products Reports 2000, 17:447-453.
    • (2000) Natural Products Reports , vol.17 , pp. 447-453
    • Wharton, C.W.1


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