Pertussis toxin, an inhibitor of Gαi PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Karimian, Golnar ^a   Buist Homan, Manon ^a   Faber, Klaas Nico ^a   Moshage, Han ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; CASPASE 3; DACTINOMYCIN; G PROTEIN COUPLED RECEPTOR; GLYCOCHENODEOXYCHOLIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROTECTION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEPATOMA CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LIVER CELL; LIVER CELL CARCINOMA; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN FUNCTION; RAT; TREATMENT RESPONSE;

ANIMALS; APOPTOSIS; BILE ACIDS AND SALTS; CASPASE 3; CYTOKINES; ENZYME ACTIVATION; GLYCOCHENODEOXYCHOLIC ACID; HEP G2 CELLS; HEPATOCYTES; HUMANS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; TIME FACTORS;

EID: 84865013126     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043156     Document Type: Article

References (44)

1. Guicciardi ME, Gores GJ, ((2010)) Apoptosis as a mechanism for liver disease progression. Semin Liver Dis 30(4):: 402--410.
2. Lemasters JJ, ((1999)) Necrapoptosis and the mitochondrial permeability transition: Shared pathways to necrosis and apoptosis. Am J Physiol 276(1 Pt 1):: G1--6.
3. Malhi H, Gores GJ, Lemasters JJ, ((2006)) Apoptosis and necrosis in the liver: A tale of two deaths. Hepatology 43(2 Suppl 1): S31--44.
4. Nagata S, Hanayama R, Kawane K, ((2010)) Autoimmunity and the clearance of dead cells. Cell 140(5):: 619--630.
5. Kimple AJ, Bosch DE, Giguere PM, Siderovski DP, ((2011)) Regulators of G-protein signaling and their Gα substrates: Promises and challenges in their use as drug discovery targets. Pharmacol Rev 63(3):: 728--749.
6. Lappano R, Maggiolini M, ((2011)) G protein-coupled receptors: Novel targets for drug discovery in cancer. Nat Rev Drug Discov 10(1):: 47--60.
7. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, et al. ((2003)) The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A 100(8):: 4903--4908.
8. Milligan G, Kostenis E, ((2006)) Heterotrimeric G-proteins: A short history. Br J Pharmacol 147 Suppl 1: S46--55.
9. Tamura M, Nogimori K, Murai S, Yajima M, Ito K, et al. ((1982)) Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. Biochemistry 21(22):: 5516--5522.
10. Katada T, Ui M, ((1982)) ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity. J Biol Chem 257(12):: 7210--7216.
11. Burns DL, ((1988)) Subunit structure and enzymic activity of pertussis toxin. Microbiol Sci 5(9):: 285--287.
12. James ND, Caty A, Payne H, Borre M, Zonnenberg BA, et al. ((2010)) Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration-resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: A double-blind, placebo-controlled, randomized phase II trial. BJU Int 106(7):: 966--973.
13. Cao R, Cronk ZX, Zha W, Sun L, Wang X, et al. ((2010)) Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway. J Lipid Res 51(8):: 2234--2244.
14. Dent P, Fang Y, Gupta S, Studer E, Mitchell C, et al. ((2005)) Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. Hepatology 42(6):: 1291--1299.
15. Han MS, Park SY, Shinzawa K, Kim S, Chung KW, et al. ((2008)) Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. J Lipid Res 49(1):: 84--97.
16. Gupta NA, Mells J, Dunham RM, Grakoui A, Handy J, et al. ((2010)) Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 51(5):: 1584--1592.
17. Moshage H, Casini A, Lieber C, ((1990)) Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes. Hepatology 12(3 Pt 1):: 511--8.
18. Schoemaker M, Conde de la Rosa L, Buist-Homan M, Vrenken T, Havinga R, et al. ((2004)) Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology 39(6):: 1563--73.
19. Kullak-Ublick GA, Ismair MG, Kubitz R, Schmitt M, Haussinger D, et al. ((2000)) Stable expression and functional characterization of a na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells. Cytotechnology 34(1-2):: 1--9.
