-
1
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
DOI 10.1038/ng2048, PII NG2048
-
Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-726 (Pubitemid 46848595)
-
(2007)
Nature Genetics
, vol.39
, Issue.6
, pp. 724-726
-
-
Dina, C.1
Meyre, D.2
Gallina, S.3
Durand, E.4
Korner, A.5
Jacobson, P.6
Carlsson, L.M.S.7
Kiess, W.8
Vatin, V.9
Lecoeur, C.10
Delplanque, J.11
Vaillant, E.12
Pattou, F.13
Ruiz, J.14
Weill, J.15
Levy-Marchal, C.16
Horber, F.17
Potoczna, N.18
Hercberg, S.19
Le, S.C.20
Bougneres, P.21
Kovacs, P.22
Marre, M.23
Balkau, B.24
Cauchi, S.25
Chevre, J.-C.26
Froguel, P.27
more..
-
2
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
DOI 10.1126/science.1141634
-
Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894 (Pubitemid 46764279)
-
(2007)
Science
, vol.316
, Issue.5826
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
Lindgren, C.M.6
Perry, J.R.B.7
Elliott, K.S.8
Lango, H.9
Rayner, N.W.10
Shields, B.11
Harries, L.W.12
Barrett, J.C.13
Ellard, S.14
Groves, C.J.15
Knight, B.16
Patch, A.-M.17
Ness, A.R.18
Ebrahim, S.19
Lawlor, D.A.20
Ring, S.M.21
Ben-Shlomo, Y.22
Jarvelin, M.-R.23
Sovio, U.24
Bennett, A.J.25
Melzer, D.26
Ferrucci, L.27
Loos, R.J.F.28
Barroso, I.29
Wareham, N.J.30
Karpe, F.31
Owen, K.R.32
Cardon, L.R.33
Walker, M.34
Hitman, G.A.35
Palmer, C.N.A.36
Doney, A.S.F.37
Morris, A.D.38
Smith, G.D.39
Hattersley, A.T.40
McCarthy, M.I.41
more..
-
3
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants
-
DOI 10.1126/science.1142382
-
Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007;316:1341-1345 (Pubitemid 46871655)
-
(2007)
Science
, vol.316
, Issue.5829
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
Willer, C.J.4
Li, Y.5
Duren, W.L.6
Erdos, M.R.7
Stringham, H.M.8
Chines, P.S.9
Jackson, A.U.10
Prokunina-Olsson, L.11
Ding, C.-J.12
Swift, A.J.13
Narisu14
Hu, T.15
Pruim, R.16
Xiao, R.17
Li, X.-Y.18
Conneely, K.N.19
Riebow, N.L.20
Sprau, A.G.21
Tong, M.22
White, P.P.23
Hetrick, K.N.24
Barnhart, M.W.25
Bark, C.W.26
Goldstein, J.L.27
Watkins, L.28
Xiang, F.29
Saramies, J.30
Buchanan, T.A.31
Watanabe, R.M.32
Valle, T.T.33
Kinnunen, L.34
Abecasis, G.R.35
Pugh, E.W.36
Doheny, K.F.37
Bergman, R.N.38
Tuomilehto, J.39
Collins, F.S.40
Boehnke, M.41
more..
