Dioscorea alata Attenuates Renal Interstitial Cellular Fibrosis by Regulating Smad- and Epithelial-Mesenchymal Transition Signaling Pathways

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Liu, Shu Fen ^a   Chang, Shan Yu ^b   Lee, Tao Chen ^c   Chuang, Lea Yea ^a   Guh, Jinn Yuh ^a   Hung, Chien Ya ^b   Hung, Tsung Jen ^b   Hung, Yu Ju ^d   Chen, Po Yi ^b   Hsieh, Pei fang ^b   Yang, Yu Lin ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALPHA SMOOTH MUSCLE ACTIN; DIOSCOREA ALATA EXTRACT; FIBRONECTIN; GELATINASE A; PLANT EXTRACT; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; URINARY TRACT AGENT; UVOMORULIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIOSCOREA ALATA; DRUG EFFECT; DRUG MECHANISM; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; IMMUNOFLUORESCENCE; KIDNEY FIBROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

3-HYDROXYBUTYRIC ACID; ANIMALS; CADHERINS; CELL LINE; CELL SURVIVAL; DRUGS, CHINESE HERBAL; EPITHELIAL-MESENCHYMAL TRANSITION; FIBRONECTINS; FIBROSIS; KIDNEY; KIDNEY DISEASES; RATS; SIGNAL TRANSDUCTION; SMAD PROTEINS, RECEPTOR-REGULATED; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

DIOSCOREA ALATA; GASTROPODA; RATTUS;

EID: 84869077659     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047482     Document Type: Article

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