20. Plass JR, Mol O, Heegsma J, Geuken M, Faber KN, et al. ((2002)) Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology 35(3):: 589--596.
21. Ros JE, Schuetz JD, Geuken M, Streetz K, Moshage H, et al. ((2001)) Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling. Hepatology 33(6):: 1425--1431.
22. Woudenberg-Vrenken TE, Buist-Homan M, Conde de la Rosa L, Faber KN, Moshage H, ((2010)) Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes. Liver Int 30(10):: 1511--1521.
23. Yang L, Camoratto AM, Baffy G, Raj S, Manning DR, et al. ((1993)) Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes. J Biol Chem 268(5):: 3739--3746.
24. Katada T, Ui M, ((1982)) Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc Natl Acad Sci U S A 79(10):: 3129--3133.
25. Schoemaker M, Ros J, Homan M, Trautwein C, Liston P, et al. ((2002)) Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis. J Hepatol 36(6):: 742--50.
26. Kukkonen JP, ((2011)) A menage a trois made in heaven: G-protein-coupled receptors, lipids and TRP channels. Cell Calcium 50(1):: 9--26.
27. Stein PE, Boodhoo A, Armstrong GD, Cockle SA, Klein MH, et al. ((1994)) The crystal structure of pertussis toxin. Structure 2(1):: 45--57.
28. Conde de la Rosa L, Schoemaker M, Vrenken T, Buist-Homan M, Havinga R, et al. ((2006)) Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: Involvement of JNK and ERK MAP kinases. J Hepatol 44(5):: 918--29.
29. Datta S, Dudek H, Tao X, Masters S, Fu H, et al. ((1997)) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91(2):: 231--41.
30. Gonzalez B, Fisher C, Rosser B, ((2000)) Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem 207(1-2):: 19--27.
31. Schoemaker M, Moshage H, ((2004)) Defying death: The hepatocyte's survival kit. Clin Sci (Lond) 107(1):: 13--25.
32. Waters C, Pyne S, Pyne NJ, ((2004)) The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. Semin Cell Dev Biol 15(3):: 309--323.
33. Schoemaker M, Gommans W, Conde de la Rosa L, Homan M, Klok P, et al. ((2003)) Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. J Hepatol 39(2):: 153--61.
34. Sola S, Aranha MM, Steer CJ, Rodrigues CM, ((2007)) Game and players: Mitochondrial apoptosis and the therapeutic potential of ursodeoxycholic acid. Curr Issues Mol Biol 9(2):: 123--138.
35. Reinehr R, Haussinger D, ((2009)) Epidermal growth factor receptor signaling in liver cell proliferation and apoptosis. Biol Chem 390(10):: 1033--1037.
36. Almendro V, Garcia-Recio S, Gascon P, ((2010)) Tyrosine kinase receptor transactivation associated to G protein-coupled receptors. Curr Drug Targets 11(9):: 1169--1180.
37. Yang LJ, Baffy G, Rhee SG, Manning D, Hansen CA, et al. ((1991)) Pertussis toxin-sensitive gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes. J Biol Chem 266(33):: 22451--22458.
38. Wang K, Shindoh H, Inoue T, Horii I, ((2002)) Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines. J Toxicol Sci 27(3):: 229--237.
39. Olsavsky KM, Page JL, Johnson MC, Zarbl H, Strom SC, et al. ((2007)) Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicol Appl Pharmacol 222(1):: 42--56.
40. Malhi H, Guicciardi ME, Gores GJ, ((2010)) Hepatocyte death: A clear and present danger. Physiol Rev 90(3):: 1165--1194.
41. Kramer L, ((2004)) Acute liver failure. Wien Klin Wochenschr 116(3):: 67--81.
42. Maiga A, Mourier G, Quinton L, Rouget C, Gales C, et al. (2011) G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors. Toxicon.
43. Gonzalez-Maeso J, ((2011)) GPCR oligomers in pharmacology and signaling. Mol Brain 4(1):: 20.
44. Muntane J, ((2011)) Targeting cell death and survival receptors in hepatocellular carcinoma. Anticancer Agents Med Chem 11(6):: 576--584.