메뉴 건너뛰기




Volumn 152, Issue 3, 2005, Pages 153-160

Synergistic control of oscillations in the NF-κB signalling pathway

Author keywords

[No Author keywords available]

Indexed keywords

BIOCONTROL; CELLS; GROWTH KINETICS; IMMUNOLOGY; MATHEMATICAL MODELS; NEUROPHYSIOLOGY; RATE CONSTANTS; RNA; SENSITIVITY ANALYSIS;

EID: 27244454289     PISSN: 17412471     EISSN: None     Source Type: Journal    
DOI: 10.1049/ip-syb:20050050     Document Type: Article
Times cited : (47)

References (73)
  • 1
    • 0034625005 scopus 로고    scopus 로고
    • 'Cell signaling pathways as control modules: Complexity for simplicity?'
    • Lauffenburger, D.A.: 'Cell signaling pathways as control modules: complexity for simplicity?', Proc. Natl. Acad. Sci. USA, 2000, 97, pp. 5031-5033
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5031-5033
    • Lauffenburger, D.A.1
  • 2
    • 0038048325 scopus 로고    scopus 로고
    • 'Inferring genetic networks and identifying compound mode of action via expression profiling'
    • Gardner, T.S., di Bernardo, D., Lorenz, D., and Collins, J.J.: 'Inferring genetic networks and identifying compound mode of action via expression profiling', Science, 2003, 301, pp. 102-105
    • (2003) Science , vol.301 , pp. 102-105
    • Gardner, T.S.1    di Bernardo, D.2    Lorenz, D.3    Collins, J.J.4
  • 3
    • 4444226267 scopus 로고    scopus 로고
    • 'Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data'
    • Sontag, E., Kiyatkin, A., and Kholodenko, B.N.: 'Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data', Bioinformatics, 2004, 20, pp. 1877-1886
    • (2004) Bioinformatics , vol.20 , pp. 1877-1886
    • Sontag, E.1    Kiyatkin, A.2    Kholodenko, B.N.3
  • 5
    • 13444278821 scopus 로고    scopus 로고
    • 'Reconstruction of cellular signalling networks and analysis of their properties'
    • Papin, J.A., Hunter, T., Palsson, B.O., and Subramaniam, S.: 'Reconstruction of cellular signalling networks and analysis of their properties', Nat. Rev. Mol. Cell. Biol., 2005, 6, pp. 99-111
    • (2005) Nat. Rev. Mol. Cell. Biol. , vol.6 , pp. 99-111
    • Papin, J.A.1    Hunter, T.2    Palsson, B.O.3    Subramaniam, S.4
  • 6
    • 0742305866 scopus 로고    scopus 로고
    • 'Network biology: Understanding the cell's functional organization'
    • Barabási, A.-L., and Oltvai, Z.N.: 'Network biology: understanding the cell's functional organization', Nat. Rev. Genet., 2004, 5, pp. 101-113
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 101-113
    • Barabási, A.-L.1    Oltvai, Z.N.2
  • 7
    • 3242729569 scopus 로고    scopus 로고
    • 'Quantitative analysis of signaling networks'
    • Santo, H.M., and Kholodenko, B.N.: 'Quantitative analysis of signaling networks', Prog. Biophys. Mol. Biol., 2004, 86, pp. 5-43
    • (2004) Prog. Biophys. Mol. Biol. , vol.86 , pp. 5-43
    • Santo, H.M.1    Kholodenko, B.N.2
  • 8
    • 17644427718 scopus 로고    scopus 로고
    • 'Causal protein-signaling networks derived from multiparameter single-cell data'
    • Sachs, K., Perez, O., Pe'er, D., Lauffenburger, D.A., and Nolan, G.P.: 'Causal protein-signaling networks derived from multiparameter single-cell data', Science, 2005, 308, pp. 523-529
    • (2005) Science , vol.308 , pp. 523-529
    • Sachs, K.1    Perez, O.2    Pe'er, D.3    Lauffenburger, D.A.4    Nolan, G.P.5
  • 9
    • 0037376655 scopus 로고    scopus 로고
    • 'Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell'
    • Tyson, J.J., Chen, K.C., and Novak, B.: 'Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell', Curr. Opin. Cell. Biol., 2003, 15, pp. 221-231
    • (2003) Curr. Opin. Cell. Biol. , vol.15 , pp. 221-231