-
4
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115
-
(2007)
PLoS Genet
, vol.3
-
-
Scuteri, A.1
Sanna, S.2
Chen, W.M.3
-
5
-
-
77953292057
-
The genetics of obesity: FTO leads the way
-
Fawcett KA, Barroso I. The genetics of obesity: FTO leads the way. Trends Genet 2010;26:266-274
-
(2010)
Trends Genet
, vol.26
, pp. 266-274
-
-
Fawcett, K.A.1
Barroso, I.2
-
6
-
-
41549129937
-
Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
-
Al-Attar SA, Pollex RL, Ban MR, et al. Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Cardiovasc Diabetol 2008;7:5
-
(2008)
Cardiovasc Diabetol
, vol.7
, pp. 5
-
-
Al-Attar, S.A.1
Pollex, R.L.2
Ban, M.R.3
-
7
-
-
44749088973
-
Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome
-
Barber TM, Bennett AJ, Groves CJ, et al. Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetologia 2008;51:1153-1158
-
(2008)
Diabetologia
, vol.51
, pp. 1153-1158
-
-
Barber, T.M.1
Bennett, A.J.2
Groves, C.J.3
-
8
-
-
44749083224
-
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
-
Freathy RM, Timpson NJ, Lawlor DA, et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes 2008;57:1419-1426
-
(2008)
Diabetes
, vol.57
, pp. 1419-1426
-
-
Freathy, R.M.1
Timpson, N.J.2
Lawlor, D.A.3
-
9
-
-
43049149732
-
Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
-
Hertel JK, Johansson S, Raeder H, et al. Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). Diabetologia 2008;51:971-977
-
(2008)
Diabetologia
, vol.51
, pp. 971-977
-
-
Hertel, J.K.1
Johansson, S.2
Raeder, H.3
-
10
-
-
41549127655
-
Association of the FTO gene with BMI
-
DOI 10.1038/oby.2007.126, PII OBY2007126
-
Hunt SC, Stone S, Xin Y, et al. Association of the FTO gene with BMI. Obesity (Silver Spring) 2008;16:902-904 (Pubitemid 351465652)
-
(2008)
Obesity
, vol.16
, Issue.4
, pp. 902-904
-
-
Hunt, S.C.1
Stone, S.2
Xin, Y.3
Scherer, C.A.4
Magness, C.L.5
Iadonato, S.P.6
Hopkins, P.N.7
Adams, T.D.8
-
11
-
-
51849166353
-
Impact on weight dynamics and general growth of the common FTO rs9939609: A longitudinal Danish cohort study
-
Lond
-
Jess T, Zimmermann E, Kring SI, et al. Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study. Int J Obes (Lond) 2008;32:1388-1394
-
(2008)
Int J Obes
, vol.32
, pp. 1388-1394
-
-
Jess, T.1
Zimmermann, E.2
Kring, S.I.3
-
12
-
-
48249100977
-
Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort
-
Marvelle AF, Lange LA, Qin L, Adair LS, Mohlke KL. Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Diabetes 2008;57:1987-1991
-
(2008)
Diabetes
, vol.57
, pp. 1987-1991
-
-
Marvelle, A.F.1
Lange, L.A.2
Qin, L.3
Adair, L.S.4
Mohlke, K.L.5
-
13
-
-
58149340093
-
Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: Longitudinal analyses in two cohort studies and functional test
-
Qi L, Kang K, Zhang C, et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes 2008;57:3145-3151
-
(2008)
Diabetes
, vol.57
, pp. 3145-3151
-
-
Qi, L.1
Kang, K.2
Zhang, C.3
-
14
-
-
70450285199
-
Prognostic significance of FTO genotype in the development of obesity in Japanese: The J-SHIPP study
-
Lond
-
Tabara Y, Osawa H, Guo H, et al. Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study. Int J Obes (Lond) 2009;33:1243-1248
-
(2009)
Int J Obes
, vol.33
, pp. 1243-1248
-
-
Tabara, Y.1
Osawa, H.2
Guo, H.3
-
15
-
-
77958149766
-
FTO Genotype and Weight Gain in Obese and Normal Weight Adults from a Norwegian Population Based Cohort (the HUNT Study)
-
Wangensteen T, Egeland T, Akselsen H, Holmen J, Undlien D, Retterstol L. FTO Genotype and Weight Gain in Obese and Normal Weight Adults From a Norwegian Population Based Cohort (the HUNT Study). Exp Clin Endocrinol Diabetes, 2010;118:649-652
-
(2010)
Exp Clin Endocrinol Diabetes
, vol.118
, pp. 649-652
-
-
Wangensteen, T.1
Egeland, T.2
Akselsen, H.3
Holmen, J.4
Undlien, D.5
Retterstol, L.6
-
16
-
-
73249138412
-
The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924
