The effect of an anti-CD3 monoclonal antibody on bleomycin-induced lymphokine production and lung injury

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 1, 1996, Pages 193-200

  Sharma, Surender K ^b   MacLean, James A ^b   Pinto, Clare ^b   Kradin, Richard L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CD3 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 4; LYMPHOKINE; MONOCLONAL ANTIBODY;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; FEMALE; HISTOPATHOLOGY; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATRACHEAL DRUG ADMINISTRATION; LUNG FIBROSIS; LUNG INJURY; LUNG TOXICITY; LUNG WEIGHT; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE;

EID: 0030017322     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.154.1.8680680     Document Type: Article

References (35)

1. Blum, R., S. Carter, and K. Agre. 1973. A clinical review of bleomycin: a new antineoplastic agent. Cancer 31:903-913.
2. Kuo, M., and C. Haidl. 1974. Characterization of chain breakage in DNA induced by bleomycin. Biochem. Biophys. Acta 335:109-114.
3. Adamson, I., and D. Bowden. 1974. The pathogenesis of bleomycin induced pulmonary fibrosis. Am. J. Pathol. 77:185-190.
4. Thrall, R. S., J. R. McCormick, R. M. Jack, R. A. McReynolds, and P. A. Ward. 1979. Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. Am. J. Pathol. 95:117-130.
5. Jules, E. K., and D. A. White. 1990. Bleomycin-induced pulmonary toxicity. Clin. Chest Med. 11:1-20.
6. Chandler, D. B. 1990. Possible mechanisms of bleomycin-induced fibrosis. Clin. Chest Med. 11:21-30.
7. Schrier, D. J., R. G. Kunkel, and S. H. Phan. 1983. The role of strain variation in murine bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 127:63-66.
8. Janick-Buckner, D., G. E. Ranges, and M. P. Hacker. 1989. Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice. Toxicol. Appl. Pharmacol. 100:465-473.
9. Thrall, R. S., and R. W. Barton. 1984. A comparison of lymphocyte populations in lung tissue and in bronchoalveolar lavage fluid of rats at various times during the development of bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 129:279-283.
10. Schrier, D. J., S. H. Phan, and B. M. McGarry. 1983. The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis: a biochemical evaluation. Am. Rev. Respir. Dis. 127:614-617.
11. Thrall, R., J. McCormick, S. Phan, R. Jack, and P. Ward. 1979. The effect of antilymphocyte globulin on the development of bleomycin induced fibrosis in the rat (abstract). Am. Rev. Respir. Dis. 119:A83.
12. Thrall, R., R. Lovett, R. Barton, J. McCormick, S. Phan, and P. Ward. 1980. The effect of T cell depletion on the development of bleomycin induced pulmonary fibrosis in the rat (abstract). Am. Rev. Respir. Dis. 121:A99.
13. Szapiel, S. V., N. A. Elson, J. D. Fulmer, G. W. Hunninghake, and R. G. Crystal. 1979. Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. Am. Rev. Respir. Dis. 120:893-899.
14. Janick-Buckner, D., G. E. Ranges, and M. P. Hacker. 1989. Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice. Toxicol. Appl. Pharmacol. 100:474-484.
15. Piguet, P., M. Collart, G. Grau, Y. Kapanci, and P. Vassalli. 1989. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170:655-663.
16. Portoles, P., J. Rojo, A Golby, M. Bonneville, S. Gromkowski, L. Greenbaum, C. A. Janeway, D. B. Murphy, and K. Bottomly. 1989. Monoclonal antibodies to murine CD3e define distinct epitopes, one of which may interact with CD4 during T cell activation. J. Immunol. 142:4169-4175.
17. Kaplan, E., and P. Meier. 1958. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:457-481.
18. Yankelvich, B., C. Knobloch, M. Nowicki, and G. Dennert. 1989. A novel cell type responsible for marrow graft rejection in mice: T cells with NK phenotype cause acute rejection of marrow grafts. J. Immunol. 142:3423-3428.
19. + cells responsible for acute marrow graft rejection are present in thymus-deficient mice. J. Immunol. 149: 403-412.
20. + cells responsible for acute marrow graft rejection are present in thymus-deficient mice. Cell. Immunol. 134:296-313.
21. + T cells with augmented cytolytic activities in the lung (abstract). Am. J. Respir. Crit. Care Med. 149:A337.
22. Phan, S. H., and S. L. Kunkel. 1992. Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp. Lung Res. 18:29-43.
23. Everson, M., and D. Chandler. 1992. Changes in distribution, morphology, and tumor necrosis factor alpha secretion of alveolar macrophage subpopulations during the development of bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 140:503-512.
24. Scheule, R., R. Perkins, R. Hamilton, and A. Holian. 1992. Bleomycin stimulation of cytokine secretion by the human alveolar macrophages. Am. J. Physiol. 262:386-391.
25. Baecher-Allan, C., and R. Barth. 1993. PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis. Reg. Immunol. 5:207-217.
26. Giri, S., D. Hyde, and M. Hollinger. 1993. Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice. Thorax 48:953-954.
27. Smith, R., R. Strieter, S. Phan, N. Lukacs, G. Huffnagle, C. Wilke, M. Burdick, P. Lincoln, H. Evanoff, and S. Kunkel. 1994. Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury. J. Immunol. 153:4704-4712.
28. Marathias, K. P., F. I. Preffer, C. Pinto, and R. L. Kradin. 1991. Most human pulmonary infiltrating lymphocytes display the surface immune phenotype and functional responses of sensitized T cells. Am. J. Respir. Cell Mol. Biol. 5:470-476.
29. Pernis, A., S. Gupta, K. Gollob, E. Garfein, R. Coffman, C. Schindler, and P. Rothman. 1995. Lack of interferon-gamma receptor beta chain and the prevention of intereferon-gamma signaling in Th1 cells. Science 269:245-247.
30. Rosenstein, M., S. Ettinghausen, and S. Rosenberg. 1986. Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2. J. Immunol. 137:1735-1742.
31. Anderson, T., T. Hayes, M. Gately, L. Stern, and G. Truitt. 1988. Toxicity of human recombinant interleukin-2 in the mouse is mediated by interleukin-activated lymphocytes: separation of efficacy and toxicity by selective lymphocyte depletion. Lab. Invest. 59:598-612.
32. Damle, N., L. Doyle, J. Bender, and E. Bradley. 1987. Interleukin-2-activated human lymphocytes exhibit enhanced adhesion to normal vascular endothelilum cells and cause their lysis. J. Immunol. 138: 1779-1785.
33. Reiter, J. 1993. Interferon: a major regulator of natural killer cell-mediated cytotoxicity. J. Interferon Res. 13:247-257.
34. Hirsch, R., J. Archibald, and R. Gress. 1991. Differential T cell hyporesponsiveness induced by in vivo administration of intact or F(ab′)2 fragments of anti-CD3 monoclonal antibody: F(ab′)2 fragments induce a selective T helper dysfunction. J. Immunol. 147:2088-2093.
35. Kradin, R., M. Divertie, R. Colvin, J. Ramirez, J. Ryu, H. Carpenter, and A. Bhan. 1986. Usual interstitial pneumonitis is a T-cell alveolitis. Clin. Immunol. Immunopathol. 40:224-235.