Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes

Gene

Volumn 527, Issue 2, 2013, Pages 462-468

  Kalnina, Ineta ^a,b   Zaharenko, Linda ^a   Vaivade, Iveta ^a   Rovite, Vita ^a   Nikitina Zake, Liene ^a   Peculis, Raitis ^a   Fridmanis, Davids ^a   Geldnere, Kristine ^c   Jacobsson, Josefin A ^d   Almen, Markus S ^d   Pirags, Valdis ^a,b,c   Schiöth, Helgi B ^d   Klovins, Janis ^a  

^a LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^b UNIVERSITY OF LATVIA   (Latvia)

^c PAULS STRADINS CLINICAL UNIVERSITY HOSPITAL   (Latvia)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Association study; FTO; Latvian population; Obesity; TMEM18; Type 2 diabetes

Indexed keywords

MEMBRANE PROTEIN; TRANSMEMBRANE PROTEIN 18; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; FAT MASS AND OBESITY ASSOCIATED GENE; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN RESISTANCE; INTRON; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADD; ADDITIVE; ASSOCIATION STUDY; BMI; BODY MASS INDEX; CEU; CI; CONFIDENCE INTERVAL; CORRECTED EMPIRICAL P-VALUE; EMP2; FREQ; FREQUENCY; FTO; GENOME WIDE ASSOCIATION; GWA; ICD-10; INTERNATIONAL STATISTICAL CLASSIFICATION OF DISEASES 10TH REVISION; IROQUOIS HOMEOBOX 3; IRX3; LATVIAN GENOME DATA BASE; LATVIAN POPULATION; LD; LGDB; LINKAGE DISEQUILIBRIUM; LOGARITHMICALLY TRANSFORMED BODY MASS INDEX VALUES; LOGBMI; N; NON-SIGNIFICANT; NS; NUMBER; OBESITY; ODDS RATIO; OR; P - VALUES DERIVED PERFORMING PERMUTATION TESTS SPECIFYING 100000 PERMUTATIONS AND CORRECTED FOR MULTIPLE TESTING (EMP2); P-PERM; RAF; REC; RECESSIVE; RISK ALLELE FREQUENCY; SD; SINGLE NUCLEOTIDE POLYMORPHISMS; SNP; STANDARD DEVIATION; T2D; THE FAT MASS AND OBESITY ASSOCIATED; TMEM18; TRANSMEMBRANE 18; TYPE 2 DIABETES; UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE;

AGE FACTORS; AGE OF ONSET; DIABETES MELLITUS, TYPE 2; HUMANS; MEMBRANE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS;

EID: 84881556838     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.06.079     Document Type: Article

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