-
Jacobsson JA, Risérus U, Axelsson T, Lannfelt L, Schiöth HB, Fredriksson R. The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924. BMC Med Genet 2009;10:131
-
(2009)
BMC Med Genet
, vol.10
, pp. 131
-
-
Jacobsson, J.A.1
Risérus, U.2
Axelsson, T.3
Lannfelt, L.4
Schiöth, H.B.5
Fredriksson, R.6
-
17
-
-
71249132095
-
A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data
-
Luan J, Kerner B, Zhao JH, et al. A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data. BMC Proc 2009;3(Suppl. 7):S115
-
(2009)
BMC Proc
, vol.3
, Issue.SUPPL. 7
-
-
Luan, J.1
Kerner, B.2
Zhao, J.H.3
-
18
-
-
77956894257
-
Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling
-
Kaakinen M, Läärä E, Pouta A, et al. Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling. Am J Epidemiol 2010;172:653-665
-
(2010)
Am J Epidemiol
, vol.172
, pp. 653-665
-
-
Kaakinen, M.1
Läärä, E.2
Pouta, A.3
-
19
-
-
1542327893
-
The Nord-Trøndelag Health Study 1995-97 (HUNT2): Objectives, contents, methods and participation
-
Holmen J, Midthjell K, Krüger Ø, et al. The Nord-Trøndelag Health Study 1995-97 (HUNT2): objectives, contents, methods and participation. Nor Epidemiol 2003;13:19-32
-
(2003)
Nor Epidemiol
, vol.13
, pp. 19-32
-
-
Holmen, J.1
Midthjell, K.2
Krüger, Ø.3
-
21
-
-
0034520384
-
Prevention of cardiovascular disease and diabetes: Lessons from the Malmö Preventive Project
-
DOI 10.1046/j.1365-2796.2000.00766.x
-
Nilsson P, Berglund G. Prevention of cardiovascular disease and diabetes: lessons from the Malmö Preventive Project. J Intern Med 2000;248:455-462 (Pubitemid 32052001)
-
(2000)
Journal of Internal Medicine
, vol.248
, Issue.6
, pp. 455-462
-
-
Nilsson, P.1
Berglund, G.2
-
22
-
-
34548292504
-
PLINK: A tool set for whole-genome association and population-based linkage analyses
-
DOI 10.1086/519795
-
Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575 (Pubitemid 47330214)
-
(2007)
American Journal of Human Genetics
, vol.81
, Issue.3
, pp. 559-575
-
-
Purcell, S.1
Neale, B.2
Todd-Brown, K.3
Thomas, L.4
Ferreira, M.A.R.5
Bender, D.6
Maller, J.7
Sklar, P.8
De Bakker, P.I.W.9
Daly, M.J.10
Sham, P.C.11
-
23
-
-
66649127113
-
METAN: Stata module for fixed and random effects meta-analysis
-
Chestnut Hill, MA, Boston College Department of Economics, Revised 19 May
-
Harris R, Bradburn M, Deeks J, et al. METAN: Stata module for fixed and random effects meta-analysis. In Statistical Software Components S456798. Chestnut Hill, MA, Boston College Department of Economics, Revised 19 May 2009
-
(2009)
Statistical Software Components S456798
-
-
Harris, R.1
Bradburn, M.2
Deeks, J.3
-
24
-
-
77952714079
-
GWAMA: Software for genome-wide association meta-analysis
-
Mägi R, Morris AP. GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics 2010;11:288
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 288
-
-
Mägi, R.1
Morris, A.P.2
-
25
-
-
47749128415
-
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
-
Sanghera DK, Ortega L, Han S, et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 2008;9:59
-
(2008)
BMC Med Genet
, vol.9
, pp. 59
-
-
Sanghera, D.K.1
Ortega, L.2
Han, S.3
-
26
-
-
77956283111
-
Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study
-
Bressler J, Kao WH, Pankow JS, Boerwinkle E. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. PLoS ONE 2010;5:e10521
-
(2010)
PLoS ONE
, vol.5
-
-
Bressler, J.1
Kao, W.H.2
Pankow, J.S.3
Boerwinkle, E.4
-
27
-
-
58149470594
-
FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians
-
Yajnik CS, Janipalli CS, Bhaskar S, et al. FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia 2009;52:247-252
-
(2009)
Diabetologia
, vol.52
, pp. 247-252
-
-
Yajnik, C.S.1
Janipalli, C.S.2
Bhaskar, S.3
-
28
-
-
77955981202
-
The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels
-
Berulava T, Horsthemke B. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur J Hum Genet 2010;18:1054-1056