    • Tyson, J.J.1    Chen, K.C.2    Novak, B.3
  • 10
    • 0036500834 scopus 로고    scopus 로고
    • 'Reverse engineering of biological complexity'
    • Csete M.E., and, Doyle, J.C.: 'Reverse engineering of biological complexity', Science, 2002, 295, pp. 1664-1669
    • (2002) Science , vol.295 , pp. 1664-1669
    • Csete, M.E.1    Doyle, J.C.2
  • 11
    • 0037212568 scopus 로고    scopus 로고
    • 'Understanding complex signaling networks through models and metaphors'
    • Bhalla, U.S.: 'Understanding complex signaling networks through models and metaphors', Prog. Biophys. Mol. Biol., 2003, 81, pp. 45-65
    • (2003) Prog. Biophys. Mol. Biol. , vol.81 , pp. 45-65
    • Bhalla, U.S.1
  • 12
    • 4944258252 scopus 로고    scopus 로고
    • 'Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate'
    • Hornberg, J.J., Tijssen, M.R., and Lankelma, J.: 'Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate', Eur. J. Biochem., 2004, 271, pp. 3905-3913
    • (2004) Eur. J. Biochem. , vol.271 , pp. 3905-3913
    • Hornberg, J.J.1    Tijssen, M.R.2    Lankelma, J.3
  • 13
    • 0036729047 scopus 로고    scopus 로고
    • 'Can a biologist fix a radio?-Or, what I learned while studying apoptosis'
    • Lazebnik, Y.: 'Can a biologist fix a radio?-Or, what I learned while studying apoptosis', Cancer Cell, 2002, 2, pp. 179-182
    • (2002) Cancer Cell , vol.2 , pp. 179-182
    • Lazebnik, Y.1
  • 14
    • 0037079015 scopus 로고    scopus 로고
    • 'Computational approaches to cellular rhythms'
    • Goldbeter, A.: 'Computational approaches to cellular rhythms', Nature, 2002, 420, pp. 238-245
    • (2002) Nature , vol.420 , pp. 238-245
    • Goldbeter, A.1
  • 15
    • 0019497941 scopus 로고
    • 'Frequency encoded biochemical regulation is more accurate than amplitude dependent control'
    • Rapp, P.E., Mees, A.I., and Sparrow C.T.: 'Frequency encoded biochemical regulation is more accurate than amplitude dependent control', J. Theor. Biol., 1981, 90, pp. 531-544
    • (1981) J. Theor. Biol. , vol.90 , pp. 531-544
    • Rapp, P.E.1    Mees, A.I.2    Sparrow, C.T.3
  • 17
    • 0347506766 scopus 로고    scopus 로고
    • 'Signalling networks, inflammation and innate immunity'
    • Dower, S.K., and Qwarnstrom, E.E.: 'Signalling networks, inflammation and innate immunity', Biochem. Soc. Trans., 2003, 31, pp. 1462-1471
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 1462-1471
    • Dower, S.K.1    Qwarnstrom, E.E.2
  • 18
    • 15744374885 scopus 로고    scopus 로고
    • 'Molecular biology. Signal processing in single cells'
    • Isaacs, F.J., Blake, W.J., and Collins, J.J.: 'Molecular biology. Signal processing in single cells', Science, 2005, 307, pp. 1886-1888
    • (2005) Science , vol.307 , pp. 1886-1888
    • Isaacs, F.J.1    Blake, W.J.2    Collins, J.J.3
  • 20
    • 10644221132 scopus 로고    scopus 로고
    • 'Oscillations in transcription factor dynamics: A new way to control gene expression'
    • Nelson, D.E., See, V., Nelson, G., and White, M.R.: 'Oscillations in transcription factor dynamics: a new way to control gene expression', Biochem. Soc. Trans., 2004, 32, pp. 1090-1092
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 1090-1092
    • Nelson, D.E.1    See, V.2    Nelson, G.3    White, M.R.4
  • 21
    • 17644427530 scopus 로고    scopus 로고
    • 'Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kB pathway: The roles of IKK and IkBa'
    • Ihekwaba, A.E,C., Broomhead, D.S., Grimley, R.L., Benson, N., and Kell, D.B.: 'Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kB pathway: the roles of IKK and IkBa', Systems Biology, 2004, 1, pp. 93-103
    • (2004) Systems Biology , vol.1 , pp. 93-103
