CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak

Journal of Biological Chemistry

Volumn 288, Issue 32, 2013, Pages 22899-22914

  Kremer, Kimberly N ^a   Peterson, Kevin L ^b   Schneider, Paula A ^b   Meng, X Wei ^b   Dai, Haiming ^b   Hess, Allan D ^a   Smith, B Douglas ^a   Rodriguez Ramirez, Christie ^a   Karp, Judith E ^a   Kaufmann, Scott H ^b,c   Hedin, Karen E ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE MYELOID LEUKEMIA; BCL-2 FAMILY; BONE MARROW; CELL APOPTOSIS; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTORS; DOWN-REGULATION; UP-REGULATION;

CELL CULTURE; CELL DEATH;

CELL SIGNALING;

CASPASE 8; CHEMOKINE RECEPTOR CXCR4; CYTARABINE; LIPOCORTIN 5; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROCASPASE 9; PROTEIN BAK; PROTEIN BCL XL; PROTEIN NOXA; STROMAL CELL DERIVED FACTOR 1;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL MIGRATION; CELL SURVIVAL; CHROMATIN CONDENSATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UPREGULATION;

AML; APOPTOSIS; BCL-2 FAMILY PROTEINS; CANCER; CASPASE; CHEMOKINES; CXCL12; CXCR4; LEUKEMIA; SDF-1;

ANNEXIN A5; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; CELL SURVIVAL; CHEMOKINE CXCL12; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HEK293 CELLS; HUMANS; JURKAT CELLS; LEUKEMIA, MYELOID, ACUTE; MALE; MAP KINASE SIGNALING SYSTEM; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, CXCR4; U937 CELLS; UP-REGULATION;

EID: 84881398673     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.449926     Document Type: Article

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