-
(2010)
Eur J Hum Genet
, vol.18
, pp. 1054-1056
-
-
Berulava, T.1
Horsthemke, B.2
-
29
-
-
58149302895
-
The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients
-
Zabena C, González-Sánchez JL, Martínez-Larrad MT, et al. The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients. Obes Surg 2009;19:87-95
-
(2009)
Obes Surg
, vol.19
, pp. 87-95
-
-
Zabena, C.1
González-Sánchez, J.L.2
Martínez-Larrad, M.T.3
-
30
-
-
77955261951
-
Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: Correlations with age or BMI of islet donors
-
Kirkpatrick CL, Marchetti P, Purrello F, et al. Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors. PLoS ONE 2010;5:e11053
-
(2010)
PLoS ONE
, vol.5
-
-
Kirkpatrick, C.L.1
Marchetti, P.2
Purrello, F.3
-
31
-
-
77957277779
-
Relationship between blood glucose levels and hepatic Fto mRNA expression in mice
-
Poritsanos NJ, Lew PS, Mizuno TM. Relationship between blood glucose levels and hepatic Fto mRNA expression in mice. Biochem Biophys Res Commun 2010;400:713-717
-
(2010)
Biochem Biophys Res Commun
, vol.400
, pp. 713-717
-
-
Poritsanos, N.J.1
Lew, P.S.2
Mizuno, T.M.3
-
32
-
-
78751542337
-
FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction
-
Bravard A, Lefai E, Meugnier E, et al. FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes 2011;60:258-268
-
(2011)
Diabetes
, vol.60
, pp. 258-268
-
-
Bravard, A.1
Lefai, E.2
Meugnier, E.3
-
33
-
-
76249098866
-
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3
-
Ragvin A, Moro E, Fredman D, et al. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci USA 2010;107:775-780
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 775-780
-
-
Ragvin, A.1
Moro, E.2
Fredman, D.3
-
34
-
-
42049117134
-
The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks
-
DOI 10.1210/jc.2007-2343
-
López-Bermejo A, Petry CJ, Díaz M, et al. The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks. J Clin Endocrinol Metab 2008;93:1501-1505 (Pubitemid 351519755)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, Issue.4
, pp. 1501-1505
-
-
Lopez-Bermejo, A.1
Petry, C.J.2
Diaz, M.3
Sebastiani, G.4
De Zegher, F.5
Dunger, D.B.6
Ibanez, L.7
-
35
-
-
65249108267
-
FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity
-
Hakanen M, Raitakari OT, Lehtimäki T, et al. FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab 2009;94:1281-1287
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1281-1287
-
-
Hakanen, M.1
Raitakari, O.T.2
Lehtimäki, T.3
-
36
-
-
77954517269
-
Associations between BMI and the FTO gene are age dependent: Results from the GINI and LISA birth cohort studies up to age 6 years
-
GINI and LISA Study Group
-
Rzehak P, Scherag A, Grallert H, et al.; GINI and LISA Study Group. Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years. Obes Facts 2010;3:173-180
-
(2010)
Obes Facts
, vol.3
, pp. 173-180
-
-
Rzehak, P.1
Scherag, A.2
Grallert, H.3
-
37
-
-
70350686380
-
Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity
-
Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfält E, Orho-Melander M. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr 2009;90:1418-1425
-
(2009)
Am J Clin Nutr
, vol.90
, pp. 1418-1425
-
-
Sonestedt, E.1
Roos, C.2
Gullberg, B.3
Ericson, U.4
Wirfält, E.5
Orho-Melander, M.6
-
38
-
-
67949120377
-
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
-
Vimaleswaran KS, Li S, Zhao JH, et al. Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr 2009;90:425-428
-
(2009)
Am J Clin Nutr
, vol.90
, pp. 425-428
-
-
Vimaleswaran, K.S.1
Li, S.2
Zhao, J.H.3
-
39
-
-
38449098674
-
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
-
Andreasen CH, Stender-Petersen KL, Mogensen MS, et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008;57:95-101
-
(2008)
Diabetes
, vol.57
, pp. 95-101
-
-
Andreasen, C.H.1
Stender-Petersen, K.L.2
Mogensen, M.S.3
|