Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-Β/Smad activity

Laboratory Investigation

Volumn 90, Issue 3, 2010, Pages 436-447

  Zhang, Dongshan ^a   Sun, Lin ^a   Xian, Wang ^a   Liu, Fuyou ^a   Ling, Guanghui ^a   Xiao, Li ^a   Liu, Yanhong ^a   Peng, Youmin ^a   Haruna, Yoshisuke ^b   Kanwar, Yashpal S ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Microtubule; Paclitaxel; Smad; TGF ; Tubulointerstitial fibrosis; UUO

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; INTEGRIN LINKED KINASE; PACLITAXEL; SCLEROPROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG INHIBITION; DRUG MECHANISM; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; URETER OBSTRUCTION; WESTERN BLOTTING;

ANIMALS; EXTRACELLULAR MATRIX; KIDNEY; MALE; NEPHROSCLEROSIS; PACLITAXEL; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TUBULIN MODULATORS; URETERAL OBSTRUCTION;

EID: 77649134470     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.149     Document Type: Article

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