    • Ihekwaba, A.E.C.1    Broomhead, D.S.2    Grimley, R.L.3    Benson, N.4    Kell, D.B.5
  • 22
    • 21144442700 scopus 로고    scopus 로고
    • 'Metabolomics, machine learning and modelling: Towards an understanding of the language of cells'
    • Kell, D.B.: 'Metabolomics, machine learning and modelling: towards an understanding of the language of cells', Biochem. Soc. Trans., 2005, 33, pp. 520-524
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 520-524
    • Kell, D.B.1
  • 24
    • 0842332416 scopus 로고    scopus 로고
    • 'Monitoring p53's pulse'
    • Tyson, J.J.: 'Monitoring p53's pulse', Nat. Genet., 2004, 36, pp. 113-114
    • (2004) Nat. Genet. , vol.36 , pp. 113-114
    • Tyson, J.J.1
  • 25
    • 17344362384 scopus 로고    scopus 로고
    • 'Prediction and validation of the distinct dynamics of transient and sustained ERK activation'
    • Sasagawa, S., Ozaki, Y., Fujita, K., and Kuroda, S.: 'Prediction and validation of the distinct dynamics of transient and sustained ERK activation', Nat. Cell. Biol., 2005, 7, pp. 365-373
    • (2005) Nat. Cell. Biol. , vol.7 , pp. 365-373
    • Sasagawa, S.1    Ozaki, Y.2    Fujita, K.3    Kuroda, S.4
  • 26
    • 0034613112 scopus 로고    scopus 로고
    • 'Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells'
    • Brightman, F.A., and Fell, D.A.: 'Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells', FEBS Lett., 2000, 482, pp. 169-174
    • (2000) FEBS Lett. , vol.482 , pp. 169-174
    • Brightman, F.A.1    Fell, D.A.2
  • 27
    • 0034019315 scopus 로고    scopus 로고
    • 'Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades'
    • Kholodenko, B.N.: 'Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades', Eur. J. Biochem., 2000, 267, pp. 1583-1588
    • (2000) Eur. J. Biochem. , vol.267 , pp. 1583-1588
    • Kholodenko, B.N.1
  • 28
    • 0037047611 scopus 로고    scopus 로고
    • 'MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network'
    • Bhalla, U.S., Ram, P.T., and Iyengar, R.: 'MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network', Science, 2002, 297, pp. 1018-1023
    • (2002) Science , vol.297 , pp. 1018-1023
    • Bhalla, U.S.1    Ram, P.T.2    Iyengar, R.3
  • 30
    • 0035458732 scopus 로고    scopus 로고
    • 'Time zones: A comparative genetics of circadian clocks'
    • Young, M.W., and Kay, S.A.: 'Time zones: a comparative genetics of circadian clocks', Nat. Rev. Genet., 2001, 2, pp. 702-715
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 702-715
    • Young, M.W.1    Kay, S.A.2
  • 31
    • 12244296161 scopus 로고    scopus 로고
    • 'No transcription-translation feedback in circadian rhythm of KaiC phosphorylation'
    • Tomita, J., Nakajima, M., Kondo, T., and Iwasaki, H.: 'No transcription-translation feedback in circadian rhythm of KaiC phosphorylation', Science, 2005, 307, pp. 251-254
    • (2005) Science , vol.307 , pp. 251-254
    • Tomita, J.1    Nakajima, M.2    Kondo, T.3    Iwasaki, H.4
  • 32
    • 17244373578 scopus 로고    scopus 로고
    • 'Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro'
    • Nakajima, M., Imai, K., Ito, H., Nishiwaki, T., Murayama, Y., Iwasaki, H., Oyama, T., and Kondo, T.: 'Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro', Science, 2005, 308, pp. 414-415
    • (2005) Science , vol.308 , pp. 414-415
    • Nakajima, M.1    Imai, K.2    Ito, H.3    Nishiwaki, T.4    Murayama, Y.5    Iwasaki, H.6    Oyama, T.7    Kondo, T.8
  • 34
    • 0043180477 scopus 로고    scopus 로고
    • 'Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays'
    • Monk, N.A.: 'Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays', Curr. Biol., 2003, 13, pp. 1409-1413
    • (2003) Curr. Biol. , vol.13 , pp. 1409-1413
    • Monk, N.A.1
  • 35
    • 0036234459 scopus 로고    scopus 로고
    • 'Missing pieces in the NF-kappa B puzzle'
    • Ghosh, S., and Karin, M.: 'Missing pieces in the NF-kappa B puzzle', Cell, 2002, 109, pp. 81-96
    • (2002) Cell , vol.109 , pp. 81-96
    • Ghosh, S.1    Karin, M.2
  • 36
    • 0036717195 scopus 로고    scopus 로고
    • 'NF-κB, chemokine gene transcription and tumour growth'
    • Richmond, A.: 'NF-κB, chemokine gene transcription and tumour growth', Nat. Rev. Immunol., 2002, 2, pp. 664-674
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 664-674
    • Richmond, A.1
  • 37
    • 0042809629 scopus 로고    scopus 로고
    • 'Identification of a nuclear factor kappa B-dependent gene network'
    • Tian, B., and Brasier, A.R.: 'Identification of a nuclear factor kappa B-dependent gene network', Recent Prog. Horm. Res., 2003, 58, pp. 95-130
    • (2003) Recent Prog. Horm. Res. , vol.58 , pp. 95-130
    • Tian, B.1    Brasier, A.R.2
  • 38
    • 2342464085 scopus 로고    scopus 로고
    • 'The two NF-kappaB activation pathways and their role in innate and adaptive immunity'
    • Bonizzi, G., and Karin, M.: 'The two NF-kappaB activation pathways and their role in innate and adaptive immunity', Trends Immunol., 2004, 25, pp. 280-288
    • (2004) Trends Immunol. , vol.25 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 39
    • 0024294357 scopus 로고
    • 'Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor'
    • Baeuerle, P.A., and Baltimore, D.: 'Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor', Cell, 1988, 53, pp. 211-217
    • (1988) Cell , vol.53 , pp. 211-217
    • Baeuerle, P.A.1    Baltimore, D.2
  • 40
    • 20444478655 scopus 로고    scopus 로고
    • 'Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling'
    • Tian, B., Nowak, D.E., Jamaluddin, M., Wang, S., and Brasier, A.R.: 'Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling', J. Biol. Chem., 2005, 280, pp. 17435-17448
    • (2005) J. Biol. Chem. , vol.280 , pp. 17435-17448
    • Tian, B.1    Nowak, D.E.2    Jamaluddin, M.3    Wang, S.4    Brasier, A.R.5
  • 41
    • 0027168447 scopus 로고
    • 'NF-kappa B controls expression of inhibitor I kappa B alpha: Evidence for an inducible autoregulatory pathway'
    • Sun, S.C., Ganchi, P.A., Ballard, D.W., and Greene, W.C.: 'NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway', Science, 1993, 259, pp. 1912-1915
    • (1993) Science , vol.259 , pp. 1912-1915
    • Sun, S.C.1    Ganchi, P.A.2    Ballard, D.W.3    Greene, W.C.4
  • 44
    • 0042426090 scopus 로고    scopus 로고
    • 'Segmentation clock: Insights from computational models'
    • Pourquie, O., and Goldbeter, A.: 'Segmentation clock: insights from computational models', Curr. Biol., 2003, 13, R632-R634
    • (2003) Curr. Biol. , vol.13
    • Pourquie, O.1    Goldbeter, A.2
  • 45
    • 0037044575 scopus 로고    scopus 로고
    • 'The IκB-NF-κB signaling module: Temporal control and selective gene activation'
    • Hoffmann, A., Levchenko, A., Scott, M.L., and Baltimore, D.: 'The IκB-NF-κB signaling module: temporal control and selective gene activation', Science, 2002, 298, pp. 1241-1245
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 47
    • 0027513359 scopus 로고
    • 'Responses of metabolic systems to large changes in enzyme activities and effectors. 1. The linear treatment of unbranched chains'
    • Small, J.R., and Kacser, H.: 'Responses of metabolic systems to large changes in enzyme activities and effectors. 1. The linear treatment of unbranched chains', Eur. J. Biochem., 1993, 213, pp. 613-624
    • (1993) Eur. J. Biochem. , vol.213 , pp. 613-624
    • Small, J.R.1    Kacser, H.2
  • 48
    • 0027403498 scopus 로고
    • 'Responses of metabolic systems to large changes in enzyme activities and effectors. 2. The linear treatment of branched pathways and metabolite concentrations - Assessment of the general nonlinear case'
    • Small, J.R., and Kacser, H.: 'Responses of metabolic systems to large changes in enzyme activities and effectors. 2. The linear treatment of branched pathways and metabolite concentrations - assessment of the general nonlinear case', Eur. J. Biochem., 1993, 213, pp. 625-640
    • (1993) Eur. J. Biochem. , vol.213 , pp. 625-640
    • Small, J.R.1    Kacser, H.2
  • 51
    • 0020490497 scopus 로고
    • 'Quantification of the contribution of various steps to the control of mitochondrial respiration'
    • Groen, A.K., Wanders, R.J., Westerhoff, H.V., van der Meer, R., and Tager, J.M.: 'Quantification of the contribution of various steps to the control of mitochondrial respiration', J. Biol. Chem., 1982, 257, pp. 2754-2757
    • (1982) J. Biol. Chem. , vol.257 , pp. 2754-2757
    • Groen, A.K.1    Wanders, R.J.2    Westerhoff, H.V.3    van der Meer, R.4    Tager, J.M.5
  • 52
    • 0027370376 scopus 로고
    • 'GEPASI: A software package for modelling the dynamics, steady states and control of biochemical and other systems'
    • Mendes, P.: 'GEPASI: a software package for modelling the dynamics, steady states and control of biochemical and other systems', Comput. Appl. Biosci., 1993, 9, pp. 563-571
    • (1993) Comput. Appl. Biosci. , vol.9 , pp. 563-571
    • Mendes, P.1
  • 53
    • 0030921160 scopus 로고    scopus 로고
    • 'Biochemistry by numbers: Simulation of biochemical pathways with Gepasi 3'
    • Mendes, P.: 'Biochemistry by numbers: simulation of biochemical pathways with Gepasi 3', Trends Biochem. Sci., 1997, 22, pp. 361-363
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 361-363
    • Mendes, P.1
  • 54
    • 0032406131 scopus 로고    scopus 로고
    • 'Non-linear optimization of biochemical pathways: Applications to metabolic engineering and parameter estimation'
    • Mendes, P., and Kell, D.: 'Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation', Bioinformatics, 1998, 14, pp. 869-883
    • (1998) Bioinformatics , vol.14 , pp. 869-883
    • Mendes, P.1    Kell, D.2
  • 56
    • 0015989446 scopus 로고
    • 'A linear steady-state treatment of enzymatic chains. General properties, control and effector strength'
    • Heinrich, R., and Rapoport, T.A.: 'A linear steady-state treatment of enzymatic chains. General properties, control and effector strength', Eur. J. Biochem., 1974, 42, pp. 89-95
    • (1974) Eur. J. Biochem. , vol.42 , pp. 89-95
    • Heinrich, R.1    Rapoport, T.A.2
  • 57
    • 9744248681 scopus 로고    scopus 로고
    • 'Yeast glycolytic oscillations that are not controlled by a single oscillophore: A new definition of oscillophore strength'
    • Reijenga, K.A., van Megen, Y.M., Kooi, B.W., Bakker, B.M., Snoep, J.L., van Verseveld, H.W., and Westerhoff, H.V.: 'Yeast glycolytic oscillations that are not controlled by a single oscillophore: a new definition of oscillophore strength', J. Theor. Biol., 2005, 232, pp. 385-398
    • (2005) J. Theor. Biol. , vol.232 , pp. 385-398
    • Reijenga, K.A.1    van Megen, Y.M.2    Kooi, B.W.3    Bakker, B.M.4    Snoep, J.L.5    van Verseveld, H.W.6    Westerhoff, H.V.7
  • 58
    • 0000944264 scopus 로고
    • 'Metabolic control theory: Its role in microbiology and biotechnology'
    • Kell, D.B., and Westerhoff, H.V.: 'Metabolic control theory: its role in microbiology and biotechnology', FEMS Microbiol. Rev., 1986, 39, pp. 305-320
    • (1986) FEMS Microbiol. Rev. , vol.39 , pp. 305-320
    • Kell, D.B.1    Westerhoff, H.V.2
  • 59
    • 3042647771 scopus 로고    scopus 로고
    • 'Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs'
    • White, T.A., and Kell, D.B.: 'Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs', Comp. Func. Genomics, 2004, 5, pp. 304-327
    • (2004) Comp. Func. Genomics , vol.5 , pp. 304-327
    • White, T.A.1    Kell, D.B.2
  • 60
    • 0026802334 scopus 로고
    • 'Metabolic Control Analysis - A Survey of Its Theoretical and Experimental Development'
    • Fell, D.A.: 'Metabolic Control Analysis - a Survey of Its Theoretical and Experimental Development', Biochemical Journal, 1992, 286, pp. 313-330
    • (1992) Biochemical Journal , vol.286 , pp. 313-330
    • Fell, D.A.1
  • 61
    • 0017185443 scopus 로고
    • 'Simple mathematical models with very complicated dynamics'
    • May, R.M.: 'Simple mathematical models with very complicated dynamics', Nature, 1976, 261, pp. 459-467
    • (1976) Nature , vol.261 , pp. 459-467
    • May, R.M.1
  • 63
    • 0029993759 scopus 로고    scopus 로고
    • 'Why and when channeling can decrease pool size at constant net flux in a simple dynamic channel'
    • Mendes, P., Kell, D.B., and Westerhoff, H.V.: 'Why and when channeling can decrease pool size at constant net flux in a simple dynamic channel', Biochim. Biophys. Acta, 1996, 1289, pp. 175-186
    • (1996) Biochim. Biophys. Acta , vol.1289 , pp. 175-186
    • Mendes, P.1    Kell, D.B.2    Westerhoff, H.V.3
  • 64
    • 27244434254 scopus 로고    scopus 로고
    • 'The role of modeling in systems biology'
    • Stelling, J., Periwal, V., Szallasi, Z. (Eds.): (MIT Press, Cambridge,)
    • Kell, D.B., and Knowles, J.D.: 'The role of modeling in systems biology', in Stelling, J., Periwal, V., Szallasi, Z. (Eds.): 'System modeling in cellular biology: from concepts to nuts and bolts' (MIT Press, Cambridge, 2005), pp. 1-29
    • (2005) 'System Modeling in Cellular Biology: From Concepts to Nuts and Bolts' , pp. 1-29
    • Kell, D.B.1    Knowles, J.D.2
  • 65
  • 67
    • 0029585284 scopus 로고
    • 'Strategies for manipulating metabolic fluxes in biotechnology'
    • Cornish-Bowden, A., Hofmeyr, J.-H.S., and Cárdenas, M.L.: 'Strategies for manipulating metabolic fluxes in biotechnology', Bioorg. Chem., 1995, 23, pp. 439-449
    • (1995) Bioorg. Chem. , vol.23 , pp. 439-449
    • Cornish-Bowden, A.1    Hofmeyr, J.-H.S.2    Cárdenas, M.L.3
  • 68
    • 0029094167 scopus 로고
    • 'Physiological control of metabolic flux: The requirement for multisite modulation'
    • Fell, D.A., and Thomas, S.: 'Physiological control of metabolic flux: the requirement for multisite modulation', Biochem. J., 1995, 311, pp. 35-39
    • (1995) Biochem. J. , vol.311 , pp. 35-39
    • Fell, D.A.1    Thomas, S.2
  • 69
    • 0032485905 scopus 로고    scopus 로고
    • 'Increasing the flux in metabolic pathways: A metabolic control analysis perspective'
    • Fell, D.A.: 'Increasing the flux in metabolic pathways: A metabolic control analysis perspective', Biotechnol. Bioeng, 1998, 58, pp. 121-124
    • (1998) Biotechnol. Bioeng. , vol.58 , pp. 121-124
    • Fell, D.A.1
  • 73
    • 0346690261 scopus 로고    scopus 로고
    • 'Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach'
    • Fan, Q.W., Specht, K.M., Zhang, C., Goldenberg, D.D., Shokat, K.M., and Weiss, W.A.: 'Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach', Cancer Res, 2003, 63, pp. 8930-8938
    • (2003) Cancer Res. , vol.63 , pp. 8930-8938
    • Fan, Q.W.1    Specht, K.M.2    Zhang, C.3    Goldenberg, D.D.4    Shokat, K.M.5    Weiss, W.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.